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AGIO Overview

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0.000(0.000%)Aft-market
ET
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0.000
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ET
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Intellectia

Loading chart...

High
29.700
Open
29.580
VWAP
27.61
Vol
5.82M
Mkt Cap
2.06B
Low
26.050
Amount
160.76M
EV/EBITDA(TTM)
--
Total Shares
58.59M
EV
731.66M
EV/OCF(TTM)
--
P/S(TTM)
29.05
Agios Pharmaceuticals, Inc. is a biopharmaceutical company. The Company is focused on developing and delivering transformative therapies for patients living with rare diseases. It markets a first-in-class pyruvate kinase (PK) activator for adults with PK deficiency, the first disease-modifying therapy for debilitating hemolytic anemia. Its lead product candidate in its portfolio, PYRUKYND (mitapivat), is an activator of both wild-type and mutant pyruvate kinase, or PK, enzymes for the potential treatment of hemolytic anemias. It is also developing tebapivat, a novel PK activator, for the potential treatment of lower-risk myelodysplastic syndromes, or LR MDS, and hemolytic anemias; AG-181, its phenylalanine hydroxylase, or PAH, stabilizer for the potential treatment of phenylketonuria, or PKU; and AG-236, an siRNA in-licensed from Alnylam Pharmaceuticals, Inc., targeting the transmembrane serine protease 6, or TMPRSS6 gene for the potential treatment of polycythemia vera, or PV.
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Events Timeline

(ET)
2026-04-20
16:30:00
Major Averages Decline Amid Escalating Tensions with Iran
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2026-04-20
12:10:00
Agios Pharmaceuticals Stock Down 23.4% to $26.90
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2026-04-20
12:00:00
Major Averages Decline Amid Rising Tensions with Iran
select
2026-04-20
10:10:00
Agios Pharmaceuticals Stock Drops 23.7% to $26.82
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2026-04-20
08:40:00
Agios Pharmaceuticals Shares Drop 15% After Novo Nordisk Data
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2026-03-31 (ET)
2026-03-31
16:30:00
Dow Jones Index Rises 2.49% to 46,341.51
select

News

moomoo
4.0
03:20 AMmoomoo
AGIOS PHARMACEUTICALS INC: H.C. Wainwright Lowers Price Target from $65 to $50
  • Price Adjustment: The price of H.C. Wainwright's target for A.G.I.O. Pharmaceuticals has been reduced from $65 to $50.
  • Market Impact: This price cut may reflect changes in market conditions or company performance expectations.
stocktwits
9.5
04-20stocktwits
Novo's Successful Trial Impacts Agios Stock Performance
  • Novo Trial Success: Novo's Phase 3 trial of Etavopivat for sickle cell disease met both primary endpoints, significantly reducing painful vaso-occlusive crises and delaying the median time to first crisis by nearly four months, showcasing its competitive edge in the treatment landscape.
  • Agios Stock Decline: Following Novo's positive trial results, Agios Pharmaceuticals (AGIO) shares plummeted over 25% on Monday, snapping a five-day winning streak, raising concerns about its future competitiveness with AGIO trading around $27.
  • Competitive Pressure: Truist analyst noted that Novo's favorable data could exert pressure on Agios' stock, limiting its ability to rebound towards $40, although he remains optimistic about Mitapivat's potential in treating sickle cell disease.
  • Investor Sentiment Shift: Despite the sharp decline in AGIO shares, retail investor sentiment shifted to 'bullish', indicating confidence in AGIO as a long-term investment, reflecting the market's complex view on its future performance.
Fool
9.5
04-20Fool
Agios Pharmaceuticals Shares Plunge 23% Amid Competitive Drug News
  • Significant Stock Drop: Agios Pharmaceuticals' shares plummeted by 23% today, falling from $26.99 to $20.84, reflecting market concerns over its earnings potential amid competitive pressures from rival drugs.
  • Competitive Drug Success: Novo Nordisk's etavopivat successfully met both co-primary endpoints in the HIBISCUS phase 3 trial, demonstrating significant efficacy, which poses a direct threat to Agios' mitapavit and its market position.
  • Trial Results Comparison: While Agios' mitapavit showed improvements in hemoglobin levels for sickle cell disease patients, it failed to achieve statistically significant results in reducing pain crisis rates, further complicating its market outlook.
  • Extended FDA Approval Path: Agios is working with the FDA to align on the confirmatory clinical trial required for submission, but compared to Novo's advancements, its path to approval appears longer and more uncertain, potentially undermining investor confidence.
Newsfilter
7.0
04-01Newsfilter
Agios Pharmaceuticals Under Investigation Following Phase 3 Trial Results, Stock Plummets
  • Investigation Launched: Levi & Korsinsky has initiated an investigation into Agios Pharmaceuticals, Inc. regarding potential violations of federal securities laws, indicating serious concerns about the company's compliance practices.
  • Clinical Trial Results: On November 19, 2025, Agios reported that its RISE UP Phase 3 trial met one primary endpoint but failed to show statistically significant improvement in annualized pain crises, highlighting limitations in treatment efficacy.
  • Stock Price Reaction: Following the trial results, Agios' stock plummeted by $22.33 to open at $23.16, reflecting a significant decline in market confidence regarding the company's future prospects, which may impact its ability to raise capital.
  • Investor Impact: The investigation and stock drop could erode investor trust in Agios, further affecting its market performance and shareholder value, underscoring the company's inadequate risk management in clinical development.
Yahoo Finance
4.5
03-31Yahoo Finance
Health Care Stocks Rise 2% Boosting Market
  • Strong Performance in Health Care: Late Tuesday afternoon, the NYSE Health Care Index rose by 2%, indicating a rebound in investor confidence towards the health sector, likely driven by an overall improvement in market sentiment.
  • Signs of Market Recovery: The rise in health care stocks reflects optimistic expectations for economic recovery, particularly post-pandemic, as demand for health services continues to grow, potentially boosting the performance of related companies.
  • Increased Investor Attention: With the improved performance of the health care sector, investors may reassess their portfolios and increase allocations to health stocks, thereby driving further growth and stability in the industry.
  • Optimistic Industry Outlook: The strong performance in the health sector could attract more capital inflows, especially in the fields of innovative drugs and medical technologies, which are expected to provide momentum for future growth.
Fool
9.0
03-31Fool
Agios Pharmaceuticals Accelerates FDA Approval for Mitapivat
  • Accelerated FDA Approval: Agios Pharmaceuticals' recent meeting with the FDA has laid the groundwork for a proposal for a confirmatory clinical trial for mitapivat, with expectations to submit a request for accelerated full approval within the next few months, potentially expediting the drug's market entry for sickle cell disease treatment.
  • Significant Market Potential: The sickle cell disease therapy market, currently valued at approximately $4 billion, is projected to grow to over $14 billion by 2034, with mitapivat poised to expand market size by providing a much-needed effective treatment option.
  • Strong Clinical Trial Performance: Mitapivat has shown promising results in the RISE UP trials and is already approved for various forms of anemia, with the FDA's special regulatory consideration highlighting the urgent need for new therapies in the sickle cell disease space.
  • Positive Investor Reaction: Following the FDA's recommendation for a simplified confirmatory trial, Agios shares surged by 21.7%, indicating strong market optimism regarding the drug's prospects, despite the company's ongoing losses, suggesting potential for further stock price appreciation for risk-tolerant investors.
Wall Street analysts forecast AGIO stock price to rise
9 Analyst Rating
Wall Street analysts forecast AGIO stock price to rise
6 Buy
3 Hold
0 Sell
Moderate Buy
Current: 0.000
sliders
Low
25.00
Averages
36.14
High
62.00
Current: 0.000
sliders
Low
25.00
Averages
36.14
High
62.00
BofA
Alec Stranahan
Buy
to
Buy
downgrade
$44 -> $41
AI Analysis
2026-04-21
New
Reason
BofA
Alec Stranahan
Price Target
$44 -> $41
AI Analysis
2026-04-21
New
downgrade
Buy
to
Buy
Reason
BofA analyst Alec Stranahan lowered the firm's price target on Agios Pharmaceuticals (AGIO) to $41 from $44 and keeps a Buy rating on the shares. While the firm notes Agios plans to file for accelerated approval and has already submitted a confirmatory trial proposal with a new primary endpoint, it says the topline HIBISCUS data from Novo Nordisk's (NVO) etavopivat in sickle cell disease may increase the regulatory risk for Agios' mitapivat.
H.C. Wainwright
Emily Bodnar
Buy
downgrade
$65 -> $50
2026-04-20
New
Reason
H.C. Wainwright
Emily Bodnar
Price Target
$65 -> $50
2026-04-20
New
downgrade
Buy
Reason
H.C. Wainwright analyst Emily Bodnar lowered the firm's price target on Agios Pharmaceuticals (AGIO) to $50 from $65 and keeps a Buy rating on the shares. Novo Nordisk's (NVO) Phase 3 HIBISCUS trial hits both co-primary endpoints, which should ensure success in sickle cell disease, the analyst tells investors in a research note. Given that Novo's etavopivat hit on both endpoints, is administered once daily versus Agios' mitapivat twice-daily, and the company markets several drugs for reducing bleeding episodes in hemophilia A or B, H.C. Wainwright believes it could capture significantly more market share than Agios' mitapivat. It believes the HIBISCUS data will likely lower the market potential for mitapivat.
Unlock Full Analyst Thesis, Get the complete breakdown of rating reason for AGIO
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Valuation Metrics

The current forward P/E ratio for Agios Pharmaceuticals Inc (AGIO.O) is 2.47, compared to its 5-year average forward P/E of -1.49. For a more detailed relative valuation and DCF analysis to assess Agios Pharmaceuticals Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-1.49
Current PE
2.47
Overvalued PE
6.11
Undervalued PE
-9.08

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-1.93
Current EV/EBITDA
-1.37
Overvalued EV/EBITDA
-0.45
Undervalued EV/EBITDA
-3.42

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
76.19
Current PS
8.53
Overvalued PS
163.24
Undervalued PS
-10.86

Financials

AI Analysis
Annual
Quarterly

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Whales Holding AGIO

V
Vestal Point Capital, LP
Holding
AGIO
+12.47%
3M Return
T
TCG Crossover Management, LLC
Holding
AGIO
+12.38%
3M Return
E
Erste Asset Management GmbH
Holding
AGIO
+9.39%
3M Return
F
Frazier Life Sciences Management, LP
Holding
AGIO
+6.89%
3M Return
A
Armistice Capital LLC
Holding
AGIO
+4.77%
3M Return
S
SCS Capital Management LLC
Holding
AGIO
+3.96%
3M Return

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Frequently Asked Questions

What is Agios Pharmaceuticals Inc (AGIO) stock price today?

The current price of AGIO is 27.07 USD — it has decreased -22.97

What is Agios Pharmaceuticals Inc (AGIO)'s business?

Agios Pharmaceuticals, Inc. is a biopharmaceutical company. The Company is focused on developing and delivering transformative therapies for patients living with rare diseases. It markets a first-in-class pyruvate kinase (PK) activator for adults with PK deficiency, the first disease-modifying therapy for debilitating hemolytic anemia. Its lead product candidate in its portfolio, PYRUKYND (mitapivat), is an activator of both wild-type and mutant pyruvate kinase, or PK, enzymes for the potential treatment of hemolytic anemias. It is also developing tebapivat, a novel PK activator, for the potential treatment of lower-risk myelodysplastic syndromes, or LR MDS, and hemolytic anemias; AG-181, its phenylalanine hydroxylase, or PAH, stabilizer for the potential treatment of phenylketonuria, or PKU; and AG-236, an siRNA in-licensed from Alnylam Pharmaceuticals, Inc., targeting the transmembrane serine protease 6, or TMPRSS6 gene for the potential treatment of polycythemia vera, or PV.

What is the price predicton of AGIO Stock?

Wall Street analysts forecast AGIO stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for AGIO is36.14 USD with a low forecast of 25.00 USD and a high forecast of 62.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Agios Pharmaceuticals Inc (AGIO)'s revenue for the last quarter?

Agios Pharmaceuticals Inc revenue for the last quarter amounts to 19.97M USD, increased 86.09

What is Agios Pharmaceuticals Inc (AGIO)'s earnings per share (EPS) for the last quarter?

Agios Pharmaceuticals Inc. EPS for the last quarter amounts to -1.85 USD, increased 9.47

How many employees does Agios Pharmaceuticals Inc (AGIO). have?

Agios Pharmaceuticals Inc (AGIO) has 539 emplpoyees as of April 21 2026.

What is Agios Pharmaceuticals Inc (AGIO) market cap?

Today AGIO has the market capitalization of 2.06B USD.