CRISPR Therapeutics Stock Rises Despite Poor Q4 Earnings
Written by Emily J. Thompson, Senior Investment Analyst
Updated: 4 days ago
0mins
Should l Buy CRSP?
Source: Fool
CRISPR Therapeutics' stock rose 7.64% as it crossed above the 5-day SMA, reflecting market optimism despite disappointing Q4 earnings.
The company reported a Q4 revenue of only $864,000, resulting in a loss of $1.37 per share, which was significantly worse than analysts' expectations. However, its partner Vertex Pharmaceuticals is expected to generate over $500 million in revenue from non-cystic fibrosis products in 2026, suggesting potential for CRISPR's gene-editing therapy Casgevy. This positive outlook contributed to the stock's rise amid ongoing financial struggles.
Despite the challenges, analysts project CRISPR's revenue to increase significantly in 2026, indicating market confidence in its product pipeline and future growth potential.
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Analyst Views on CRSP
Wall Street analysts forecast CRSP stock price to rise
10 Analyst Rating
8 Buy
2 Hold
0 Sell
Strong Buy
Current: 53.170
Low
50.00
Averages
78.89
High
105.00
Current: 53.170
Low
50.00
Averages
78.89
High
105.00
About CRSP
CRISPR Therapeutics AG is a Switzerland-based gene editing company focused on the development of CRISPR/Cas9-based therapeutics. CRISPR/Cas9 stands for Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) and is a technology for gene editing, the process of precisely altering specific sequences of genomic DNA. The Company aims to apply this technology to disrupt, delete, correct and insert genes to treat genetically-defined diseases and to engineer advanced cellular therapies. The Company has acquired the rights to the intellectual property (IP) encompassing CRISPR/Cas9 and related technologies and is also involved in its own IP research and additional in-licensing efforts. The Company product development and partnership strategies are designed to exploit the full potential of the CRISPR/Cas9 platform while maximizing the probability of successfully developing their product candidates.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
Analysis of CRISPR Therapeutics' Future Prospects
- Market Leadership: CRISPR Therapeutics' gene-editing therapy Casgevy, approved by the FDA in December 2023 in partnership with Vertex Pharmaceuticals, stands as the only approved CRISPR gene-editing therapy, marking the company's leading position in the gene therapy market.
- Sales Growth Potential: Although only 64 patients received Casgevy treatment in 2025, sales are projected to soar from $37.3 million in 2025 to $374.9 million by 2027, indicating strong growth potential as market education progresses.
- Rich R&D Pipeline: CRISPR Therapeutics has five therapies in clinical trials, four of which are wholly owned by the company, targeting autoimmune diseases, cardiovascular conditions, and Type 1 diabetes, showcasing a broad strategic focus in gene therapy.
- Strong Financial Position: Despite burning through $345.9 million in cash in 2025, the company retains nearly $2 billion in cash and only $188 million in long-term debt, demonstrating financial resilience for future R&D and market expansion.
See More
CRISPR Therapeutics: A Biotech Stock Poised for Growth
- Gene Editing Leader: CRISPR Therapeutics stands out as a leader in gene editing, utilizing CRISPR technology to repair specific genes for disease treatment, having secured the first-ever FDA approval for its CRISPR product, Casgevy, marking a significant breakthrough in the biotech industry.
- Massive Market Potential: The launch of Casgevy is gaining momentum, with CRISPR Therapeutics stating that the product has 'multi-billion-dollar potential'; although profits are shared with partner Vertex Pharmaceuticals, it still represents substantial growth opportunities for the company.
- Catalysts in 2026: The company expects to release clinical trial updates for cardiovascular candidate CTX310 and thromboembolic candidate CTX611 in the second half of 2026, along with trials for refractory hypertension and lung/liver disease, which could provide short-term stock support.
- Long-Term Growth Outlook: With a robust pipeline and the success of Casgevy, CRISPR Therapeutics is well-positioned for long-term growth, making it a stock that investors may regret missing out on in 2026.
See More
CRISPR Therapeutics Shows Growth Potential
- Technological Breakthrough: CRISPR Therapeutics received FDA approval for its first CRISPR product, Casgevy, marking a successful application of gene editing technology, which is expected to generate multi-billion-dollar revenue potential and further solidify its leadership in the biotech sector.
- Product Launch Progress: The market launch of Casgevy is gaining momentum, and although profits are shared with partner Vertex Pharmaceuticals, it still presents significant growth opportunities for CRISPR Therapeutics, reflecting the company's innovative capabilities in treating blood disorders.
- Future Catalysts: Multiple clinical trial updates are expected in the second half of 2026, including cardiovascular candidate CTX310 and thromboembolic candidate CTX611, which could provide short-term support for the stock price and enhance investor confidence.
- Pipeline Development: CRISPR Therapeutics plans to initiate clinical trials for refractory hypertension candidates in the first half of 2026 and for lung and liver disease candidates in mid-2026, establishing a robust product pipeline that lays a solid foundation for long-term growth.
See More
CRISPR Therapeutics Stock Rises Despite Poor Q4 Earnings
- Disappointing Earnings: CRISPR Therapeutics reported only $864,000 in revenue for Q4, resulting in a loss of $1.37 per share, significantly worse than analysts' expectations of a $1.20 loss, highlighting ongoing financial struggles.
- Partner Support: Despite CRISPR's poor revenue, its partner Vertex Pharmaceuticals anticipates over $500 million in revenue from non-cystic fibrosis products in 2026, indicating that CRISPR's gene-editing therapy Casgevy may achieve greater market potential in the future.
- Positive Market Reaction: CRISPR's stock rose 9.7% on Friday despite the disappointing earnings report, reflecting market optimism about its long-term growth potential, particularly in the innovative gene-editing sector.
- Future Outlook: Analysts project CRISPR's revenue to reach nearly $130 million in 2026, a significant increase from $3.5 million in 2025, although the company remains unprofitable, indicating market confidence in its product pipeline.
See More
Casgevy Therapy Revenue Shows Significant Growth
- Revenue Growth: Casgevy gene-editing therapy generated $54 million in Q4 2025 and $116 million for the full year, indicating strong market demand and significant business growth potential.
- Increased Patient Treatments: A total of 147 patients initiated treatment in 2025, nearly tripling from 2024, with 30 infusions occurring in Q4, reflecting heightened acceptance and confidence in the therapy.
- Pipeline Advancement: The company continues to advance its in vivo liver editing programs, with CTX310 in Phase 1b trials for lipid disorders and CTX321 progressing through enabling studies, with updates expected in the second half of 2026.
- Financial Position: CRISPR Therapeutics ended 2025 with $1.98 billion in cash and marketable securities, despite R&D expenses rising to $83.5 million in Q4 and net loss widening to $130.6 million, market confidence in its future growth remains strong.
See More
CRISPR Therapeutics Reports Q4 Losses Amid Revenue Decline
- Earnings Miss: CRISPR Therapeutics reported a Q4 GAAP EPS of -$1.37, missing estimates by $0.22, indicating significant challenges in achieving profitability.
- Revenue Plunge: The company’s Q4 revenue of $0.86 million represents a staggering 97.6% year-over-year decline, falling short of expectations by $3.16 million, highlighting a sharp decrease in market demand for its products.
- Strong Cash Position: As of December 31, 2025, CRISPR held $1,975.8 million in cash, cash equivalents, and marketable securities, up from $1,903.8 million a year earlier, reflecting a solid liquidity management strategy.
- Market Reaction: Despite the disappointing earnings report, CRISPR Therapeutics managed to pare losses amid takeover speculation, suggesting that investors are attentive to potential restructuring or strategic shifts in the company’s future.
See More
Analysis of CRISPR Therapeutics' Future Prospects
- Market Leadership: CRISPR Therapeutics' gene-editing therapy Casgevy, approved by the FDA in December 2023 in partnership with Vertex Pharmaceuticals, stands as the only approved CRISPR gene-editing therapy, marking the company's leading position in the gene therapy market.
- Sales Growth Potential: Although only 64 patients received Casgevy treatment in 2025, sales are projected to soar from $37.3 million in 2025 to $374.9 million by 2027, indicating strong growth potential as market education progresses.
- Rich R&D Pipeline: CRISPR Therapeutics has five therapies in clinical trials, four of which are wholly owned by the company, targeting autoimmune diseases, cardiovascular conditions, and Type 1 diabetes, showcasing a broad strategic focus in gene therapy.
- Strong Financial Position: Despite burning through $345.9 million in cash in 2025, the company retains nearly $2 billion in cash and only $188 million in long-term debt, demonstrating financial resilience for future R&D and market expansion.
See More
CRISPR Therapeutics: A Biotech Stock Poised for Growth
- Gene Editing Leader: CRISPR Therapeutics stands out as a leader in gene editing, utilizing CRISPR technology to repair specific genes for disease treatment, having secured the first-ever FDA approval for its CRISPR product, Casgevy, marking a significant breakthrough in the biotech industry.
- Massive Market Potential: The launch of Casgevy is gaining momentum, with CRISPR Therapeutics stating that the product has 'multi-billion-dollar potential'; although profits are shared with partner Vertex Pharmaceuticals, it still represents substantial growth opportunities for the company.
- Catalysts in 2026: The company expects to release clinical trial updates for cardiovascular candidate CTX310 and thromboembolic candidate CTX611 in the second half of 2026, along with trials for refractory hypertension and lung/liver disease, which could provide short-term stock support.
- Long-Term Growth Outlook: With a robust pipeline and the success of Casgevy, CRISPR Therapeutics is well-positioned for long-term growth, making it a stock that investors may regret missing out on in 2026.
See More
CRISPR Therapeutics Shows Growth Potential
- Technological Breakthrough: CRISPR Therapeutics received FDA approval for its first CRISPR product, Casgevy, marking a successful application of gene editing technology, which is expected to generate multi-billion-dollar revenue potential and further solidify its leadership in the biotech sector.
- Product Launch Progress: The market launch of Casgevy is gaining momentum, and although profits are shared with partner Vertex Pharmaceuticals, it still presents significant growth opportunities for CRISPR Therapeutics, reflecting the company's innovative capabilities in treating blood disorders.
- Future Catalysts: Multiple clinical trial updates are expected in the second half of 2026, including cardiovascular candidate CTX310 and thromboembolic candidate CTX611, which could provide short-term support for the stock price and enhance investor confidence.
- Pipeline Development: CRISPR Therapeutics plans to initiate clinical trials for refractory hypertension candidates in the first half of 2026 and for lung and liver disease candidates in mid-2026, establishing a robust product pipeline that lays a solid foundation for long-term growth.
See More
CRISPR Therapeutics Stock Rises Despite Poor Q4 Earnings
- Disappointing Earnings: CRISPR Therapeutics reported only $864,000 in revenue for Q4, resulting in a loss of $1.37 per share, significantly worse than analysts' expectations of a $1.20 loss, highlighting ongoing financial struggles.
- Partner Support: Despite CRISPR's poor revenue, its partner Vertex Pharmaceuticals anticipates over $500 million in revenue from non-cystic fibrosis products in 2026, indicating that CRISPR's gene-editing therapy Casgevy may achieve greater market potential in the future.
- Positive Market Reaction: CRISPR's stock rose 9.7% on Friday despite the disappointing earnings report, reflecting market optimism about its long-term growth potential, particularly in the innovative gene-editing sector.
- Future Outlook: Analysts project CRISPR's revenue to reach nearly $130 million in 2026, a significant increase from $3.5 million in 2025, although the company remains unprofitable, indicating market confidence in its product pipeline.
See More
Casgevy Therapy Revenue Shows Significant Growth
- Revenue Growth: Casgevy gene-editing therapy generated $54 million in Q4 2025 and $116 million for the full year, indicating strong market demand and significant business growth potential.
- Increased Patient Treatments: A total of 147 patients initiated treatment in 2025, nearly tripling from 2024, with 30 infusions occurring in Q4, reflecting heightened acceptance and confidence in the therapy.
- Pipeline Advancement: The company continues to advance its in vivo liver editing programs, with CTX310 in Phase 1b trials for lipid disorders and CTX321 progressing through enabling studies, with updates expected in the second half of 2026.
- Financial Position: CRISPR Therapeutics ended 2025 with $1.98 billion in cash and marketable securities, despite R&D expenses rising to $83.5 million in Q4 and net loss widening to $130.6 million, market confidence in its future growth remains strong.
See More
CRISPR Therapeutics Reports Q4 Losses Amid Revenue Decline
- Earnings Miss: CRISPR Therapeutics reported a Q4 GAAP EPS of -$1.37, missing estimates by $0.22, indicating significant challenges in achieving profitability.
- Revenue Plunge: The company’s Q4 revenue of $0.86 million represents a staggering 97.6% year-over-year decline, falling short of expectations by $3.16 million, highlighting a sharp decrease in market demand for its products.
- Strong Cash Position: As of December 31, 2025, CRISPR held $1,975.8 million in cash, cash equivalents, and marketable securities, up from $1,903.8 million a year earlier, reflecting a solid liquidity management strategy.
- Market Reaction: Despite the disappointing earnings report, CRISPR Therapeutics managed to pare losses amid takeover speculation, suggesting that investors are attentive to potential restructuring or strategic shifts in the company’s future.
See More
