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IOVA Overview

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$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
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Intellectia

Loading chart...

High
4.050
Open
3.970
VWAP
3.94
Vol
23.71M
Mkt Cap
1.75B
Low
3.850
Amount
93.36M
EV/EBITDA(TTM)
--
Total Shares
446.50M
EV
1.43B
EV/OCF(TTM)
--
P/S(TTM)
5.22
Iovance Biotherapeutics, Inc. is a commercial biotechnology company. The Company is focused on developing and delivering novel polyclonal tumor infiltrating lymphocyte (TIL) therapies for patients with cancer. Its products include Amtagvi and Proleukin. Amtagvi is indicated for the treatment of adult patients with melanoma previously treated with a PD-1 blocking antibody, and if BRAF V600 mutation positive, a BRAF inhibitor, with or without a MEK inhibitor. It is marketing Proleukin (aldesleukin), an interleukin-2 (IL-2) product used in the Amtagvi treatment regimen and in other applications. Amtagvi and Proleukin are part of a treatment regimen that includes lymphodepletion. Its development pipeline includes multicenter trials of TIL cell therapies in additional treatment settings and indications for solid tumor cancers. Its TIL therapy includes melanoma, non-small cell lung cancer and gynecologic cancer.
Show More

Events Timeline

(ET)
2026-06-03
16:50:00
Iovance Receives Australian Approval for Amtagvi to Treat Melanoma
select
2026-06-01 (ET)
2026-06-01
08:00:00
Iovance Receives FDA Approval for IOV-5001 Clinical Trial
select
2026-05-07 (ET)
2026-05-07
08:20:00
Amtagvi Sees Q2 Revenue of $79M-$81M
select
2026-05-07
08:20:00
Iovance Q1 Revenue at $71.43M, Below Consensus
select
2026-05-07
08:20:00
Iovance Biotherapeutics Sees FY26 Revenue $350M-$370M
select

News

Yahoo Finance
8.5
06-18Yahoo Finance
PinnedIovance Biotherapeutics Files Registration Statement for sec
  • Registration Statement Filed: Iovance Biotherapeutics filed a registration statement on Thursday, marking the formal initiation of its potential sale, although specific sales details remain undisclosed, indicating the company's proactive stance in the biotherapeutics sector.
  • Market Reaction Anticipated: The filing of this registration statement may prompt market interest in Iovance's future financing capabilities, particularly against the backdrop of increasing competition in the biopharmaceutical industry, with investors eager to gauge the market potential of its products.
  • Strategic Implications: By submitting the registration statement, Iovance may be paving the way for future capital operations, especially in advancing its therapeutic solutions through clinical trials and market promotion, reflecting the company's confidence in its future development.
  • Industry Context: The biotherapeutics sector is experiencing rapid growth, and Iovance's registration statement could attract more investor attention, further driving its innovation and market share in the cell therapy domain.
Globenewswire
8.5
06-08Globenewswire
GT Biopharma Advances Three Drug Candidates into Clinical Trials
  • Clinical Trial Progress: GT Biopharma has advanced three TriKE® candidates into clinical trials, with GTB-5550's first patient dosing on May 14, 2026, marking the company's expansion from blood cancers to the broader solid tumor market, despite its market capitalization remaining below many peers.
  • Drug Development Platform: The TriKE® platform developed by GT Biopharma aims to enhance the immune system's ability to target tumors by linking natural killer cells to specific cancer targets, demonstrating potential across various disease targets, particularly in hematologic malignancies and solid tumors.
  • Clinical Trial Design: The clinical trial for GTB-3650 involves approximately 14 patients and employs a dose-escalation approach, with doses ranging from 1.25 µg/kg/day to 100 µg/kg/day, aimed at evaluating its efficacy in acute myeloid leukemia and high-risk myelodysplastic syndrome.
  • Valuation Gap: Despite significant clinical advancements, GT Biopharma's market valuation remains relatively low, creating a mismatch that attracts speculative interest; if any of its programs succeed, it could lead to substantial stock price appreciation.
Newsfilter
9.0
06-08Newsfilter
GT Biopharma Advances Three Cancer Drug Candidates into Clinical Trials
  • Clinical Trial Progress: GT Biopharma has advanced three TriKE® candidates into clinical stages, with GTB-5550's first patient dosing on May 14, 2026, marking the company's expansion from blood cancers to the broader solid tumor market, indicating its potential in tumor immunotherapy.
  • Drug Development Platform: GT Biopharma's TriKE® platform aims to enhance immune responses by linking natural killer cells to specific cancer targets, with current clinical projects including GTB-3650 for acute myeloid leukemia and GTB-5550 targeting B7-H3-marked solid tumors, showcasing a diversified treatment strategy.
  • Valuation Gap: Despite advancing three candidates into clinical trials, GT Biopharma's market valuation remains below many peers, reflecting a tension between funding and clinical progress that attracts speculative interest; if any program succeeds, it could significantly enhance the company's value.
  • Trial Design: The GTB-5550 trial employs a basket trial design, allowing patients with multiple tumor types to enroll under one protocol, which is an efficient approach for the company to quickly gather early signals and assess responses across different cancers while managing limited resources.
seekingalpha
8.5
06-04seekingalpha
Iovance Biotherapeutics Secures Conditional Approval for Amtagvi in Australia
  • Australia Approval: Iovance Biotherapeutics' cell therapy Amtagvi has received conditional approval from the Therapeutic Goods Administration of Australia as a late-line treatment option for melanoma, marking a significant advancement for the company in the country with the highest melanoma rates globally.
  • Market Potential: With 17,000 new melanoma patients diagnosed annually in Australia, this approval positions Iovance to capture a critical share of the market and address the growing demand for effective treatments.
  • Treatment Center Plans: Iovance plans to obtain authorization for its first Amtagvi treatment center in Australia, which will further enhance its business expansion in the region and provide patients with more accessible treatment options.
  • Strategic Importance: This approval represents the third marketing authorization for Amtagvi in Australia, demonstrating Iovance's capability to expand in global markets and its commitment to innovative therapies, which is expected to drive future revenue growth.
Fool
9.5
06-02Fool
Iovance Biotherapeutics Stock Volatility Analysis
  • Stock Performance: Iovance Biotherapeutics shares have risen 50% year-to-date and over 125% in the past 12 months, despite a nearly 80% decline over the past five years, indicating high volatility and market risk.
  • Product Commercialization: Iovance focuses on developing tumor-infiltrating lymphocytes (TILs) for cancer treatment, with its flagship drug Amtagvi now in the commercialization stage, projected to exceed $1 billion in annual sales, showcasing significant potential.
  • Financial Status: Although first-quarter sales of $71 million fell short of analysts' expectations of $75.6 million, the company achieved a 45% year-over-year growth rate, with management forecasting revenue growth of 30% to 40% for the full year.
  • Funding Assurance: With $319 million in cash on hand, Iovance is positioned to fund operations through 2028, reducing the risk of near-term shareholder dilution, and if Amtagvi sales continue to rise, the stock could rebound to previous levels.
NASDAQ.COM
9.5
06-02NASDAQ.COM
Iovance Biotherapeutics Stock Volatility and Growth Prospects
  • Sales Growth Potential: Iovance Biotherapeutics has seen a 50% stock price increase over the past year, despite an almost 80% decline over the last five years; with a 45% year-over-year sales growth, the company anticipates a revenue increase of 30% to 40% for the full year, presenting potential returns for investors.
  • Cash Flow Position: The company currently holds $319 million in cash, which is expected to fund operations through 2028, thereby reducing the risk of near-term shareholder dilution and enhancing investor confidence, particularly in the high-risk biotech sector.
  • Product Commercialization Progress: Iovance's flagship drug, Amtagvi, has reached the commercialization stage, with management suggesting it could achieve over $1 billion in annual sales; although the market introduction has been time-consuming and capital-intensive, successful launch will significantly enhance company valuation.
  • Market Reaction Volatility: Despite Iovance reporting first-quarter sales of $71 million, which fell short of analysts' expectations of $75.6 million, leading to a brief stock price drop, the overall sales growth trend and future clinical trial advancements may attract more investor interest.
Wall Street analysts forecast IOVA stock price to rise
8 Analyst Rating
Wall Street analysts forecast IOVA stock price to rise
6 Buy
1 Hold
1 Sell
Moderate Buy
Current: 0.000
sliders
Low
1.50
Averages
9.50
High
17.00
Current: 0.000
sliders
Low
1.50
Averages
9.50
High
17.00
Chardan
Buy
maintain
$16 -> $14
AI Analysis
2026-05-07
Reason
Chardan
Price Target
$16 -> $14
AI Analysis
2026-05-07
maintain
Buy
Reason
Chardan lowered the firm's price target on Iovance Biotherapeutics to $14 from $16 and keeps a Buy rating on the shares. The firm is adjusting its model to reflect the updated Amtagvi launch guidance, the analyst tells investors in a research note.
Jefferies
Andrew Tsai
Buy
maintain
$12
2026-04-10
Reason
Jefferies
Andrew Tsai
Price Target
$12
2026-04-10
maintain
Buy
Reason
Jefferies analyst Andrew Tsai noted that the FDA has issued another complete response letter rejection to Replimune (REPL) for Tudriqev in second-line advanced melanoma. Although Replimune was "technically not an overhang" on Iovance Biotherapeutics (IOVA) stock, the situation does mean one less competitor in the near-term, says the analyst, who can see a potential 5%-15% stock move on the news. The firm, which adds that the Iovance story "remains centered on" Amtagvi's sales acceleration and margin expansion in 2026, has a Buy rating and $12 price target on the shares.
Unlock Full Analyst Thesis, Get the complete breakdown of rating reason for IOVA
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Valuation Metrics

The current forward P/E ratio for Iovance Biotherapeutics Inc (IOVA.O) is 0.00, compared to its 5-year average forward P/E of -5.89. For a more detailed relative valuation and DCF analysis to assess Iovance Biotherapeutics Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-5.89
Current PE
0.00
Overvalued PE
-2.96
Undervalued PE
-8.83

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-4.74
Current EV/EBITDA
-2.94
Overvalued EV/EBITDA
-1.86
Undervalued EV/EBITDA
-7.61

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
43.15
Current PS
3.34
Overvalued PS
171.12
Undervalued PS
-84.83

Financials

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Whales Holding IOVA

L
Long Focus Capital Management LLC
Holding
IOVA
+13.52%
3M Return
I
Invenomic Capital Management LP
Holding
IOVA
+2.03%
3M Return

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Frequently Asked Questions

What is Iovance Biotherapeutics Inc (IOVA) stock price today?

The current price of IOVA is 3.91 USD — it has decreased -0.51

What is Iovance Biotherapeutics Inc (IOVA)'s business?

Iovance Biotherapeutics, Inc. is a commercial biotechnology company. The Company is focused on developing and delivering novel polyclonal tumor infiltrating lymphocyte (TIL) therapies for patients with cancer. Its products include Amtagvi and Proleukin. Amtagvi is indicated for the treatment of adult patients with melanoma previously treated with a PD-1 blocking antibody, and if BRAF V600 mutation positive, a BRAF inhibitor, with or without a MEK inhibitor. It is marketing Proleukin (aldesleukin), an interleukin-2 (IL-2) product used in the Amtagvi treatment regimen and in other applications. Amtagvi and Proleukin are part of a treatment regimen that includes lymphodepletion. Its development pipeline includes multicenter trials of TIL cell therapies in additional treatment settings and indications for solid tumor cancers. Its TIL therapy includes melanoma, non-small cell lung cancer and gynecologic cancer.

What is the price predicton of IOVA Stock?

Wall Street analysts forecast IOVA stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for IOVA is9.50 USD with a low forecast of 1.50 USD and a high forecast of 17.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Iovance Biotherapeutics Inc (IOVA)'s revenue for the last quarter?

Iovance Biotherapeutics Inc revenue for the last quarter amounts to 71.43M USD, increased 44.82

What is Iovance Biotherapeutics Inc (IOVA)'s earnings per share (EPS) for the last quarter?

Iovance Biotherapeutics Inc. EPS for the last quarter amounts to -0.19 USD, decreased -47.22

How many employees does Iovance Biotherapeutics Inc (IOVA). have?

Iovance Biotherapeutics Inc (IOVA) has 975 emplpoyees as of June 20 2026.

What is Iovance Biotherapeutics Inc (IOVA) market cap?

Today IOVA has the market capitalization of 1.75B USD.