Cyclerion Signs Licensing Deal with MIT and Unveils Strategic Relaunch
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Sep 23 2025
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Licensing Agreement: Cyclerion Therapeutics has secured a licensing agreement with MIT, which will be pivotal for its strategic relaunch focused on therapies for neuropsychiatric conditions, starting with treatment-resistant depression (TRD).
Lead Program Development: The company’s lead program aims to restore functional connectivity in the brain using anesthetic agents and is set to begin a Phase 2 proof-of-concept trial in 2026, with initial data expected in 2027.
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Analyst Views on CYCN
About CYCN
Cyclerion Therapeutics, Inc. is a biopharmaceutical company dedicated to identifying, developing, and delivering therapies for central nervous system (CNS) diseases. The Company is focused on building a pipeline with therapeutics to treat certain neuropsychiatric diseases. It is focused on an individualized therapy for treatment-resistant depression (TRD) - a condition with significant unmet medical need. Its assets include Olinciguat and Praliciguat. The Company has entered into an exclusive license option agreement for its vascular soluble guanylate cyclase (sGC) stimulator, olinciguat. Praliciguat is an oral, once-daily, systemic sGC stimulator that is licensed to Akeibia Therapeutics, Inc and is being advanced in rare kidney disease.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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