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IOVA Overview

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$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
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Intellectia

Loading chart...

High
3.860
Open
3.750
VWAP
3.77
Vol
9.75M
Mkt Cap
1.56B
Low
3.660
Amount
36.73M
EV/EBITDA(TTM)
--
Total Shares
411.96M
EV
1.26B
EV/OCF(TTM)
--
P/S(TTM)
5.12
Iovance Biotherapeutics, Inc. is a commercial biotechnology company. The Company is focused on developing and delivering novel polyclonal tumor infiltrating lymphocyte (TIL) therapies for patients with cancer. Its products include Amtagvi and Proleukin. Amtagvi is indicated for the treatment of adult patients with melanoma previously treated with a PD-1 blocking antibody, and if BRAF V600 mutation positive, a BRAF inhibitor, with or without a MEK inhibitor. It is marketing Proleukin (aldesleukin), an interleukin-2 (IL-2) product used in the Amtagvi treatment regimen and in other applications. Amtagvi and Proleukin are part of a treatment regimen that includes lymphodepletion. Its development pipeline includes multicenter trials of TIL cell therapies in additional treatment settings and indications for solid tumor cancers. Its TIL therapy includes melanoma, non-small cell lung cancer and gynecologic cancer.
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Events Timeline

(ET)
2026-02-24
12:00:00
Major Averages Bounce Back, Investors Focus on AI News
select

News

stocktwits
6.5
04-10stocktwits
IOVA Benefits from Rival Drug Rejection, Analysts Bullish
  • FDA Drug Rejection Impact: The FDA's rejection of Replimune's RP1 due to insufficient data is viewed positively for Iovance's Amtagvi, enhancing its competitive position in the near term and potentially increasing market share.
  • Sales Growth Expectations: Iovance's Amtagvi is projected to generate approximately $220 million in revenue for 2025, with analysts highlighting that sales acceleration and margin expansion will be central to the company's future growth.
  • Market Reaction Analysis: Despite the FDA rejection being seen as a positive development, IOVA's stock fell 8%, surprising retail investors and indicating the complexity of market sentiment surrounding the stock.
  • Analyst Ratings Optimistic: Among 11 analysts, 8 have rated IOVA as a 'Buy', with an average 12-month price target of $9, representing a potential upside of about 144%, reflecting strong confidence in its future performance.
Fool
7.5
04-10Fool
Investment Outlook for Iovance Biotherapeutics
  • Significant Sales Growth: Iovance Biotherapeutics reported sales of $263.5 million in 2023, reflecting a nearly 61% increase from the previous year, primarily driven by the performance of its advanced melanoma treatment, Amtagvi, indicating the company's potential in the biotech sector.
  • Market Expansion Opportunities: As the first approved treatment for melanoma, Amtagvi is gradually expanding its global market reach, with projections suggesting annual sales could exceed $1 billion by 2030, which would significantly boost Iovance's revenue.
  • Clinical Trial Progress: Iovance recently announced positive early results from its lifileucel drug in treating rare soft tissue sarcomas, indicating potential for expansion into new indications, with over 8,000 patients diagnosed annually in the U.S. and Europe expected to benefit.
  • Significant Risk Factors: Despite the optimistic outlook for Amtagvi, Iovance faces clinical and regulatory risks, particularly due to the complexity and high costs associated with its tumor-infiltrating lymphocyte therapies, which could lead to substantial short-term losses for investors.
NASDAQ.COM
9.5
04-10NASDAQ.COM
Iovance Biotherapeutics Sees Rapid Sales Growth Amid Risks
  • Significant Sales Growth: Iovance Biotherapeutics' primary product, Amtagvi, generated $263.5 million in sales in 2024, reflecting a nearly 61% increase year-over-year, indicating strong market demand and product acceptance.
  • Global Expansion Potential: As the first treatment for advanced melanoma, Amtagvi is gradually expanding into Canada and may enter European and Australian markets in the coming years, with projections suggesting annual sales could exceed $1 billion by 2030, further solidifying its market position.
  • Clinical Trial Progress: Iovance recently announced positive early results from a pivotal trial for advanced soft-tissue sarcomas, indicating a potential market of over 8,000 patients diagnosed annually in the U.S. and Europe, which could drive future label expansions and sales growth.
  • Investment Risk Advisory: Despite the optimistic sales outlook, Iovance faces clinical and regulatory risks, and the complexity and high costs associated with its tumor-infiltrating lymphocyte therapies may impact profitability, necessitating cautious risk assessment by investors.
stocktwits
9.0
04-10stocktwits
REPL and IOVA Await FDA Decision Amid Market Dynamics
  • FDA Decision Approaches: Replimune's lead candidate RP1 is under FDA review, with analysts projecting a price target of $12.86, indicating a 116% upside; however, the stock is on track for its worst weekly decline in nearly seven months, reflecting market concerns about its prospects.
  • IOVA's Commercial Edge: Iovance's Amtagvi received FDA approval in 2024, with projected product revenue of $264 million in 2025, including $220 million from Amtagvi, showcasing its competitive position and increasing treatment-center adoption, with an analyst price target of $9 representing a 124% upside.
  • Divergent Market Sentiment: On Stocktwits, retail sentiment for REPL is 'bearish' while IOVA is 'bullish', indicating differing investor expectations for future performance; REPL shares have fallen 19% over the past year, while IOVA has risen 23%, suggesting stronger confidence in IOVA.
  • Clinical Data Support: Clinical trials for RP1 combined with Nivolumab showed that about one-third of PD-1 failed melanoma patients experienced tumor shrinkage, with complete disappearance in 15% of patients; despite this, market sentiment remains cautious, with analysts raising approval probability expectations from 50% to 85%.
stocktwits
9.0
04-09stocktwits
Iovance Shares Surge 16% as FDA Decision on Replimune Approaches
  • FDA Decision Approaches: The FDA is set to decide on Replimune's RP1 application for advanced melanoma by April 10, prompting a 16% surge in Iovance's stock as investors react to the impending decision.
  • Strong Iovance Performance: Iovance's Amtagvi cellular therapy is already approved for previously treated melanoma, with projected U.S. revenues of approximately $220 million for 2025, indicating robust market demand and growth potential for the company.
  • Investor Sentiment Shift: Retail sentiment around Iovance stock has shifted from 'bearish' to 'bullish' in the past 24 hours, while sentiment for Replimune has trended 'extremely bearish', reflecting heightened market focus on the FDA's decision.
  • Competitive Drug History Issues: Replimune received a complete response letter from the FDA in July 2025, indicating that its RP1 application lacked sufficient evidence of effectiveness, and the subsequent resubmission demonstrates the company's commitment to addressing regulatory feedback and improving its application.
Newsfilter
8.5
04-01Newsfilter
Avaí Bio Initiates Master Cell Bank Manufacturing
  • Market Potential: The regenerative medicine market is projected to reach $578 billion by 2033, with cell therapy alone surpassing $8.2 billion this year, indicating significant growth potential that attracts investor interest.
  • Manufacturing Challenge Solution: Avaí Bio has initiated the manufacturing of a Master Cell Bank for genetically modified cells overexpressing α-Klotho in collaboration with Austrianova, aiming to address the production bottlenecks in cell therapy and lay the groundwork for future commercialization.
  • Innovative Delivery Mechanism: Austrianova's Cell-in-a-Box® technology protects therapeutic cells within a biocompatible shell, allowing continuous secretion of α-Klotho, which eliminates the manufacturing and logistical burdens of patient-specific autologous therapies, transforming it into a scalable product.
  • Dual-Program Strategy: Avaí Bio's dual-program approach targets both the Klothonova α-Klotho anti-aging platform and the Insulinova diabetes program, expected to tap into multi-billion dollar markets, showcasing the company's strategic positioning in the regenerative medicine sector.
Wall Street analysts forecast IOVA stock price to rise
8 Analyst Rating
Wall Street analysts forecast IOVA stock price to rise
6 Buy
1 Hold
1 Sell
Moderate Buy
Current: 0.000
sliders
Low
1.50
Averages
9.50
High
17.00
Current: 0.000
sliders
Low
1.50
Averages
9.50
High
17.00
Jefferies
Andrew Tsai
Buy
maintain
$12
AI Analysis
2026-04-10
Reason
Jefferies
Andrew Tsai
Price Target
$12
AI Analysis
2026-04-10
maintain
Buy
Reason
Jefferies analyst Andrew Tsai noted that the FDA has issued another complete response letter rejection to Replimune (REPL) for Tudriqev in second-line advanced melanoma. Although Replimune was "technically not an overhang" on Iovance Biotherapeutics (IOVA) stock, the situation does mean one less competitor in the near-term, says the analyst, who can see a potential 5%-15% stock move on the news. The firm, which adds that the Iovance story "remains centered on" Amtagvi's sales acceleration and margin expansion in 2026, has a Buy rating and $12 price target on the shares.
Chardan
Geulah Livshits
Buy
maintain
$16
2026-04-10
Reason
Chardan
Geulah Livshits
Price Target
$16
2026-04-10
maintain
Buy
Reason
Chardan analyst Geulah Livshits keeps a Buy rating on Iovance Biotherapeutics (IOVA) with a $16 price target after Replimune (REPL) received a second complete response letter from the FDA for RP1 in combination with nivolumab in adults with unresectable advanced cutaneous melanoma who had progressed after anti-PD-1 therapy. The CRL is a positive for Iovance's Amtagvi's near-term competitive position in post-checkpoint melanoma, the analyst tells investors in a research note. However, the firm says more direction competition from cell therapies "could be on the horizon" in 2027.
Unlock Full Analyst Thesis, Get the complete breakdown of rating reason for IOVA
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Valuation Metrics

The current forward P/E ratio for Iovance Biotherapeutics Inc (IOVA.O) is 0.00, compared to its 5-year average forward P/E of -6.10. For a more detailed relative valuation and DCF analysis to assess Iovance Biotherapeutics Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-6.10
Current PE
0.00
Overvalued PE
-2.99
Undervalued PE
-9.20

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-4.94
Current EV/EBITDA
-3.74
Overvalued EV/EBITDA
-1.95
Undervalued EV/EBITDA
-7.94

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
43.04
Current PS
3.01
Overvalued PS
171.05
Undervalued PS
-84.98

Financials

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Whales Holding IOVA

L
Long Focus Capital Management LLC
Holding
IOVA
+0.81%
3M Return

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Frequently Asked Questions

What is Iovance Biotherapeutics Inc (IOVA) stock price today?

The current price of IOVA is 3.78 USD — it has decreased -2.07

What is Iovance Biotherapeutics Inc (IOVA)'s business?

Iovance Biotherapeutics, Inc. is a commercial biotechnology company. The Company is focused on developing and delivering novel polyclonal tumor infiltrating lymphocyte (TIL) therapies for patients with cancer. Its products include Amtagvi and Proleukin. Amtagvi is indicated for the treatment of adult patients with melanoma previously treated with a PD-1 blocking antibody, and if BRAF V600 mutation positive, a BRAF inhibitor, with or without a MEK inhibitor. It is marketing Proleukin (aldesleukin), an interleukin-2 (IL-2) product used in the Amtagvi treatment regimen and in other applications. Amtagvi and Proleukin are part of a treatment regimen that includes lymphodepletion. Its development pipeline includes multicenter trials of TIL cell therapies in additional treatment settings and indications for solid tumor cancers. Its TIL therapy includes melanoma, non-small cell lung cancer and gynecologic cancer.

What is the price predicton of IOVA Stock?

Wall Street analysts forecast IOVA stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for IOVA is9.50 USD with a low forecast of 1.50 USD and a high forecast of 17.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Iovance Biotherapeutics Inc (IOVA)'s revenue for the last quarter?

Iovance Biotherapeutics Inc revenue for the last quarter amounts to 86.77M USD, increased 17.74

What is Iovance Biotherapeutics Inc (IOVA)'s earnings per share (EPS) for the last quarter?

Iovance Biotherapeutics Inc. EPS for the last quarter amounts to -0.18 USD, decreased -30.77

How many employees does Iovance Biotherapeutics Inc (IOVA). have?

Iovance Biotherapeutics Inc (IOVA) has 975 emplpoyees as of April 21 2026.

What is Iovance Biotherapeutics Inc (IOVA) market cap?

Today IOVA has the market capitalization of 1.56B USD.