Rigel's R289 Demonstrates Potential for RBC Transfusion Independence in Phase 1b Trial for Lower-Risk MDS
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Dec 08 2025
0mins
Should l Buy RIGL?
Source: NASDAQ.COM
Rigel Pharmaceuticals Update: Rigel Pharmaceuticals announced positive results from its Phase 1b study of drug candidate R289 for patients with relapsed or refractory lower-risk myelodysplastic syndrome (MDS), showing preliminary efficacy and good tolerability at higher doses.
Study Details: The study consists of dose escalation and expansion phases, with the dose escalation completed in July. Preliminary results indicated that 33% of transfusion-dependent patients achieved red blood cell transfusion independence at doses of 500 mg or higher.
Future Plans: The first patient in the dose expansion phase was dosed in October, with plans to randomize up to 40 patients to determine the recommended Phase 2 dose for future trials, expected to be finalized in the second half of 2026.
Market Reaction: Following the announcement, Rigel's shares rose by 3.25%, closing at $48.92.
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Analyst Views on RIGL
Wall Street analysts forecast RIGL stock price to rise
4 Analyst Rating
2 Buy
2 Hold
0 Sell
Moderate Buy
Current: 25.810
Low
38.00
Averages
52.00
High
71.00
Current: 25.810
Low
38.00
Averages
52.00
High
71.00
About RIGL
Rigel Pharmaceuticals, Inc. is a biotechnology company. The Company is engaged in developing and providing novel therapies that significantly improve the lives of patients with hematologic disorders and cancer. It is focused on products that address signaling pathways that are critical to disease mechanisms. Its first product is TAVALISSE (fostamatinib disodium hexahydrate) tablets, the approved oral spleen tyrosine kinase inhibitor for the treatment of adult patients with chronic immune thrombocytopenia (ITP) who have had an insufficient response to a previous treatment. Its second product is REZLIDHIA (olutasidenib) capsules for the treatment of adult patients with relapsed or refractory (R/R) acute myeloid leukemia (AML) with a susceptible isocitrate dehydrogenase-1 (IDH1) mutation as detected by an FDA-approved test. Its GAVRETO (pralsetinib) product is a once daily, small molecule, oral, kinase inhibitor of wild type rearranged during transfection (RET) and oncogenic RET fusions.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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- Clinical Data Highlights: CytomX's Phase 1 data for Varseta-M in metastatic colorectal cancer shows an objective response rate of up to 32% and approximately seven months of progression-free survival, enhancing confidence for FDA registrational trial discussions expected in 2026.
- Surge in Trading Volume: The company's trading volume reached 118 million shares on Monday, a staggering 2,211% increase over the three-month average of 5.1 million shares, indicating strong market reaction to the new data and potentially attracting more investor interest.
- Transparent Financial Position: CytomX projects approximately $76 million in revenue for 2025, with cash reserves around $137 million, providing funding clarity into the second quarter of 2027, although wider-than-expected losses remind investors of the financial risks associated with clinical progress.
- Positive Market Reaction: CytomX's stock surged 44.23% to $6.75, reflecting investor optimism regarding its clinical advancements, which also positively impacted peer companies like XOMA and Rigel Pharmaceuticals, underscoring broader interest in drug developers.
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- Surge in Trading Volume: On Monday, trading volume reached 118 million shares, a staggering 2,211% increase over the three-month average of 5.1 million shares, indicating strong market interest and active investor participation, which could further propel the stock price upward.
- Transparent Financial Outlook: CytomX anticipates approximately $76 million in revenue for 2025, with cash reserves around $137 million, providing financial runway into the second quarter of 2027; however, wider-than-expected losses remind investors of the inherent financial risks associated with clinical progress.
- Positive Market Reaction: Following the data release, analysts reacted positively, driving the stock price up to $6.75, a 44.23% increase from the previous trading day, reflecting strong market interest in the biotech sector and recognition of CytomX's future potential.
See More
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- Surge in Trading Volume: The company's trading volume reached 118 million shares on Monday, a staggering 2,211% increase over the three-month average of 5.1 million shares, indicating strong market reaction to the new data and potentially attracting more investor interest.
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- Product Sales Growth: Despite the overall revenue decline, Rigel expects net product sales to reach approximately $255 million to $265 million, reflecting an ~11% year-over-year increase, suggesting strong market demand for its core products, which may provide some financial stability.
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See More
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See More
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- Future Outlook: Rigel anticipates total revenues for 2026 to be between $275 million and $290 million, with net product sales projected at $255 million to $265 million and contract revenues at $20 million to $25 million, showcasing confidence in future growth.
- Positive Market Response: Rigel Pharmaceuticals presented its ongoing financial performance and future catalysts at the 44th Annual J.P. Morgan Healthcare Conference, further solidifying its market position in the biopharmaceutical sector.
See More
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- Clinical Data Highlights: CytomX's Phase 1 data for Varseta-M in metastatic colorectal cancer shows an objective response rate of up to 32% and approximately seven months of progression-free survival, enhancing confidence for FDA registrational trial discussions expected in 2026.
- Surge in Trading Volume: The company's trading volume reached 118 million shares on Monday, a staggering 2,211% increase over the three-month average of 5.1 million shares, indicating strong market reaction to the new data and potentially attracting more investor interest.
- Transparent Financial Position: CytomX projects approximately $76 million in revenue for 2025, with cash reserves around $137 million, providing funding clarity into the second quarter of 2027, although wider-than-expected losses remind investors of the financial risks associated with clinical progress.
- Positive Market Reaction: CytomX's stock surged 44.23% to $6.75, reflecting investor optimism regarding its clinical advancements, which also positively impacted peer companies like XOMA and Rigel Pharmaceuticals, underscoring broader interest in drug developers.
See More
CytomX Therapeutics Stock Soars 44.23% After Positive Phase 1 Data
- Promising Clinical Data: CytomX's Phase 1 Varseta-M data in metastatic colorectal cancer reveals an objective response rate of 32% and a progression-free survival of approximately seven months, laying a solid foundation for future FDA registrational trial discussions and boosting investor confidence.
- Surge in Trading Volume: On Monday, trading volume reached 118 million shares, a staggering 2,211% increase over the three-month average of 5.1 million shares, indicating strong market interest and active investor participation, which could further propel the stock price upward.
- Transparent Financial Outlook: CytomX anticipates approximately $76 million in revenue for 2025, with cash reserves around $137 million, providing financial runway into the second quarter of 2027; however, wider-than-expected losses remind investors of the inherent financial risks associated with clinical progress.
- Positive Market Reaction: Following the data release, analysts reacted positively, driving the stock price up to $6.75, a 44.23% increase from the previous trading day, reflecting strong market interest in the biotech sector and recognition of CytomX's future potential.
See More
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- Promising Clinical Data: CytomX's Phase 1 data for Varseta-M in metastatic colorectal cancer shows an objective response rate of up to 32% and approximately seven months of progression-free survival, bolstering confidence for FDA registrational trial discussions expected in 2026.
- Surge in Trading Volume: The company's trading volume reached 118 million shares on Monday, a staggering 2,211% increase over the three-month average of 5.1 million shares, indicating strong market reaction to the new data and potentially attracting more investor interest.
- Solid Financial Position: CytomX anticipates approximately $76 million in revenue for 2025, and while net losses have widened, the company holds around $137 million in cash reserves, ensuring funding needs are met through the second quarter of 2027 to support ongoing oncology programs.
- Positive Market Reaction: Despite a 48% decline in stock price since its 2015 IPO, the recent surge reflects investor optimism about the company's future potential, particularly against the backdrop of strong performance in the biotechnology sector.
See More
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- Revenue Decline Projection: Rigel Pharmaceuticals projects a revenue decline for 2026, estimating total revenue between $275 million and $290 million, which represents a ~4% year-over-year drop from last year's $294.3 million, indicating potential challenges ahead for the company's financial health.
- Sharp Drop in Contract Revenue: The company anticipates contract revenue to be between $20 million and $25 million, implying a staggering ~64% year-over-year decline, highlighting significant challenges in its collaborative partnerships that could impact its competitive position in the biotech sector.
- Product Sales Growth: Despite the overall revenue decline, Rigel expects net product sales to reach approximately $255 million to $265 million, reflecting an ~11% year-over-year increase, suggesting strong market demand for its core products, which may provide some financial stability.
- Earnings Exceed Expectations: Rigel reported Q4 2025 earnings of $13.54 per share on $69.8 million in revenue, both surpassing market expectations, demonstrating effective financial management and cost control, although the outlook remains concerning due to projected declines in revenue.
See More
Rigel Pharmaceuticals Reports Strong 2025 Financial Results
- Revenue Growth: Rigel Pharmaceuticals reported total revenues of $69.8 million for Q4 2025, with net product sales reaching $65.4 million, reflecting a 41% increase year-over-year, indicating strong market demand in hematologic disorders and cancer treatments.
- Product Sales Performance: Net product sales for TAVALISSE, GAVRETO, and REZLIDHIA were $45.6 million, $10.2 million, and $9.6 million respectively, representing growth of 47%, 27%, and 29% compared to 2024, demonstrating increasing market acceptance of the company's product line.
- Significant Net Income Increase: Rigel achieved a net income of $268.1 million in Q4 2025, with earnings per share of $14.72, a substantial rise from $14.3 million and $0.81 in the same quarter of 2024, reflecting a marked improvement in the company's profitability.
- Optimistic 2026 Outlook: Rigel anticipates total revenues of approximately $275 to $290 million for 2026 and plans to advance its R289 program, showcasing the company's confidence and strategic positioning for future growth.
See More
Rigel Pharmaceuticals Q4 Earnings Exceed Expectations
- Strong Earnings Report: Rigel Pharmaceuticals reported a Q4 GAAP EPS of $13.54, surpassing expectations by $12.31, which highlights a significant improvement in profitability and boosts investor confidence.
- Revenue Growth: The company achieved Q4 revenues of $69.8 million, reflecting a 21.2% year-over-year increase and exceeding market expectations by $1.1 million, indicating sustained competitiveness of its products in the market.
- Future Outlook: Rigel anticipates total revenues for 2026 to be between $275 million and $290 million, with net product sales projected at $255 million to $265 million and contract revenues at $20 million to $25 million, showcasing confidence in future growth.
- Positive Market Response: Rigel Pharmaceuticals presented its ongoing financial performance and future catalysts at the 44th Annual J.P. Morgan Healthcare Conference, further solidifying its market position in the biopharmaceutical sector.
See More
