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IOVA Overview

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$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
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Intellectia

Loading chart...

High
3.580
Open
3.430
VWAP
3.49
Vol
10.97M
Mkt Cap
1.45B
Low
3.370
Amount
38.26M
EV/EBITDA(TTM)
--
Total Shares
411.96M
EV
1.07B
EV/OCF(TTM)
--
P/S(TTM)
4.50
Iovance Biotherapeutics, Inc. is a commercial biotechnology company. The Company is focused on developing and delivering novel polyclonal tumor infiltrating lymphocyte (TIL) therapies for patients with cancer. Its products include Amtagvi and Proleukin. Amtagvi is indicated for the treatment of adult patients with melanoma previously treated with a PD-1 blocking antibody, and if BRAF V600 mutation positive, a BRAF inhibitor, with or without a MEK inhibitor. It is marketing Proleukin (aldesleukin), an interleukin-2 (IL-2) product used in the Amtagvi treatment regimen and in other applications. Amtagvi and Proleukin are part of a treatment regimen that includes lymphodepletion. Its development pipeline includes multicenter trials of TIL cell therapies in additional treatment settings and indications for solid tumor cancers. Its TIL therapy includes melanoma, non-small cell lung cancer and gynecologic cancer.
Show More

Events Timeline

(ET)
2026-02-24
12:00:00
Major Averages Bounce Back, Investors Focus on AI News
select
2026-02-24
07:20:00
Iovance Reports Q4 Revenue of $86.711M
select
2026-02-24
07:10:00
Iovance Biotherapeutics Announces Positive Clinical Trial Data
select

News

Newsfilter
8.5
01:43 AMNewsfilter
Avaí Bio Initiates Master Cell Bank Manufacturing
  • Market Potential: The regenerative medicine market is projected to reach $578 billion by 2033, with cell therapy alone surpassing $8.2 billion this year, indicating significant growth potential that attracts investor interest.
  • Manufacturing Challenge Solution: Avaí Bio has initiated the manufacturing of a Master Cell Bank for genetically modified cells overexpressing α-Klotho in collaboration with Austrianova, aiming to address the production bottlenecks in cell therapy and lay the groundwork for future commercialization.
  • Innovative Delivery Mechanism: Austrianova's Cell-in-a-Box® technology protects therapeutic cells within a biocompatible shell, allowing continuous secretion of α-Klotho, which eliminates the manufacturing and logistical burdens of patient-specific autologous therapies, transforming it into a scalable product.
  • Dual-Program Strategy: Avaí Bio's dual-program approach targets both the Klothonova α-Klotho anti-aging platform and the Insulinova diabetes program, expected to tap into multi-billion dollar markets, showcasing the company's strategic positioning in the regenerative medicine sector.
PRnewswire
8.5
00:57 AMPRnewswire
Avaí Bio Initiates Master Cell Bank Manufacturing
  • Market Potential: The regenerative medicine market is projected to reach $578 billion by 2033, with cell therapy alone surpassing $8.2 billion this year, indicating strong growth potential that attracts investor interest.
  • Manufacturing Challenges: The primary bottleneck for cell therapy companies is how to manufacture living therapeutics reliably and affordably at scale, and those who solve this issue will dominate the market.
  • Innovative Technology: Avaí Bio has initiated the manufacturing of a Master Cell Bank of genetically modified cells overexpressing the α-Klotho protein in collaboration with Austrianova, utilizing Cell-in-a-Box® technology to ensure continuous secretion of the protein without immune rejection.
  • Broad Market Demand: α-Klotho is linked to various diseases such as Alzheimer's, cardiovascular disease, and kidney disease, presenting significant market opportunities, and Avaí Bio's dual-program approach aims to effectively address treatment needs in these areas.
PRnewswire
8.5
03-24PRnewswire
Avaí Bio Initiates Key Cell Bank Project for Therapy Development
  • Market Outlook: The regenerative medicine market is projected to reach $578 billion by 2026, with cell therapy alone surpassing $8.2 billion this year, indicating strong growth potential that attracts investor interest.
  • Infrastructure Development: Avaí Bio has initiated the creation of a Master Cell Bank (MCB) for the α-Klotho protein in collaboration with Austrianova, ensuring a standardized foundation for future cell therapies, enhancing the feasibility and consistency of product development.
  • Scientific Research Support: The α-Klotho protein is extensively studied and linked to reduced risks of Alzheimer's, cardiovascular diseases, and certain cancers, with a significant market potential, as the Alzheimer's market is expected to reach $32.8 billion by 2033.
  • Dual-Program Strategy: Avaí Bio's Insulinova platform also utilizes Cell-in-a-Box® technology to target diabetes, showcasing the company's diversified approach in the cell therapy field, thereby enhancing its competitive position in the market.
Newsfilter
8.5
03-24Newsfilter
Avaí Bio Initiates Key Cell Bank Project for Therapy Development
  • Market Potential: The regenerative medicine market is projected to reach $578 billion by 2033, with cell therapy alone surpassing $8.2 billion in 2026, indicating a rapid growth trajectory that is attracting significant investment and research resources.
  • Infrastructure Importance: Avaí Bio has initiated a Master Cell Bank (MCB) project in collaboration with Austrianova to create a standardized cellular starting material by cloning a single genetically engineered cell into tens of millions of identical copies, ensuring consistency and scalability for future therapy development.
  • Clinical Application Outlook: The α-Klotho protein is linked to various age-related diseases, with the Alzheimer's market expected to reach $32.8 billion by 2033, positioning Avaí Bio's research to potentially achieve groundbreaking advancements in these critical health areas.
  • Technological Innovation and Market Competitiveness: Avaí Bio's Insulinova platform also leverages Cell-in-a-Box® technology to address diabetes by protecting therapeutic cells, showcasing the company's innovative capabilities and competitive edge in the cell therapy landscape.
Marketbeat
9.0
03-12Marketbeat
How Two Small Biotech Companies Could Pave the Way for Innovative Cancer Therapies
  • Cancer as a Medical Challenge: Cancer remains a significant challenge for biotechnology firms, with the oncology market projected to surge to $366 billion in the next 80 years, prompting companies to develop targeted treatments for specific cancer types.

  • Promising Treatments and Market Growth: Several promising cancer treatments have shown incredible potential, leading to significant sales opportunities for biotech firms, particularly those focusing on oncology medicines.

  • Iovance's Market Performance: Iovance Biotherapeutics has experienced substantial share price growth, driven by its leading cancer drug, which has the potential to generate over $1 billion in U.S. sales, despite facing production challenges.

  • Immunity Bio's Growth and Challenges: Immunity Bio has seen impressive sales growth for its bladder cancer drug, Anktiva, following regulatory approvals, but it still faces risks and challenges in manufacturing and market competition.

Benzinga
7.5
03-06Benzinga
Iovance Biotherapeutics Stock Rises Amid High Short Interest
  • Short Interest Pressure: Iovance Biotherapeutics has a high short interest of 39.6%, which, against a market cap of $1.66 billion, indicates market caution regarding its future performance and could lead to increased stock volatility.
  • Positive Clinical Trial Data: The company reported a 50% objective response rate in its TIL cell therapy clinical trial for advanced soft-tissue sarcomas, suggesting potential for new market opportunities and enhancing investor confidence in its product pipeline.
  • Strong Stock Performance: The stock is trading 59.6% above its 20-day SMA and 98.5% above its 100-day SMA, reflecting robust upward momentum over the past year, although the RSI at 83.41 indicates it may be overbought and due for a pullback.
  • Optimistic Analyst Ratings: Iovance's stock carries a Buy rating with an average price target of $11.23, and recent upward adjustments in analysts' targets reflect growing confidence in its future growth, further supporting the upward trend in its stock price.
Wall Street analysts forecast IOVA stock price to rise
8 Analyst Rating
Wall Street analysts forecast IOVA stock price to rise
6 Buy
1 Hold
1 Sell
Moderate Buy
Current: 0.000
sliders
Low
1.50
Averages
9.50
High
17.00
Current: 0.000
sliders
Low
1.50
Averages
9.50
High
17.00
UBS
David Dai
Neutral
maintain
$2 -> $4
AI Analysis
2026-03-05
Reason
UBS
David Dai
Price Target
$2 -> $4
AI Analysis
2026-03-05
maintain
Neutral
Reason
UBS analyst David Dai raised the firm's price target on Iovance Biotherapeutics to $4 from $2 and keeps a Neutral rating on the shares. Fundamentals improved in Q4, but Amtagvi acceleration remains uncertain, the analyst tells investors in a research note.
Baird
Neutral
maintain
$3 -> $4
2026-02-25
Reason
Baird
Price Target
$3 -> $4
2026-02-25
maintain
Neutral
Reason
Baird raised the firm's price target on Iovance Biotherapeutics to $4 from $3 and keeps a Neutral rating on the shares. The firm updated its model following Q4 results which showed nice momentum ending 2025 and continuing margin improvements into 2026.
Unlock Full Analyst Thesis, Get the complete breakdown of rating reason for IOVA
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Valuation Metrics

The current forward P/E ratio for Iovance Biotherapeutics Inc (IOVA.O) is 0.00, compared to its 5-year average forward P/E of -6.19. For a more detailed relative valuation and DCF analysis to assess Iovance Biotherapeutics Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-6.19
Current PE
0.00
Overvalued PE
-2.97
Undervalued PE
-9.40

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-5.03
Current EV/EBITDA
-1.81
Overvalued EV/EBITDA
-1.96
Undervalued EV/EBITDA
-8.09

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
43.04
Current PS
2.76
Overvalued PS
171.11
Undervalued PS
-85.03

Financials

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Whales Holding IOVA

I
Invenomic Capital Management LP
Holding
IOVA
+4.02%
3M Return
L
Long Focus Capital Management LLC
Holding
IOVA
-1.32%
3M Return

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Frequently Asked Questions

What is Iovance Biotherapeutics Inc (IOVA) stock price today?

The current price of IOVA is 3.51 USD — it has increased 5.72

What is Iovance Biotherapeutics Inc (IOVA)'s business?

Iovance Biotherapeutics, Inc. is a commercial biotechnology company. The Company is focused on developing and delivering novel polyclonal tumor infiltrating lymphocyte (TIL) therapies for patients with cancer. Its products include Amtagvi and Proleukin. Amtagvi is indicated for the treatment of adult patients with melanoma previously treated with a PD-1 blocking antibody, and if BRAF V600 mutation positive, a BRAF inhibitor, with or without a MEK inhibitor. It is marketing Proleukin (aldesleukin), an interleukin-2 (IL-2) product used in the Amtagvi treatment regimen and in other applications. Amtagvi and Proleukin are part of a treatment regimen that includes lymphodepletion. Its development pipeline includes multicenter trials of TIL cell therapies in additional treatment settings and indications for solid tumor cancers. Its TIL therapy includes melanoma, non-small cell lung cancer and gynecologic cancer.

What is the price predicton of IOVA Stock?

Wall Street analysts forecast IOVA stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for IOVA is9.50 USD with a low forecast of 1.50 USD and a high forecast of 17.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Iovance Biotherapeutics Inc (IOVA)'s revenue for the last quarter?

Iovance Biotherapeutics Inc revenue for the last quarter amounts to 86.77M USD, increased 17.74

What is Iovance Biotherapeutics Inc (IOVA)'s earnings per share (EPS) for the last quarter?

Iovance Biotherapeutics Inc. EPS for the last quarter amounts to -0.18 USD, decreased -30.77

How many employees does Iovance Biotherapeutics Inc (IOVA). have?

Iovance Biotherapeutics Inc (IOVA) has 975 emplpoyees as of April 01 2026.

What is Iovance Biotherapeutics Inc (IOVA) market cap?

Today IOVA has the market capitalization of 1.45B USD.