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AGIO Overview

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ET
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Intellectia

Loading chart...

High
29.010
Open
27.790
VWAP
28.24
Vol
794.28K
Mkt Cap
1.66B
Low
27.710
Amount
22.43M
EV/EBITDA(TTM)
--
Total Shares
59.47M
EV
915.68M
EV/OCF(TTM)
--
P/S(TTM)
24.53
Agios Pharmaceuticals, Inc. is a biopharmaceutical company. The Company is focused on developing and delivering transformative therapies for patients living with rare diseases. It markets a first-in-class pyruvate kinase (PK) activator for adults with PK deficiency, the first disease-modifying therapy for debilitating hemolytic anemia. Its lead product candidate in its portfolio, PYRUKYND (mitapivat), is an activator of both wild-type and mutant pyruvate kinase, or PK, enzymes for the potential treatment of hemolytic anemias. It is also developing tebapivat, a novel PK activator, for the potential treatment of lower-risk myelodysplastic syndromes, or LR MDS, and hemolytic anemias; AG-181, its phenylalanine hydroxylase, or PAH, stabilizer for the potential treatment of phenylketonuria, or PKU; and AG-236, an siRNA in-licensed from Alnylam Pharmaceuticals, Inc., targeting the transmembrane serine protease 6, or TMPRSS6 gene for the potential treatment of polycythemia vera, or PV.
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Events Timeline

(ET)
2026-04-29
06:40:00
Agios Reports Q1 Revenue of $20.75M, Beating Consensus
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2026-04-20 (ET)
2026-04-20
16:30:00
Major Averages Decline Amid Escalating Tensions with Iran
select
2026-04-20
12:10:00
Agios Pharmaceuticals Stock Down 23.4% to $26.90
select
2026-04-20
12:00:00
Major Averages Decline Amid Rising Tensions with Iran
select
2026-04-20
10:10:00
Agios Pharmaceuticals Stock Drops 23.7% to $26.82
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2026-04-20
08:40:00
Agios Pharmaceuticals Shares Drop 15% After Novo Nordisk Data
select

News

Fool
9.5
05-02Fool
Agios Pharmaceuticals Shares Rise 11.2% Following Strong Earnings Report
  • Stock Surge: Agios Pharmaceuticals saw an 11.2% increase in shares this week, marking a positive turnaround for the year, reflecting market confidence in the company's future, particularly following the successful launch of Aqvesme.
  • Significant Sales Growth: Aqvesme's sales reached $20.7 million in Q1 2026, a substantial increase from $8.7 million in the same quarter of 2025, which not only boosts overall revenue but also establishes a solid foundation for future market demand.
  • New Drug Progress: Management confirmed alignment with the FDA, expecting to file for accelerated approval of mitapivat for sickle cell disease in Q2 2026, despite facing competition from Novo Nordisk, indicating strong market potential.
  • Optimistic Future Outlook: Management is optimistic about the Phase 2 trial results for tebapivat, expected in the first half of 2026 for MDS and the second half for SCD, which will provide new momentum for the company's growth trajectory.
Fool
9.5
04-29Fool
Agios Pharmaceuticals Shares Surge 13.11% After Earnings Report
  • Strong Earnings Report: Agios Pharmaceuticals reported a significant revenue increase from $8.7 million to $20.7 million year-over-year, demonstrating robust market performance for its new drug Aqvesme, highlighting the company's competitiveness in the anemia treatment sector.
  • Widening Net Loss: Despite revenue growth, Agios' net loss expanded from $89 million to over $99 million, with a loss per share of $1.69, which, while exceeding analyst expectations, indicates ongoing investment in research and development.
  • FDA Application Plans: Agios intends to submit a supplemental New Drug Application (sNDA) to the FDA this quarter for mitapivat to treat adult sickle cell disease, which, if approved, could further expand its market potential and enhance future revenue streams.
  • Positive Market Reaction: Following a strong U.S. launch of Aqvesme, Agios' stock surged over 13% during trading, reflecting investor confidence in the company's future growth and strong market recognition of its products.
NASDAQ.COM
9.5
04-29NASDAQ.COM
Agios Pharmaceuticals Reports $21 Million Revenue in Q1
  • Significant Revenue Growth: Agios Pharmaceuticals reported a revenue of $20.7 million in Q1, a 138% increase from $8.7 million in the same quarter last year, indicating strong market acceptance and sales potential for its new drug Aqvesme.
  • FDA Approval for New Drug: Mitapivat has received FDA approval for the treatment of two blood disorders, further solidifying Agios's market position in the hematology sector and laying the groundwork for future revenue growth.
  • Deepening Net Loss: Despite the revenue increase, Agios's net loss deepened to over $99 million in Q1, translating to a loss of $1.69 per share, which exceeded analyst expectations, yet the company remains optimistic about its future prospects.
  • Future Development Plans: Agios plans to submit a supplemental New Drug Application (sNDA) to the FDA this quarter for mitapivat's use in treating adult sickle cell disease, which, if successful, will further expand its market share and product line.
seekingalpha
9.5
04-29seekingalpha
Agios Pharmaceuticals Q1 2026 Earnings Call Highlights
  • Significant Revenue Growth: Agios Pharmaceuticals reported net revenues of $20.7 million in Q1 2026, reflecting a 138% year-over-year increase, indicating strong market performance and growth potential, particularly driven by the new product AQVESME.
  • Increase in AQVESME Prescriptions: As of March 31, the number of prescriptions for AQVESME reached 242, demonstrating early market acceptance in thalassemia treatment, which is expected to be a key driver of future growth for the company.
  • sNDA Submission Plans: The company plans to submit an sNDA for mitapivat in sickle cell disease to the FDA in Q2, aiming for accelerated approval, a strategic move that will help expand market share and enhance competitive positioning.
  • Cost Control Strategy: The CFO indicated that operating expenses for 2026 are expected to remain flat compared to 2025, demonstrating the company's commitment to strict cost management while expanding its business to ensure financial health and sustainable growth.
seekingalpha
9.5
04-29seekingalpha
Agios Pharmaceuticals Q1 2026 Earnings Highlights
  • Earnings Beat: Agios Pharmaceuticals reported a Q1 2026 GAAP EPS of -$1.69, beating estimates by $0.11, indicating an improvement in financial performance.
  • Significant Revenue Growth: The company achieved revenues of $20.75 million, a 137.7% year-over-year increase, surpassing market expectations by $7.41 million, reflecting strong product sales and market demand.
  • Cash Reserves Update: As of March 31, 2026, Agios reported cash, cash equivalents, and marketable securities totaling $1.0 billion, down from $1.2 billion as of December 31, 2025, highlighting expenditures in investments and operations.
  • Future Outlook: Agios anticipates that its cash reserves will support the U.S. launch of AQVESME for thalassemia, prepare for mitapivat in sickle cell disease, advance clinical programs, and expand its pipeline, demonstrating confidence in future growth.
Newsfilter
9.5
04-29Newsfilter
Agios Pharmaceuticals Reports Strong Q1 2026 Financial Results and Strategic Updates
  • Significant Revenue Growth: In Q1 2026, Mitapivat (PYRUKYND® and AQVESME™) generated worldwide net revenues of $20.7 million, a remarkable 137% increase from $8.7 million in Q1 2025, indicating strong performance in the rare disease market.
  • Successful U.S. Launch: As of March 31, 2026, 242 prescriptions for AQVESME in thalassemia were written, reflecting active engagement from both physicians and patients, which further solidifies Agios's market position in this therapeutic area.
  • Accelerated R&D Progress: The company plans to submit a supplemental New Drug Application (sNDA) for Mitapivat in sickle cell disease in Q2 2026, which will expedite its product launch in the U.S. market to address unmet medical needs.
  • Strong Financial Position: As of March 31, 2026, Agios reported $1.0 billion in cash and cash equivalents, providing sufficient resources to support its commercialization strategies and R&D activities, ensuring ongoing growth and innovation in the rare disease sector.
Wall Street analysts forecast AGIO stock price to rise
9 Analyst Rating
Wall Street analysts forecast AGIO stock price to rise
6 Buy
3 Hold
0 Sell
Moderate Buy
Current: 0.000
sliders
Low
25.00
Averages
36.14
High
62.00
Current: 0.000
sliders
Low
25.00
Averages
36.14
High
62.00
Truist
Buy
downgrade
$39 -> $36
AI Analysis
2026-04-30
Reason
Truist
Price Target
$39 -> $36
AI Analysis
2026-04-30
downgrade
Buy
Reason
Truist lowered the firm's price target on Agios Pharmaceuticals to $36 from $39 and keeps a Buy rating on the shares. The company's Q1 earnings included a more rapid than anticipated launch for Aqvesme, which comes as a welcome surprise to the firm, the analyst tells investors in a research note.
BofA
Alec Stranahan
Buy
to
Buy
downgrade
$44 -> $41
2026-04-21
Reason
BofA
Alec Stranahan
Price Target
$44 -> $41
2026-04-21
downgrade
Buy
to
Buy
Reason
BofA analyst Alec Stranahan lowered the firm's price target on Agios Pharmaceuticals (AGIO) to $41 from $44 and keeps a Buy rating on the shares. While the firm notes Agios plans to file for accelerated approval and has already submitted a confirmatory trial proposal with a new primary endpoint, it says the topline HIBISCUS data from Novo Nordisk's (NVO) etavopivat in sickle cell disease may increase the regulatory risk for Agios' mitapivat.
Unlock Full Analyst Thesis, Get the complete breakdown of rating reason for AGIO
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Valuation Metrics

The current forward P/E ratio for Agios Pharmaceuticals Inc (AGIO.O) is 2.47, compared to its 5-year average forward P/E of -1.36. For a more detailed relative valuation and DCF analysis to assess Agios Pharmaceuticals Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-1.36
Current PE
2.47
Overvalued PE
6.21
Undervalued PE
-8.93

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-1.87
Current EV/EBITDA
-1.14
Overvalued EV/EBITDA
-0.51
Undervalued EV/EBITDA
-3.23

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
71.90
Current PS
6.30
Overvalued PS
152.44
Undervalued PS
-8.63

Financials

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Whales Holding AGIO

T
TCG Crossover Management, LLC
Holding
AGIO
+11.42%
3M Return
V
Vestal Point Capital, LP
Holding
AGIO
+10.67%
3M Return
F
Farallon Capital Management, L.L.C.
Holding
AGIO
+9.48%
3M Return
E
Erste Asset Management GmbH
Holding
AGIO
+8.11%
3M Return
F
Frazier Life Sciences Management, LP
Holding
AGIO
+7.23%
3M Return
A
Armistice Capital LLC
Holding
AGIO
+5.94%
3M Return

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Frequently Asked Questions

What is Agios Pharmaceuticals Inc (AGIO) stock price today?

The current price of AGIO is 27.99 USD — it has increased 0.72

What is Agios Pharmaceuticals Inc (AGIO)'s business?

Agios Pharmaceuticals, Inc. is a biopharmaceutical company. The Company is focused on developing and delivering transformative therapies for patients living with rare diseases. It markets a first-in-class pyruvate kinase (PK) activator for adults with PK deficiency, the first disease-modifying therapy for debilitating hemolytic anemia. Its lead product candidate in its portfolio, PYRUKYND (mitapivat), is an activator of both wild-type and mutant pyruvate kinase, or PK, enzymes for the potential treatment of hemolytic anemias. It is also developing tebapivat, a novel PK activator, for the potential treatment of lower-risk myelodysplastic syndromes, or LR MDS, and hemolytic anemias; AG-181, its phenylalanine hydroxylase, or PAH, stabilizer for the potential treatment of phenylketonuria, or PKU; and AG-236, an siRNA in-licensed from Alnylam Pharmaceuticals, Inc., targeting the transmembrane serine protease 6, or TMPRSS6 gene for the potential treatment of polycythemia vera, or PV.

What is the price predicton of AGIO Stock?

Wall Street analysts forecast AGIO stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for AGIO is36.14 USD with a low forecast of 25.00 USD and a high forecast of 62.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Agios Pharmaceuticals Inc (AGIO)'s revenue for the last quarter?

Agios Pharmaceuticals Inc revenue for the last quarter amounts to 20.75M USD, increased 137.75

What is Agios Pharmaceuticals Inc (AGIO)'s earnings per share (EPS) for the last quarter?

Agios Pharmaceuticals Inc. EPS for the last quarter amounts to -1.69 USD, increased 9.03

How many employees does Agios Pharmaceuticals Inc (AGIO). have?

Agios Pharmaceuticals Inc (AGIO) has 539 emplpoyees as of May 12 2026.

What is Agios Pharmaceuticals Inc (AGIO) market cap?

Today AGIO has the market capitalization of 1.66B USD.