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MDGL Overview

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$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
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Intellectia

Loading chart...

High
547.980
Open
531.190
VWAP
539.12
Vol
345.03K
Mkt Cap
12.55B
Low
522.490
Amount
186.01M
EV/EBITDA(TTM)
--
Total Shares
22.94M
EV
11.90B
EV/OCF(TTM)
--
P/S(TTM)
12.80
Madrigal Pharmaceuticals, Inc. is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a liver disease with high unmet medical need. The Company’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-b agonist designed to target key underlying causes of MASH. Rezdiffra is the medication approved by the United States Food and Drug Administration (FDA) for the treatment of MASH with moderate to advanced fibrosis (consistent with stages F2 to F3). Rezdiffra is a prescribed medicine used along with diet and exercise to treat adults with nonalcoholic steatohepatitis (NASH) with moderate to advanced liver scarring (fibrosis), but not with cirrhosis of the liver. An ongoing Phase III outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (consistent with stage F4c).
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Events Timeline

(ET)
2026-03-26
15:00:00
Madrigal Pharmaceuticals Off Highs, Remains Up 13% in Afternoon Trading
select
2026-02-19 (ET)
2026-02-19
07:10:00
Madrigal Reports Q4 Revenue of $321.083M, Beating Consensus
select
2026-02-11 (ET)
2026-02-11
05:10:00
Madrigal Signs Exclusive License Agreement with Suzhou Ribo
select
2026-01-09 (ET)
2026-01-09
08:10:00
Madrigal Signs Exclusive License Agreement with Pfizer for Ervogastat
select

News

Newsfilter
8.5
04-01Newsfilter
Avaí Bio Initiates Master Cell Bank Manufacturing
  • Market Potential: The regenerative medicine market is projected to reach $578 billion by 2033, with cell therapy alone surpassing $8.2 billion this year, indicating significant growth potential that attracts investor interest.
  • Manufacturing Challenge Solution: Avaí Bio has initiated the manufacturing of a Master Cell Bank for genetically modified cells overexpressing α-Klotho in collaboration with Austrianova, aiming to address the production bottlenecks in cell therapy and lay the groundwork for future commercialization.
  • Innovative Delivery Mechanism: Austrianova's Cell-in-a-Box® technology protects therapeutic cells within a biocompatible shell, allowing continuous secretion of α-Klotho, which eliminates the manufacturing and logistical burdens of patient-specific autologous therapies, transforming it into a scalable product.
  • Dual-Program Strategy: Avaí Bio's dual-program approach targets both the Klothonova α-Klotho anti-aging platform and the Insulinova diabetes program, expected to tap into multi-billion dollar markets, showcasing the company's strategic positioning in the regenerative medicine sector.
PRnewswire
8.5
04-01PRnewswire
Avaí Bio Initiates Master Cell Bank Manufacturing
  • Market Potential: The regenerative medicine market is projected to reach $578 billion by 2033, with cell therapy alone surpassing $8.2 billion this year, indicating strong growth potential that attracts investor interest.
  • Manufacturing Challenges: The primary bottleneck for cell therapy companies is how to manufacture living therapeutics reliably and affordably at scale, and those who solve this issue will dominate the market.
  • Innovative Technology: Avaí Bio has initiated the manufacturing of a Master Cell Bank of genetically modified cells overexpressing the α-Klotho protein in collaboration with Austrianova, utilizing Cell-in-a-Box® technology to ensure continuous secretion of the protein without immune rejection.
  • Broad Market Demand: α-Klotho is linked to various diseases such as Alzheimer's, cardiovascular disease, and kidney disease, presenting significant market opportunities, and Avaí Bio's dual-program approach aims to effectively address treatment needs in these areas.
stocktwits
8.5
03-26stocktwits
MDGL Stock Rises Significantly in a Month Amid Eli Lilly Acquisition Rumors
  • Madrigal's Focus: Madrigal is concentrating on developing therapies for metabolic dysfunction associated with MASH, with its Rezdiffran drug already approved by the U.S. FDA for treating moderate to advanced fibrosis.

  • Financial Performance: The company reported Rezdiffran sales of $958.4 million for the full year 2025, with over 36,250 patients on the drug by the end of that year.

  • Expansion Plans: Madrigal has licensed global rights to six pre-clinical siRNA programs for up to $4.4 billion to expand its pipeline and is evaluating the drug for treating compensated MASH cirrhosis.

  • Market Reaction: Following speculation about a potential buyout by Eli Lilly, Madrigal's stock saw a significant increase, with retail sentiment shifting from neutral to extremely bullish.

seekingalpha
2.0
03-26seekingalpha
Wall Street Declines Amid Rising U.S.-Iran Tensions
  • Market Decline: Wall Street ended lower on Thursday as investors monitored escalating U.S.-Iran tensions, with the Nasdaq Composite down 2.3%, the S&P 500 down 1.7%, and the Dow Jones Industrial Average down 1%, indicating market sensitivity to geopolitical risks.
  • Madrigal Stock Surge: Madrigal Pharmaceuticals saw a 12% increase in stock price amid renewed speculation of a potential takeover, as traders cited a Betaville report indicating the company has hired advisers for talks with a buyer, reflecting optimistic market sentiment regarding its future.
  • Macy's Mixed Results: Despite reporting positive early results from its Google Gemini-powered chatbot, Macy's stock dipped 0.5%, with data showing customers using the “Ask Macy’s” assistant spent approximately 4.75 times more than those who did not, suggesting cautious market sentiment about its long-term growth potential.
  • Modular Medical Stock Split: Modular Medical announced a 1-for-30 reverse stock split effective March 31, 2026, aimed at raising its share price to meet Nasdaq's $1 minimum bid requirement, reducing outstanding shares from approximately 139.8 million to about 4.66 million, highlighting the company's commitment to maintaining its listing status.
seekingalpha
8.5
03-26seekingalpha
Madrigal Pharmaceuticals Shares Surge 12% Amid Takeover Speculation
  • Takeover Speculation: Madrigal Pharmaceuticals (MDGL) shares rose 12% amid renewed speculation of a potential acquisition, reflecting investor optimism about the company's future prospects.
  • Market Capitalization: With a market cap of $12 billion, Madrigal demonstrates a strong position in the biopharmaceutical sector, attracting interest from potential buyers.
  • Short Interest Ratio: Madrigal's short interest stands at 16%, indicating market expectations for stock price volatility, which may influence future investment decisions.
  • Future Growth Potential: Madrigal anticipates robust net sales growth in 2026 and an expanding pipeline, coupled with a 50% surge in the MASH market, further enhancing its attractiveness.
Barron's
4.5
03-26Barron's
U.S. Markets Declined on Thursday; Karman Holdings Experienced Largest Loss
  • Stock Market Decline: U.S. stock indexes experienced a decline on Thursday, with significant drops across major indices.
  • Index Performance: The S&P 500 fell by 2.38%, the Dow Jones dropped 1.74%, and the Nasdaq decreased by 1.01%.
Wall Street analysts forecast MDGL stock price to rise
12 Analyst Rating
Wall Street analysts forecast MDGL stock price to rise
10 Buy
2 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
527.00
Averages
636.22
High
900.00
Current: 0.000
sliders
Low
527.00
Averages
636.22
High
900.00
BofA
Neutral
downgrade
$570 -> $529
AI Analysis
2026-02-20
Reason
BofA
Price Target
$570 -> $529
AI Analysis
2026-02-20
downgrade
Neutral
Reason
BofA lowered the firm's price target on Madrigal Pharmaceuticals to $529 from $570 and keeps a Neutral rating on the shares. Following quarterly results and the associated call, the firm is "modestly" lowering forecasts after incorporating the team's comments on gross-to-net adjustments, the analyst tells investors.
BofA
Neutral
downgrade
$595 -> $570
2026-02-03
Reason
BofA
Price Target
$595 -> $570
2026-02-03
downgrade
Neutral
Reason
BofA lowered the firm's price target on Madrigal Pharmaceuticals to $570 from $595 and keeps a Neutral rating on the shares. Given the level of pre-announcements, upcoming Q4 earnings "may not have the same impact they've had in prior years," the analyst tells investors in a preview for the firm's biopharma coverage.
Unlock Full Analyst Thesis, Get the complete breakdown of rating reason for MDGL
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Valuation Metrics

The current forward P/E ratio for Madrigal Pharmaceuticals Inc (MDGL.O) is 666.67, compared to its 5-year average forward P/E of 46.78. For a more detailed relative valuation and DCF analysis to assess Madrigal Pharmaceuticals Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
46.78
Current PE
666.67
Overvalued PE
263.68
Undervalued PE
-170.11

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-23.10
Current EV/EBITDA
-30.79
Overvalued EV/EBITDA
31.63
Undervalued EV/EBITDA
-77.83

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
48.05
Current PS
5.60
Overvalued PS
147.28
Undervalued PS
-51.18

Financials

AI Analysis
Annual
Quarterly

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Whales Holding MDGL

P
Polar Capital Holdings Plc
Holding
MDGL
+14.88%
3M Return
J
Journey Strategic Wealth LLC
Holding
MDGL
+11.93%
3M Return
A
Avoro Capital Advisors LLC
Holding
MDGL
+9.26%
3M Return
H
Hood River Capital Management LLC
Holding
MDGL
+7.75%
3M Return
B
Baker Bros. Advisors LP
Holding
MDGL
+3.58%
3M Return
P
Paulson & Co. Inc.
Holding
MDGL
-0.90%
3M Return

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Frequently Asked Questions

What is Madrigal Pharmaceuticals Inc (MDGL) stock price today?

The current price of MDGL is 546.89 USD — it has increased 3.22

What is Madrigal Pharmaceuticals Inc (MDGL)'s business?

Madrigal Pharmaceuticals, Inc. is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a liver disease with high unmet medical need. The Company’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-b agonist designed to target key underlying causes of MASH. Rezdiffra is the medication approved by the United States Food and Drug Administration (FDA) for the treatment of MASH with moderate to advanced fibrosis (consistent with stages F2 to F3). Rezdiffra is a prescribed medicine used along with diet and exercise to treat adults with nonalcoholic steatohepatitis (NASH) with moderate to advanced liver scarring (fibrosis), but not with cirrhosis of the liver. An ongoing Phase III outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (consistent with stage F4c).

What is the price predicton of MDGL Stock?

Wall Street analysts forecast MDGL stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for MDGL is636.22 USD with a low forecast of 527.00 USD and a high forecast of 900.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Madrigal Pharmaceuticals Inc (MDGL)'s revenue for the last quarter?

Madrigal Pharmaceuticals Inc revenue for the last quarter amounts to 321.08M USD, increased 210.77

What is Madrigal Pharmaceuticals Inc (MDGL)'s earnings per share (EPS) for the last quarter?

Madrigal Pharmaceuticals Inc. EPS for the last quarter amounts to -2.55 USD, decreased -5.90

How many employees does Madrigal Pharmaceuticals Inc (MDGL). have?

Madrigal Pharmaceuticals Inc (MDGL) has 915 emplpoyees as of April 03 2026.

What is Madrigal Pharmaceuticals Inc (MDGL) market cap?

Today MDGL has the market capitalization of 12.55B USD.