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MDGL Overview

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$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
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Intellectia

Loading chart...

High
522.000
Open
513.360
VWAP
514.33
Vol
266.38K
Mkt Cap
11.84B
Low
507.570
Amount
137.01M
EV/EBITDA(TTM)
--
Total Shares
23.06M
EV
11.35B
EV/OCF(TTM)
--
P/S(TTM)
10.95
Madrigal Pharmaceuticals, Inc. is a biopharmaceutical company. The Company is focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a liver disease with high unmet medical need. The Company’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-b agonist designed to target key underlying causes of MASH. Rezdiffra is the medication approved by the United States Food and Drug Administration (FDA) for the treatment of MASH with moderate to advanced fibrosis (consistent with stages F2 to F3). Rezdiffra is a prescribed medicine used along with diet and exercise to treat adults with nonalcoholic steatohepatitis (NASH) with moderate to advanced liver scarring (fibrosis), but not with cirrhosis of the liver. An ongoing Phase III outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (consistent with stage F4c).
Show More

Events Timeline

(ET)
2026-05-27
08:20:00
Madrigal Pharmaceuticals Shows Rezdiffra Reduces Cardiovascular Risk in MASH Patients
select
2026-05-06 (ET)
2026-05-06
07:40:00
Madrigal Reports Q1 Revenue of $311.34M, Beating Expectations
select
2026-05-05 (ET)
2026-05-05
08:10:00
Arrowhead Signs Exclusive License Agreement with Madrigal for ARO-PNPLA3
select

News

NASDAQ.COM
8.5
06-16NASDAQ.COM
Three Innovative Biotechs with Promising Prospects
  • Madrigal Approval: Madrigal Pharmaceuticals made history in 2024 by earning approval for Rezdiffra, the first treatment for metabolic dysfunction-associated steatohepatitis, addressing the urgent needs of millions of patients in the U.S., and is expected to see significant revenue growth over the next decade.
  • Axsome Sales Surge: Axsome Therapeutics reported first-quarter sales of $153.2 million for its Auvelity drug, a 59% year-over-year increase, and has received label expansion for treating Alzheimer's disease agitation, projecting peak sales of $8 billion in the future.
  • Kailera's Market Potential: Kailera Therapeutics focuses on developing weight loss medications and, despite not having marketed products, its leading candidate ribupatide is currently in phase 3 trials, potentially positioning it well in the rapidly growing anti-obesity market.
  • Investment Risks and Opportunities: While Madrigal and Axsome face competition and regulatory risks, their market prospects and pipeline potential make them attractive for investors, particularly for those looking at long-term investments in the biotech sector.
Fool
2.0
06-16Fool
Analysis of Three Promising Biotech Companies
  • Madrigal Pharmaceuticals Breakthrough: Madrigal Pharmaceuticals made history in 2024 by earning approval for Rezdiffra, the first medicine for metabolic dysfunction-associated steatohepatitis, with over 42,250 patients treated and a 127% year-over-year revenue increase to $311.3 million in Q1, indicating strong market demand and growth potential.
  • Axsome Therapeutics Progress: Axsome Therapeutics' Auvelity achieved $153.2 million in sales in Q1, a 59% increase year-over-year, and received label expansion for treating Alzheimer's disease agitation, with projected peak sales of $8 billion, showcasing its robust growth potential in mental health.
  • Kailera Risks and Opportunities: Kailera Therapeutics focuses on developing weight loss medications and, despite having no marketed products, its leading candidate ribupatide is in phase 3 trials, potentially positioning it in the rapidly growing anti-obesity market, appealing to risk-tolerant investors.
  • Market Competition and Challenges: While Madrigal and Axsome excel in their respective fields, they face competition from large pharmaceutical companies like Novo Nordisk, and Kailera's lack of marketed products increases investment risk, necessitating careful evaluation of potential clinical and regulatory challenges.
seekingalpha
9.5
05-06seekingalpha
Madrigal Pharmaceuticals Q1 2026 Earnings Call Highlights
  • Strong Sales Performance: Madrigal Pharmaceuticals reported net sales of $311.3 million in Q1 2026, a remarkable 127% increase year-over-year, indicating robust market demand for Rezdiffra despite challenges of low penetration and diagnosis rates.
  • Growing Patient Base: The number of active patients on Rezdiffra exceeded 42,250 by the end of Q1, with CEO Sibold noting that this growth momentum is expected to carry into Q2, reflecting the company's positive progress in market expansion.
  • Pipeline Update: The recent in-licensing of ARO-PNPLA3, a clinical-stage siRNA, aims to leverage Rezdiffra as a foundation for delivering better therapies, thereby strengthening its competitive position in the market with an industry-leading pipeline.
  • Adjusted Financial Outlook: CFO Dier projected that R&D expenses for the full year 2026 will remain consistent with 2025, while SG&A expenses are expected to rise, highlighting the company's ongoing investment in commercial activities and marketing efforts for Rezdiffra.
seekingalpha
9.5
05-06seekingalpha
Madrigal Pharmaceuticals Q1 Earnings Exceed Expectations
  • Earnings Highlights: Madrigal Pharmaceuticals reported a Q1 GAAP EPS of -$3.25, beating expectations by $0.79, indicating an improving trend in the company's profitability.
  • Revenue Surge: The company achieved revenues of $311.3 million, representing a 126.7% year-over-year increase, surpassing market expectations by $10.38 million, reflecting strong market performance of its products.
  • Patient Growth: As of March 31, 2026, over 42,250 patients are on Rezdiffra, a 2.5x increase from Q1 2025, demonstrating continued strong physician adoption and high patient demand.
  • Market Outlook: The robust earnings report and patient growth data may boost investor confidence, although there remains divergence in market sentiment regarding the company's future performance.
seekingalpha
9.5
05-05seekingalpha
Madrigal Pharmaceuticals Q1 Earnings Preview
  • Earnings Announcement Date: Madrigal Pharmaceuticals is set to release its Q1 earnings on May 6 before market open, with a consensus EPS estimate of -$4.14, indicating significant profitability challenges ahead.
  • Revenue Expectations Comparison: The projected revenue for Q1 stands at $300.92 million, up from $137.3 million in Q1 2025, suggesting growth potential, yet market confidence in profitability remains low.
  • Estimate Revision Trends: Over the past three months, EPS estimates have seen no upward revisions and three downward adjustments, reflecting analysts' pessimism about the company's future performance, while revenue estimates experienced one upward and eight downward revisions, indicating concerns about growth prospects.
  • Market Sentiment Analysis: Madrigal Pharmaceuticals is currently among the most shorted large-cap stocks, with a bearish market sentiment prevailing, leading investors to adopt a cautious stance that could impact stock price movements.
NASDAQ.COM
5.0
04-16NASDAQ.COM
Three Biotech Companies Worth Watching
  • Krystal Biotech's Breakthrough: In 2023, Krystal Biotech received approval for Vyjuvek, a gene therapy for Dystrophic Epidermolysis Bullosa, achieving $389.1 million in revenue, a 34% year-over-year increase, indicating strong market potential in rare diseases.
  • Madrigal Pharmaceuticals' FDA Approval: In 2024, Madrigal gained FDA approval for Rezdiffra, the first drug for metabolic dysfunction-associated steatohepatitis, with 2025 revenue reaching $958.4 million, a staggering 432% increase, showcasing robust growth in an emerging market.
  • Exelixis' Oncology Innovations: Exelixis' Cabometyx remains the leading treatment for liver and kidney cancers, with no generic competition expected until 2030, while the company plans to launch several next-gen cancer therapies in the next five years, further solidifying its market position.
  • Significant Market Potential: The combination of innovation and market demand in these three companies suggests that their stocks could yield substantial returns in the future, particularly in the ongoing developments within rare diseases and oncology.
Wall Street analysts forecast MDGL stock price to rise
12 Analyst Rating
Wall Street analysts forecast MDGL stock price to rise
10 Buy
2 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
527.00
Averages
636.22
High
900.00
Current: 0.000
sliders
Low
527.00
Averages
636.22
High
900.00
BofA
Neutral
maintain
$550 -> $542
AI Analysis
2026-06-11
Reason
BofA
Price Target
$550 -> $542
AI Analysis
2026-06-11
maintain
Neutral
Reason
BofA lowered the firm's price target on Madrigal Pharmaceuticals to $542 from $550 and keeps a Neutral rating on the shares. While Rezdiffra's launch in MASH has impressed, debate has shifted to whether it can sustain this pace, says the analyst, who lowered the firm's 2028 Rezdiffra revenue forecast to $2.6B from $2.7B following conversations with key opinion leaders and prior management feedback.
Truist
Buy
maintain
$640 -> $709
2026-05-13
Reason
Truist
Price Target
$640 -> $709
2026-05-13
maintain
Buy
Reason
Truist raised the firm's price target on Madrigal Pharmaceuticals to $709 from $640 and keeps a Buy rating on the shares. The firm's survey work reinforces its belief in the sizable MASH patient numbers eligible for treatment that will translate to significant Rezdiffra revenues for Madrigal, the analyst tells investors in a research note, adding that Truist is increasing the US peak MASH patients treated with Rezdiffra estimates to 193K from 158K prior.
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Valuation Metrics

The current forward P/E ratio for Madrigal Pharmaceuticals Inc (MDGL.O) is 666.67, compared to its 5-year average forward P/E of 76.66. For a more detailed relative valuation and DCF analysis to assess Madrigal Pharmaceuticals Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
76.66
Current PE
666.67
Overvalued PE
327.74
Undervalued PE
-174.42

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-23.88
Current EV/EBITDA
-18.07
Overvalued EV/EBITDA
30.76
Undervalued EV/EBITDA
-78.52

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
48.33
Current PS
5.30
Overvalued PS
147.48
Undervalued PS
-50.82

Financials

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Whales Holding MDGL

H
Hood River Capital Management LLC
Holding
MDGL
+35.29%
3M Return
A
Avoro Capital Advisors LLC
Holding
MDGL
+22.72%
3M Return
A
Alkeon Capital Management, LLC
Holding
MDGL
+22.46%
3M Return
A
Armistice Capital LLC
Holding
MDGL
+16.74%
3M Return
A
Affinity Asset Advisors, LLC
Holding
MDGL
+16.45%
3M Return
J
Janus Henderson Group plc
Holding
MDGL
+15.75%
3M Return

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Frequently Asked Questions

What is Madrigal Pharmaceuticals Inc (MDGL) stock price today?

The current price of MDGL is 513.43 USD — it has increased 0.11

What is Madrigal Pharmaceuticals Inc (MDGL)'s business?

Madrigal Pharmaceuticals, Inc. is a biopharmaceutical company. The Company is focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a liver disease with high unmet medical need. The Company’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-b agonist designed to target key underlying causes of MASH. Rezdiffra is the medication approved by the United States Food and Drug Administration (FDA) for the treatment of MASH with moderate to advanced fibrosis (consistent with stages F2 to F3). Rezdiffra is a prescribed medicine used along with diet and exercise to treat adults with nonalcoholic steatohepatitis (NASH) with moderate to advanced liver scarring (fibrosis), but not with cirrhosis of the liver. An ongoing Phase III outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (consistent with stage F4c).

What is the price predicton of MDGL Stock?

Wall Street analysts forecast MDGL stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for MDGL is636.22 USD with a low forecast of 527.00 USD and a high forecast of 900.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Madrigal Pharmaceuticals Inc (MDGL)'s revenue for the last quarter?

Madrigal Pharmaceuticals Inc revenue for the last quarter amounts to 311.34M USD, increased 126.84

What is Madrigal Pharmaceuticals Inc (MDGL)'s earnings per share (EPS) for the last quarter?

Madrigal Pharmaceuticals Inc. EPS for the last quarter amounts to -3.25 USD, decreased -2.11

How many employees does Madrigal Pharmaceuticals Inc (MDGL). have?

Madrigal Pharmaceuticals Inc (MDGL) has 915 emplpoyees as of June 24 2026.

What is Madrigal Pharmaceuticals Inc (MDGL) market cap?

Today MDGL has the market capitalization of 11.84B USD.