Aprea Therapeutics Inc. is experiencing a significant pre-market decline of 8.74%, as the stock crosses below its 5-day SMA.
The company has signed a securities purchase agreement with healthcare-focused institutional investors to sell 6.29 million shares at $0.89 each, with warrants priced at $0.765. This proactive financing effort, expected to close on January 30, 2026, aims to provide liquidity support and fund research and development. However, the stock price dropped by 7.83% following the announcement, indicating market caution regarding the company's financing strategy.
This financing move may position Aprea for future growth, but the immediate market reaction suggests investors are wary of the implications of such an offering.
Wall Street analysts forecast APRE stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for APRE is 5.00 USD with a low forecast of 5.00 USD and a high forecast of 5.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
2 Analyst Rating
Wall Street analysts forecast APRE stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for APRE is 5.00 USD with a low forecast of 5.00 USD and a high forecast of 5.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
2 Buy
0 Hold
0 Sell
Moderate Buy
Current: 0.796
Low
5.00
Averages
5.00
High
5.00
Current: 0.796
Low
5.00
Averages
5.00
High
5.00
H.C. Wainwright
Joseph Pantginis
Buy
downgrade
$5 -> $4
2026-01-29
New
Reason
H.C. Wainwright
Joseph Pantginis
Price Target
$5 -> $4
AI Analysis
2026-01-29
New
downgrade
Buy
Reason
H.C. Wainwright analyst Joseph Pantginis lowered the firm's price target on Aprea Therapeutics to $4 from $5 and keeps a Buy rating on the shares. The firm is "encouraged by the positive," early proof-of-concept data from the ACESOT-1051 study. Aprea reported "promising" preliminary signals from an endometrial cancer patient, the analyst tells investors in a research note. H.C. Wainwright cites dilution for the target cut.
H.C. Wainwright
Buy
downgrade
$20 -> $5
2025-12-18
Reason
H.C. Wainwright
Price Target
$20 -> $5
2025-12-18
downgrade
Buy
Reason
H.C. Wainwright lowered the firm's price target on Aprea Therapeutics to $5 from $20 and keeps a Buy rating on the shares after Aprea provided an update on its pipeline progress and corporate outlook for 2026. The company will be shifting focus from its monotherapy study of ATRN-119 to focus on potential combination strategies, notes the analyst, who is adjusting focus to APR-1051, which now provides 100% of the valuation contribution to the firm's model. APR-1051 is currently being evaluated in the ongoing Phase 1 ACESOT-1051 dose-escalation trial and near term catalysts include updated safety and efficacy data due in Q1 and completion of dose escalation expected in 2026, the analyst noted.
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About APRE
Aprea Therapeutics, Inc. is a clinical-stage biopharmaceutical company focused on precision oncology through synthetic lethality. The Company’s pipeline includes two clinical-stage synthetic lethality programs. Its lead programs are APR-1051, an oral, small-molecule inhibitor of WEE1 kinase, and ATRN-119, a small-molecule ATR inhibitor, both in clinical development for solid tumor indications. Its ATRN-119 is an oral small molecule inhibitor of ataxia telangiectasia and Rad3-related (ATR). The ATR kinase is a master regulator of Deoxyribonucleic Acid (DNA) damage response, with roles in cell cycle control and DNA repair following replication stress. It is evaluating potential combination opportunities within its pipeline, including research on the combination of ATRN-119 and APR-1051 that is supported by a Phase II SBIR grant from the National Cancer Institute. It also has an early-stage program, in the lead optimization stage, for an undisclosed DNA-damage response (DDR) target.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.