Moleculin Biotech Increases Enrollment to 78% for MIRACLE Trial
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Dec 09 2025
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Should l Buy MBRX?
Source: Newsfilter
- Enrollment Progress: Moleculin's MIRACLE trial enrollment has increased to 78%, up from 60% in November, with expectations to complete treatment of the first 45 subjects by Q1 2026, thereby laying the groundwork for data unblinding.
- Clinical Activity Tracking: The company reports that blinded clinical activity remains within expected ranges, indicating positive responses from investigators, particularly as recruitment improves in the US and Europe.
- Trial Design Advantages: The MIRACLE trial is a global, multi-center, randomized, double-blind, placebo-controlled adaptive design, with the first unblinding set to provide preliminary efficacy data for 45 subjects, potentially offering strong support for Annamycin's approval.
- Market Potential: Annamycin, as a next-generation anticancer drug, has received FDA Fast Track and Orphan Drug Designations, expected to fill a significant gap in acute myeloid leukemia treatment, presenting substantial market opportunities.
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Analyst Views on MBRX
Wall Street analysts forecast MBRX stock price to rise
3 Analyst Rating
3 Buy
0 Hold
0 Sell
Strong Buy
Current: 2.440
Low
20.00
Averages
24.33
High
31.00
Current: 2.440
Low
20.00
Averages
24.33
High
31.00
About MBRX
Moleculin Biotech, Inc. is a Phase III clinical-stage pharmaceutical company advancing a pipeline of therapeutic candidates addressing tumors and viruses. The Company is conducting a pivotal Phase III trial evaluating Annamycin, a non-cardiotoxic anthracycline, in combination with Cytarabine for the treatment of subjects with relapsed/refractory acute myeloid leukemia (AML). It has three core technologies and six drug candidates, three of which have shown human activity in clinical trials. Its core technologies consist of Annamycin, WP1066 Portfolio, and WP1122 Portfolio. Annamycin is designed to avoid multidrug resistance mechanisms and cardiotoxicity. Its WP1066, is an Immune/Transcription Modulator capable of inhibiting p-STAT3 and other transcription factors, and its portfolio includes WP1193, and WP1220. Its WP1122 contains compounds including WP1096, and WP1097, which is designed to exploit the potential uses of inhibitors of glycolysis such as 2-deoxy-D-glucose (2-DG).
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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- Financing Background: The company recently secured $8.3 million from warrant exercises and issued new 5-year warrants, indicating its efforts to diversify financing channels to support future growth.
See More
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- Cell Bank Development: Avaí Bio, in partnership with Austrianova, has begun manufacturing a Master Cell Bank (MCB) for α-Klotho protein, establishing a stable production foundation that ensures product quality and consistency for future cell therapies.
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See More
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