Madrigal Pharmaceuticals downgraded, stock drops over 5%
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Jan 07 2026
0mins
Should l Buy MDGL?
Source: Fool
Madrigal Pharmaceuticals Inc. experienced a price drop of 5.33%, hitting a 20-day low amid broader market strength, with the Nasdaq-100 up 0.31% and the S&P 500 up 0.27%.
This decline follows a downgrade by Wolfe Research, where analyst Andy Chen lowered the rating from outperform to hold, raising concerns about the company's future performance. Chen set a price target of $572 per share, reflecting skepticism about Madrigal's growth potential despite optimistic revenue projections for its drug Rezdiffra.
The downgrade indicates a cautious sentiment among investors, suggesting that while Madrigal has strong sales potential, the current stock valuation may not be justified, leading to a reevaluation of investment strategies in the biotech sector.
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Analyst Views on MDGL
Wall Street analysts forecast MDGL stock price to rise
12 Analyst Rating
10 Buy
2 Hold
0 Sell
Strong Buy
Current: 436.870
Low
527.00
Averages
636.22
High
900.00
Current: 436.870
Low
527.00
Averages
636.22
High
900.00
About MDGL
Madrigal Pharmaceuticals, Inc. is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a liver disease with high unmet medical need. The Company’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-b agonist designed to target key underlying causes of MASH. Rezdiffra is the medication approved by the United States Food and Drug Administration (FDA) for the treatment of MASH with moderate to advanced fibrosis (consistent with stages F2 to F3). Rezdiffra is a prescribed medicine used along with diet and exercise to treat adults with nonalcoholic steatohepatitis (NASH) with moderate to advanced liver scarring (fibrosis), but not with cirrhosis of the liver. An ongoing Phase III outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (consistent with stage F4c).
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
Madrigal Pharmaceuticals Q4 2025 Earnings Call Highlights
- Significant Sales Performance: Madrigal Pharmaceuticals reported net sales of $321 million in Q4 2025, more than tripling from Q4 2024, with full-year net sales reaching $958.4 million, demonstrating strong market demand for Rezdiffra as a foundational therapy.
- Sustained Patient Growth: The number of patients on Rezdiffra exceeded 36,250 by the end of Q4 2025, up from over 29,500 in Q3, indicating the company's success in patient acquisition and market penetration.
- Increased R&D and Expenses: R&D expenses for Q4 2025 were $116.3 million, totaling $388.5 million for the year, primarily driven by upfront payments for new pipeline assets, which are expected to propel future product development and market expansion.
- Optimistic Future Outlook: CFO Dier anticipates robust net sales growth in 2026, despite an increase in gross-to-net impact into the high 30% range due to contracting, indicating the company’s strong growth potential in a competitive market.
See More
U.S. Markets Fell on Thursday; Klarna Group Reported Largest Loss
- U.S. Stock Market Performance: Stock indexes in the U.S. experienced a decline on Thursday, with the overall market falling by 0.54%.
- Specific Index Movements: The S&P 500 index decreased by 0.31%, while the Dow Jones Industrial Average dropped by 0.28%.
See More
Madrigal Pharmaceuticals Reports Mixed Q4 2025 Earnings
- Mixed Financial Results: Madrigal Pharmaceuticals reported a Q4 2025 revenue of $321.1 million, reflecting over 210% year-over-year growth and beating consensus by $8.3 million, yet a loss per share of $2.57 missed analysts' expectations by $2.03, leading to an approximately 8% premarket decline in stock price.
- Rezdiffra Market Performance: The FDA-approved therapy for metabolic dysfunction-associated steatohepatitis, Rezdiffra, generated $958.4 million in 2025, with over 36,250 patients treated, indicating strong market demand and acceptance of the product.
- Significant Revenue Growth: Madrigal achieved over 400% year-over-year growth in net revenue for 2025, while net loss decreased by more than 38% to $288.2 million, demonstrating a balance between revenue growth and cost management, with potential for further financial improvement.
- Liquidity Concerns: As of December 31, the company's cash and cash equivalents reached $988.6 million, reflecting approximately 6% year-over-year growth, but fell short of the $1.17 billion projected by analysts, highlighting pressures from debt repayment and operational funding needs.
See More
Madrigal Pharmaceuticals Q4 2025 Earnings Analysis
- Earnings Performance: Madrigal Pharmaceuticals reported a Q4 2025 GAAP EPS of -$2.57, missing expectations by $2.03, indicating challenges in profitability that may affect investor confidence.
- Revenue Growth: The quarter's revenue reached $321.08 million, reflecting a 210.8% year-over-year increase and exceeding market expectations by $8.34 million, suggesting significant progress in product sales that could lay the groundwork for future growth.
- Cash Position: As of December 31, 2025, Madrigal had cash, cash equivalents, restricted cash, and marketable securities totaling $988.6 million, an increase from $931.3 million in 2024, primarily due to the introduction of a new credit facility in July 2025, enhancing the company's financial flexibility.
- Financing Context: The new credit facility includes a $350 million initial term loan, with a portion used to repay outstanding loan obligations, yet attention is needed on the utilization of operational funds to ensure ongoing financial health.
See More
Madrigal Pharmaceuticals Q4 Earnings Preview
- Earnings Announcement Date: Madrigal Pharmaceuticals is set to announce its Q4 2023 earnings on February 19 before the market opens, with a consensus EPS estimate of -$0.88, reflecting a 67.5% year-over-year improvement, indicating a potential recovery in financial performance.
- Revenue Growth Expectations: The anticipated revenue for Q4 is $312.74 million, representing a 202.7% year-over-year increase, which highlights Madrigal's significant growth in market demand and product sales, potentially laying a foundation for future expansion.
- EPS Forecast Variability: Over the past three months, EPS estimates have seen two upward revisions and four downward revisions, indicating mixed analyst sentiment regarding the company's profitability, which could impact investor confidence.
- Revenue Forecast Adjustments: Similarly, revenue estimates have experienced four upward revisions and six downward revisions, suggesting a divergence in market expectations for Madrigal's future performance, which may lead to stock price volatility.
See More
Madrigal Pharmaceuticals Shares Enter Oversold Territory
- Oversold Signal: Madrigal Pharmaceuticals' stock price fell to $458.067 per share on Friday, resulting in an RSI of 29.6, indicating an oversold condition that may attract bullish investors seeking buying opportunities.
- Market Comparison: Compared to the S&P 500 ETF's RSI of 42.5, MDGL's 29.6 suggests that the recent heavy selling is exhausting itself, potentially paving the way for a rebound.
- Historical Performance: MDGL's 52-week low is $265 per share, with a high of $615, and the current trading price of $464.71 reflects its performance within this volatile range, indicating market uncertainty.
- Investor Focus: As the stock enters oversold territory, investors may closely monitor MDGL's future performance, particularly in the current market environment, looking for potential rebound opportunities to realize gains.
See More
Madrigal Pharmaceuticals Q4 2025 Earnings Call Highlights
- Significant Sales Performance: Madrigal Pharmaceuticals reported net sales of $321 million in Q4 2025, more than tripling from Q4 2024, with full-year net sales reaching $958.4 million, demonstrating strong market demand for Rezdiffra as a foundational therapy.
- Sustained Patient Growth: The number of patients on Rezdiffra exceeded 36,250 by the end of Q4 2025, up from over 29,500 in Q3, indicating the company's success in patient acquisition and market penetration.
- Increased R&D and Expenses: R&D expenses for Q4 2025 were $116.3 million, totaling $388.5 million for the year, primarily driven by upfront payments for new pipeline assets, which are expected to propel future product development and market expansion.
- Optimistic Future Outlook: CFO Dier anticipates robust net sales growth in 2026, despite an increase in gross-to-net impact into the high 30% range due to contracting, indicating the company’s strong growth potential in a competitive market.
See More
U.S. Markets Fell on Thursday; Klarna Group Reported Largest Loss
- U.S. Stock Market Performance: Stock indexes in the U.S. experienced a decline on Thursday, with the overall market falling by 0.54%.
- Specific Index Movements: The S&P 500 index decreased by 0.31%, while the Dow Jones Industrial Average dropped by 0.28%.
See More
Madrigal Pharmaceuticals Reports Mixed Q4 2025 Earnings
- Mixed Financial Results: Madrigal Pharmaceuticals reported a Q4 2025 revenue of $321.1 million, reflecting over 210% year-over-year growth and beating consensus by $8.3 million, yet a loss per share of $2.57 missed analysts' expectations by $2.03, leading to an approximately 8% premarket decline in stock price.
- Rezdiffra Market Performance: The FDA-approved therapy for metabolic dysfunction-associated steatohepatitis, Rezdiffra, generated $958.4 million in 2025, with over 36,250 patients treated, indicating strong market demand and acceptance of the product.
- Significant Revenue Growth: Madrigal achieved over 400% year-over-year growth in net revenue for 2025, while net loss decreased by more than 38% to $288.2 million, demonstrating a balance between revenue growth and cost management, with potential for further financial improvement.
- Liquidity Concerns: As of December 31, the company's cash and cash equivalents reached $988.6 million, reflecting approximately 6% year-over-year growth, but fell short of the $1.17 billion projected by analysts, highlighting pressures from debt repayment and operational funding needs.
See More
Madrigal Pharmaceuticals Q4 2025 Earnings Analysis
- Earnings Performance: Madrigal Pharmaceuticals reported a Q4 2025 GAAP EPS of -$2.57, missing expectations by $2.03, indicating challenges in profitability that may affect investor confidence.
- Revenue Growth: The quarter's revenue reached $321.08 million, reflecting a 210.8% year-over-year increase and exceeding market expectations by $8.34 million, suggesting significant progress in product sales that could lay the groundwork for future growth.
- Cash Position: As of December 31, 2025, Madrigal had cash, cash equivalents, restricted cash, and marketable securities totaling $988.6 million, an increase from $931.3 million in 2024, primarily due to the introduction of a new credit facility in July 2025, enhancing the company's financial flexibility.
- Financing Context: The new credit facility includes a $350 million initial term loan, with a portion used to repay outstanding loan obligations, yet attention is needed on the utilization of operational funds to ensure ongoing financial health.
See More
Madrigal Pharmaceuticals Q4 Earnings Preview
- Earnings Announcement Date: Madrigal Pharmaceuticals is set to announce its Q4 2023 earnings on February 19 before the market opens, with a consensus EPS estimate of -$0.88, reflecting a 67.5% year-over-year improvement, indicating a potential recovery in financial performance.
- Revenue Growth Expectations: The anticipated revenue for Q4 is $312.74 million, representing a 202.7% year-over-year increase, which highlights Madrigal's significant growth in market demand and product sales, potentially laying a foundation for future expansion.
- EPS Forecast Variability: Over the past three months, EPS estimates have seen two upward revisions and four downward revisions, indicating mixed analyst sentiment regarding the company's profitability, which could impact investor confidence.
- Revenue Forecast Adjustments: Similarly, revenue estimates have experienced four upward revisions and six downward revisions, suggesting a divergence in market expectations for Madrigal's future performance, which may lead to stock price volatility.
See More
Madrigal Pharmaceuticals Shares Enter Oversold Territory
- Oversold Signal: Madrigal Pharmaceuticals' stock price fell to $458.067 per share on Friday, resulting in an RSI of 29.6, indicating an oversold condition that may attract bullish investors seeking buying opportunities.
- Market Comparison: Compared to the S&P 500 ETF's RSI of 42.5, MDGL's 29.6 suggests that the recent heavy selling is exhausting itself, potentially paving the way for a rebound.
- Historical Performance: MDGL's 52-week low is $265 per share, with a high of $615, and the current trading price of $464.71 reflects its performance within this volatile range, indicating market uncertainty.
- Investor Focus: As the stock enters oversold territory, investors may closely monitor MDGL's future performance, particularly in the current market environment, looking for potential rebound opportunities to realize gains.
See More
