Annexon Submits Marketing Authorization Application for tanruprubart to Treat GBS
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Jan 08 2026
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Annexon announced it has submitted a Marketing Authorization Application, MAA, to the European Medicines Agency, EMA, for tanruprubart for the treatment of Guillain-Barre syndrome, GBS. "Annexon's first regulatory submission marks a defining milestone for patients and for the company and represents the first of several important registrational catalysts anticipated from our lead programs in 2026," said Douglas Love, president and chief executive officer of Annexon. "In the landmark Phase 3 study, tanruprubart was shown to rapidly stop neuroinflammation, enabling GBS patients to recover faster and more completely from this sudden, life-threatening disease that has no approved disease modifying therapies. Accordingly, we look forward to working closely with the EMA during the review, and to further collaborating with regulatory authorities worldwide to make available the first targeted treatment for GBS. This submission is an important step on many fronts as we move closer to achieving our mission of helping millions of patients impacted by devastating neuroinflammatory diseases live their best lives."
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Analyst Views on ANNX
Wall Street analysts forecast ANNX stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for ANNX is 14.71 USD with a low forecast of 8.00 USD and a high forecast of 27.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
8 Analyst Rating
8 Buy
0 Hold
0 Sell
Strong Buy
Current: 6.290
Low
8.00
Averages
14.71
High
27.00
Current: 6.290
Low
8.00
Averages
14.71
High
27.00
About ANNX
Annexon, Inc. is a clinical-stage biopharmaceutical company advancing a late-stage clinical platform of novel therapies for people living with devastating classical complement-mediated neuroinflammatory diseases of the body, brain, and eye. It identifies and characterizes the role of the classical complement pathway in three therapeutic areas: autoimmune, neurodegeneration and ophthalmology, using its proprietary platform. Its lead candidate, ANX005, an investigational, full-length monoclonal antibody (mAb), is formulated for intravenous administration as the potential first targeted treatment for patients with Guillain-Barre Syndrome (GBS). It is advancing ANX1502, a novel small-molecule inhibitor of classical complement designed for oral administration in a range of chronic autoimmune diseases. It is also advancing ANX007, designed to block C1q locally in the eye, to provide complete protection against excess classical complement activity and the loss of photoreceptor neurons.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
Annexon Grants 155,000 Stock Options to New Employees to Advance Immunotherapy
- Employee Incentive Plan: Annexon has granted 155,000 stock options to two new non-executive employees under the 2022 Employment Inducement Award Plan, highlighting the company's commitment to attracting talent.
- Option Details: The options have an exercise price of $6.16 per share, based on the closing price on January 15, 2026, with a ten-year term and a four-year vesting schedule, where 25% vests on the first anniversary of the grant.
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- Strategic Significance: With a mission to provide therapies for nearly 10 million people suffering from neuroinflammatory diseases, this incentive measure will help attract and retain key talent, thereby advancing the company's objectives.
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