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AGIO Overview

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$
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0.000(0.000%)
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0.000(0.000%)Aft-market
ET
$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
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Intellectia

Loading chart...

High
34.450
Open
33.900
VWAP
34.04
Vol
2.24M
Mkt Cap
2.03B
Low
33.500
Amount
76.30M
EV/EBITDA(TTM)
--
Total Shares
59.47M
EV
1.29B
EV/OCF(TTM)
--
P/S(TTM)
30.15
Agios Pharmaceuticals, Inc. is a biopharmaceutical company. The Company is focused on developing and delivering transformative therapies for patients living with rare diseases. It markets a first-in-class pyruvate kinase (PK) activator for adults with PK deficiency, the first disease-modifying therapy for debilitating hemolytic anemia. Its lead product candidate in its portfolio, PYRUKYND (mitapivat), is an activator of both wild-type and mutant pyruvate kinase, or PK, enzymes for the potential treatment of hemolytic anemias. It is also developing tebapivat, a novel PK activator, for the potential treatment of lower-risk myelodysplastic syndromes, or LR MDS, and hemolytic anemias; AG-181, its phenylalanine hydroxylase, or PAH, stabilizer for the potential treatment of phenylketonuria, or PKU; and AG-236, an siRNA in-licensed from Alnylam Pharmaceuticals, Inc., targeting the transmembrane serine protease 6, or TMPRSS6 gene for the potential treatment of polycythemia vera, or PV.
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Events Timeline

(ET)
2026-06-14
17:00:00
Agios Pharmaceuticals Presents Mitapivat Phase 3 Trial Results
select
2026-06-01 (ET)
2026-06-01
05:10:00
Agios Pharmaceuticals Signs Exclusive Licensing Agreement with Oscotec
select
2026-05-22 (ET)
2026-05-22
10:30:00
Agios Pharmaceuticals Receives EU Approval for PYRUKYND for Anemia Treatment
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2026-05-12 (ET)
2026-05-12
09:50:00
Agios Pharmaceuticals to Present New Data on Mitapivat at European Hematology Congress
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2026-05-12
09:40:00
Agios Submits Supplemental NDA for Mitapivat Accelerated Approval
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News

Newsfilter
9.0
06-13Newsfilter
Mitapivat Shows Significant Hemoglobin Improvement in Sickle Cell Disease
  • Significant Efficacy Improvement: In the 52-week RISE UP Phase 3 trial, mitapivat demonstrated a statistically significant improvement in hemoglobin response, with 40.6% of patients achieving a ≥1.0 g/dL increase compared to placebo, highlighting its potential in treating sickle cell disease.
  • Reduction in Transfusion Burden: New analyses revealed a 41.1% reduction in the proportion of patients requiring blood transfusions in the mitapivat group, alongside a 55.9% decrease in average red blood cell units transfused per patient, which not only alleviates treatment burden but may also reduce dependence on supportive care.
  • Clinically Meaningful Benefits: Among hemoglobin responders in the mitapivat group, there was a 26% reduction in the annualized rate of sickle cell pain crises and a 34% decrease in related hospitalizations, along with a 53% reduction in emergency room visits, indicating significant improvements in patient quality of life.
  • Well-Tolerated Safety Profile: Mitapivat exhibited a safety profile consistent with previous trials, with similar rates of treatment-emergent adverse events between the mitapivat and placebo groups, demonstrating its good tolerability in patients with sickle cell disease.
NASDAQ.COM
7.5
06-01NASDAQ.COM
Agios Pharmaceuticals Enters Exclusive License Agreement with Oscotec for Cevidoplenib
  • Exclusive License Agreement: Agios Pharmaceuticals has entered into a worldwide exclusive license agreement with Oscotec to develop and commercialize Cevidoplenib, a next-generation SYK inhibitor aimed at blocking signaling pathways in immune-mediated diseases, particularly immune thrombocytopenia (ITP).
  • Clinical Data Support: Cevidoplenib has demonstrated clinically meaningful results in Phase 2 trials, successfully improving platelet counts while maintaining a manageable safety profile, positioning it as a potential best-in-class treatment for ITP.
  • Financial Terms: Under the agreement, Oscotec will receive an upfront payment of $25 million, along with up to $140 million in development, regulatory, and commercial milestone payments, plus tiered royalties on net sales, which will support Agios's capital allocation strategy.
  • Future Development Plans: Agios plans to advance Cevidoplenib into Phase 3 development for ITP in the first half of 2028, further expanding its rare hematology portfolio, reflecting the company's strategic focus on rare diseases.
Newsfilter
8.5
06-01Newsfilter
Agios Secures Exclusive Global Rights to Novel SYK Inhibitor
  • Exclusive Global Rights: Agios has entered into an agreement with Oscotec to obtain exclusive global rights to develop and commercialize cevidoplenib, a novel oral SYK inhibitor, which is expected to unlock up to $1 billion in peak U.S. sales potential, significantly enhancing its rare hematology portfolio.
  • Upfront and Milestone Payments: Oscotec will receive a $25 million upfront payment and is eligible for up to $140 million in future payments tied to development, regulatory, and commercial milestones, incentivizing collaboration in the drug development process.
  • Clinical Trial Progress: Cevidoplenib demonstrated good tolerability in a global 12-week Phase 2 trial, where, despite not achieving statistical significance on the primary endpoint, clinically meaningful platelet responses were observed on multiple secondary endpoints, with plans to advance to Phase 3 development in the first half of 2028.
  • Strategic Focus and Investment: Agios' CEO noted that this licensing agreement is a natural extension of their therapeutic focus and expertise, aiming to address the urgent need for new treatment options for ITP patients while maintaining a strong focus on executing their 2026 strategic priorities.
NASDAQ.COM
8.5
05-29NASDAQ.COM
Regulatory Approvals and Collaborations in Biotech Sector
  • FDA Approval for AZN: AstraZeneca (AZN) secured FDA approval for the IMFINZI + BCG combination in high-risk non-muscle-invasive bladder cancer, supported by Phase 3 POTOMAC data showing a 32% reduction in recurrence or death, enhancing its competitive edge in oncology.
  • JNJ TREMFYA Label Expansion: Johnson & Johnson (JNJ) received FDA approval to add structural joint-damage inhibition data to the TREMFYA label for active psoriatic arthritis, confirming its unique position in first-line treatment with no new safety signals, reinforcing its market leadership.
  • LINZESS Approved for Children: Ironwood Pharmaceuticals (IRWD) gained FDA approval for LINZESS to treat functional constipation in children aged 2-5, based on a 12-week Phase 3 trial showing significant improvement in spontaneous bowel movements, expanding its pediatric market influence.
  • AbbVie's DECNUPAZ Approval: AbbVie (ABBV) received FDA approval for DECNUPAZ to treat ultra-rare blood cancer BPDCN, supported by Phase 1 data showing a 69.7% composite complete response rate and a median duration of 9.7 months, marking a significant innovation in hematologic oncology.
seekingalpha
2.0
05-29seekingalpha
Agios Pharmaceuticals Halts Blood Cancer Treatment Trials
  • Study Discontinuation: Agios Pharmaceuticals announced the discontinuation of studies for a treatment targeting myelodysplastic syndromes, resulting in a ~6% drop in premarket trading, indicating a strategic shift in the company's focus.
  • Disappointing Trial Results: The 24-week dose-finding trial did not meet the predefined target for transfusion independence, reflecting insufficient efficacy of the treatment and impacting the company's future research direction.
  • Safety Profile Maintained: Despite the unsatisfactory trial outcomes, Agios reported that the oral pyruvate kinase activator was well-tolerated across multiple dose levels with no new safety signals, suggesting potential for use in other indications.
  • Future Research Plans: Agios is conducting another Phase 2 trial for sickle cell disease, with topline data expected in H2 2026, demonstrating the company's ongoing commitment to exploring alternative treatment avenues for growth.
Newsfilter
9.0
05-29Newsfilter
Agios Halts Development of LR-MDS Drug Tebapivat
  • Clinical Trial Results: Agios announced that its drug tebapivat for lower-risk myelodysplastic syndromes (LR-MDS) did not meet the predefined clinical advancement threshold in the Phase 2b trial, which, while showing biological activity, failed to demonstrate clinical benefit in a sufficient proportion of patients, leading to the decision to halt further development.
  • Patient Population Characteristics: The trial enrolled 65 patients with LR-MDS, evaluating different doses (10mg, 15mg, 20mg) of tebapivat in a heavily pretreated and heterogeneous population, highlighting the biological complexity of the disease and the challenges in identifying patients likely to benefit.
  • Safety Assessment: Although tebapivat was well tolerated across all dose levels with no new safety signals identified, the lack of observed clinical benefit necessitated Agios's decision to discontinue further development in LR-MDS.
  • Future Outlook: Agios remains optimistic about tebapivat's potential in sickle cell disease, with topline data from the Phase 2 trial expected in the second half of 2026, continuing to explore its applications in other rare hematologic diseases.
Wall Street analysts forecast AGIO stock price to rise
9 Analyst Rating
Wall Street analysts forecast AGIO stock price to rise
6 Buy
3 Hold
0 Sell
Moderate Buy
Current: 0.000
sliders
Low
25.00
Averages
36.14
High
62.00
Current: 0.000
sliders
Low
25.00
Averages
36.14
High
62.00
H.C. Wainwright
H.C. Wainwright
Buy
maintain
$50 -> $54
AI Analysis
2026-06-15
Reason
H.C. Wainwright
H.C. Wainwright
Price Target
$50 -> $54
AI Analysis
2026-06-15
maintain
Buy
Reason
H.C. Wainwright raised the firm's price target on Agios Pharmaceuticals to $54 from $50 and keeps a Buy rating on the shares. The company over the weekend presented numerous abstracts, showing mitapivat reduced the transfusion burden in sickle cell disease, supporting the confirmatory trial design. The firm also added cevidoplenib to Agios' model following the company's license of the SYK inhibitor for the treatment of immune thrombocytopenia.
BofA
Buy
maintain
$41 -> $40
2026-05-29
Reason
BofA
Price Target
$41 -> $40
2026-05-29
maintain
Buy
Reason
BofA lowered the firm's price target on Agios Pharmaceuticals to $40 from $41 and keeps a Buy rating on the shares after the company announced tebapivat will not advance in lower-risk myelodysplastic syndromes after the Phase 2b study failed to meet the company's predefined threshold for further development. This removes a pipeline option, but the firm does not see it meaningfully changing the core Agios debate, which it sees remaining centered on mitapivat thalassemia launch execution and the sickle cell disease regulatory path.
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Valuation Metrics

The current forward P/E ratio for Agios Pharmaceuticals Inc (AGIO.O) is 2.47, compared to its 5-year average forward P/E of -1.09. For a more detailed relative valuation and DCF analysis to assess Agios Pharmaceuticals Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-1.09
Current PE
2.47
Overvalued PE
6.39
Undervalued PE
-8.57

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-1.78
Current EV/EBITDA
-1.44
Overvalued EV/EBITDA
-0.51
Undervalued EV/EBITDA
-3.06

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
62.81
Current PS
7.91
Overvalued PS
125.73
Undervalued PS
-0.11

Financials

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Whales Holding AGIO

R
Rock Springs Capital Management LP
Holding
AGIO
+18.31%
3M Return
A
Armistice Capital LLC
Holding
AGIO
+17.03%
3M Return
F
Farallon Capital Management, L.L.C.
Holding
AGIO
+12.80%
3M Return
E
Erste Asset Management GmbH
Holding
AGIO
+11.23%
3M Return
T
TCG Crossover Management, LLC
Holding
AGIO
+7.00%
3M Return
V
Vestal Point Capital, LP
Holding
AGIO
+2.78%
3M Return

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Frequently Asked Questions

What is Agios Pharmaceuticals Inc (AGIO) stock price today?

The current price of AGIO is 34.16 USD — it has increased 3.26

What is Agios Pharmaceuticals Inc (AGIO)'s business?

Agios Pharmaceuticals, Inc. is a biopharmaceutical company. The Company is focused on developing and delivering transformative therapies for patients living with rare diseases. It markets a first-in-class pyruvate kinase (PK) activator for adults with PK deficiency, the first disease-modifying therapy for debilitating hemolytic anemia. Its lead product candidate in its portfolio, PYRUKYND (mitapivat), is an activator of both wild-type and mutant pyruvate kinase, or PK, enzymes for the potential treatment of hemolytic anemias. It is also developing tebapivat, a novel PK activator, for the potential treatment of lower-risk myelodysplastic syndromes, or LR MDS, and hemolytic anemias; AG-181, its phenylalanine hydroxylase, or PAH, stabilizer for the potential treatment of phenylketonuria, or PKU; and AG-236, an siRNA in-licensed from Alnylam Pharmaceuticals, Inc., targeting the transmembrane serine protease 6, or TMPRSS6 gene for the potential treatment of polycythemia vera, or PV.

What is the price predicton of AGIO Stock?

Wall Street analysts forecast AGIO stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for AGIO is36.14 USD with a low forecast of 25.00 USD and a high forecast of 62.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Agios Pharmaceuticals Inc (AGIO)'s revenue for the last quarter?

Agios Pharmaceuticals Inc revenue for the last quarter amounts to 20.75M USD, increased 137.75

What is Agios Pharmaceuticals Inc (AGIO)'s earnings per share (EPS) for the last quarter?

Agios Pharmaceuticals Inc. EPS for the last quarter amounts to -1.69 USD, increased 9.03

How many employees does Agios Pharmaceuticals Inc (AGIO). have?

Agios Pharmaceuticals Inc (AGIO) has 539 emplpoyees as of June 21 2026.

What is Agios Pharmaceuticals Inc (AGIO) market cap?

Today AGIO has the market capitalization of 2.03B USD.