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PRAX Overview

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ET
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0.000
0.000(0.000%)
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0.000(0.000%)Aft-market
ET
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Intellectia

Loading chart...

High
296.050
Open
291.590
VWAP
281.48
Vol
533.86K
Mkt Cap
7.70B
Low
271.945
Amount
150.27M
EV/EBITDA(TTM)
--
Total Shares
27.85M
EV
7.48B
EV/OCF(TTM)
--
P/S(TTM)
--
Praxis Precision Medicines, Inc. is a clinical-stage biopharmaceutical company translating genetic insights into the development of therapies for central nervous system disorders characterized by neuronal excitation-inhibition imbalance. The Company is applying genetic insights to the discovery and development of therapies for neurological disorders through two platforms, using its understanding of shared biological targets and circuits in the brain. Its platform includes Cerebrum, a small-molecule platform, which utilizes deep understanding of neuronal excitability and neuronal networks and applies a series of computational and experimental tools to develop orally available precision therapies, and Solidus, an antisense oligonucleotide platform, is an efficient, targeted precision medicine discovery and development engine anchored on a proprietary, computational methodology. The Company’s product candidates include ulixacaltamide, vormatrigine, relutrigine, PRAX-080, and others.
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Events Timeline

(ET)
2026-03-30
16:20:00
Praxis Precision's New Drug Application for Relutrigine Accepted for Priority Review by FDA
select
2026-02-19 (ET)
2026-02-19
07:40:00
Company Reports Q4 Revenue of $0, 2026 Revenue Potential Over $20B
select
2026-02-19
07:40:00
Praxis Cash and Securities Increase to $926.1 Million
select

News

Newsfilter
9.0
03-30Newsfilter
Praxis Receives FDA Priority Review for Relutrigine
  • FDA Review Progress: Praxis Precision Medicines announced that its New Drug Application (NDA) has been accepted for priority review by the FDA, with a target action date of September 27, 2026, marking a significant milestone in the company's evolution towards commercialization, as approval would make it the first disease-modifying therapy for SCN2A and SCN8A developmental epileptic encephalopathies.
  • Clinical Trial Results: The NDA is supported by positive results from the EMBOLD study, which was stopped early for efficacy, demonstrating significant therapeutic effects of relutrigine in patients with severe epilepsy, potentially improving their quality of life.
  • Drug Designations: Relutrigine has received Orphan Drug, Rare Pediatric Disease, and Breakthrough Therapy designations from the FDA, and if approved, it will be eligible for a Pediatric Review Voucher, enhancing its competitive position in the market.
  • Future Research Plans: The drug is also being investigated in the EMERALD trial for broader DEEs, expected to be completed by the end of 2026, showcasing Praxis's ongoing innovation and commitment in the epilepsy treatment space.
Fool
8.5
03-18Fool
5AM Venture Management Sells Entire Stake in Praxis Precision Medicines
  • Stake Sale: On February 17, 2026, 5AM Venture Management disclosed via an SEC filing the sale of its entire 170,000 shares in Praxis Precision Medicines, resulting in an estimated $9.01 million reduction in the fund's quarter-end valuation, indicating a cautious outlook on the company's future performance.
  • Market Performance: As of Wednesday, shares of Praxis were priced at $291.70, reflecting a nearly 700% increase over the past year, significantly outperforming the S&P 500's approximately 19% gain; however, the market has begun to price in execution risks, with shares down about 30% since the quarter ended.
  • Financial Condition: Praxis reported no meaningful revenue and a net loss of approximately $303 million over the past year, yet raised $621 million in early 2026, ending the year with roughly $926 million in cash, providing a runway into 2028 and highlighting its high-risk, high-reward investment profile in the biotech sector.
  • R&D Progress: Praxis focuses on clinical-stage therapies for central nervous system disorders, having filed two New Drug Applications and with multiple late-stage programs approaching key readouts; despite high spending and execution risks, the depth of its pipeline continues to attract investor interest.
Fool
6.5
03-16Fool
Cormorant Asset Management Sells Shares of Praxis Precision Medicines
  • Share Reduction Details: Cormorant Asset Management disclosed a sale of 50,000 shares of Praxis Precision Medicines in a February 17, 2026 SEC filing, with an estimated transaction value of $9.31 million, indicating a strategic risk management approach amidst significant stock appreciation.
  • Holding Value Increase: By the end of Q4 2025, the total value of Praxis shares held increased by $227 million, reflecting positive impacts from trading and price movements, suggesting strong market confidence in the company.
  • Company Overview: Praxis Precision Medicines focuses on developing clinical-stage therapies for central nervous system disorders, with lead candidates targeting major depressive disorder and severe epilepsy, showcasing its innovative potential in the biopharmaceutical sector.
  • Strong Financial Position: Praxis ended 2025 with approximately $926 million in cash and investments, and a $621 million public offering in January further bolstered its financial strength, providing ample runway for a potential transition to commercial drug development.
NASDAQ.COM
6.5
03-16NASDAQ.COM
Cormorant Asset Management Reduces PRAX Holdings
  • Share Reduction Details: Cormorant Asset Management sold 50,000 shares of PRAX in Q4 2025, with an estimated transaction value of $9.31 million, reflecting the firm's risk management strategy amid market fluctuations.
  • Increase in Holdings Value: At quarter-end, Cormorant held 950,000 shares of PRAX valued at $280 million, representing a $227 million increase from the previous quarter, indicating the firm's confidence in the biotech company.
  • Strong Financial Position: Praxis Precision Medicines ended 2025 with approximately $926 million in cash and investments, further bolstered by a $621 million public offering, providing ample runway for future operations.
  • Outstanding Market Performance: Praxis has emerged as a standout in the neuroscience biotech sector, advancing multiple late-stage therapies for neurological disorders, showcasing its potential to meet significant unmet medical needs.
Fool
5.0
03-13Fool
Deerfield Management Increases Stake in Praxis Precision Medicines
  • Increased Stake: On February 17, 2026, Deerfield Management Company purchased an additional 62,500 shares of Praxis Precision Medicines, valued at approximately $11.64 million, indicating strong confidence in the company's future prospects.
  • Value Growth: Deerfield's PRAX position saw an increase of $221.69 million in value during Q4 2025, reflecting the positive impact of both trading activity and stock price movements, thereby solidifying its position in the investment portfolio.
  • Outstanding Market Performance: As of last Friday, PRAX shares were priced at $303.37, soaring 685% over the past year, significantly outperforming the S&P 500's 19% gain, showcasing the market's high expectations for its future potential.
  • Strong Financial Position: Praxis ended 2025 with approximately $926 million in cash and investments, and a follow-on offering in early 2026 added another $621 million, extending its operational runway into 2028, which enhances its competitive edge in the neuroscience sector.
NASDAQ.COM
6.5
03-13NASDAQ.COM
Deerfield Management Increases PRAX Stake by 62,500 Shares
  • Stake Increase: Deerfield Management Company increased its stake in PRAX by 62,500 shares in Q4 2025, with an estimated transaction value of $11.64 million, indicating continued confidence in the company.
  • Value Growth: As of December 31, 2025, Deerfield held 903,351 shares of PRAX valued at $266.25 million, reflecting a $221.69 million increase over the quarter due to both share additions and price appreciation.
  • Strong Financial Position: Praxis Precision Medicines ended 2025 with approximately $926 million in cash and investments, and a follow-on offering in early 2026 added another $621 million, extending its operational runway into 2028.
  • Optimistic Market Outlook: If successfully commercialized, Praxis's four leading development programs could represent over $20 billion in potential revenue, highlighting its strategic significance in the neuroscience sector.
Wall Street analysts forecast PRAX stock price to rise
15 Analyst Rating
Wall Street analysts forecast PRAX stock price to rise
14 Buy
0 Hold
1 Sell
Strong Buy
Current: 0.000
sliders
Low
95.00
Averages
456.71
High
843.00
Current: 0.000
sliders
Low
95.00
Averages
456.71
High
843.00
Wolfe Research
Outperform
initiated
$500
AI Analysis
2026-02-23
Reason
Wolfe Research
Price Target
$500
AI Analysis
2026-02-23
initiated
Outperform
Reason
Wolfe Research initiated coverage of Praxis Precision with an Outperform rating and $500 price target. The firm launched coverage of the neuroscience biotech sector with a "portfolio of high conviction names across multiple therapeutic areas." Wolfe believes Praxis could become a key player in neurology for both essential tremor and epilepsy.
Baird
NULL -> Outperform
upgrade
$275 -> $433
2026-02-20
Reason
Baird
Price Target
$275 -> $433
2026-02-20
upgrade
NULL -> Outperform
Reason
Baird raised the firm's price target on Praxis Precision to $433 from $275 and keeps an Outperform rating on the shares. The firm raised its target as two NDA submissions kick off the FDA review process.
Unlock Full Analyst Thesis, Get the complete breakdown of rating reason for PRAX
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Valuation Metrics

The current forward P/E ratio for Praxis Precision Medicines Inc (PRAX.O) is -21.34, compared to its 5-year average forward P/E of -4.15. For a more detailed relative valuation and DCF analysis to assess Praxis Precision Medicines Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-4.15
Current PE
-21.34
Overvalued PE
-0.59
Undervalued PE
-7.71

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-2.58
Current EV/EBITDA
-20.94
Overvalued EV/EBITDA
0.86
Undervalued EV/EBITDA
-6.02

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
705.95
Current PS
8230.35
Overvalued PS
2150.99
Undervalued PS
-739.10

Financials

AI Analysis
Annual
Quarterly

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Whales Holding PRAX

A
Allan Gray Australia Pty Ltd.
Holding
PRAX
+19.61%
3M Return
A
Algert Global LLC
Holding
PRAX
+14.57%
3M Return
V
Vivo Capital, LLC
Holding
PRAX
+7.04%
3M Return
H
Hood River Capital Management LLC
Holding
PRAX
+6.16%
3M Return
D
Driehaus Capital Management LLC
Holding
PRAX
+2.90%
3M Return
P
Perceptive Advisors LLC
Holding
PRAX
-0.51%
3M Return

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Frequently Asked Questions

What is Praxis Precision Medicines Inc (PRAX) stock price today?

The current price of PRAX is 276.44 USD — it has decreased -4.71

What is Praxis Precision Medicines Inc (PRAX)'s business?

Praxis Precision Medicines, Inc. is a clinical-stage biopharmaceutical company translating genetic insights into the development of therapies for central nervous system disorders characterized by neuronal excitation-inhibition imbalance. The Company is applying genetic insights to the discovery and development of therapies for neurological disorders through two platforms, using its understanding of shared biological targets and circuits in the brain. Its platform includes Cerebrum, a small-molecule platform, which utilizes deep understanding of neuronal excitability and neuronal networks and applies a series of computational and experimental tools to develop orally available precision therapies, and Solidus, an antisense oligonucleotide platform, is an efficient, targeted precision medicine discovery and development engine anchored on a proprietary, computational methodology. The Company’s product candidates include ulixacaltamide, vormatrigine, relutrigine, PRAX-080, and others.

What is the price predicton of PRAX Stock?

Wall Street analysts forecast PRAX stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for PRAX is456.71 USD with a low forecast of 95.00 USD and a high forecast of 843.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Praxis Precision Medicines Inc (PRAX)'s revenue for the last quarter?

Praxis Precision Medicines Inc revenue for the last quarter amounts to 0.00 USD, decreased -100.00

What is Praxis Precision Medicines Inc (PRAX)'s earnings per share (EPS) for the last quarter?

Praxis Precision Medicines Inc. EPS for the last quarter amounts to -3.49 USD, increased 19.11

How many employees does Praxis Precision Medicines Inc (PRAX). have?

Praxis Precision Medicines Inc (PRAX) has 168 emplpoyees as of March 31 2026.

What is Praxis Precision Medicines Inc (PRAX) market cap?

Today PRAX has the market capitalization of 7.70B USD.