Gyre Therapeutics Emerges as a Notable Player in Liver Fibrosis Drug Development
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Aug 26 2025
0mins
Should l Buy MDGL?
Source: Benzinga
Gyre Therapeutics Overview: Gyre Therapeutics Inc. is a biopharmaceutical company focusing on organ fibrosis treatments, with its flagship product ETUARY being the first approved treatment for idiopathic pulmonary fibrosis in China.
Financial Performance: The company reported second-quarter sales of $26.78 million, falling short of expectations, but anticipates revenue growth in 2025 driven by new product launches and existing sales.
Hydronidone Development: Gyre's lead asset, hydronidone, has shown promising results in clinical trials for liver fibrosis and is expected to enter Phase 2 assessment in the U.S. by late 2025, with plans for accelerated approval in China.
Market Potential: Analysts predict significant market potential for hydronidone, estimating it could generate approximately $6 billion in annual sales by 2033, similar to the success anticipated for Madrigal Pharmaceuticals' recent liver disease treatment.
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Analyst Views on MDGL
Wall Street analysts forecast MDGL stock price to rise
12 Analyst Rating
10 Buy
2 Hold
0 Sell
Strong Buy
Current: 473.790
Low
527.00
Averages
636.22
High
900.00
Current: 473.790
Low
527.00
Averages
636.22
High
900.00
About MDGL
Madrigal Pharmaceuticals, Inc. is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a liver disease with high unmet medical need. The Company’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-b agonist designed to target key underlying causes of MASH. Rezdiffra is the medication approved by the United States Food and Drug Administration (FDA) for the treatment of MASH with moderate to advanced fibrosis (consistent with stages F2 to F3). Rezdiffra is a prescribed medicine used along with diet and exercise to treat adults with nonalcoholic steatohepatitis (NASH) with moderate to advanced liver scarring (fibrosis), but not with cirrhosis of the liver. An ongoing Phase III outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (consistent with stage F4c).
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
Madrigal Pharmaceuticals Shares Enter Oversold Territory
- Oversold Signal: Madrigal Pharmaceuticals' stock price fell to $458.067 per share on Friday, resulting in an RSI of 29.6, indicating an oversold condition that may attract bullish investors seeking buying opportunities.
- Market Comparison: Compared to the S&P 500 ETF's RSI of 42.5, MDGL's 29.6 suggests that the recent heavy selling is exhausting itself, potentially paving the way for a rebound.
- Historical Performance: MDGL's 52-week low is $265 per share, with a high of $615, and the current trading price of $464.71 reflects its performance within this volatile range, indicating market uncertainty.
- Investor Focus: As the stock enters oversold territory, investors may closely monitor MDGL's future performance, particularly in the current market environment, looking for potential rebound opportunities to realize gains.
See More
Ribo Life Science and Madrigal Sign siRNA Licensing Agreement
- Exclusive Global Licensing Agreement: Ribo Life Science has signed an exclusive global licensing agreement with Madrigal for six preclinical siRNA programs targeting metabolic dysfunction-associated steatohepatitis (MASH), which is expected to drive the development of new therapies to meet urgent market needs for MASH treatment.
- Financial Upside Potential: Under the agreement, Ribo will receive a $60 million upfront payment, with cumulative payments potentially reaching $4.4 billion upon achieving specific development and commercial milestones, significantly enhancing the company's financial position and supporting future R&D investments.
- Technological Platform Advantage: This collaboration will leverage Ribo's siRNA-GalSTARTM platform in conjunction with Madrigal's expertise in MASH, aiming to develop more effective treatment options, thereby enhancing the company's competitiveness in the biopharmaceutical market.
- Growing Market Demand: As the number of MASH patients rises and its association with various severe comorbidities becomes clearer, the demand for effective treatment solutions is increasingly urgent, positioning Ribo favorably in the rapidly growing biopharmaceutical sector.
See More
Ribo and Madrigal Sign Exclusive Global License Agreement
- Exclusive Global License Agreement: Ribo Life Science and Madrigal Pharmaceuticals have entered into an exclusive global license agreement covering six preclinical small RNA interference programs targeting Metabolic dysfunction-Associated SteatoHepatitis (MASH), which is expected to drive the development of new therapies to meet increasing market demand.
- Financial Upside Potential: Under the agreement, Ribo will receive an initial payment of $60 million, with cumulative payments potentially reaching $4.4 billion upon achieving specific development and commercialization milestones, significantly enhancing the company's financial position and supporting future R&D investments.
- Urgent Treatment Need: MASH is a serious liver disease with rising prevalence, and the collaboration between Ribo and Madrigal aims to provide more effective treatment options through innovative pARNi platforms to address the current market's lack of effective therapies.
- Broad Market Outlook: With increasing awareness of MASH, more patients are expected to be diagnosed with moderate to advanced liver fibrosis, and Ribo's technological collaboration will help expand its influence in the global biopharmaceutical market, addressing unmet medical needs.
See More
Ribo and Madrigal Announce Exclusive Global License Agreement
- Exclusive Global License Agreement: Ribo and Madrigal have signed an exclusive global license agreement covering six preclinical siRNA programs targeting Metabolic Dysfunction-Associated Steatotic Liver Disease (MASH), which is expected to drive the development of new therapies to meet urgent market needs.
- Financial Upside Potential: Under the agreement, Ribo will receive an initial payment of $60 million, with cumulative payments potentially reaching $4.4 billion upon achieving specific development and commercial milestones, significantly enhancing the company's financial position and supporting future R&D.
- Growing Treatment Demand: MASH is the leading cause of liver transplants, and with increasing awareness of the disease, more patients are expected to be diagnosed; Ribo's collaboration will help develop more targeted treatment options to meet the rising market demand.
- Technological Platform Advantage: Ribo will leverage its validated GalSTARTM siRNA platform to develop multiple new therapies aimed at improving the quality of life for MASH patients through multi-mechanistic approaches, further solidifying its competitive position in the biopharmaceutical sector.
See More
Madrigal Pharmaceuticals Enters $4.46B Licensing Deal with Suzhou Ribo
- Deal Value: Madrigal Pharmaceuticals has entered into an exclusive licensing agreement with Suzhou Ribo Life Science worth up to $4.46 billion, representing a significant advancement in the treatment of metabolic dysfunction-associated steatohepatitis (MASH).
- Upfront Investment and Potential Earnings: Under the terms, Madrigal will pay Ribo $60 million upfront, with additional payments of up to $4.4 billion contingent on achieving development, regulatory, and commercial milestones, reflecting strong confidence in the collaboration.
- Technology Platform Utilization: Madrigal will leverage Ribo's liver-targeting small-interfering RNA (siRNA) GalSTAR platform to advance six preclinical programs aimed at developing new therapies for MASH, thereby enhancing treatment efficacy and addressing patient needs.
- Future Collaboration Expansion: The agreement includes provisions to expand the collaboration to new siRNA programs, such as bispecific siRNAs, indicating a long-term strategic partnership focused on innovative treatment solutions.
See More
Ribo Life Science Enters Exclusive Licensing Agreement with Madrigal Pharmaceuticals
- Exclusive Licensing Agreement: Ribo Life Science has entered into a global exclusive licensing agreement with Madrigal Pharmaceuticals for six pre-clinical small interfering RNA (siRNA) programs targeting metabolic dysfunction-associated steatohepatitis (MASH), which is expected to drive the development of new therapies to meet growing market demand.
- Financial Gains: Under the agreement, Ribo will receive an upfront payment of $60 million, with cumulative payments potentially reaching $4.4 billion upon achieving specific development, regulatory, and commercial milestones, highlighting the economic value and market potential of this collaboration.
- Technological Platform Advantage: The collaboration will leverage Ribo's GalSTARTM platform to develop bi-specific siRNAs, aiming to expand the therapeutic landscape for MASH through complementary multi-mechanistic approaches, thereby enhancing treatment efficacy and addressing unmet medical needs for patients.
- Growing Market Demand: As awareness of MASH disease increases and prevalence rises, the number of patients with moderate to advanced fibrosis is expected to grow, further driving the demand for new therapies and underscoring the significance of this collaboration.
See More
Madrigal Pharmaceuticals Shares Enter Oversold Territory
- Oversold Signal: Madrigal Pharmaceuticals' stock price fell to $458.067 per share on Friday, resulting in an RSI of 29.6, indicating an oversold condition that may attract bullish investors seeking buying opportunities.
- Market Comparison: Compared to the S&P 500 ETF's RSI of 42.5, MDGL's 29.6 suggests that the recent heavy selling is exhausting itself, potentially paving the way for a rebound.
- Historical Performance: MDGL's 52-week low is $265 per share, with a high of $615, and the current trading price of $464.71 reflects its performance within this volatile range, indicating market uncertainty.
- Investor Focus: As the stock enters oversold territory, investors may closely monitor MDGL's future performance, particularly in the current market environment, looking for potential rebound opportunities to realize gains.
See More
Ribo Life Science and Madrigal Sign siRNA Licensing Agreement
- Exclusive Global Licensing Agreement: Ribo Life Science has signed an exclusive global licensing agreement with Madrigal for six preclinical siRNA programs targeting metabolic dysfunction-associated steatohepatitis (MASH), which is expected to drive the development of new therapies to meet urgent market needs for MASH treatment.
- Financial Upside Potential: Under the agreement, Ribo will receive a $60 million upfront payment, with cumulative payments potentially reaching $4.4 billion upon achieving specific development and commercial milestones, significantly enhancing the company's financial position and supporting future R&D investments.
- Technological Platform Advantage: This collaboration will leverage Ribo's siRNA-GalSTARTM platform in conjunction with Madrigal's expertise in MASH, aiming to develop more effective treatment options, thereby enhancing the company's competitiveness in the biopharmaceutical market.
- Growing Market Demand: As the number of MASH patients rises and its association with various severe comorbidities becomes clearer, the demand for effective treatment solutions is increasingly urgent, positioning Ribo favorably in the rapidly growing biopharmaceutical sector.
See More
Ribo and Madrigal Sign Exclusive Global License Agreement
- Exclusive Global License Agreement: Ribo Life Science and Madrigal Pharmaceuticals have entered into an exclusive global license agreement covering six preclinical small RNA interference programs targeting Metabolic dysfunction-Associated SteatoHepatitis (MASH), which is expected to drive the development of new therapies to meet increasing market demand.
- Financial Upside Potential: Under the agreement, Ribo will receive an initial payment of $60 million, with cumulative payments potentially reaching $4.4 billion upon achieving specific development and commercialization milestones, significantly enhancing the company's financial position and supporting future R&D investments.
- Urgent Treatment Need: MASH is a serious liver disease with rising prevalence, and the collaboration between Ribo and Madrigal aims to provide more effective treatment options through innovative pARNi platforms to address the current market's lack of effective therapies.
- Broad Market Outlook: With increasing awareness of MASH, more patients are expected to be diagnosed with moderate to advanced liver fibrosis, and Ribo's technological collaboration will help expand its influence in the global biopharmaceutical market, addressing unmet medical needs.
See More
Ribo and Madrigal Announce Exclusive Global License Agreement
- Exclusive Global License Agreement: Ribo and Madrigal have signed an exclusive global license agreement covering six preclinical siRNA programs targeting Metabolic Dysfunction-Associated Steatotic Liver Disease (MASH), which is expected to drive the development of new therapies to meet urgent market needs.
- Financial Upside Potential: Under the agreement, Ribo will receive an initial payment of $60 million, with cumulative payments potentially reaching $4.4 billion upon achieving specific development and commercial milestones, significantly enhancing the company's financial position and supporting future R&D.
- Growing Treatment Demand: MASH is the leading cause of liver transplants, and with increasing awareness of the disease, more patients are expected to be diagnosed; Ribo's collaboration will help develop more targeted treatment options to meet the rising market demand.
- Technological Platform Advantage: Ribo will leverage its validated GalSTARTM siRNA platform to develop multiple new therapies aimed at improving the quality of life for MASH patients through multi-mechanistic approaches, further solidifying its competitive position in the biopharmaceutical sector.
See More
Madrigal Pharmaceuticals Enters $4.46B Licensing Deal with Suzhou Ribo
- Deal Value: Madrigal Pharmaceuticals has entered into an exclusive licensing agreement with Suzhou Ribo Life Science worth up to $4.46 billion, representing a significant advancement in the treatment of metabolic dysfunction-associated steatohepatitis (MASH).
- Upfront Investment and Potential Earnings: Under the terms, Madrigal will pay Ribo $60 million upfront, with additional payments of up to $4.4 billion contingent on achieving development, regulatory, and commercial milestones, reflecting strong confidence in the collaboration.
- Technology Platform Utilization: Madrigal will leverage Ribo's liver-targeting small-interfering RNA (siRNA) GalSTAR platform to advance six preclinical programs aimed at developing new therapies for MASH, thereby enhancing treatment efficacy and addressing patient needs.
- Future Collaboration Expansion: The agreement includes provisions to expand the collaboration to new siRNA programs, such as bispecific siRNAs, indicating a long-term strategic partnership focused on innovative treatment solutions.
See More
Ribo Life Science Enters Exclusive Licensing Agreement with Madrigal Pharmaceuticals
- Exclusive Licensing Agreement: Ribo Life Science has entered into a global exclusive licensing agreement with Madrigal Pharmaceuticals for six pre-clinical small interfering RNA (siRNA) programs targeting metabolic dysfunction-associated steatohepatitis (MASH), which is expected to drive the development of new therapies to meet growing market demand.
- Financial Gains: Under the agreement, Ribo will receive an upfront payment of $60 million, with cumulative payments potentially reaching $4.4 billion upon achieving specific development, regulatory, and commercial milestones, highlighting the economic value and market potential of this collaboration.
- Technological Platform Advantage: The collaboration will leverage Ribo's GalSTARTM platform to develop bi-specific siRNAs, aiming to expand the therapeutic landscape for MASH through complementary multi-mechanistic approaches, thereby enhancing treatment efficacy and addressing unmet medical needs for patients.
- Growing Market Demand: As awareness of MASH disease increases and prevalence rises, the number of patients with moderate to advanced fibrosis is expected to grow, further driving the demand for new therapies and underscoring the significance of this collaboration.
See More
