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MDGL Overview

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$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
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Intellectia

Loading chart...

High
448.070
Open
440.640
VWAP
442.40
Vol
220.75K
Mkt Cap
10.20B
Low
434.300
Amount
97.66M
EV/EBITDA(TTM)
--
Total Shares
22.94M
EV
9.56B
EV/OCF(TTM)
--
P/S(TTM)
10.41
Madrigal Pharmaceuticals, Inc. is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a liver disease with high unmet medical need. The Company’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-b agonist designed to target key underlying causes of MASH. Rezdiffra is the medication approved by the United States Food and Drug Administration (FDA) for the treatment of MASH with moderate to advanced fibrosis (consistent with stages F2 to F3). Rezdiffra is a prescribed medicine used along with diet and exercise to treat adults with nonalcoholic steatohepatitis (NASH) with moderate to advanced liver scarring (fibrosis), but not with cirrhosis of the liver. An ongoing Phase III outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (consistent with stage F4c).
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Events Timeline

(ET)
2026-02-19
07:10:00
Madrigal Reports Q4 Revenue of $321.083M, Beating Consensus
select
2026-02-11 (ET)
2026-02-11
05:10:00
Madrigal Signs Exclusive License Agreement with Suzhou Ribo
select
2026-01-09 (ET)
2026-01-09
08:10:00
Madrigal Signs Exclusive License Agreement with Pfizer for Ervogastat
select
2026-01-06 (ET)
2026-01-06
09:00:00
Stock Futures Show Modest Movement, S&P 500 Futures Up 0.01%
select

News

Fool
2.0
03-10Fool
Undervalued Investment Opportunities: Axsome and Madrigal
  • Axsome's Growth Potential: Axsome Therapeutics' stock has more than doubled over the past five years, primarily due to clinical and commercial progress with its leading candidate Auvelity, with new approvals and label expansions expected to significantly enhance financial performance and potentially lead to profitability in the next five years.
  • Significant Revenue Increase: In 2025, Axsome's revenue surged by 66% to $638.5 million, while its net loss per share improved to $3.68 from $5.99 in 2024, indicating strong performance in large, underserved markets.
  • Madrigal's FDA Approval: Madrigal Pharmaceuticals received FDA approval for Rezdiffra in 2024, the first drug indicated for metabolic dysfunction-associated steatohepatitis, generating $958.4 million in revenue last year, highlighting robust market demand.
  • Huge Market Demand: Madrigal targets 315,000 patients, having treated about 36,250 so far, indicating significant market potential in the MASH area, with prospects for sustained financial growth and competitive returns in the future.
NASDAQ.COM
9.5
03-10NASDAQ.COM
Axsome and Madrigal's Market Potential
  • Axsome's Growth Potential: Axsome Therapeutics' stock has more than doubled over the past five years, primarily due to clinical and commercial progress with its leading candidate Auvelity, which is expected to significantly improve financial performance through new approvals and label expansions over the next five years.
  • Significant Revenue Increase: In 2025, Axsome's revenue surged by 66% to $638.5 million, and although the net loss per share was $3.68, it showed improvement compared to the $5.99 loss per share reported in 2024, indicating potential for profitability.
  • Madrigal's Market Breakthrough: Madrigal Pharmaceuticals received FDA approval for Rezdiffra in 2024, the first drug indicated for metabolic dysfunction-associated steatohepatitis, generating $958.4 million in revenue last year solely from this product, highlighting strong market demand.
  • Unmet Medical Needs: Madrigal has treated approximately 36,250 patients, targeting 315,000, indicating a significant unmet need in the metabolic dysfunction-associated steatohepatitis space, which is likely to drive continued financial growth.
NASDAQ.COM
2.0
02-23NASDAQ.COM
Madrigal (MDGL) Q4 2025 Earnings Call Transcript
Yahoo Finance
6.5
02-23Yahoo Finance
Baker Bros. Advisors Increases Stake in Kymera Therapeutics
  • Stake Increase: Baker Bros. Advisors reported a purchase of 2,005,813 shares of Kymera Therapeutics in its February 17, 2026 SEC filing, representing an estimated trade value of $135.45 million, indicating strong confidence in the company.
  • Market Value Growth: The fund's quarter-end position in Kymera Therapeutics increased by $297.15 million due to this purchase, reflecting the dual impact of trading activity and share price appreciation, further solidifying its market position.
  • Stock Performance: As of February 17, 2026, Kymera's shares were priced at $84.84, marking a 130% increase over the past year, significantly outperforming the S&P 500 by 118.13 percentage points, showcasing its robust performance in the biotech sector.
  • R&D Outlook: With approximately $1.6 billion in cash at the beginning of 2026, Kymera supports its leading oral immunology pipeline, which is expected to drive sustained growth for the company in the coming years.
Barron's
4.5
02-19Barron's
U.S. Markets Fell on Thursday; Klarna Group Reported Largest Loss
  • U.S. Stock Market Performance: Stock indexes in the U.S. experienced a decline on Thursday, with the overall market falling by 0.54%.
  • Specific Index Movements: The S&P 500 index decreased by 0.31%, while the Dow Jones Industrial Average dropped by 0.28%.
seekingalpha
9.5
02-19seekingalpha
Madrigal Pharmaceuticals Q4 2025 Earnings Call Highlights
  • Significant Sales Performance: Madrigal Pharmaceuticals reported net sales of $321 million in Q4 2025, more than tripling from Q4 2024, with full-year net sales reaching $958.4 million, demonstrating strong market demand for Rezdiffra as a foundational therapy.
  • Sustained Patient Growth: The number of patients on Rezdiffra exceeded 36,250 by the end of Q4 2025, up from over 29,500 in Q3, indicating the company's success in patient acquisition and market penetration.
  • Increased R&D and Expenses: R&D expenses for Q4 2025 were $116.3 million, totaling $388.5 million for the year, primarily driven by upfront payments for new pipeline assets, which are expected to propel future product development and market expansion.
  • Optimistic Future Outlook: CFO Dier anticipates robust net sales growth in 2026, despite an increase in gross-to-net impact into the high 30% range due to contracting, indicating the company’s strong growth potential in a competitive market.
Wall Street analysts forecast MDGL stock price to rise
12 Analyst Rating
Wall Street analysts forecast MDGL stock price to rise
10 Buy
2 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
527.00
Averages
636.22
High
900.00
Current: 0.000
sliders
Low
527.00
Averages
636.22
High
900.00
BofA
Neutral
downgrade
$570 -> $529
AI Analysis
2026-02-20
Reason
BofA
Price Target
$570 -> $529
AI Analysis
2026-02-20
downgrade
Neutral
Reason
BofA lowered the firm's price target on Madrigal Pharmaceuticals to $529 from $570 and keeps a Neutral rating on the shares. Following quarterly results and the associated call, the firm is "modestly" lowering forecasts after incorporating the team's comments on gross-to-net adjustments, the analyst tells investors.
BofA
Neutral
downgrade
$595 -> $570
2026-02-03
Reason
BofA
Price Target
$595 -> $570
2026-02-03
downgrade
Neutral
Reason
BofA lowered the firm's price target on Madrigal Pharmaceuticals to $570 from $595 and keeps a Neutral rating on the shares. Given the level of pre-announcements, upcoming Q4 earnings "may not have the same impact they've had in prior years," the analyst tells investors in a preview for the firm's biopharma coverage.
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Valuation Metrics

The current forward P/E ratio for Madrigal Pharmaceuticals Inc (MDGL.O) is 726.27, compared to its 5-year average forward P/E of 17.24. For a more detailed relative valuation and DCF analysis to assess Madrigal Pharmaceuticals Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
17.24
Current PE
726.27
Overvalued PE
195.68
Undervalued PE
-161.21

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-23.31
Current EV/EBITDA
-237.96
Overvalued EV/EBITDA
32.87
Undervalued EV/EBITDA
-79.49

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
49.72
Current PS
9.90
Overvalued PS
150.56
Undervalued PS
-51.12

Financials

AI Analysis
Annual
Quarterly

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Whales Holding MDGL

H
Hood River Capital Management LLC
Holding
MDGL
+19.11%
3M Return
P
Polar Capital Holdings Plc
Holding
MDGL
+18.65%
3M Return
J
Journey Strategic Wealth LLC
Holding
MDGL
+7.43%
3M Return
A
Alkeon Capital Management, LLC
Holding
MDGL
+1.35%
3M Return
E
EULAV Asset Management
Holding
MDGL
+1.17%
3M Return
E
Erste Asset Management GmbH
Holding
MDGL
+0.77%
3M Return

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Frequently Asked Questions

What is Madrigal Pharmaceuticals Inc (MDGL) stock price today?

The current price of MDGL is 444.83 USD — it has increased 1.39

What is Madrigal Pharmaceuticals Inc (MDGL)'s business?

Madrigal Pharmaceuticals, Inc. is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a liver disease with high unmet medical need. The Company’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-b agonist designed to target key underlying causes of MASH. Rezdiffra is the medication approved by the United States Food and Drug Administration (FDA) for the treatment of MASH with moderate to advanced fibrosis (consistent with stages F2 to F3). Rezdiffra is a prescribed medicine used along with diet and exercise to treat adults with nonalcoholic steatohepatitis (NASH) with moderate to advanced liver scarring (fibrosis), but not with cirrhosis of the liver. An ongoing Phase III outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (consistent with stage F4c).

What is the price predicton of MDGL Stock?

Wall Street analysts forecast MDGL stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for MDGL is636.22 USD with a low forecast of 527.00 USD and a high forecast of 900.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Madrigal Pharmaceuticals Inc (MDGL)'s revenue for the last quarter?

Madrigal Pharmaceuticals Inc revenue for the last quarter amounts to 321.08M USD, increased 210.77

What is Madrigal Pharmaceuticals Inc (MDGL)'s earnings per share (EPS) for the last quarter?

Madrigal Pharmaceuticals Inc. EPS for the last quarter amounts to -2.55 USD, decreased -5.90

How many employees does Madrigal Pharmaceuticals Inc (MDGL). have?

Madrigal Pharmaceuticals Inc (MDGL) has 915 emplpoyees as of March 14 2026.

What is Madrigal Pharmaceuticals Inc (MDGL) market cap?

Today MDGL has the market capitalization of 10.20B USD.