Krystal Biotech Projects $389M Revenue for VYJUVEK in 2025
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Jan 12 2026
0mins
Source: NASDAQ.COM
- Strong Financial Performance: Krystal Biotech anticipates fourth-quarter net product revenue for VYJUVEK to be between $106 million and $107 million, with full-year revenue projected at $388 million to $389 million, highlighting its market potential in rare disease therapies.
- Robust Cash Reserves: As of December 31, 2025, Krystal reported approximately $955 million in cash, cash equivalents, and investments, providing strong financial support for future R&D and market expansion initiatives.
- Clinical Trial Expansion: To expedite the development of KB801, Krystal has expanded enrollment in its ongoing registrational study from 27 to 60 patients, with top-line data expected before year-end 2026, demonstrating the company's proactive approach in rare disease drug development.
- Long-term Strategic Goals: Krystal aims to have at least four marketed rare disease medicines, including VYJUVEK, by 2030, reaching over 10,000 patients globally, reflecting its strong commitment to addressing the unmet needs of over 300 million people living with rare diseases worldwide.
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Analyst Views on KRYS
Wall Street analysts forecast KRYS stock price to fall over the next 12 months. According to Wall Street analysts, the average 1-year price target for KRYS is 229.25 USD with a low forecast of 198.00 USD and a high forecast of 278.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
9 Analyst Rating
8 Buy
1 Hold
0 Sell
Strong Buy
Current: 272.910
Low
198.00
Averages
229.25
High
278.00
Current: 272.910
Low
198.00
Averages
229.25
High
278.00
About KRYS
Krystal Biotech, Inc. is an integrated, commercial-stage biotechnology company. The Company is focused on the discovery, development, and commercialization of genetic medicines to treat diseases with high unmet medical needs. Its product candidates in various stages of clinical and preclinical development include KB407, KB408, KB707, KB105, KB801, KB803, KB304 and KB301. Its commercial product, VYJUVEK, is a redosable gene therapy, and a genetic medicine approved in the United States and Europe for the treatment of dystrophic epidermolysis bullosa. KB407 is being developed for the treatment of Cystic Fibrosis. KB408 is being developed for the treatment of Alpha-1 Antitrypsin Deficiency, a rare lung disease. KB707 is being developed for the treatment of solid tumors. KB105 is being developed for TGM1-Deficient Autosomal Recessive Congenital Ichthyosis. KB803 is a redosable eye drop formulation of B-VEC, designed for the treatment of ocular complications.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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