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MGNX Overview

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ET
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Intellectia

Loading chart...

High
3.660
Open
3.540
VWAP
3.53
Vol
721.70K
Mkt Cap
221.19M
Low
3.455
Amount
2.55M
EV/EBITDA(TTM)
--
Total Shares
63.56M
EV
101.28M
EV/OCF(TTM)
--
P/S(TTM)
1.47
MacroGenics, Inc. is a biopharmaceutical company focused on discovering, developing, manufacturing and commercializing monoclonal antibody-based therapeutics for the treatment of cancer. The Company generates its pipeline of product candidates primarily from its suite of antibody-based technology platforms, which have applicability across broad therapeutic domains. It is advancing three proprietary product candidates in clinical development: lorigerlimab, a bispecific DART molecule that targets checkpoint inhibitors PD-1 and CTLA-4; MGC026, an ADC that targets B7-H3 and delivers a novel topoisomerase I inhibitor (TOP1i)-based linker-payload, and MGC028, an ADC that targets ADAM9 and delivers a novel TOP1i-based linker-payload. Its other product candidates are MGD024, retifanlimab, enoblituzumab, and vobramitamab duocarmazine. MGD024 is an investigational, next-generation, bispecific CD123 CD3 DART molecule designed to engage CD3 expressed on immune effector cells, such as T cells.
Show More

Events Timeline

(ET)
2026-04-08
16:40:00
MacroGenics LINNET Study Partially Lifted by FDA
select
2026-02-23 (ET)
2026-02-23
18:20:00
MacroGenics Faces Partial Clinical Hold on LINNET Study
select
2025-11-12 (ET)
2025-11-12
16:16:12
MacroGenics anticipates sufficient cash to sustain operations through late 2027.
select
2025-11-12
16:15:45
MacroGenics Announces Q3 EPS of 27 Cents Compared to 90 Cents Last Year
select

News

stocktwits
8.5
04-10stocktwits
MGNX Positioned for Growth in Antibody-Drug Conjugate Market
  • FDA Lifts Clinical Hold: MGNX announced that the U.S. FDA has lifted the partial clinical hold on its Phase 2 trial of Lorigerlimab, allowing the study to resume enrolling patients with advanced ovarian and gynecologic cancers, which is expected to accelerate clinical progress and patient recruitment.
  • Significant Stock Surge: Following a bullish analyst call, MGNX shares surged approximately 10% on Friday, reaching their highest levels since November 2024, indicating strong market confidence in the company's growth potential, with a year-to-date increase of around 133%.
  • Analyst Upgrade: B. Riley upgraded MGNX from ‘Neutral’ to ‘Buy’ with a price target of $9, driven by optimistic projections for the Antibody-Drug Conjugate (ADC) market, asserting that MGNX is uniquely positioned in the emerging “ADAM9 TOPO1i ADC” space.
  • Shift in Market Sentiment: Retail sentiment for MGNX on Stocktwits shifted from ‘bearish’ to ‘bullish’, with users expressing increased optimism about the stock's valuation, reflecting a growing confidence among investors regarding the company's future prospects.
seekingalpha
9.0
04-09seekingalpha
Macrogenics Shares Rise as FDA Lifts Clinical Hold on Lorigerlimab Trial
  • Clinical Hold Lifted: The FDA's removal of the partial clinical hold on Macrogenics' lorigerlimab mid-stage trial allows the company to begin enrolling new patients under a revised protocol, which is expected to significantly accelerate research progress and enhance market confidence.
  • Enhanced Safety Measures: The new protocol includes additional safety measures targeting potential blood and heart-related side effects, aimed at improving patient safety and reducing risks in future trials, thereby enhancing the company's reputation in the biotech sector.
  • Trial Progress Update: Macrogenics plans to provide a program update on the LINNET trial in mid-2026, indicating strong confidence in the long-term prospects of lorigerlimab, which may attract more investor interest in its future performance.
  • Positive Market Reaction: Following the FDA's lift of the partial hold, Macrogenics shares rose in premarket trading, reflecting investor optimism about the company's resumption of clinical trials, potentially driving further increases in stock price.
NASDAQ.COM
9.0
04-09NASDAQ.COM
MacroGenics FDA Lifts Partial Hold on LINNET Study
  • Clinical Study Progress: The FDA's lifting of the partial hold on MacroGenics' LINNET study of Lorigerlimab allows the company to resume enrollment under a revised protocol, with plans to provide a program update by mid-2026, indicating positive momentum in clinical development.
  • Safety Event Management: During the FDA hold, MacroGenics worked closely with the agency to address the recruitment pause caused by Grade 4 and 5 safety events reported in four patients, demonstrating the company's commitment to patient safety and regulatory compliance.
  • Financial Performance: Total revenue for 2025 slipped to $149.50 million from $149.96 million in the previous year, while net loss widened to $74.62 million or $1.18 per share, reflecting the high costs and market challenges faced during the clinical trial phase.
  • Cash Flow Assurance: As of December 31, 2025, MacroGenics had a cash, cash equivalents, and marketable securities balance of $189.91 million, expected to support operations into late 2027, showcasing the company's robust financial management.
Newsfilter
9.0
04-08Newsfilter
MacroGenics Resumes Lorigerlimab Clinical Study Enrollment
  • Clinical Study Resumption: MacroGenics announced that the FDA has lifted the partial clinical hold on lorigerlimab, allowing new participants to enroll under a revised protocol, thereby accelerating research into treatments for ovarian and gynecologic cancers.
  • Participant Status: The LINNET study has dosed 41 patients to date and plans to evaluate the drug's efficacy in approximately 60 eligible participants, demonstrating the company's ongoing commitment and investment in cancer treatment.
  • Risk Mitigation Measures: The new protocol includes additional risk mitigation measures for potential hematologic and cardiac toxicities, aimed at enhancing patient safety and increasing the feasibility of clinical trials, thus boosting the company's competitiveness in the biopharmaceutical industry.
  • Future Outlook: MacroGenics expects to provide a mid-2026 clinical update on the program, indicating confidence in future clinical data and market potential, further solidifying its position in the innovative antibody therapeutics space.
NASDAQ.COM
6.0
03-11NASDAQ.COM
MacroGenics Stock Surpasses Analyst Target Price
  • Price Target Breakthrough: MacroGenics, Inc (MGNX) shares recently rose to $3.43, surpassing the average analyst 12-month target price of $3.40, indicating optimistic market sentiment that may attract more investor interest.
  • Diverse Analyst Reactions: Among analysts covered by Zacks, target prices range from $2.00 to $5.00, with a standard deviation of $1.14, highlighting significant divergence in market views on MGNX's future performance, necessitating careful risk assessment by investors.
  • Investor Decision Signal: The stock's rise above the target price provides a signal for investors to reassess the company, prompting them to consider whether the current price is merely a stop on the way to higher targets or if it's time to think about taking profits.
  • Wisdom of the Market: The average target price reflects the collective wisdom of multiple experts, and investors should pay attention to this data to better understand the overall market sentiment and potential trends for MGNX.
stocktwits
9.5
03-10stocktwits
MacroGenics Antibody Drug Progress Expected in 2026
  • Clinical Data Expectations: MacroGenics CEO Eric Risser indicated that the company anticipates reporting clinical data for antibody drug MGC026 in mid-2026 and for MGC028 in the second half of 2026, which could provide positive signals for the company's future market performance.
  • Trial Application Plans: The company plans to submit a clinical trial application for MGC030 in the third quarter of 2026, further expanding its antibody drug pipeline and demonstrating its strategic positioning in the cancer treatment sector.
  • FDA Clinical Hold: Although the company faced a partial clinical hold from the FDA on its study evaluating lorigerlimab, it is actively working with the agency and expects to provide updates in mid-2026, showcasing its ability to navigate regulatory challenges.
  • Strong Financial Position: As of the end of 2022, the company reported cash and cash equivalents of $189.9 million, which is expected to support its operations into late 2027, providing a solid financial foundation for future R&D and market expansion.
Wall Street analysts forecast MGNX stock price to rise
4 Analyst Rating
Wall Street analysts forecast MGNX stock price to rise
1 Buy
3 Hold
0 Sell
Hold
Current: 0.000
sliders
Low
2.00
Averages
3.00
High
4.00
Current: 0.000
sliders
Low
2.00
Averages
3.00
High
4.00
Barclays
NULL -> Overweight
maintain
$4 -> $6
AI Analysis
2026-04-20
New
Reason
Barclays
Price Target
$4 -> $6
AI Analysis
2026-04-20
New
maintain
NULL -> Overweight
Reason
Barclays raised the firm's price target on MacroGenics to $6 from $4 and keeps an Overweight rating on the shares. The firm adjusted ratings and targets in the small and mid cap biotechnology group as part of a Q1 earnings preview.
B. Riley
Neutral
to
Buy
upgrade
$9
2026-04-10
Reason
B. Riley
Price Target
$9
2026-04-10
upgrade
Neutral
to
Buy
Reason
B. Riley upgraded MacroGenics to Buy from Neutral with a $9 price target.
Unlock Full Analyst Thesis, Get the complete breakdown of rating reason for MGNX
Unlock Now

Valuation Metrics

The current forward P/E ratio for MacroGenics Inc (MGNX.O) is 60.98, compared to its 5-year average forward P/E of 0.02. For a more detailed relative valuation and DCF analysis to assess MacroGenics Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
0.02
Current PE
60.98
Overvalued PE
13.44
Undervalued PE
-13.39

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-3.02
Current EV/EBITDA
-12.37
Overvalued EV/EBITDA
0.68
Undervalued EV/EBITDA
-6.72

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
5Y Average PS
4.08
Current PS
2.24
Overvalued PS
7.34
Undervalued PS
0.81

Financials

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Whales Holding MGNX

F
Frazier Life Sciences Management, LP
Holding
MGNX
+6.89%
3M Return

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Frequently Asked Questions

What is MacroGenics Inc (MGNX) stock price today?

The current price of MGNX is 3.47 USD — it has decreased -0.29

What is MacroGenics Inc (MGNX)'s business?

MacroGenics, Inc. is a biopharmaceutical company focused on discovering, developing, manufacturing and commercializing monoclonal antibody-based therapeutics for the treatment of cancer. The Company generates its pipeline of product candidates primarily from its suite of antibody-based technology platforms, which have applicability across broad therapeutic domains. It is advancing three proprietary product candidates in clinical development: lorigerlimab, a bispecific DART molecule that targets checkpoint inhibitors PD-1 and CTLA-4; MGC026, an ADC that targets B7-H3 and delivers a novel topoisomerase I inhibitor (TOP1i)-based linker-payload, and MGC028, an ADC that targets ADAM9 and delivers a novel TOP1i-based linker-payload. Its other product candidates are MGD024, retifanlimab, enoblituzumab, and vobramitamab duocarmazine. MGD024 is an investigational, next-generation, bispecific CD123 CD3 DART molecule designed to engage CD3 expressed on immune effector cells, such as T cells.

What is the price predicton of MGNX Stock?

Wall Street analysts forecast MGNX stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for MGNX is3.00 USD with a low forecast of 2.00 USD and a high forecast of 4.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is MacroGenics Inc (MGNX)'s revenue for the last quarter?

MacroGenics Inc revenue for the last quarter amounts to 41.23M USD, increased 113.03

What is MacroGenics Inc (MGNX)'s earnings per share (EPS) for the last quarter?

MacroGenics Inc. EPS for the last quarter amounts to -0.22 USD, decreased -12.00

How many employees does MacroGenics Inc (MGNX). have?

MacroGenics Inc (MGNX) has 293 emplpoyees as of April 22 2026.

What is MacroGenics Inc (MGNX) market cap?

Today MGNX has the market capitalization of 221.19M USD.