Clear Street Initiates Buy Rating on Annexon with $17 Price Target
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Dec 01 2025
0mins
Clear Street initiated coverage of Annexon with a Buy rating and $17 price target. In Phase 2 study, data from the company's lead asset vonaprument for geographic atrophy, GA, showed vision sparing, a critical differentiator the class, and the firm believes that strong pivotal data in the second half would provide key clinical de-risking and access to a large and growing market, the analyst tells investors in a research note. Investor pessimism around complement inhibitors for GA is contradicted by vonaprument's strong Phase 2 data, presenting a buying opportunity, Clear Street added.
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Analyst Views on ANNX
Wall Street analysts forecast ANNX stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for ANNX is 14.71 USD with a low forecast of 8.00 USD and a high forecast of 27.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
8 Analyst Rating
8 Buy
0 Hold
0 Sell
Strong Buy
Current: 6.290
Low
8.00
Averages
14.71
High
27.00
Current: 6.290
Low
8.00
Averages
14.71
High
27.00
About ANNX
Annexon, Inc. is a clinical-stage biopharmaceutical company advancing a late-stage clinical platform of novel therapies for people living with devastating classical complement-mediated neuroinflammatory diseases of the body, brain, and eye. It identifies and characterizes the role of the classical complement pathway in three therapeutic areas: autoimmune, neurodegeneration and ophthalmology, using its proprietary platform. Its lead candidate, ANX005, an investigational, full-length monoclonal antibody (mAb), is formulated for intravenous administration as the potential first targeted treatment for patients with Guillain-Barre Syndrome (GBS). It is advancing ANX1502, a novel small-molecule inhibitor of classical complement designed for oral administration in a range of chronic autoimmune diseases. It is also advancing ANX007, designed to block C1q locally in the eye, to provide complete protection against excess classical complement activity and the loss of photoreceptor neurons.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
Annexon Grants 155,000 Stock Options to New Employees to Advance Immunotherapy
- Employee Incentive Plan: Annexon has granted 155,000 stock options to two new non-executive employees under the 2022 Employment Inducement Award Plan, highlighting the company's commitment to attracting talent.
- Option Details: The options have an exercise price of $6.16 per share, based on the closing price on January 15, 2026, with a ten-year term and a four-year vesting schedule, where 25% vests on the first anniversary of the grant.
- Market Impact: This option grant not only enhances employee loyalty but may also improve the company's competitive position in the biopharmaceutical sector, particularly in the development of immunotherapies for neuroinflammatory diseases.
- Strategic Significance: With a mission to provide therapies for nearly 10 million people suffering from neuroinflammatory diseases, this incentive measure will help attract and retain key talent, thereby advancing the company's objectives.
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Biotech Insider Buying Signals Strong, Three Companies Draw Attention
- Insider Buying Signals: Summit Therapeutics has recently seen insider purchases, indicating management's confidence in its cancer drug's market potential, which could lead to significant stock price volatility in the future.
- Neurological Drug Development: Annexon also reported insider buying, reflecting confidence in its antibody drugs targeting neurological diseases, despite the high clinical trial risks, the potential for success is substantial.
- Cognitive Disorder Treatment: CervoMed's insider trading is noteworthy as its drug for Lewy body dementia shows market expectations for new therapies, although challenges in clinical trials remain significant.
- Investor Strategy: Insider buying in biotech stocks is not a buy signal but a research prompt, urging investors to carefully assess company cash flow and market sentiment to avoid losses from market fluctuations.
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