Enliven Therapeutics Reports Promising Phase 1b Data for ELVN-001 in CML Patients
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Jan 08 2026
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Source: Benzinga
- Clinical Trial Progress: Enliven Therapeutics reported promising initial data from the ongoing Phase 1b ENABLE trial for ELVN-001 in chronic myeloid leukemia patients, with 38% achieving major molecular response (MMR) and 16% achieving deep molecular response (DMR) among 60 heavily pre-treated patients, indicating competitive efficacy compared to existing therapies.
- Dose Response Observation: In the randomized 60 mg and 120 mg cohorts, MMR reached 53% and DMR 35%, with all evaluable patients maintaining or deepening their responses, demonstrating robust clinical activity across different dosing regimens.
- Safety Assessment: ELVN-001 exhibited a favorable safety and tolerability profile across doses from 60 mg to 120 mg, with no new safety signals identified and consistent with previously reported data, highlighting its potential market viability.
- Future Plans: The company plans to initiate the ENABLE-2 Phase 3 trial in the second half of 2026, further validating the efficacy and safety of ELVN-001, marking a strategic move in the treatment landscape for chronic myeloid leukemia.
Analyst Views on ELVN
Wall Street analysts forecast ELVN stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for ELVN is 40.20 USD with a low forecast of 35.00 USD and a high forecast of 48.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
6 Analyst Rating
6 Buy
0 Hold
0 Sell
Strong Buy
Current: 26.160
Low
35.00
Averages
40.20
High
48.00
Current: 26.160
Low
35.00
Averages
40.20
High
48.00
About ELVN
Enliven Therapeutics, Inc. is a clinical-stage biopharmaceutical company focused on the discovery and development of small molecule inhibitors to help patients with cancer. It is advancing two parallel lead product candidates, ELVN-001 and ELVN-002, and pursuing several additional research stage opportunities that align with its development approach. Its first product candidate, ELVN-001, is a potent, highly selective, small molecule kinase inhibitor designed to specifically target the breakpoint cluster region-Abelson (BCR-ABL) gene fusion, the oncogenic driver for patients with chronic myeloid leukemia. Its second product candidate, ELVN-002, is a potent, highly selective, central nervous system penetrant and irreversible human epidermal growth factor receptor 2 (HER2) inhibitor with activity against wild type HER2 and various HER2 mutations. ELVN-002 is designed to inhibit wild type HER2 and key mutations of HER2, while sparing wild-type EGFR and avoiding EGFR-related toxicities.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
