Annexon Announces Completion of Enrollment in Pivotal Phase 3 ARCHER II Trial of Vonaprument (formerly ANX007) for Dry Age-Related Macular Degeneration (AMD) with Geographic Atrophy
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Jul 24 2025
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Should l Buy ANNX?
Source: Newsfilter
Clinical Trial Enrollment and Expectations: Annexon, Inc. has successfully completed the enrollment of over 630 participants in its Phase 3 ARCHER II trial for vonaprument, a treatment aimed at preserving vision in patients with dry age-related macular degeneration (AMD) and geographic atrophy (GA), with topline data expected in the second half of 2026.
Innovative Mechanism and Design: Vonaprument is designed to inhibit C1q, a key driver of neurodegeneration, and has shown promising results in previous trials, making it a potential first approved therapy for dry AMD with GA in Europe and the U.S., addressing an urgent need for effective treatments in this area.
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Analyst Views on ANNX
Wall Street analysts forecast ANNX stock price to rise
6 Analyst Rating
6 Buy
0 Hold
0 Sell
Strong Buy
Current: 5.190
Low
8.00
Averages
16.40
High
27.00
Current: 5.190
Low
8.00
Averages
16.40
High
27.00
About ANNX
Annexon, Inc. is a clinical-stage biopharmaceutical company advancing a late-stage clinical platform of novel therapies for people living with devastating classical complement-mediated neuroinflammatory diseases of the body, brain, and eye. It identifies and characterizes the role of the classical complement pathway in three therapeutic areas: autoimmune, neurodegeneration and ophthalmology, using its proprietary platform. Its lead candidate, ANX005, an investigational, full-length monoclonal antibody (mAb), is formulated for intravenous administration as the potential first targeted treatment for patients with Guillain-Barre Syndrome (GBS). It is advancing ANX1502, a novel small-molecule inhibitor of classical complement designed for oral administration in a range of chronic autoimmune diseases. It is also advancing ANX007, designed to block C1q locally in the eye, to provide complete protection against excess classical complement activity and the loss of photoreceptor neurons.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
Annexon Grants 155,000 Stock Options to New Employees to Advance Immunotherapy
- Employee Incentive Plan: Annexon has granted 155,000 stock options to two new non-executive employees under the 2022 Employment Inducement Award Plan, highlighting the company's commitment to attracting talent.
- Option Details: The options have an exercise price of $6.16 per share, based on the closing price on January 15, 2026, with a ten-year term and a four-year vesting schedule, where 25% vests on the first anniversary of the grant.
- Market Impact: This option grant not only enhances employee loyalty but may also improve the company's competitive position in the biopharmaceutical sector, particularly in the development of immunotherapies for neuroinflammatory diseases.
- Strategic Significance: With a mission to provide therapies for nearly 10 million people suffering from neuroinflammatory diseases, this incentive measure will help attract and retain key talent, thereby advancing the company's objectives.
See More
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- Insider Buying Signals: Summit Therapeutics has recently seen insider purchases, indicating management's confidence in its cancer drug's market potential, which could lead to significant stock price volatility in the future.
- Neurological Drug Development: Annexon also reported insider buying, reflecting confidence in its antibody drugs targeting neurological diseases, despite the high clinical trial risks, the potential for success is substantial.
- Cognitive Disorder Treatment: CervoMed's insider trading is noteworthy as its drug for Lewy body dementia shows market expectations for new therapies, although challenges in clinical trials remain significant.
- Investor Strategy: Insider buying in biotech stocks is not a buy signal but a research prompt, urging investors to carefully assess company cash flow and market sentiment to avoid losses from market fluctuations.
See More
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- Income Support for Families: San Francisco's plan provides free childcare for children under five to families earning less than $230,000, while those earning up to $310,000 qualify for partial subsidies, potentially saving families tens of thousands of dollars annually.
- Addressing Living Costs: The initiative targets childcare costs that can reach $30,000 annually for full-time infant care, with city officials stating that this move offers meaningful economic relief for middle-class families, helping them remain in the city.
- Funding Assurance: Funding for the initiative will come from a commercial rent tax approved by voters in 2018, with estimates suggesting that unused revenue will support approximately 20,000 children through 2032, ensuring the program's sustainability.
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See More
Annexon Grants 19,000 Stock Options to New Employee at $4.91 Exercise Price
- Employee Incentive Program: Annexon has granted 19,000 stock options to a new non-executive employee under the 2022 Employment Inducement Award Plan, with an exercise price of $4.91 per share, highlighting the company's commitment to attracting and retaining talent.
- Long-Term Incentive Mechanism: The options have a ten-year term and vest over four years, with 25% vesting on the first anniversary and the remainder vesting monthly, aimed at promoting employee retention and contribution through sustained incentives.
- Market Reaction Potential: The options are priced based on the closing price on December 15, 2025, reflecting the company's confidence in future stock price appreciation, which could positively influence investor sentiment.
- Strategic Development Focus: Annexon is dedicated to developing complement inhibitors targeting neuroinflammation to address the unmet medical needs of nearly 10 million patients worldwide, indicating a long-term strategic positioning in the biopharmaceutical sector.
See More
Annexon Grants 19,000 Stock Options to New Employee at $4.91 Exercise Price
- Employee Incentive Program: Annexon has granted 19,000 stock options to a new non-executive employee under the 2022 Employment Inducement Award Plan, with an exercise price of $4.91 per share, reflecting the company's commitment to attracting and retaining talent.
- Long-Term Incentive Structure: The options have a ten-year term and vest over four years, with 25% vesting on the first anniversary and the remainder vesting monthly, designed to enhance employee retention and motivation through a long-term incentive mechanism.
- Compliance Assurance: This grant complies with Nasdaq Listing Rule 5635(c)(4), ensuring the company's adherence to regulations while strengthening its position in attracting and retaining key talent in the competitive biopharmaceutical sector.
- Strategic Development Focus: Annexon is focused on developing complement inhibitors targeting neuroinflammation to address unmet medical needs for nearly 10 million people globally, and this incentive measure will help attract more professionals to advance its research and development efforts.
See More
Annexon Stock Soars Following Director's $5.06 Million Share Acquisition
- Stock Performance: Annexon (ANNX) stock experienced an 8.6% increase in trading on Thursday.
- Director Purchase: The rise in stock price followed the purchase of $5.06 million worth of shares by director Muneer Satter.
See More
Annexon Grants 155,000 Stock Options to New Employees to Advance Immunotherapy
- Employee Incentive Plan: Annexon has granted 155,000 stock options to two new non-executive employees under the 2022 Employment Inducement Award Plan, highlighting the company's commitment to attracting talent.
- Option Details: The options have an exercise price of $6.16 per share, based on the closing price on January 15, 2026, with a ten-year term and a four-year vesting schedule, where 25% vests on the first anniversary of the grant.
- Market Impact: This option grant not only enhances employee loyalty but may also improve the company's competitive position in the biopharmaceutical sector, particularly in the development of immunotherapies for neuroinflammatory diseases.
- Strategic Significance: With a mission to provide therapies for nearly 10 million people suffering from neuroinflammatory diseases, this incentive measure will help attract and retain key talent, thereby advancing the company's objectives.
See More
Biotech Insider Buying Signals Strong, Three Companies Draw Attention
- Insider Buying Signals: Summit Therapeutics has recently seen insider purchases, indicating management's confidence in its cancer drug's market potential, which could lead to significant stock price volatility in the future.
- Neurological Drug Development: Annexon also reported insider buying, reflecting confidence in its antibody drugs targeting neurological diseases, despite the high clinical trial risks, the potential for success is substantial.
- Cognitive Disorder Treatment: CervoMed's insider trading is noteworthy as its drug for Lewy body dementia shows market expectations for new therapies, although challenges in clinical trials remain significant.
- Investor Strategy: Insider buying in biotech stocks is not a buy signal but a research prompt, urging investors to carefully assess company cash flow and market sentiment to avoid losses from market fluctuations.
See More
San Francisco Expands Free Childcare Access, Saving Families Thousands Annually
- Income Support for Families: San Francisco's plan provides free childcare for children under five to families earning less than $230,000, while those earning up to $310,000 qualify for partial subsidies, potentially saving families tens of thousands of dollars annually.
- Addressing Living Costs: The initiative targets childcare costs that can reach $30,000 annually for full-time infant care, with city officials stating that this move offers meaningful economic relief for middle-class families, helping them remain in the city.
- Funding Assurance: Funding for the initiative will come from a commercial rent tax approved by voters in 2018, with estimates suggesting that unused revenue will support approximately 20,000 children through 2032, ensuring the program's sustainability.
- Political Context: Mayor Daniel Lurie, as part of a growing group of Democratic leaders, is pushing this affordability agenda, reflecting a broader focus on the economic pressures facing middle-class families post-2024 election cycle, with similar efforts underway in New York.
See More
Annexon Grants 19,000 Stock Options to New Employee at $4.91 Exercise Price
- Employee Incentive Program: Annexon has granted 19,000 stock options to a new non-executive employee under the 2022 Employment Inducement Award Plan, with an exercise price of $4.91 per share, highlighting the company's commitment to attracting and retaining talent.
- Long-Term Incentive Mechanism: The options have a ten-year term and vest over four years, with 25% vesting on the first anniversary and the remainder vesting monthly, aimed at promoting employee retention and contribution through sustained incentives.
- Market Reaction Potential: The options are priced based on the closing price on December 15, 2025, reflecting the company's confidence in future stock price appreciation, which could positively influence investor sentiment.
- Strategic Development Focus: Annexon is dedicated to developing complement inhibitors targeting neuroinflammation to address the unmet medical needs of nearly 10 million patients worldwide, indicating a long-term strategic positioning in the biopharmaceutical sector.
See More
Annexon Grants 19,000 Stock Options to New Employee at $4.91 Exercise Price
- Employee Incentive Program: Annexon has granted 19,000 stock options to a new non-executive employee under the 2022 Employment Inducement Award Plan, with an exercise price of $4.91 per share, reflecting the company's commitment to attracting and retaining talent.
- Long-Term Incentive Structure: The options have a ten-year term and vest over four years, with 25% vesting on the first anniversary and the remainder vesting monthly, designed to enhance employee retention and motivation through a long-term incentive mechanism.
- Compliance Assurance: This grant complies with Nasdaq Listing Rule 5635(c)(4), ensuring the company's adherence to regulations while strengthening its position in attracting and retaining key talent in the competitive biopharmaceutical sector.
- Strategic Development Focus: Annexon is focused on developing complement inhibitors targeting neuroinflammation to address unmet medical needs for nearly 10 million people globally, and this incentive measure will help attract more professionals to advance its research and development efforts.
See More
Annexon Stock Soars Following Director's $5.06 Million Share Acquisition
- Stock Performance: Annexon (ANNX) stock experienced an 8.6% increase in trading on Thursday.
- Director Purchase: The rise in stock price followed the purchase of $5.06 million worth of shares by director Muneer Satter.
See More
