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APRE Overview

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0.000(0.000%)Aft-market
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0.000
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0.000(0.000%)Aft-market
ET
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Intellectia

Loading chart...

High
0.695
Open
0.695
VWAP
0.68
Vol
53.53K
Mkt Cap
8.01M
Low
0.657
Amount
36.32K
EV/EBITDA(TTM)
--
Total Shares
11.45M
EV
-5.86M
EV/OCF(TTM)
--
P/S(TTM)
16.00
Aprea Therapeutics, Inc. is a clinical-stage biopharmaceutical company focused on precision oncology through synthetic lethality. The Company’s pipeline includes two clinical-stage synthetic lethality programs. Its lead programs are APR-1051, an oral, small-molecule inhibitor of WEE1 kinase, and ATRN-119, a small-molecule ATR inhibitor, both in clinical development for solid tumor indications. Its ATRN-119 is an oral small molecule inhibitor of ataxia telangiectasia and Rad3-related (ATR). The ATR kinase is a master regulator of Deoxyribonucleic Acid (DNA) damage response, with roles in cell cycle control and DNA repair following replication stress. It is evaluating potential combination opportunities within its pipeline, including research on the combination of ATRN-119 and APR-1051 that is supported by a Phase II SBIR grant from the National Cancer Institute. It also has an early-stage program, in the lead optimization stage, for an undisclosed DNA-damage response (DDR) target.
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Events Timeline

(ET)
2026-03-30
08:20:00
Aprea Therapeutics Confirms Partial Response for APR-1051
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2026-03-16 (ET)
2026-03-16
08:10:00
Aprea Reports Revenue of $3,337 for 2026
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2026-03-16
08:10:00
Aprea Cash and Cash Equivalents Drop to $14.6 Million
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2026-02-20 (ET)
2026-02-20
06:10:00
Aprea Therapeutics Files to Sell 12.58M Shares of Common Stock
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2026-02-18 (ET)
2026-02-18
08:20:00
Aprea Therapeutics Reports Preliminary Data on APR-1051 Clinical Trial
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2026-02-12 (ET)
2026-02-12
08:40:00
Aprea Therapeutics Expands Global Intellectual Property Estate
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2026-02-04 (ET)
2026-02-04
08:40:00
Aprea Therapeutics Appoints Eugene Kennedy as Chief Medical Advisor
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News

NASDAQ.COM
9.5
04-02NASDAQ.COM
Aprea Therapeutics Closes $30 Million Oversubscribed Financing
  • Successful Financing: Aprea Therapeutics closed an oversubscribed $30 million private placement on March 31, 2026, with proceeds allocated for general corporate purposes and R&D expenses, thereby enhancing financial flexibility to support its clinical projects.
  • Clinical Trial Progress: The company's lead candidate APR-1051 is undergoing a Phase 1 trial for advanced solid tumors, showing promising clinical activity, with further updates expected in Q2 2026, which could drive stock price appreciation.
  • Analyst Rating Maintained: Wedbush analyst Robert Driscoll reaffirmed an Outperform rating for Aprea with a 12-month price target of $7, reflecting market confidence in its product potential and likely attracting more investor interest.
  • Cash Flow Status: As of December 31, 2025, Aprea reported cash and cash equivalents of $14.6 million, and with the recent financing, projected a cash runway through Q1 2027, providing a safeguard for the company's future development.
Newsfilter
8.5
04-01Newsfilter
Aprea Therapeutics Closes $30 Million Financing
  • Significant Financing: Aprea Therapeutics has successfully closed an oversubscribed private placement financing, raising approximately $30 million, which will provide robust funding for the company's research and operational needs, expected to accelerate the development of targeted therapies for biomarker-defined cancers.
  • Investor Confidence: The financing was led by top-tier biotech investor Soleus Capital, with participation from new investors such as Vestal Point Capital and Squadron Capital Management, reflecting strong market confidence in the potential of APR-1051 to impact cancer treatment.
  • Clinical Trial Expansion: Aprea plans to enroll at least 50 patients with uterine serous carcinoma and platinum-resistant ovarian cancer to evaluate the efficacy of APR-1051, a strategy that will help clarify the clinical development path and accelerate insight generation in biomarker-defined patient populations.
  • Future Development Outlook: The company intends to exercise the newly issued warrants before 2029, further strengthening its capital structure to support innovation and competitiveness in the cancer treatment market.
NASDAQ.COM
9.5
03-31NASDAQ.COM
Wedbush Reiterates Outperform Rating for Aprea Therapeutics
  • Successful Financing: Aprea Therapeutics announced the completion of an oversubscribed private placement financing totaling approximately $30 million, which will provide crucial funding for its clinical trials and product development, enhancing the company's competitiveness in the biopharmaceutical sector.
  • Clinical Trial Progress: The company's lead product candidate, APR-1051, is undergoing a Phase 1 clinical trial for patients with advanced solid tumors harboring cancer-associated genetic alterations, with preliminary data showing positive clinical activity, laying the groundwork for future market introduction.
  • Dose Escalation Study: The dose-escalation study for APR-1051 is ongoing, with plans to advance to the 300 mg once-daily dose cohort in the second quarter of 2026, which will include patients with uterine serous carcinoma, colorectal cancer, and HPV+ tumors, demonstrating the company's continued commitment to clinical research.
  • Market Performance: Aprea Therapeutics' stock has traded between $0.54 and $2.30 over the past year, currently priced at $0.78, reflecting a 5.98% increase, indicating positive market sentiment regarding its clinical advancements.
NASDAQ.COM
8.5
03-30NASDAQ.COM
Aprea Therapeutics Secures $30 Million Financing for APR-1051 Development
  • Clinical Trial Progress: Aprea Therapeutics reported a confirmed partial response in a patient with PPP2R1A-mutated endometrial cancer during its ongoing Phase 1 ACESOT-1051 trial, with a 50% reduction in tumor size at the first imaging assessment and an additional 9.5% reduction at the second assessment, indicating the drug's potential efficacy.
  • Enrollment Expansion Plans: The company plans to enroll at least 50 patients with uterine serous carcinoma and other high-need patient groups beyond the existing biomarker-enriched cohorts, addressing significant unmet medical needs, with dose escalation expected to complete by the second quarter of 2027.
  • Financing Details: Aprea announced an oversubscribed $30 million private placement led by Soleus Capital, with proceeds intended for general corporate purposes and R&D activities, which is expected to extend the company's cash runway into the first quarter of 2028.
  • Stock Performance: APRE shares have traded between $0.54 and $2.30 over the past year, closing at $0.68, down 2.43% on the last trading day, but showing an 8.35% increase in pre-market trading, reflecting positive market sentiment regarding its financing and clinical advancements.
seekingalpha
9.5
03-16seekingalpha
Aprea Therapeutics Reports Q4 2025 Financial Results
  • Financial Highlights: Aprea Therapeutics reported a Q4 2025 GAAP EPS of -$0.32, beating expectations by $0.07, indicating a slight improvement in financial performance despite remaining in a loss position.
  • Revenue Comparison: The company generated revenue of $3,340 this quarter, a significant drop from $210,000 in the same period last year, reflecting a notable decline in product sales or service demand, which may impact future cash flow.
  • Cash Position: As of December 31, 2025, Aprea reported cash and cash equivalents of $14.6 million, down from $22.8 million in 2024, indicating pressure on the company's financial management and raising concerns about its future financing capabilities.
  • Financing Strategy: Aprea plans to utilize proceeds from a $5.6 million private placement completed in January 2026 to support operations, with expectations that these funds will be sufficient to cover operating and capital expenditure needs into Q1 2027, demonstrating strategic planning for its cash flow.
stocktwits
9.0
02-18stocktwits
Aprea Therapeutics Reports Significant Tumor Shrinkage in Early Trial
  • Significant Tumor Reduction: Aprea Therapeutics reported a 50% tumor shrinkage in a patient from its early-stage trial of APR-1051, alongside a notable decline in the tumor biomarker CA-125, indicating the drug's potential therapeutic impact and strengthening the company's market outlook.
  • Mild Side Effects: The patient experienced only low-grade treatment-emergent adverse effects and continued treatment, suggesting good tolerability of APR-1051, which provides positive safety data for future clinical trials.
  • Follow-Up Assessment Plans: The company is eyeing confirmation of the partial responses observed in both patients through subsequent imaging assessments, with further updates expected in Q2 2026, which could positively influence investor confidence.
  • Positive Market Reaction: Following the announcement, Aprea's shares surged 15%, with all analysts covering the stock rating it as 'Buy' or higher, and a 12-month average price target of $5.33, representing a potential upside of approximately 788%, reflecting optimistic market sentiment regarding its future performance.
Wall Street analysts forecast APRE stock price to rise
3 Analyst Rating
Wall Street analysts forecast APRE stock price to rise
3 Buy
0 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
4.00
Averages
5.33
High
7.00
Current: 0.000
sliders
Low
4.00
Averages
5.33
High
7.00
H.C. Wainwright
H.C. Wainwright
Buy
downgrade
$4
AI Analysis
2026-03-31
Reason
H.C. Wainwright
H.C. Wainwright
Price Target
$4
AI Analysis
2026-03-31
downgrade
Buy
Reason
H.C. Wainwright lowered the firm's price target on Aprea Therapeutics to $1.20 from $4 and keeps a Buy rating on the shares. The firm cites the "significant dilution" from yesterday's financing through pre-funded warrants and warrant to buy common shares for the target cut.
Wedbush
Outperform -> NULL
downgrade
$11 -> $7
2026-02-10
Reason
Wedbush
Price Target
$11 -> $7
2026-02-10
downgrade
Outperform -> NULL
Reason
Wedbush lowered the firm's price target on Aprea Therapeutics to $7 from $11 and keeps an Outperform rating on the shares. The firm notes the company announced preliminary proof-of-concept data for WEE1 inhibitor APR-1051. Wedbush believes the recent partial response is further validating of the clinical potential for APR-1051, and the firm expects to continue to see dose responses as higher dosing cohorts are enrolled.
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Valuation Metrics

The current forward P/E ratio for Aprea Therapeutics Inc (APRE.O) is 0.00, compared to its 5-year average forward P/E of -1.40. For a more detailed relative valuation and DCF analysis to assess Aprea Therapeutics Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-1.40
Current PE
0.00
Overvalued PE
-0.81
Undervalued PE
-1.99

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
0.26
Current EV/EBITDA
0.01
Overvalued EV/EBITDA
0.68
Undervalued EV/EBITDA
-0.16

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
51.98
Current PS
7.65
Overvalued PS
119.69
Undervalued PS
-15.73

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Frequently Asked Questions

What is Aprea Therapeutics Inc (APRE) stock price today?

The current price of APRE is 0.6832 USD — it has decreased -2.29

What is Aprea Therapeutics Inc (APRE)'s business?

Aprea Therapeutics, Inc. is a clinical-stage biopharmaceutical company focused on precision oncology through synthetic lethality. The Company’s pipeline includes two clinical-stage synthetic lethality programs. Its lead programs are APR-1051, an oral, small-molecule inhibitor of WEE1 kinase, and ATRN-119, a small-molecule ATR inhibitor, both in clinical development for solid tumor indications. Its ATRN-119 is an oral small molecule inhibitor of ataxia telangiectasia and Rad3-related (ATR). The ATR kinase is a master regulator of Deoxyribonucleic Acid (DNA) damage response, with roles in cell cycle control and DNA repair following replication stress. It is evaluating potential combination opportunities within its pipeline, including research on the combination of ATRN-119 and APR-1051 that is supported by a Phase II SBIR grant from the National Cancer Institute. It also has an early-stage program, in the lead optimization stage, for an undisclosed DNA-damage response (DDR) target.

What is the price predicton of APRE Stock?

Wall Street analysts forecast APRE stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for APRE is5.33 USD with a low forecast of 4.00 USD and a high forecast of 7.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Aprea Therapeutics Inc (APRE)'s revenue for the last quarter?

Aprea Therapeutics Inc revenue for the last quarter amounts to 3.34K USD, decreased -98.38

What is Aprea Therapeutics Inc (APRE)'s earnings per share (EPS) for the last quarter?

Aprea Therapeutics Inc. EPS for the last quarter amounts to -0.32 USD, decreased -34.69

How many employees does Aprea Therapeutics Inc (APRE). have?

Aprea Therapeutics Inc (APRE) has 8 emplpoyees as of April 07 2026.

What is Aprea Therapeutics Inc (APRE) market cap?

Today APRE has the market capitalization of 8.01M USD.