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APRE Overview

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Intellectia

Loading chart...

High
0.840
Open
0.840
VWAP
0.78
Vol
115.68K
Mkt Cap
8.66M
Low
0.729
Amount
89.69K
EV/EBITDA(TTM)
--
Total Shares
11.45M
EV
-7.84M
EV/OCF(TTM)
--
P/S(TTM)
9.20
Aprea Therapeutics, Inc. is a clinical-stage biopharmaceutical company focused on precision oncology through synthetic lethality. The Company’s pipeline includes two clinical-stage synthetic lethality programs. Its lead programs are APR-1051, an oral, small-molecule inhibitor of WEE1 kinase, and ATRN-119, a small-molecule ATR inhibitor, both in clinical development for solid tumor indications. Its ATRN-119 is an oral small molecule inhibitor of ataxia telangiectasia and Rad3-related (ATR). The ATR kinase is a master regulator of Deoxyribonucleic Acid (DNA) damage response, with roles in cell cycle control and DNA repair following replication stress. It is evaluating potential combination opportunities within its pipeline, including research on the combination of ATRN-119 and APR-1051 that is supported by a Phase II SBIR grant from the National Cancer Institute. It also has an early-stage program, in the lead optimization stage, for an undisclosed DNA-damage response (DDR) target.
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Events Timeline

(ET)
2026-03-16
08:10:00
Aprea Cash and Cash Equivalents Drop to $14.6 Million
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2026-03-16
08:10:00
Aprea Reports Revenue of $3,337 for 2026
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2026-02-20 (ET)
2026-02-20
06:10:00
Aprea Therapeutics Files to Sell 12.58M Shares of Common Stock
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2026-02-18 (ET)
2026-02-18
08:20:00
Aprea Therapeutics Reports Preliminary Data on APR-1051 Clinical Trial
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2026-02-12 (ET)
2026-02-12
08:40:00
Aprea Therapeutics Expands Global Intellectual Property Estate
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2026-02-04 (ET)
2026-02-04
08:40:00
Aprea Therapeutics Appoints Eugene Kennedy as Chief Medical Advisor
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2026-01-29 (ET)
2026-01-29
08:40:00
Aprea Therapeutics Reports Initial Efficacy of APR-1051 in Uterine Cancer Patient
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2026-01-29
08:30:00
Aprea Therapeutics Completes $5.6M Private Placement
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News

seekingalpha
9.5
03-16seekingalpha
PinnedAprea Therapeutics Reports Q4 2025 Financial Results
  • Financial Highlights: Aprea Therapeutics reported a Q4 2025 GAAP EPS of -$0.32, beating expectations by $0.07, indicating a slight improvement in financial performance despite remaining in a loss position.
  • Revenue Comparison: The company generated revenue of $3,340 this quarter, a significant drop from $210,000 in the same period last year, reflecting a notable decline in product sales or service demand, which may impact future cash flow.
  • Cash Position: As of December 31, 2025, Aprea reported cash and cash equivalents of $14.6 million, down from $22.8 million in 2024, indicating pressure on the company's financial management and raising concerns about its future financing capabilities.
  • Financing Strategy: Aprea plans to utilize proceeds from a $5.6 million private placement completed in January 2026 to support operations, with expectations that these funds will be sufficient to cover operating and capital expenditure needs into Q1 2027, demonstrating strategic planning for its cash flow.
stocktwits
9.0
02-18stocktwits
Aprea Therapeutics Reports Significant Tumor Shrinkage in Early Trial
  • Significant Tumor Reduction: Aprea Therapeutics reported a 50% tumor shrinkage in a patient from its early-stage trial of APR-1051, alongside a notable decline in the tumor biomarker CA-125, indicating the drug's potential therapeutic impact and strengthening the company's market outlook.
  • Mild Side Effects: The patient experienced only low-grade treatment-emergent adverse effects and continued treatment, suggesting good tolerability of APR-1051, which provides positive safety data for future clinical trials.
  • Follow-Up Assessment Plans: The company is eyeing confirmation of the partial responses observed in both patients through subsequent imaging assessments, with further updates expected in Q2 2026, which could positively influence investor confidence.
  • Positive Market Reaction: Following the announcement, Aprea's shares surged 15%, with all analysts covering the stock rating it as 'Buy' or higher, and a 12-month average price target of $5.33, representing a potential upside of approximately 788%, reflecting optimistic market sentiment regarding its future performance.
Benzinga
9.0
02-18Benzinga
Aprea Therapeutics Reports Positive Cancer Trial Data
  • Clinical Trial Progress: Aprea Therapeutics announced a second unconfirmed partial response in a patient with advanced endometrial cancer during its ongoing Phase 1 trial of APR-1051, with a 50% reduction in target lesion measurements, indicating the drug's potential efficacy.
  • Significant Biomarker Drop: The CA-125 tumor biomarker levels decreased dramatically from a baseline of 362 U/mL to 47 U/mL during the trial, suggesting promising anti-tumor activity of APR-1051, potentially offering new treatment hope for patients.
  • Study Expansion Plans: Aprea plans to expand the study to include more patients with specific genetic alterations to further evaluate the safety and efficacy of APR-1051, with further updates expected in the second quarter of 2026.
  • Positive Market Reaction: Aprea Therapeutics shares rose 16.62% to $0.70 at the time of publication, reflecting a positive market response to its clinical data, with analysts generally rating it as a “Buy,” indicating strong investor confidence.
NASDAQ.COM
9.0
02-18NASDAQ.COM
Aprea Therapeutics Reports New Clinical Activity in APR-1051 Trial
  • Clinical Trial Progress: Aprea Therapeutics announced new preliminary clinical activity from its ongoing Phase 1 ACESOT-1051 trial of APR-1051, where a patient with advanced endometrial cancer achieved a 50% reduction in target lesions at the 220 mg dose level, indicating the drug's potential in patients with specific genetic mutations.
  • Safety and Tolerability: Only Grade 1 adverse events were reported during treatment, demonstrating favorable tolerability of APR-1051 at doses up to 220 mg, which reinforces confidence in its application in genomically defined cancers.
  • Stable Disease Cases: The trial also reported five cases of stable disease across multiple tumor types, showcasing APR-1051's potential efficacy in various cancers and further supporting the company's targeted strategy against WEE1.
  • Future Outlook: Aprea plans to continue enrolling PPP2R1A-mutated endometrial and HPV-positive head and neck cancer patients in the 220 mg cohort, with an additional update expected in the second quarter of 2026, reflecting the company's positive outlook on future research.
Newsfilter
8.5
02-12Newsfilter
Aprea Secures New Patents to Strengthen Global IP Coverage
  • Patent Protection Expansion: Aprea's newly granted patents in 2025, including those in Australia and Japan, are expected to provide exclusivity for its WEE1 and ATR programs until 2045, significantly enhancing the company's competitive position in the global market.
  • Clinical Progress: Aprea's lead WEE1 inhibitor, APR-1051, is currently in Phase 1 trials, with early clinical data demonstrating proof of concept, and multiple data readouts anticipated in 2026, further driving its market potential.
  • Intellectual Property Strategy: Aprea's IP portfolio includes multiple new patents designed to provide long-term protection for its core compounds and therapeutic methods, thereby de-risking clinical development and maximizing commercial value.
  • Therapeutic Innovation: Aprea's ATR inhibitor, ATRN-119, is also in clinical trials, with existing patents expected to protect its new compounds until 2035-2037, while pending applications could extend protection into 2045, supporting the company's long-term growth in oncology treatment.
moomoo
3.5
02-12moomoo
APREA THERAPEUTICS EXPANDS GLOBAL PATENT PORTFOLIO IN DNA DAMAGE RESPONSE (DDR) CANCER TREATMENTS, FOSTERING PIPELINE EXPANSION
  • Company Overview: Aprea Therapeutics is enhancing its global patent portfolio, particularly in the area of DNA damage response (DDR) cancer therapeutics.

  • Strategic Focus: The company is paving the way for potential growth in the pipeline of its cancer therapies, indicating a commitment to advancing treatment options.

Wall Street analysts forecast APRE stock price to rise
3 Analyst Rating
Wall Street analysts forecast APRE stock price to rise
3 Buy
0 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
4.00
Averages
5.33
High
7.00
Current: 0.000
sliders
Low
4.00
Averages
5.33
High
7.00
Wedbush
Outperform -> NULL
downgrade
$11 -> $7
AI Analysis
2026-02-10
Reason
Wedbush
Price Target
$11 -> $7
AI Analysis
2026-02-10
downgrade
Outperform -> NULL
Reason
Wedbush lowered the firm's price target on Aprea Therapeutics to $7 from $11 and keeps an Outperform rating on the shares. The firm notes the company announced preliminary proof-of-concept data for WEE1 inhibitor APR-1051. Wedbush believes the recent partial response is further validating of the clinical potential for APR-1051, and the firm expects to continue to see dose responses as higher dosing cohorts are enrolled.
H.C. Wainwright
Joseph Pantginis
Buy
downgrade
$5 -> $4
2026-01-29
Reason
H.C. Wainwright
Joseph Pantginis
Price Target
$5 -> $4
2026-01-29
downgrade
Buy
Reason
H.C. Wainwright analyst Joseph Pantginis lowered the firm's price target on Aprea Therapeutics to $4 from $5 and keeps a Buy rating on the shares. The firm is "encouraged by the positive," early proof-of-concept data from the ACESOT-1051 study. Aprea reported "promising" preliminary signals from an endometrial cancer patient, the analyst tells investors in a research note. H.C. Wainwright cites dilution for the target cut.
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Valuation Metrics

The current forward P/E ratio for Aprea Therapeutics Inc (APRE.O) is -1.47, compared to its 5-year average forward P/E of -1.40. For a more detailed relative valuation and DCF analysis to assess Aprea Therapeutics Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-1.40
Current PE
-1.47
Overvalued PE
-0.81
Undervalued PE
-1.99

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
0.27
Current EV/EBITDA
0.64
Overvalued EV/EBITDA
0.71
Undervalued EV/EBITDA
-0.16

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
55.88
Current PS
22.95
Overvalued PS
125.10
Undervalued PS
-13.34

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Frequently Asked Questions

What is Aprea Therapeutics Inc (APRE) stock price today?

The current price of APRE is 0.7561 USD — it has increased 2.72

What is Aprea Therapeutics Inc (APRE)'s business?

Aprea Therapeutics, Inc. is a clinical-stage biopharmaceutical company focused on precision oncology through synthetic lethality. The Company’s pipeline includes two clinical-stage synthetic lethality programs. Its lead programs are APR-1051, an oral, small-molecule inhibitor of WEE1 kinase, and ATRN-119, a small-molecule ATR inhibitor, both in clinical development for solid tumor indications. Its ATRN-119 is an oral small molecule inhibitor of ataxia telangiectasia and Rad3-related (ATR). The ATR kinase is a master regulator of Deoxyribonucleic Acid (DNA) damage response, with roles in cell cycle control and DNA repair following replication stress. It is evaluating potential combination opportunities within its pipeline, including research on the combination of ATRN-119 and APR-1051 that is supported by a Phase II SBIR grant from the National Cancer Institute. It also has an early-stage program, in the lead optimization stage, for an undisclosed DNA-damage response (DDR) target.

What is the price predicton of APRE Stock?

Wall Street analysts forecast APRE stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for APRE is5.33 USD with a low forecast of 4.00 USD and a high forecast of 7.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Aprea Therapeutics Inc (APRE)'s revenue for the last quarter?

Aprea Therapeutics Inc revenue for the last quarter amounts to 1.85K USD, decreased -99.48

What is Aprea Therapeutics Inc (APRE)'s earnings per share (EPS) for the last quarter?

Aprea Therapeutics Inc. EPS for the last quarter amounts to -0.47 USD, decreased -26.56

How many employees does Aprea Therapeutics Inc (APRE). have?

Aprea Therapeutics Inc (APRE) has 8 emplpoyees as of March 17 2026.

What is Aprea Therapeutics Inc (APRE) market cap?

Today APRE has the market capitalization of 8.66M USD.