Genmab Reports EPCORE DLBCL-1 Trial Results, Survival Rate Not Statistically Significant
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Jan 20 2026
0mins
Should l Buy ABBV?
Source: Benzinga
- Trial Results Released: Genmab's EPCORE DLBCL-1 trial results for epcoritamab showed no statistically significant overall survival (OS) with a hazard ratio of 0.96, raising investor concerns about the risk to its accelerated approval status.
- Patient Recruitment: The global study enrolled 483 patients, all of whom had received at least one prior line of therapy and were ineligible for high-dose chemotherapy and autologous stem cell transplant, with the trial commencing in January 2021 and still ongoing.
- Efficacy Observations: Despite the lack of significant OS results, epcoritamab monotherapy demonstrated improvements in progression-free survival (PFS), complete response rates, duration of response, and time to next treatment, indicating its potential clinical value.
- Future Plans: Genmab and AbbVie will engage with global regulatory authorities to discuss next steps, with data from two Phase 3 trials evaluating fixed-duration epcoritamab for DLBCL expected in 2026, further bolstering market confidence.
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Analyst Views on ABBV
Wall Street analysts forecast ABBV stock price to rise
18 Analyst Rating
12 Buy
6 Hold
0 Sell
Moderate Buy
Current: 227.500
Low
223.00
Averages
252.00
High
289.00
Current: 227.500
Low
223.00
Averages
252.00
High
289.00
About ABBV
AbbVie Inc. is a global, diversified research-based biopharmaceutical company. It is engaged in research and development, manufacturing, commercialization and sale of medicines and therapies. Its product portfolio includes Immunology, Oncology, Aesthetics, Neuroscience, Eye Care and Other Key Products. Immunology products include rheumatology, dermatology and gastroenterology. Oncology products include Imbruvica, Venclexta/Venclyxto, Elahere and Epkinly. Aesthetics portfolio consists of facial injectables, plastics and regenerative medicine, body contouring, and skincare products. Its Neuroscience products include Botox Therapeutic, Vraylar, Duopa and Duodopa, Ubrelvy, and Qulipta. Eye Care products include Ozurdex, Lumigan/Ganfort, Alphagan/Combigan, Restasis, and other eye care. Other key products include Mavyret/Maviret, Creon, and Linzess/Constella. Its investigational candidate, bretisilocin, is for the treatment of patients with moderate-to-severe major depressive disorder (MDD).
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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