Avant Technologies Drives Gene Therapy Market to $36.55 Billion by 2032
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Jan 02 2026
0mins
Should l Buy MDGL?
Source: PRnewswire
- Market Growth Potential: The gene therapy market is projected to reach $36.55 billion by 2032, growing at a compound annual rate of 17.98%, reflecting a surge in demand for curative treatments that drives investor confidence in functional cures.
- FDA Approval of New Therapies: The FDA's approval of three transformative cell therapies in December marks a shift from experimental concepts to commercial reality, providing new market opportunities for companies like Avant Technologies.
- Strategic Partnerships: Avant's collaboration with SGAustria focuses on developing cell-based therapies for type 1 and insulin-dependent type 2 diabetes using encapsulation technology to address immune rejection, which is expected to significantly enhance patient quality of life.
- Anti-Aging Therapy Development: Avant's second joint venture, Klothonova, partners with Austrianova to develop anti-aging therapies that restore circulating α-Klotho levels using genetically modified human cells, with potential markets spanning Alzheimer's disease and cardiovascular conditions.
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Analyst Views on MDGL
Wall Street analysts forecast MDGL stock price to rise
12 Analyst Rating
10 Buy
2 Hold
0 Sell
Strong Buy
Current: 491.490
Low
527.00
Averages
636.22
High
900.00
Current: 491.490
Low
527.00
Averages
636.22
High
900.00
About MDGL
Madrigal Pharmaceuticals, Inc. is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a liver disease with high unmet medical need. The Company’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-b agonist designed to target key underlying causes of MASH. Rezdiffra is the medication approved by the United States Food and Drug Administration (FDA) for the treatment of MASH with moderate to advanced fibrosis (consistent with stages F2 to F3). Rezdiffra is a prescribed medicine used along with diet and exercise to treat adults with nonalcoholic steatohepatitis (NASH) with moderate to advanced liver scarring (fibrosis), but not with cirrhosis of the liver. An ongoing Phase III outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (consistent with stage F4c).
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
Madrigal Pharmaceuticals Q4 Earnings Preview
- Earnings Announcement Date: Madrigal Pharmaceuticals is set to announce its Q4 2023 earnings on February 19 before the market opens, with a consensus EPS estimate of -$0.88, reflecting a 67.5% year-over-year improvement, indicating a potential recovery in financial performance.
- Revenue Growth Expectations: The anticipated revenue for Q4 is $312.74 million, representing a 202.7% year-over-year increase, which highlights Madrigal's significant growth in market demand and product sales, potentially laying a foundation for future expansion.
- EPS Forecast Variability: Over the past three months, EPS estimates have seen two upward revisions and four downward revisions, indicating mixed analyst sentiment regarding the company's profitability, which could impact investor confidence.
- Revenue Forecast Adjustments: Similarly, revenue estimates have experienced four upward revisions and six downward revisions, suggesting a divergence in market expectations for Madrigal's future performance, which may lead to stock price volatility.
See More
Madrigal Pharmaceuticals Reports Mixed Q4 2025 Earnings
- Mixed Financial Results: Madrigal Pharmaceuticals reported a Q4 2025 revenue of $321.1 million, reflecting over 210% year-over-year growth and beating consensus by $8.3 million, yet a loss per share of $2.57 missed analysts' expectations by $2.03, leading to an approximately 8% premarket decline in stock price.
- Rezdiffra Market Performance: The FDA-approved therapy for metabolic dysfunction-associated steatohepatitis, Rezdiffra, generated $958.4 million in 2025, with over 36,250 patients treated, indicating strong market demand and acceptance of the product.
- Significant Revenue Growth: Madrigal achieved over 400% year-over-year growth in net revenue for 2025, while net loss decreased by more than 38% to $288.2 million, demonstrating a balance between revenue growth and cost management, with potential for further financial improvement.
- Liquidity Concerns: As of December 31, the company's cash and cash equivalents reached $988.6 million, reflecting approximately 6% year-over-year growth, but fell short of the $1.17 billion projected by analysts, highlighting pressures from debt repayment and operational funding needs.
See More
Madrigal Pharmaceuticals Q4 2025 Earnings Analysis
- Earnings Performance: Madrigal Pharmaceuticals reported a Q4 2025 GAAP EPS of -$2.57, missing expectations by $2.03, indicating challenges in profitability that may affect investor confidence.
- Revenue Growth: The quarter's revenue reached $321.08 million, reflecting a 210.8% year-over-year increase and exceeding market expectations by $8.34 million, suggesting significant progress in product sales that could lay the groundwork for future growth.
- Cash Position: As of December 31, 2025, Madrigal had cash, cash equivalents, restricted cash, and marketable securities totaling $988.6 million, an increase from $931.3 million in 2024, primarily due to the introduction of a new credit facility in July 2025, enhancing the company's financial flexibility.
- Financing Context: The new credit facility includes a $350 million initial term loan, with a portion used to repay outstanding loan obligations, yet attention is needed on the utilization of operational funds to ensure ongoing financial health.
See More
Madrigal Pharmaceuticals Shares Enter Oversold Territory
- Oversold Signal: Madrigal Pharmaceuticals' stock price fell to $458.067 per share on Friday, resulting in an RSI of 29.6, indicating an oversold condition that may attract bullish investors seeking buying opportunities.
- Market Comparison: Compared to the S&P 500 ETF's RSI of 42.5, MDGL's 29.6 suggests that the recent heavy selling is exhausting itself, potentially paving the way for a rebound.
- Historical Performance: MDGL's 52-week low is $265 per share, with a high of $615, and the current trading price of $464.71 reflects its performance within this volatile range, indicating market uncertainty.
- Investor Focus: As the stock enters oversold territory, investors may closely monitor MDGL's future performance, particularly in the current market environment, looking for potential rebound opportunities to realize gains.
See More
Ribo Life Science and Madrigal Sign siRNA Licensing Agreement
- Exclusive Global Licensing Agreement: Ribo Life Science has signed an exclusive global licensing agreement with Madrigal for six preclinical siRNA programs targeting metabolic dysfunction-associated steatohepatitis (MASH), which is expected to drive the development of new therapies to meet urgent market needs for MASH treatment.
- Financial Upside Potential: Under the agreement, Ribo will receive a $60 million upfront payment, with cumulative payments potentially reaching $4.4 billion upon achieving specific development and commercial milestones, significantly enhancing the company's financial position and supporting future R&D investments.
- Technological Platform Advantage: This collaboration will leverage Ribo's siRNA-GalSTARTM platform in conjunction with Madrigal's expertise in MASH, aiming to develop more effective treatment options, thereby enhancing the company's competitiveness in the biopharmaceutical market.
- Growing Market Demand: As the number of MASH patients rises and its association with various severe comorbidities becomes clearer, the demand for effective treatment solutions is increasingly urgent, positioning Ribo favorably in the rapidly growing biopharmaceutical sector.
See More
Ribo and Madrigal Sign Exclusive Global License Agreement
- Exclusive Global License Agreement: Ribo Life Science and Madrigal Pharmaceuticals have entered into an exclusive global license agreement covering six preclinical small RNA interference programs targeting Metabolic dysfunction-Associated SteatoHepatitis (MASH), which is expected to drive the development of new therapies to meet increasing market demand.
- Financial Upside Potential: Under the agreement, Ribo will receive an initial payment of $60 million, with cumulative payments potentially reaching $4.4 billion upon achieving specific development and commercialization milestones, significantly enhancing the company's financial position and supporting future R&D investments.
- Urgent Treatment Need: MASH is a serious liver disease with rising prevalence, and the collaboration between Ribo and Madrigal aims to provide more effective treatment options through innovative pARNi platforms to address the current market's lack of effective therapies.
- Broad Market Outlook: With increasing awareness of MASH, more patients are expected to be diagnosed with moderate to advanced liver fibrosis, and Ribo's technological collaboration will help expand its influence in the global biopharmaceutical market, addressing unmet medical needs.
See More
Madrigal Pharmaceuticals Q4 Earnings Preview
- Earnings Announcement Date: Madrigal Pharmaceuticals is set to announce its Q4 2023 earnings on February 19 before the market opens, with a consensus EPS estimate of -$0.88, reflecting a 67.5% year-over-year improvement, indicating a potential recovery in financial performance.
- Revenue Growth Expectations: The anticipated revenue for Q4 is $312.74 million, representing a 202.7% year-over-year increase, which highlights Madrigal's significant growth in market demand and product sales, potentially laying a foundation for future expansion.
- EPS Forecast Variability: Over the past three months, EPS estimates have seen two upward revisions and four downward revisions, indicating mixed analyst sentiment regarding the company's profitability, which could impact investor confidence.
- Revenue Forecast Adjustments: Similarly, revenue estimates have experienced four upward revisions and six downward revisions, suggesting a divergence in market expectations for Madrigal's future performance, which may lead to stock price volatility.
See More
Madrigal Pharmaceuticals Reports Mixed Q4 2025 Earnings
- Mixed Financial Results: Madrigal Pharmaceuticals reported a Q4 2025 revenue of $321.1 million, reflecting over 210% year-over-year growth and beating consensus by $8.3 million, yet a loss per share of $2.57 missed analysts' expectations by $2.03, leading to an approximately 8% premarket decline in stock price.
- Rezdiffra Market Performance: The FDA-approved therapy for metabolic dysfunction-associated steatohepatitis, Rezdiffra, generated $958.4 million in 2025, with over 36,250 patients treated, indicating strong market demand and acceptance of the product.
- Significant Revenue Growth: Madrigal achieved over 400% year-over-year growth in net revenue for 2025, while net loss decreased by more than 38% to $288.2 million, demonstrating a balance between revenue growth and cost management, with potential for further financial improvement.
- Liquidity Concerns: As of December 31, the company's cash and cash equivalents reached $988.6 million, reflecting approximately 6% year-over-year growth, but fell short of the $1.17 billion projected by analysts, highlighting pressures from debt repayment and operational funding needs.
See More
Madrigal Pharmaceuticals Q4 2025 Earnings Analysis
- Earnings Performance: Madrigal Pharmaceuticals reported a Q4 2025 GAAP EPS of -$2.57, missing expectations by $2.03, indicating challenges in profitability that may affect investor confidence.
- Revenue Growth: The quarter's revenue reached $321.08 million, reflecting a 210.8% year-over-year increase and exceeding market expectations by $8.34 million, suggesting significant progress in product sales that could lay the groundwork for future growth.
- Cash Position: As of December 31, 2025, Madrigal had cash, cash equivalents, restricted cash, and marketable securities totaling $988.6 million, an increase from $931.3 million in 2024, primarily due to the introduction of a new credit facility in July 2025, enhancing the company's financial flexibility.
- Financing Context: The new credit facility includes a $350 million initial term loan, with a portion used to repay outstanding loan obligations, yet attention is needed on the utilization of operational funds to ensure ongoing financial health.
See More
Madrigal Pharmaceuticals Shares Enter Oversold Territory
- Oversold Signal: Madrigal Pharmaceuticals' stock price fell to $458.067 per share on Friday, resulting in an RSI of 29.6, indicating an oversold condition that may attract bullish investors seeking buying opportunities.
- Market Comparison: Compared to the S&P 500 ETF's RSI of 42.5, MDGL's 29.6 suggests that the recent heavy selling is exhausting itself, potentially paving the way for a rebound.
- Historical Performance: MDGL's 52-week low is $265 per share, with a high of $615, and the current trading price of $464.71 reflects its performance within this volatile range, indicating market uncertainty.
- Investor Focus: As the stock enters oversold territory, investors may closely monitor MDGL's future performance, particularly in the current market environment, looking for potential rebound opportunities to realize gains.
See More
Ribo Life Science and Madrigal Sign siRNA Licensing Agreement
- Exclusive Global Licensing Agreement: Ribo Life Science has signed an exclusive global licensing agreement with Madrigal for six preclinical siRNA programs targeting metabolic dysfunction-associated steatohepatitis (MASH), which is expected to drive the development of new therapies to meet urgent market needs for MASH treatment.
- Financial Upside Potential: Under the agreement, Ribo will receive a $60 million upfront payment, with cumulative payments potentially reaching $4.4 billion upon achieving specific development and commercial milestones, significantly enhancing the company's financial position and supporting future R&D investments.
- Technological Platform Advantage: This collaboration will leverage Ribo's siRNA-GalSTARTM platform in conjunction with Madrigal's expertise in MASH, aiming to develop more effective treatment options, thereby enhancing the company's competitiveness in the biopharmaceutical market.
- Growing Market Demand: As the number of MASH patients rises and its association with various severe comorbidities becomes clearer, the demand for effective treatment solutions is increasingly urgent, positioning Ribo favorably in the rapidly growing biopharmaceutical sector.
See More
Ribo and Madrigal Sign Exclusive Global License Agreement
- Exclusive Global License Agreement: Ribo Life Science and Madrigal Pharmaceuticals have entered into an exclusive global license agreement covering six preclinical small RNA interference programs targeting Metabolic dysfunction-Associated SteatoHepatitis (MASH), which is expected to drive the development of new therapies to meet increasing market demand.
- Financial Upside Potential: Under the agreement, Ribo will receive an initial payment of $60 million, with cumulative payments potentially reaching $4.4 billion upon achieving specific development and commercialization milestones, significantly enhancing the company's financial position and supporting future R&D investments.
- Urgent Treatment Need: MASH is a serious liver disease with rising prevalence, and the collaboration between Ribo and Madrigal aims to provide more effective treatment options through innovative pARNi platforms to address the current market's lack of effective therapies.
- Broad Market Outlook: With increasing awareness of MASH, more patients are expected to be diagnosed with moderate to advanced liver fibrosis, and Ribo's technological collaboration will help expand its influence in the global biopharmaceutical market, addressing unmet medical needs.
See More
