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ACRV Overview

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ET
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Intellectia

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High
1.690
Open
1.650
VWAP
1.63
Vol
428.73K
Mkt Cap
52.38M
Low
1.580
Amount
700.26K
EV/EBITDA(TTM)
--
Total Shares
31.56M
EV
-76.87M
EV/OCF(TTM)
--
P/S(TTM)
--
Acrivon Therapeutics, Inc. is a clinical-stage biopharmaceutical company developing precision oncology medicines. It uses its precision Generative Phosphoproteomics platform, Acrivon Predictive Precision Proteomics (AP3), to develop its pipeline of oncology drug candidates. Its lead candidate, ACR-368, is a selective small molecule inhibitor which targets CHK1 and CHK2 at sub single-digit nM and single-digit nM potency in intact cells, respectively, in a registrational Phase II trial across multiple solid tumor types. Using its AP3 platform, it has developed a predictive OncoSignature test for ACR-368, called ACR-368 OncoSignature, that can predict patient response to ACR-368 monotherapy and therefore improve the clinical overall response rate (ORR) and has the potential to enable drug development. Its preclinical program, ACR-2316, is advancing in investigational new drug-enabling studies. It is a novel, dual WEE1 and PKMYT1 inhibitor small molecule development candidate.
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Events Timeline

(ET)
2026-01-08
07:40:00
Acrivon Therapeutics Submits Phase 3 Confirmatory Protocol for ACR-368
select
2026-01-06 (ET)
2026-01-06
07:40:00
Acrivon Therapeutics to Release ACR-368 and ACR-2316 Clinical Data on January 8
select
2025-12-17 (ET)
2025-12-17
07:40:00
Acrivon Therapeutics to Provide Clinical Data Updates in January 2026
select
2025-11-13 (ET)
2025-11-13
16:47:03
Acrivon Therapeutics announces Q3 earnings per share of 47 cents, below consensus estimate of 58 cents.
select
2025-08-13 (ET)
2025-08-13
16:44:26
Acrivon Therapeutics reports Q2 EPS (55c), consensus (58c)
select

News

Newsfilter
9.0
02-17Newsfilter
FDA's Accelerated Approval Framework Drives Cancer Treatment Advances
  • Clinical Survival Rate Improvement: A January 2026 analysis confirmed that drugs approved through the FDA's accelerated pathway improved progression-free survival in 65% of solid tumor indications, demonstrating significant clinical efficacy and driving clinical-stage oncology companies toward registration-directed study designs in high-unmet-need tumor types.
  • Fast Track Designation: Oncolytics Biotech's cancer treatment pelareorep received FDA Fast Track designation for KRAS-mutant microsatellite-stable metastatic colorectal cancer patients, achieving a 33% response rate in combination with standard chemotherapy, significantly higher than the 10% response rate with standard treatment, and a median survival of 27 months compared to 11.2 months with standard care.
  • Substantial Market Potential: The second-line treatment market for KRAS-mutant microsatellite-stable colorectal cancer patients is estimated to be between $3 billion and $5 billion annually, with Oncolytics Biotech planning a controlled study to compare standard care versus standard care plus pelareorep, further validating its therapeutic advantage in this high-demand area.
  • Team Expansion and Strategic Positioning: Oncolytics Biotech recently appointed two key executives to support its expansion plans, with CEO Jared Kelly emphasizing that the success of pelareorep in clinical trials will present significant market opportunities, particularly in cancer areas lacking effective treatment options.
PRnewswire
5.0
01-28PRnewswire
Oncolytics Biotech Strengthens Leadership Amid Oncology Market Surge
  • Executive Appointments: Oncolytics Biotech has appointed John McAdory as Executive Vice President of Strategy and Operations and Yujun Wu as Vice President, Head of Biostatistics, both bringing extensive experience in late-stage oncology trial execution and regulatory strategy to advance the company's registration-directed programs in gastrointestinal cancers.
  • Clinical Data Breakthrough: The company reported that pelareorep achieved a 33% objective response rate in second-line KRAS-mutant microsatellite stable metastatic colorectal cancer patients when combined with standard chemotherapy, tripling the historical response rate of 6-11%, demonstrating significant efficacy in this difficult-to-treat population.
  • FDA Alignment Success: Oncolytics has secured FDA alignment on its Phase 3 study design for pelareorep in first-line metastatic pancreatic cancer, positioning it to launch the only immunotherapy registration trial currently planned for this challenging therapeutic area, further solidifying its market position.
  • Strategic Expansion: The company has also expanded its Scientific Advisory Board with globally recognized experts from Memorial Sloan Kettering Cancer Center and MD Anderson Cancer Center, aiming to accelerate clinical development across multiple indications and enhance overall R&D capabilities.
Newsfilter
8.5
01-28Newsfilter
Oncolytics Biotech Strengthens Leadership to Advance Clinical Programs
  • Leadership Enhancement: Oncolytics Biotech has appointed John McAdory as Executive Vice President of Strategy and Operations and Yujun Wu as Vice President, Head of Biostatistics, both bringing extensive experience in late-stage oncology trial execution and regulatory strategy to advance the company's registration-directed programs in gastrointestinal cancers.
  • Breakthrough Efficacy Data: The company reported that pelareorep achieved a 33% objective response rate in second-line KRAS-mutant microsatellite stable metastatic colorectal cancer patients when combined with standard chemotherapy, significantly surpassing the historical 6-11% response rate, indicating its potential in difficult-to-treat patient populations.
  • FDA Designation Approval: Oncolytics secured FDA alignment on its Phase 3 study design for pelareorep in first-line metastatic pancreatic cancer, marking the initiation of the only immunotherapy registration trial planned for this challenging area, further solidifying its market position.
  • Advisory Board Expansion: The company has expanded its Scientific Advisory Board by adding globally recognized experts from Memorial Sloan Kettering Cancer Center and MD Anderson Cancer Center, laying the groundwork for accelerated clinical development across multiple indications.
NASDAQ.COM
9.0
01-09NASDAQ.COM
ScinoPharm Secures FDA Approval for Glatiramer Acetate Injection in Multiple Sclerosis
  • FDA Approval: ScinoPharm Taiwan (TWSE:1789) received FDA approval for its Glatiramer Acetate Injection for treating adult multiple sclerosis patients, marking the company's first finished drug approval and paving the way for regulatory submissions in Europe and Asia for broader commercialization.
  • Market Reaction: Following this announcement, ScinoPharm's stock price rose by 3.08% to NT$23.40 on January 8, 2025, reflecting positive market sentiment regarding the product's prospects.
  • Clinical Trial Progress: The approval supports the company's competitiveness in the global market, as Glatiramer Acetate remains a key product despite revenue erosion from generics, highlighting its ongoing relevance in the biotech sector.
  • Strategic Positioning: This approval not only strengthens ScinoPharm's position in the biopharmaceutical landscape but also lays the groundwork for future market expansions, demonstrating the company's commitment to innovative drug development.
NASDAQ.COM
9.0
01-08NASDAQ.COM
Acrivon Therapeutics (ACRV) Shares Plunge 28.71% Following Mixed Phase 2b Clinical Results
  • Stock Volatility: Acrivon Therapeutics shares plummeted 28.71% after the release of updated clinical trial results for ACR-368, dropping from an opening price of $2.95 to $2.10, indicating investors' heightened sensitivity to clinical outcomes.
  • Clinical Results Analysis: Despite a promising overall confirmed response rate of 52% in patients with the serous subtype of endometrial cancer, mixed interpretations of the data led to shaken market confidence, adversely affecting stock performance.
  • Trial Expansion Plans: Acrivon announced plans to expand the trial into the European Union to accelerate patient enrollment, a strategic move aimed at enhancing the trial's effectiveness and market acceptance, although the stock remains under pressure in the short term.
  • Surge in Trading Volume: The trading volume significantly exceeded average levels, reflecting investors' strong reactions to the clinical results, highlighting the high volatility and uncertainty prevalent in the biotech sector.
Benzinga
9.0
01-08Benzinga
Acrivon Updates ACR-368 Phase 2 Data, Reports 39% ORR in Endometrial Cancer
  • Clinical Trial Progress: In the ACR-368 Phase 2b registrational trial for endometrial cancer, the overall response rate (ORR) was reported at 39%, with a notable 44% ORR in patients with more than two prior therapies, indicating the drug's potential in refractory cases.
  • Targeted Strategy: Following the analysis of response rates in serous endometrial cancer patients, Arm 3 of the trial will focus exclusively on subjects with ≤2 prior treatments, aiming to enhance the trial's effectiveness and specificity.
  • New Drug Development Update: Initial clinical data from ACR-2316 shows a tumor shrinkage rate of 45% in patients with small cell lung cancer and squamous non-small cell lung cancer at doses of 120 mg and above, providing a positive clinical basis for future treatment regimens.
  • Financial Overview: As of December 31, 2025, Acrivon reported approximately $119 million in cash and cash equivalents, expected to fund operations and capital expenditures into the second quarter of 2027, ensuring continued investment in R&D.
Wall Street analysts forecast ACRV stock price to rise
6 Analyst Rating
Wall Street analysts forecast ACRV stock price to rise
5 Buy
1 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
7.00
Averages
10.50
High
19.00
Current: 0.000
sliders
Low
7.00
Averages
10.50
High
19.00
Piper Sandler
Overweight
maintain
$6 -> $8
AI Analysis
2026-01-09
Reason
Piper Sandler
Price Target
$6 -> $8
AI Analysis
2026-01-09
maintain
Overweight
Reason
Piper Sandler raised the firm's price target on Acrivon Therapeutics to $8 from $6 and keeps an Overweight rating on the shares. The firm notes Acrivon hosted a virtual R&D event and updated Phase II data showing 105mg/m2 q2W ACR-368 achieved a 39% overall response rate among OncoSignature-positive endometrial cancer patients. Acrivon plans to submit an IND for newly unveiled CDK11 inhibitor ACR-6840 in Q4 2026.
Oppenheimer
Oppenheimer
Outperform
downgrade
$9 -> $8
2025-08-14
Reason
Oppenheimer
Oppenheimer
Price Target
$9 -> $8
2025-08-14
downgrade
Outperform
Reason
Oppenheimer lowered the firm's price target on Acrivon Therapeutics to $8 from $9 and keeps an Outperform rating on the shares following Q2 results. The firm notes Phase 1 trial of ACR-2316 is on track for the second half of 2025.
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Valuation Metrics

The current forward P/E ratio for Acrivon Therapeutics Inc (ACRV.O) is -1.24, compared to its 5-year average forward P/E of -2.66. For a more detailed relative valuation and DCF analysis to assess Acrivon Therapeutics Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-2.66
Current PE
-1.24
Overvalued PE
-0.97
Undervalued PE
-4.35

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
0.00
Current EV/EBITDA
0.00
Overvalued EV/EBITDA
0.00
Undervalued EV/EBITDA
0.00

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
103.62
Current PS
600.35
Overvalued PS
299.73
Undervalued PS
-92.49

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3M Return

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Frequently Asked Questions

What is Acrivon Therapeutics Inc (ACRV) stock price today?

The current price of ACRV is 1.63 USD — it has decreased -1.81

What is Acrivon Therapeutics Inc (ACRV)'s business?

Acrivon Therapeutics, Inc. is a clinical-stage biopharmaceutical company developing precision oncology medicines. It uses its precision Generative Phosphoproteomics platform, Acrivon Predictive Precision Proteomics (AP3), to develop its pipeline of oncology drug candidates. Its lead candidate, ACR-368, is a selective small molecule inhibitor which targets CHK1 and CHK2 at sub single-digit nM and single-digit nM potency in intact cells, respectively, in a registrational Phase II trial across multiple solid tumor types. Using its AP3 platform, it has developed a predictive OncoSignature test for ACR-368, called ACR-368 OncoSignature, that can predict patient response to ACR-368 monotherapy and therefore improve the clinical overall response rate (ORR) and has the potential to enable drug development. Its preclinical program, ACR-2316, is advancing in investigational new drug-enabling studies. It is a novel, dual WEE1 and PKMYT1 inhibitor small molecule development candidate.

What is the price predicton of ACRV Stock?

Wall Street analysts forecast ACRV stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for ACRV is10.50 USD with a low forecast of 7.00 USD and a high forecast of 19.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Acrivon Therapeutics Inc (ACRV)'s revenue for the last quarter?

Acrivon Therapeutics Inc revenue for the last quarter amounts to -19.69M USD, decreased -21.69

What is Acrivon Therapeutics Inc (ACRV)'s earnings per share (EPS) for the last quarter?

Acrivon Therapeutics Inc. EPS for the last quarter amounts to -13182000.00 USD, decreased -28.01

How many employees does Acrivon Therapeutics Inc (ACRV). have?

Acrivon Therapeutics Inc (ACRV) has 75 emplpoyees as of March 11 2026.

What is Acrivon Therapeutics Inc (ACRV) market cap?

Today ACRV has the market capitalization of 52.38M USD.