CervoMed's Neflamapimod Significantly Reduces Neurodegeneration Biomarker GFAP
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Dec 02 2025
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Source: Newsfilter
- Clinical Trial Results: CervoMed presented Phase 2b trial results at the CTAD conference showing that neflamapimod significantly reduced plasma GFAP levels, indicating its potential efficacy in neurodegenerative diseases and offering a new treatment option for DLB patients.
- Biomarker Correlation: The study found a positive correlation between the reduction in GFAP levels and clinical improvement (CDR-SB scores), further validating GFAP as an effective biomarker of disease activity in DLB and enhancing confidence in neflamapimod's clinical effects.
- Treatment Continuity: During the 32-week extension, patients receiving the new drug batch showed a median GFAP reduction of 16.0 pg/mL and a significant increase in the Aβ42/40 ratio, demonstrating neflamapimod's potential to improve neuroinflammatory and neurodegenerative profiles.
- Future Development Plans: CervoMed plans to initiate a global Phase 3 clinical trial in the second half of 2026 to further evaluate neflamapimod's efficacy in DLB patients, marking a strategic advancement in the treatment of neurodegenerative diseases.
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Analyst Views on CRVO
Wall Street analysts forecast CRVO stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for CRVO is 22.75 USD with a low forecast of 19.00 USD and a high forecast of 27.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
5 Analyst Rating
5 Buy
0 Hold
0 Sell
Strong Buy
Current: 5.170
Low
19.00
Averages
22.75
High
27.00
Current: 5.170
Low
19.00
Averages
22.75
High
27.00
About CRVO
CervoMed Inc. is a clinical-stage company focused on developing treatments for age-related neurologic disorders. The Company is developing neflamapimod, an investigational, orally administered small molecule brain penetrant that inhibits p38 mitogen-activated protein kinase alpha. Neflamapimod has the potential to treat synaptic dysfunction, the reversible aspect of the underlying neurodegenerative processes that cause disease in Lewy bodies (DLB) and certain other neurological disorders. It focuses on reducing the impact of inflammation in the brain, or neuroinflammation, which is a key factor in the manifestation of degenerative diseases of the brain, including DLB. Neflamapimod is being evaluated in the Company's ongoing RewinD-LB Trial, a Phase 2b trial in patients with DLB.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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CervoMed's Neflamapimod Shows Significant Improvement in DLB Patients in Phase 2b Trial
- Clinical Trial Results: CervoMed's Phase 2b RewinD-LB trial demonstrated that neflamapimod significantly improved CDR-SB scores in DLB patients, achieving a 52% reduction compared to placebo over 16 weeks, indicating its potential as a treatment.
- Biomarker Improvement: The treatment group showed a significant reduction in GFAP levels, suggesting that neflamapimod effectively targets neurodegenerative processes, reinforcing its scientific basis as a potential DLB therapy.
- Future Trial Plans: CervoMed is set to initiate a global Phase 3 registrational trial in the second half of 2026 to further validate neflamapimod's efficacy, advancing its path to market.
- Funding Support: The RewinD-LB trial received $21.3 million in NIH funding, covering 43 research sites across the U.S., U.K., and Netherlands, highlighting the broad support and potential impact of this research.
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