NeOnc Technologies Holdings Announces Q2 2025 Financial Results and Operational Insights
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Aug 19 2025
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Source: Newsfilter
Financial Partnership and Funding: NeOnc Technologies secured a $50 million strategic partnership with Quazar Investment and received $2.5 million in NIH STTR grants to support its clinical programs for CNS cancers.
Technology Acquisition and Media Presence: The company expanded its technology portfolio by acquiring AI and 3D bioprinting IP, while also increasing market visibility through media campaigns and appearances on platforms like Yahoo Finance.
Clinical Pipeline Updates: Progress is being made in clinical trials, with full enrollment of NEO100-01 expected by September 2025 and final patient dosing for NEO212 anticipated in 2025.
Financial Performance: For Q2 2025, NeOnc reported a net loss of $5.68 million, reflecting increased expenses due to expanded operations and clinical trial activities compared to the previous year.
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About NTHI
NeOnc Technologies Holdings, Inc. is a clinical-stage biopharmaceutical company. The Company is focused on establishing treatments for intracranial malignancies, such as aggressive cancers located in the brain. It is the developer of a novel molecular technology that provides enhanced targeted delivery of technologies for treating central nervous system diseases. It is developing novel drug delivery methods to be used in combination with novel drug candidates. The Company has two lead products in development: NEO100 and NEO212. NEO100 is a purified form of perillyl acid (POH) which is administered to brain cancer patients via intranasal delivery. NEO212 is a covalently conjugated molecule combining the chemotherapeutic drug temozolomide with perillyl alcohol. NEO212 is undergoing development towards intranasal application specifically for patients with uncontrolled brain metastases derived from peripheral tumors (lung, breast, skin, and others).
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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- Investor Confidence Boosted: The $10 million investment from Cinctive Capital reflects strong confidence in NeOnc's technology and clinical assets, particularly underscored by the leadership of Co-Founder Rich Schimel, enhancing the strategic significance of this investment and market recognition of the company.
- Clinical Trials Acceleration: NeOnc stated that this funding will provide essential capital to accelerate its clinical trials, especially for its NEO100 and NEO212 therapies in Phase II, which aim to bypass the blood-brain barrier and address significant challenges in CNS cancer treatment.
- Patent Protection Advantage: NeOnc's NEO™ drug development platform, with patent protections extending to 2038, demonstrates the company's long-term potential in innovative drug development, which is expected to provide strong support for future market competition.
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- Survival Rate Improvement: Among patients treated with NEO100, 36% remained alive 18 months post-treatment, suggesting that this therapy may provide durable survival benefits in heavily pretreated populations, thereby altering treatment strategies.
- No Significant Toxicity: The intranasal administration of NEO100 has shown no significant toxicity even with prolonged use, ensuring patient safety and providing strong support for its clinical application.
- Broad Treatment Prospects: As the dataset expands, NEO100 is emerging as a potential first-in-class CNS-penetrant metabolic therapy, marking a possible paradigm shift in the treatment of IDH1-mutant high-grade gliomas and pushing the industry towards more effective treatment options.
See More
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- Survival Rate Improvement: 36% of patients demonstrated survival of 18 months or longer post-NEO100 treatment, showcasing the therapy's potential for long-term survival in heavily pretreated populations, which may shift treatment paradigms in this field.
- No Significant Toxicity: The intranasal administration of NEO100 has shown no significant toxicity even with prolonged and chronic dosing, indicating a high safety profile that could enhance patient treatment experiences.
- Expanded Clinical Data: The growing clinical cohort reinforces the treatment's effectiveness, bolstering confidence in NEO100 as a first-in-class CNS-penetrant metabolic therapy, potentially driving significant advancements in neuro-oncology.
See More
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- Research Collaboration Findings: A study from the University of Southern California demonstrates that ultrasound significantly enhances NEO100's therapeutic potency, driving strong antitumor effects across various brain tumor types, indicating its potential for clinical application.
- Technological Innovation: Utilizing an AI-driven, 3D bioprinting New Approach Methodology, researchers rapidly generate physiologically relevant patient-derived tumor organoids within hours, significantly accelerating biomedical research and aligning with NIH objectives to reduce animal testing.
- Clinical Trial Prospects: Validation studies reveal that NEO100 exhibits markedly enhanced tumor-killing activity when combined with focused ultrasound, supporting its advancement into future clinical trials for a wide range of brain tumors, thereby broadening its commercial and clinical opportunities.
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