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APRE Should I Buy

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Intellectia

Should You Buy Aprea Therapeutics Inc (APRE) Today? Analysis, Price Targets, and 2026 Outlook.

Conclusion
Hold
Latest Price
0.760
1 Day change
2.72%
52 Week Range
2.650
Analysis Updated At
2026/03/13
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Aprea Therapeutics Inc (APRE) is not a strong buy for a beginner, long-term investor at this time. The stock lacks positive momentum, has weak financial performance, and no significant catalysts to drive growth in the near term. While insider buying is a positive signal, the company's declining revenue and net income, coupled with negative technical indicators, suggest a cautious approach.

Technical Analysis

The MACD is negative and expanding, indicating bearish momentum. The RSI is at 31.414, close to oversold levels but still neutral. Moving averages are converging, showing no clear trend. Key support levels are at $0.777 and $0.73, with resistance at $0.93 and $0.977. The stock has a 70% chance of declining slightly in the short term.

Positive Catalysts

  • Insiders are buying, with a 147.37% increase in buying activity over the last month. Analysts remain optimistic about the clinical potential of APR-1051, which could be a long-term growth driver.

Neutral/Negative Catalysts

  • Revenue dropped by 99.48% YoY in Q3 2025, and net income declined by 21.44% YoY. EPS also fell by 26.56% YoY. Technical indicators suggest bearish momentum, and there are no recent news or significant catalysts to drive the stock upward in the short term.

Financial Performance

In Q3 2025, revenue dropped significantly by 99.48% YoY to $1,848. Net income fell to -$2,972,410, a 21.44% decline YoY. EPS decreased by 26.56% YoY to -$0.47. Gross margin remained stable at 100%. Overall, the financial performance is weak and reflects significant challenges.

Growth

Profitability

Efficiency

Analyst Ratings and Price Target Trends

Analysts have lowered price targets consistently over the past months. Wedbush reduced the target from $11 to $7, and H.C. Wainwright cut it from $5 to $4. Despite the cuts, analysts maintain Buy or Outperform ratings, citing the clinical potential of APR-1051 as a positive factor. However, dilution and shifting focus in the pipeline are concerns.

Wall Street analysts forecast APRE stock price to rise
3 Analyst Rating
Wall Street analysts forecast APRE stock price to rise
3 Buy
0 Hold
0 Sell
Strong Buy
Current: 0.736
sliders
Low
4
Averages
5.33
High
7
Current: 0.736
sliders
Low
4
Averages
5.33
High
7
Wedbush
Outperform -> NULL
downgrade
$11 -> $7
AI Analysis
2026-02-10
Reason
Wedbush
Price Target
$11 -> $7
AI Analysis
2026-02-10
downgrade
Outperform -> NULL
Reason
Wedbush lowered the firm's price target on Aprea Therapeutics to $7 from $11 and keeps an Outperform rating on the shares. The firm notes the company announced preliminary proof-of-concept data for WEE1 inhibitor APR-1051. Wedbush believes the recent partial response is further validating of the clinical potential for APR-1051, and the firm expects to continue to see dose responses as higher dosing cohorts are enrolled.
H.C. Wainwright
Joseph Pantginis
Buy
downgrade
$5 -> $4
2026-01-29
Reason
H.C. Wainwright
Joseph Pantginis
Price Target
$5 -> $4
2026-01-29
downgrade
Buy
Reason
H.C. Wainwright analyst Joseph Pantginis lowered the firm's price target on Aprea Therapeutics to $4 from $5 and keeps a Buy rating on the shares. The firm is "encouraged by the positive," early proof-of-concept data from the ACESOT-1051 study. Aprea reported "promising" preliminary signals from an endometrial cancer patient, the analyst tells investors in a research note. H.C. Wainwright cites dilution for the target cut.
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