BeOne Showcases BRUKINSA's Leadership in CLL Treatment at ASH 2025
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Dec 08 2025
0mins
Should l Buy ONC?
Source: Newsfilter
- Clinical Data Advantage: BRUKINSA demonstrated a 74% six-year progression-free survival rate in the SEQUOIA trial, significantly surpassing the 32% of the control group, reinforcing its superior efficacy in treating treatment-naïve CLL patients and solidifying its market leadership.
- Safety Consistency: Over six years of follow-up, BRUKINSA showed no new safety signals, maintaining a safety profile consistent with prior studies, which ensures patient acceptability in long-term treatment and enhances physician confidence.
- Novel Therapy Potential: BGB-16673 exhibited an 85.3% overall response rate in heavily pretreated patients, with no treatment-related deaths among nearly 800 patients, indicating its potential first-in-class status as a BTK degrader, possibly leading a new wave in oncology treatment.
- Guideline Recommendation: The NCCN Clinical Practice Guidelines now recommend the combination of BRUKINSA and venetoclax as a preferred first-line regimen for CLL/SLL, reflecting its recognized clinical application and impact in the field.
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Analyst Views on ONC
Wall Street analysts forecast ONC stock price to rise
11 Analyst Rating
11 Buy
0 Hold
0 Sell
Strong Buy
Current: 346.420
Low
385.00
Averages
403.76
High
424.00
Current: 346.420
Low
385.00
Averages
403.76
High
424.00
About ONC
BeOne Medicines AG, formerly BeiGene, Ltd., is a global oncology company engaged in discovering and developing treatments for cancer patients worldwide. With a portfolio spanning hematology and solid tumors, the Company is engaged in the development of its diverse pipeline of novel therapeutics. Its products include Brukinsa, Tevimbra and Pamiparib. Brukinsa is an orally available, small-molecule inhibitor of Bruton’s tyrosine kinase (BTK). Tevimbra is a humanized immunoglobulin G4 (IgG4) anti-programmed cell death protein 1 (PD-1) monoclonal antibody with high affinity and binding specificity against PD-1. It is designed to minimize binding to Fc-gamma (Fcy) receptors on macrophages, helping the body’s immune cells detect and fight tumors. The Company’s product pipeline in development includes Sonrotoclax, Tarlatamab, Zanidatamab, Blinatumomab, BGB-26808, BGB-R046, BG-68501, BG-C9074, BGB-43395, Xaluritamig, and others.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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- Live Webcast Meeting: Following the earnings release, the company will host a live webcast with management at 8:00 a.m. ET, accessible via the investors section of the company's website, with participants advised to register at least 15 minutes in advance for timely connection.
- Global Team Size: BeOne Medicines boasts a growing global workforce of nearly 12,000 colleagues across six continents, dedicated to expediting the development of its diverse pipeline of innovative therapies to provide accessible treatment options for cancer patients more rapidly.
- Forward-Looking Statements: The company's press release includes forward-looking statements that may be influenced by various important factors, with actual results potentially differing significantly from expectations, prompting investors to review the risk factors discussed in BeOne's latest periodic reports filed with the SEC.
See More
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- BeOne Drug Approvals: BeOne Medicines' flagship drug, Brukinsa, has become the gold standard for treating various blood cancers, and the recent Chinese regulatory approval for sonrotoclax is expected to boost sales in both the U.S. and Europe.
- Enterprise Products Partners Appeal: With a forward distribution yield of 6.6% and 27 consecutive years of dividend increases, Enterprise Products Partners is attractive for income investors, and the anticipated growth in natural gas demand from AI data center construction could enhance its market position.
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- New Drug Application Progress: BeOne recently received Chinese regulatory approval for sonrotoclax to treat relapsed/refractory (R/R) lymphoma and is poised to file for accelerated approval of BGB-16673 pending positive Phase 2 clinical results, which could further enhance its growth trajectory.
- Enterprise Products Partners Dividends: Enterprise Products Partners (EPD) offers a forward distribution yield of 6.6%, having increased its dividends for 27 consecutive years, and the anticipated boom in AI data center construction is expected to drive natural gas demand growth, enhancing its market performance.
See More
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- Clinical Trial Results: The Phase 3 HARMONi trial showed a median overall survival of 16.8 months for ivonescimab plus chemotherapy compared to 14.1 months for chemotherapy alone, indicating significant therapeutic potential.
- Future Research Plans: Summit anticipates completing enrollment in the squamous cohort of the HARMONi-3 trial in the first half of 2026, with primary endpoint analysis expected in the second half of 2026, further advancing ivonescimab's clinical development.
- New Study Initiation: The company has initiated the Phase 3 HARMONi-GI3 study for first-line unresectable metastatic colorectal cancer, aiming to expand ivonescimab's clinical development program to meet market needs.
See More
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- Nasdaq Performance: Although the Nasdaq index initially gained, it ultimately narrowed its gains, reflecting the volatility of tech stocks and the uncertainty in the market.
- Buy Signals: Eli Lilly and Google flashed buy signals, potentially attracting investor interest in these companies' future growth prospects, especially in the current market environment.
- Investor Sentiment: The overall market reversal may lead investors to reassess their risk appetite, thereby affecting capital flows and market dynamics.
See More
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- Market Volatility: On Wednesday, the S&P 500 and Dow retreated from their highs, indicating a shift in market sentiment that could influence short-term investor decisions and risk appetite.
- Nasdaq Performance: Although the Nasdaq index pared gains, it still shows potential for growth, suggesting that volatility in tech stocks may provide short-term trading opportunities for investors.
- Buy Signals: Stocks of Eli Lilly and Google flashed buy signals, potentially attracting investor attention to the growth prospects of these companies in their respective sectors, which could drive their stock prices higher.
- Investor Strategy Adjustment: The market fluctuations and buy signals may prompt investors to reassess their portfolios, particularly in the current economic environment, seeking more promising investment opportunities.
See More
