Aprea Therapeutics Files to Sell 12.58M Shares of Common Stock
Written by Emily J. Thompson, Senior Investment Analyst
Updated: 4 days ago
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Should l Buy APRE?
Aprea Therapeutics files to sell 12.58M shares of common stock for holders
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Analyst Views on APRE
Wall Street analysts forecast APRE stock price to rise
3 Analyst Rating
3 Buy
0 Hold
0 Sell
Strong Buy
Current: 0.815
Low
4.00
Averages
5.33
High
7.00
Current: 0.815
Low
4.00
Averages
5.33
High
7.00
About APRE
Aprea Therapeutics, Inc. is a clinical-stage biopharmaceutical company focused on precision oncology through synthetic lethality. The Company’s pipeline includes two clinical-stage synthetic lethality programs. Its lead programs are APR-1051, an oral, small-molecule inhibitor of WEE1 kinase, and ATRN-119, a small-molecule ATR inhibitor, both in clinical development for solid tumor indications. Its ATRN-119 is an oral small molecule inhibitor of ataxia telangiectasia and Rad3-related (ATR). The ATR kinase is a master regulator of Deoxyribonucleic Acid (DNA) damage response, with roles in cell cycle control and DNA repair following replication stress. It is evaluating potential combination opportunities within its pipeline, including research on the combination of ATRN-119 and APR-1051 that is supported by a Phase II SBIR grant from the National Cancer Institute. It also has an early-stage program, in the lead optimization stage, for an undisclosed DNA-damage response (DDR) target.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
Aprea Therapeutics Reports Significant Tumor Shrinkage in Early Trial
- Significant Tumor Reduction: Aprea Therapeutics reported a 50% tumor shrinkage in a patient from its early-stage trial of APR-1051, alongside a notable decline in the tumor biomarker CA-125, indicating the drug's potential therapeutic impact and strengthening the company's market outlook.
- Mild Side Effects: The patient experienced only low-grade treatment-emergent adverse effects and continued treatment, suggesting good tolerability of APR-1051, which provides positive safety data for future clinical trials.
- Follow-Up Assessment Plans: The company is eyeing confirmation of the partial responses observed in both patients through subsequent imaging assessments, with further updates expected in Q2 2026, which could positively influence investor confidence.
- Positive Market Reaction: Following the announcement, Aprea's shares surged 15%, with all analysts covering the stock rating it as 'Buy' or higher, and a 12-month average price target of $5.33, representing a potential upside of approximately 788%, reflecting optimistic market sentiment regarding its future performance.
See More
Aprea Therapeutics Reports Positive Cancer Trial Data
- Clinical Trial Progress: Aprea Therapeutics announced a second unconfirmed partial response in a patient with advanced endometrial cancer during its ongoing Phase 1 trial of APR-1051, with a 50% reduction in target lesion measurements, indicating the drug's potential efficacy.
- Significant Biomarker Drop: The CA-125 tumor biomarker levels decreased dramatically from a baseline of 362 U/mL to 47 U/mL during the trial, suggesting promising anti-tumor activity of APR-1051, potentially offering new treatment hope for patients.
- Study Expansion Plans: Aprea plans to expand the study to include more patients with specific genetic alterations to further evaluate the safety and efficacy of APR-1051, with further updates expected in the second quarter of 2026.
- Positive Market Reaction: Aprea Therapeutics shares rose 16.62% to $0.70 at the time of publication, reflecting a positive market response to its clinical data, with analysts generally rating it as a “Buy,” indicating strong investor confidence.
See More
Aprea Therapeutics Reports New Clinical Activity in APR-1051 Trial
- Clinical Trial Progress: Aprea Therapeutics announced new preliminary clinical activity from its ongoing Phase 1 ACESOT-1051 trial of APR-1051, where a patient with advanced endometrial cancer achieved a 50% reduction in target lesions at the 220 mg dose level, indicating the drug's potential in patients with specific genetic mutations.
- Safety and Tolerability: Only Grade 1 adverse events were reported during treatment, demonstrating favorable tolerability of APR-1051 at doses up to 220 mg, which reinforces confidence in its application in genomically defined cancers.
- Stable Disease Cases: The trial also reported five cases of stable disease across multiple tumor types, showcasing APR-1051's potential efficacy in various cancers and further supporting the company's targeted strategy against WEE1.
- Future Outlook: Aprea plans to continue enrolling PPP2R1A-mutated endometrial and HPV-positive head and neck cancer patients in the 220 mg cohort, with an additional update expected in the second quarter of 2026, reflecting the company's positive outlook on future research.
See More
Aprea Secures New Patents to Strengthen Global IP Coverage
- Patent Protection Expansion: Aprea's newly granted patents in 2025, including those in Australia and Japan, are expected to provide exclusivity for its WEE1 and ATR programs until 2045, significantly enhancing the company's competitive position in the global market.
- Clinical Progress: Aprea's lead WEE1 inhibitor, APR-1051, is currently in Phase 1 trials, with early clinical data demonstrating proof of concept, and multiple data readouts anticipated in 2026, further driving its market potential.
- Intellectual Property Strategy: Aprea's IP portfolio includes multiple new patents designed to provide long-term protection for its core compounds and therapeutic methods, thereby de-risking clinical development and maximizing commercial value.
- Therapeutic Innovation: Aprea's ATR inhibitor, ATRN-119, is also in clinical trials, with existing patents expected to protect its new compounds until 2035-2037, while pending applications could extend protection into 2045, supporting the company's long-term growth in oncology treatment.
See More
APREA THERAPEUTICS EXPANDS GLOBAL PATENT PORTFOLIO IN DNA DAMAGE RESPONSE (DDR) CANCER TREATMENTS, FOSTERING PIPELINE EXPANSION
Company Overview: Aprea Therapeutics is enhancing its global patent portfolio, particularly in the area of DNA damage response (DDR) cancer therapeutics.
Strategic Focus: The company is paving the way for potential growth in the pipeline of its cancer therapies, indicating a commitment to advancing treatment options.
See More
Aprea Therapeutics Appoints New Chief Medical Advisor
- New Chief Medical Advisor: Aprea Therapeutics has appointed Dr. Eugene Kennedy as Chief Medical Advisor, aiming to strengthen the company's clinical leadership in advancing the dose-escalation study of the WEE1 inhibitor APR-1051 in patients with advanced solid tumors.
- Clinical Trial Progress: Dr. Kennedy's appointment coincides with the company's recent early clinical proof-of-concept success in its ongoing Phase 1 dose-escalation study, which is expected to optimize patient selection and advance the DNA damage response program.
- Extensive Industry Experience: With over 20 years of experience in oncology clinical development and regulatory strategy, Dr. Kennedy has held senior positions in multiple biotechnology companies, which is anticipated to provide critical support for Aprea's clinical decision-making.
- Aligned Strategic Goals: Dr. Kennedy expressed alignment with Aprea's strategy to leverage DNA damage response inhibitors to transform treatment approaches for difficult-to-treat cancers, further advancing the company's clinical asset development.
See More
Aprea Therapeutics Reports Significant Tumor Shrinkage in Early Trial
- Significant Tumor Reduction: Aprea Therapeutics reported a 50% tumor shrinkage in a patient from its early-stage trial of APR-1051, alongside a notable decline in the tumor biomarker CA-125, indicating the drug's potential therapeutic impact and strengthening the company's market outlook.
- Mild Side Effects: The patient experienced only low-grade treatment-emergent adverse effects and continued treatment, suggesting good tolerability of APR-1051, which provides positive safety data for future clinical trials.
- Follow-Up Assessment Plans: The company is eyeing confirmation of the partial responses observed in both patients through subsequent imaging assessments, with further updates expected in Q2 2026, which could positively influence investor confidence.
- Positive Market Reaction: Following the announcement, Aprea's shares surged 15%, with all analysts covering the stock rating it as 'Buy' or higher, and a 12-month average price target of $5.33, representing a potential upside of approximately 788%, reflecting optimistic market sentiment regarding its future performance.
See More
Aprea Therapeutics Reports Positive Cancer Trial Data
- Clinical Trial Progress: Aprea Therapeutics announced a second unconfirmed partial response in a patient with advanced endometrial cancer during its ongoing Phase 1 trial of APR-1051, with a 50% reduction in target lesion measurements, indicating the drug's potential efficacy.
- Significant Biomarker Drop: The CA-125 tumor biomarker levels decreased dramatically from a baseline of 362 U/mL to 47 U/mL during the trial, suggesting promising anti-tumor activity of APR-1051, potentially offering new treatment hope for patients.
- Study Expansion Plans: Aprea plans to expand the study to include more patients with specific genetic alterations to further evaluate the safety and efficacy of APR-1051, with further updates expected in the second quarter of 2026.
- Positive Market Reaction: Aprea Therapeutics shares rose 16.62% to $0.70 at the time of publication, reflecting a positive market response to its clinical data, with analysts generally rating it as a “Buy,” indicating strong investor confidence.
See More
Aprea Therapeutics Reports New Clinical Activity in APR-1051 Trial
- Clinical Trial Progress: Aprea Therapeutics announced new preliminary clinical activity from its ongoing Phase 1 ACESOT-1051 trial of APR-1051, where a patient with advanced endometrial cancer achieved a 50% reduction in target lesions at the 220 mg dose level, indicating the drug's potential in patients with specific genetic mutations.
- Safety and Tolerability: Only Grade 1 adverse events were reported during treatment, demonstrating favorable tolerability of APR-1051 at doses up to 220 mg, which reinforces confidence in its application in genomically defined cancers.
- Stable Disease Cases: The trial also reported five cases of stable disease across multiple tumor types, showcasing APR-1051's potential efficacy in various cancers and further supporting the company's targeted strategy against WEE1.
- Future Outlook: Aprea plans to continue enrolling PPP2R1A-mutated endometrial and HPV-positive head and neck cancer patients in the 220 mg cohort, with an additional update expected in the second quarter of 2026, reflecting the company's positive outlook on future research.
See More
Aprea Secures New Patents to Strengthen Global IP Coverage
- Patent Protection Expansion: Aprea's newly granted patents in 2025, including those in Australia and Japan, are expected to provide exclusivity for its WEE1 and ATR programs until 2045, significantly enhancing the company's competitive position in the global market.
- Clinical Progress: Aprea's lead WEE1 inhibitor, APR-1051, is currently in Phase 1 trials, with early clinical data demonstrating proof of concept, and multiple data readouts anticipated in 2026, further driving its market potential.
- Intellectual Property Strategy: Aprea's IP portfolio includes multiple new patents designed to provide long-term protection for its core compounds and therapeutic methods, thereby de-risking clinical development and maximizing commercial value.
- Therapeutic Innovation: Aprea's ATR inhibitor, ATRN-119, is also in clinical trials, with existing patents expected to protect its new compounds until 2035-2037, while pending applications could extend protection into 2045, supporting the company's long-term growth in oncology treatment.
See More
APREA THERAPEUTICS EXPANDS GLOBAL PATENT PORTFOLIO IN DNA DAMAGE RESPONSE (DDR) CANCER TREATMENTS, FOSTERING PIPELINE EXPANSION
Company Overview: Aprea Therapeutics is enhancing its global patent portfolio, particularly in the area of DNA damage response (DDR) cancer therapeutics.
Strategic Focus: The company is paving the way for potential growth in the pipeline of its cancer therapies, indicating a commitment to advancing treatment options.
See More
Aprea Therapeutics Appoints New Chief Medical Advisor
- New Chief Medical Advisor: Aprea Therapeutics has appointed Dr. Eugene Kennedy as Chief Medical Advisor, aiming to strengthen the company's clinical leadership in advancing the dose-escalation study of the WEE1 inhibitor APR-1051 in patients with advanced solid tumors.
- Clinical Trial Progress: Dr. Kennedy's appointment coincides with the company's recent early clinical proof-of-concept success in its ongoing Phase 1 dose-escalation study, which is expected to optimize patient selection and advance the DNA damage response program.
- Extensive Industry Experience: With over 20 years of experience in oncology clinical development and regulatory strategy, Dr. Kennedy has held senior positions in multiple biotechnology companies, which is anticipated to provide critical support for Aprea's clinical decision-making.
- Aligned Strategic Goals: Dr. Kennedy expressed alignment with Aprea's strategy to leverage DNA damage response inhibitors to transform treatment approaches for difficult-to-treat cancers, further advancing the company's clinical asset development.
See More
