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KRYS Overview

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$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
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Intellectia

Loading chart...

High
278.860
Open
274.370
VWAP
275.79
Vol
210.39K
Mkt Cap
8.14B
Low
272.000
Amount
58.02M
EV/EBITDA(TTM)
43.41
Total Shares
29.44M
EV
7.24B
EV/OCF(TTM)
36.06
P/S(TTM)
21.10
Krystal Biotech, Inc. is an integrated, commercial-stage biotechnology company. The Company is focused on the discovery, development, and commercialization of genetic medicines to treat diseases with high unmet medical needs. Its product candidates in various stages of clinical and preclinical development include KB407, KB408, KB707, KB105, KB801, KB803, KB304 and KB301. Its commercial product, VYJUVEK, is a redosable gene therapy, and a genetic medicine approved in the United States and Europe for the treatment of dystrophic epidermolysis bullosa. KB407 is being developed for the treatment of Cystic Fibrosis. KB408 is being developed for the treatment of Alpha-1 Antitrypsin Deficiency, a rare lung disease. KB707 is being developed for the treatment of solid tumors. KB105 is being developed for TGM1-Deficient Autosomal Recessive Congenital Ichthyosis. KB803 is a redosable eye drop formulation of B-VEC, designed for the treatment of ocular complications.
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Events Timeline

(ET)
2026-02-17
07:10:00
Krystal Biotech Q4 Revenue $107.1M Beats Expectations
select
2026-02-17
07:10:00
Krystal Biotech Sees FY26 Non-GAAP R&D, SG&A Expense $175M-$195M
select
2026-02-09 (ET)
2026-02-09
08:10:00
Krystal Biotech's KB707 Receives FDA Regenerative Medicine Advanced Therapy Designation
select

News

NASDAQ.COM
5.0
04-16NASDAQ.COM
Three Biotech Companies Worth Watching
  • Krystal Biotech's Breakthrough: In 2023, Krystal Biotech received approval for Vyjuvek, a gene therapy for Dystrophic Epidermolysis Bullosa, achieving $389.1 million in revenue, a 34% year-over-year increase, indicating strong market potential in rare diseases.
  • Madrigal Pharmaceuticals' FDA Approval: In 2024, Madrigal gained FDA approval for Rezdiffra, the first drug for metabolic dysfunction-associated steatohepatitis, with 2025 revenue reaching $958.4 million, a staggering 432% increase, showcasing robust growth in an emerging market.
  • Exelixis' Oncology Innovations: Exelixis' Cabometyx remains the leading treatment for liver and kidney cancers, with no generic competition expected until 2030, while the company plans to launch several next-gen cancer therapies in the next five years, further solidifying its market position.
  • Significant Market Potential: The combination of innovation and market demand in these three companies suggests that their stocks could yield substantial returns in the future, particularly in the ongoing developments within rare diseases and oncology.
Fool
2.0
04-16Fool
Three Biotech Stocks Worth Watching
  • Krystal Biotech's Breakthrough: Focused on rare diseases, Krystal Biotech received approval for Vyjuvek, a gene therapy for Dystrophic Epidermolysis Bullosa, achieving $389.1 million in revenue in 2023, a 34% year-over-year increase, indicating strong market performance.
  • Madrigal Pharmaceuticals' Market Potential: Madrigal's Rezdiffra, approved by the FDA in 2024 as the first treatment for metabolic dysfunction-associated steatohepatitis, generated $958.4 million in revenue in 2025, a staggering 432% increase, showcasing its potential in a large patient market.
  • Exelixis' Innovative Drugs: Exelixis' Cabometyx, a leading treatment for liver and kidney cancers, is expected to face no generic competition until 2030, while its development of next-gen cancer therapies could further drive growth in the coming years.
  • Competitive Advantages: These three companies demonstrate significant market potential and innovation capabilities, with Krystal Biotech and Madrigal expanding their product lines to enhance market share, while Exelixis maintains a strong position in oncology through robust financial performance and R&D efforts.
Fool
7.5
04-16Fool
Vertex Pharmaceuticals Faces Challenges in Cystic Fibrosis Market Dominance
  • Market Dominance: Over the past decade, Vertex Pharmaceuticals has delivered market-beating returns primarily due to its monopoly in the cystic fibrosis drug market, which provides stable revenue but also exposes the company to threats from new entrants.
  • Competitive Drug Development: Krystal Biotech's KB407 gene therapy has shown promising results in phase 1 studies, targeting all cystic fibrosis patients, while Vertex's drugs only address specific mutations, potentially leading to a loss of market share for Vertex.
  • Diversification Strategy: To counter potential competition, Vertex has actively diversified its product lineup over the past three years, launching new drugs like Casgevy for sickle cell disease and Journavx for acute pain, with expectations for more approvals in the coming years.
  • Strong Financial Performance: Despite facing competitive risks, Vertex is expected to continue delivering strong financial results, with its core products protected by patents until the late 2030s, making its stock still attractive for investors.
NASDAQ.COM
7.5
04-16NASDAQ.COM
Vertex Pharmaceuticals Faces Competitive Threats
  • Market Competition Risk: Vertex Pharmaceuticals faces significant threats as companies like Krystal Biotech develop new cystic fibrosis drugs, particularly KB407, which has the potential to treat all CF patients and could lead to Vertex losing market share for 95% of U.S. patients.
  • Core Business Security: Despite the competitive landscape, Vertex's core franchise appears secure for the foreseeable future, primarily due to its monopoly in the cystic fibrosis drug market, with key products protected by patents until the late 2030s.
  • Product Diversification Strategy: Vertex is actively pursuing diversification of its product lineup, having launched new drugs like Casgevy and Journavx over the past three years, and is expected to gain additional approvals in the coming years, enhancing its competitive edge.
  • R&D Progress: Vertex recently reported strong phase 3 results for povetacicept, an investigational drug for IgA nephropathy, and plans to announce more phase 3 results by year-end, potentially leading to regulatory approvals for treatments targeting APOL1-mediated kidney disease, further solidifying its market position.
Fool
8.5
04-07Fool
Krystal Biotech Shares Surge Over 230% Since 2021
  • Innovative Drug Approval: In 2023, Krystal Biotech received FDA approval for Vyjuvek, a gene therapy for Dystrophic Epidermolysis Bullosa (DEB), marking it as the first approved treatment for this condition, showcasing the company's strength in drug innovation.
  • Significant Sales Growth: In 2025, Krystal Biotech's revenue increased by 34% year-over-year to $389.1 million, and the company achieved profitability with earnings per share of $6.84 in 2024, indicating strong performance and pricing power in the DEB market.
  • Huge Market Potential: The company targets approximately 1,200 DEB patients in the U.S. and around 1,300 in Japan and some European nations, with unmet market needs suggesting significant opportunities for further market share expansion through new product launches.
  • Long-Term Uncertainty: Despite strong performance in the DEB sector, Krystal Biotech faces potential competition and clinical or regulatory risks, making its ability to sustain growth uncertain, thus investors should carefully assess its long-term investment value.
Yahoo Finance
8.5
04-07Yahoo Finance
Krystal Biotech Shares Surge Over 230% Since 2021
  • Strong Market Performance: Krystal Biotech's stock has surged over 230% since 2021, and despite having only one marketed product, its promising drug pipeline indicates significant growth potential, positioning it as a key player in the biotech sector.
  • Innovative Therapy Approval: In 2023, Krystal Biotech received FDA approval for Vyjuvek, the first gene therapy for Dystrophic Epidermolysis Bullosa (DEB), addressing a critical unmet need in the market and further solidifying the company's market position.
  • Solid Financial Performance: In 2025, the company reported a 34% year-over-year revenue increase to $389.1 million, with earnings per share at $6.84, showcasing a rare achievement of profitability in the biotech space, which boosts investor confidence.
  • Future Growth Potential: Krystal Biotech's pipeline includes candidates for cystic fibrosis and alpha-1 antitrypsin deficiency lung disease, and if successful in launching new products, it could significantly enhance sales and profits, driving sustained growth over the next two decades.
Wall Street analysts forecast KRYS stock price to rise
9 Analyst Rating
Wall Street analysts forecast KRYS stock price to rise
8 Buy
1 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
198.00
Averages
229.25
High
278.00
Current: 0.000
sliders
Low
198.00
Averages
229.25
High
278.00
Wolfe Research
Peer Perform
initiated
AI Analysis
2026-03-26
Reason
Wolfe Research
Price Target
AI Analysis
2026-03-26
initiated
Peer Perform
Reason
Wolfe Research initiated coverage of Krystal Biotech with a Peer Perform rating and no price target. Krystal is "performing well" commercially with Vyjuvek and the firm thinks shares are fairly valued, but it adds that it is "cautiously optimistic" heading into the company's key catalysts this year that include KB801/803 in eye conditions and KB407 in cystic fibrosis.
BofA
analyst
Buy
maintain
$318 -> $325
2026-03-24
Reason
BofA
analyst
Price Target
$318 -> $325
2026-03-24
maintain
Buy
Reason
BofA raised the firm's price target on Krystal Biotech to $325 from $318 and keeps a Buy rating on the shares. The firm increased Vyjuvek expectations, removed KB104 and KB105 builds and added a Hailey-Hailey disease build, with its updates resulting in changes to its per share contributions from dermatology programs, respiratory programs, aesthetics, oncology and cash, the analyst tells investors.
Unlock Full Analyst Thesis, Get the complete breakdown of rating reason for KRYS
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Valuation Metrics

The current forward P/E ratio for Krystal Biotech Inc (KRYS.O) is 47.39, compared to its 5-year average forward P/E of -10.17. For a more detailed relative valuation and DCF analysis to assess Krystal Biotech Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-10.17
Current PE
47.39
Overvalued PE
58.35
Undervalued PE
-78.70

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
15.85
Current EV/EBITDA
25.95
Overvalued EV/EBITDA
61.45
Undervalued EV/EBITDA
-29.74

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
165.25
Current PS
11.68
Overvalued PS
744.45
Undervalued PS
-413.95

Financials

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Whales Holding KRYS

H
Hood River Capital Management LLC
Holding
KRYS
+20.51%
3M Return
A
Avoro Capital Advisors LLC
Holding
KRYS
+13.76%
3M Return
B
Braidwell LP
Holding
KRYS
+12.09%
3M Return
F
Frazier Life Sciences Management, LP
Holding
KRYS
+6.89%
3M Return
S
Soleus Capital Management, L.P.
Holding
KRYS
+0.53%
3M Return
B
Bellevue Asset Management AG
Holding
KRYS
-3.42%
3M Return

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Frequently Asked Questions

What is Krystal Biotech Inc (KRYS) stock price today?

The current price of KRYS is 276.5 USD — it has increased 0.84

What is Krystal Biotech Inc (KRYS)'s business?

Krystal Biotech, Inc. is an integrated, commercial-stage biotechnology company. The Company is focused on the discovery, development, and commercialization of genetic medicines to treat diseases with high unmet medical needs. Its product candidates in various stages of clinical and preclinical development include KB407, KB408, KB707, KB105, KB801, KB803, KB304 and KB301. Its commercial product, VYJUVEK, is a redosable gene therapy, and a genetic medicine approved in the United States and Europe for the treatment of dystrophic epidermolysis bullosa. KB407 is being developed for the treatment of Cystic Fibrosis. KB408 is being developed for the treatment of Alpha-1 Antitrypsin Deficiency, a rare lung disease. KB707 is being developed for the treatment of solid tumors. KB105 is being developed for TGM1-Deficient Autosomal Recessive Congenital Ichthyosis. KB803 is a redosable eye drop formulation of B-VEC, designed for the treatment of ocular complications.

What is the price predicton of KRYS Stock?

Wall Street analysts forecast KRYS stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for KRYS is229.25 USD with a low forecast of 198.00 USD and a high forecast of 278.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Krystal Biotech Inc (KRYS)'s revenue for the last quarter?

Krystal Biotech Inc revenue for the last quarter amounts to 107.11M USD, increased 17.52

What is Krystal Biotech Inc (KRYS)'s earnings per share (EPS) for the last quarter?

Krystal Biotech Inc. EPS for the last quarter amounts to 1.70 USD, increased 11.84

How many employees does Krystal Biotech Inc (KRYS). have?

Krystal Biotech Inc (KRYS) has 295 emplpoyees as of April 21 2026.

What is Krystal Biotech Inc (KRYS) market cap?

Today KRYS has the market capitalization of 8.14B USD.