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HOTH Overview

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Intellectia

Loading chart...

High
1.180
Open
0.980
VWAP
1.10
Vol
1.38M
Mkt Cap
17.69M
Low
0.975
Amount
1.51M
EV/EBITDA(TTM)
--
Total Shares
15.51M
EV
7.74M
EV/OCF(TTM)
--
P/S(TTM)
--
Hoth Therapeutics, Inc. is a clinical-stage biopharmaceutical company focused on developing new generation therapies for unmet medical needs. The Company is focused on developing a topical formulation for treating side effects from drugs used for the treatment of cancer (HT-001); a treatment for mast-cell derived cancers and anaphylaxis (HT-KIT), and a treatment and/or prevention for Alzheimer's or other neuroinflammatory diseases (HT-ALZ). The Company also has assets being developed for atopic dermatitis (also known as eczema) (BioLexa); a treatment for asthma and allergies using inhalational administration (HT-004), and a treatment for obesity, and obesity-related diseases and conditions (HT-VA).
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Events Timeline

(ET)
2026-03-10
08:20:00
Hoth Therapeutics Announces New Female-Specific Metabolic Disease Study Results
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2026-02-24 (ET)
2026-02-24
16:30:00
Hoth Therapeutics Expands CLEER-001 Clinical Trial
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2026-02-12 (ET)
2026-02-12
08:40:00
Hoth Therapeutics Receives Patent Allowance for Allergy Treatment
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2026-02-10 (ET)
2026-02-10
08:40:00
Hoth Therapeutics Releases Compelling GDNF Preclinical Data Showing Significant Weight Loss Effects
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2026-01-22 (ET)
2026-01-22
08:30:00
Hoth Therapeutics Reports Positive Interim Results from CLEER-001 Trial
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2026-01-21 (ET)
2026-01-21
08:20:00
Hoth Therapeutics Secures Key Patent for HT-KIT
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2026-01-15 (ET)
2026-01-15
08:20:00
Hoth Therapeutics Achieves EU Regulatory Approval for HT-001 Clinical Program
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2026-01-02 (ET)
2026-01-02
08:30:00
Hoth Therapeutics Files Two New Patent Applications Expanding Oncology Dermatology Platform
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2025-11-20 (ET)
2025-11-20
08:17:13
Hoth Therapeutics Joins Nvidia Connect Program
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News

PRnewswire
8.5
03-10PRnewswire
PinnedHoth Therapeutics Advances GDNF for Metabolic Dysfunction
  • Cholesterol Restoration: GDNF treatment in western diet-fed female mice restored cholesterol levels to control diet ranges, indicating its effectiveness in improving metabolic dysfunction models associated with obesity, thus offering new hope for treating obesity-related metabolic diseases.
  • Triglyceride Level Comparison: Compared to female mice treated with Semaglutide, those treated with GDNF maintained lower triglyceride levels, demonstrating a more favorable lipid profile, which could provide critical insights for developing new therapeutic options.
  • Hepatic Autophagy Preservation: GDNF treatment showed protective effects on liver autophagy markers, maintaining normal cellular recycling pathways, while Semaglutide led to p62 accumulation, suggesting GDNF's potential advantage in preserving liver cellular homeostasis.
  • Molecular Signaling Characteristics: GDNF treatment did not significantly alter AKT signaling, while Semaglutide increased AKT phosphorylation, highlighting significant differences in molecular mechanisms between the two treatments, paving the way for future research directions.
PRnewswire
8.5
03-04PRnewswire
Hoth Therapeutics Integrates AI for IND Preparation and Phase 1 Progression
  • AI Integration: Hoth Therapeutics has announced the integration of OpenAI's API into the HT-KIT development workflow to support IND preparation for rare KIT-driven cancers, enhancing data analysis and molecular modeling efficiency, thereby accelerating preclinical research progress.
  • IND Strategy Advancement: CEO Robb Knie stated that the application of AI not only optimizes the HT-KIT development process but also prepares necessary regulatory documentation for the upcoming IND submission, marking a significant step towards Phase 1 clinical trials.
  • Patient-Centric R&D: Hoth Therapeutics is dedicated to developing innovative therapies, leveraging AI technology to improve patient quality of life, indicating the company's crucial role in early-stage drug development, which may attract more investor interest.
  • Market Potential Outlook: With the increasing demand for treatments for rare cancers, Hoth's AI integration strategy not only enhances R&D efficiency but also positions the company favorably in the future market, driving long-term growth.
Newsfilter
8.5
03-04Newsfilter
Hoth Therapeutics Integrates AI to Support Rare Cancer Therapy Progression
  • AI Integration: Hoth Therapeutics has announced the integration of OpenAI's API into the HT-KIT development workflow to support IND preparation and preclinical data analysis, thereby accelerating the advancement of treatments for rare KIT-driven cancers.
  • Significant Efficacy: HT-KIT achieved over 80% suppression of KIT mRNA and protein in both in vitro and in vivo models, demonstrating its potential efficacy in treating systemic mastocytosis and gastrointestinal stromal tumors, highlighting its significant promise in addressing rare cancers.
  • Favorable Tolerability: No dose-limiting toxicities were observed in early studies, indicating the safety of HT-KIT for clinical applications and laying a solid foundation for subsequent clinical trials.
  • Bioanalytical Readiness: GLP-validated bioanalytical methods have been completed to support pharmacokinetic, biodistribution, and exposure-response analyses for IND, ensuring HT-KIT's smooth transition into clinical trial phases.
moomoo
3.5
03-04moomoo
Hoth Therapeutics Utilizes OpenAI API to Enhance Progress of Orphan HT-KIT Oncology Initiative
  • Company Overview: Hoth Therapeutics is advancing its development of a new program focused on oncology, specifically targeting orphan diseases.

  • Technology Utilization: The company is deploying its proprietary platform, OpenAI API, to enhance the research and development processes within its oncology program.

Benzinga
8.5
03-04Benzinga
Hoth Therapeutics Deploys OpenAI API to Support HT-KIT Development
  • Technology Integration: Hoth Therapeutics announced the integration of OpenAI API into the HT-KIT development workflow to support IND-enabling development for rare and aggressive KIT-driven cancers, enhancing data analysis and molecular modeling efficiency.
  • Preclinical Results: HT-KIT achieved over 80% reduction of KIT mRNA/protein in both in vitro and in vivo models, with no dose-limiting toxicities observed, demonstrating its potential in systemic mastocytosis and gastrointestinal stromal tumors.
  • Tumor Reduction Effects: Statistically significant tumor volume reduction was observed by Day 8 in xenograft models, accompanied by apoptotic signaling consistent with KIT pathway knockdown, indicating substantial therapeutic efficacy.
  • Regulatory Readiness: Hoth Therapeutics has completed GLP-validated bioanalytical methods to support pharmacokinetic, biodistribution, and exposure-response analyses for IND, with HT-KIT advancing toward IND submission and Phase 1 clinical evaluation, having received Orphan Drug Designation.
PRnewswire
2.0
02-24PRnewswire
Hoth Therapeutics Expands CLEER-001 Clinical Trial Amid Rising Patient Demand
  • Trial Expansion: Hoth Therapeutics announces the expansion of its CLEER-001 Phase 2a clinical trial with the addition of Regis Clinical Research in Miami, Florida, reflecting surging patient demand and strong interest in the promising early clinical results of HT-001.
  • Rising Patient Demand: Approximately 200,000 Americans undergo EGFR inhibitor therapy annually, facing severe skin toxicities that can lead one-third to reduce or discontinue chemotherapy, highlighting the urgent need for HT-001 as a potential solution.
  • Accelerated Enrollment: The addition of Regis Clinical Research will expedite patient enrollment, enabling Hoth to achieve a complete data set more quickly and reach critical regulatory milestones, enhancing its competitive position in cancer treatment.
  • Significant Market Potential: With positive interim data generating increased interest from physicians and patients, Hoth plans to build robust infrastructure to meet growing demand, potentially transforming treatment paradigms in cancer care.

Valuation Metrics

The current forward P/E ratio for Hoth Therapeutics Inc (HOTH.O) is -2.04, compared to its 5-year average forward P/E of -1.51. For a more detailed relative valuation and DCF analysis to assess Hoth Therapeutics Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-1.51
Current PE
-2.04
Overvalued PE
-0.72
Undervalued PE
-2.29

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
0.24
Current EV/EBITDA
0.00
Overvalued EV/EBITDA
2.96
Undervalued EV/EBITDA
-2.49

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
0.00
Current PS
0.00
Overvalued PS
0.00
Undervalued PS
0.00

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Frequently Asked Questions

What is Hoth Therapeutics Inc (HOTH) stock price today?

The current price of HOTH is 1.14 USD — it has increased 13.43

What is Hoth Therapeutics Inc (HOTH)'s business?

Hoth Therapeutics, Inc. is a clinical-stage biopharmaceutical company focused on developing new generation therapies for unmet medical needs. The Company is focused on developing a topical formulation for treating side effects from drugs used for the treatment of cancer (HT-001); a treatment for mast-cell derived cancers and anaphylaxis (HT-KIT), and a treatment and/or prevention for Alzheimer's or other neuroinflammatory diseases (HT-ALZ). The Company also has assets being developed for atopic dermatitis (also known as eczema) (BioLexa); a treatment for asthma and allergies using inhalational administration (HT-004), and a treatment for obesity, and obesity-related diseases and conditions (HT-VA).

What is the price predicton of HOTH Stock?

Wall Street analysts forecast HOTH stock price to fall over the next 12 months. According to Wall Street analysts, the average 1-year price target for HOTH is USD with a low forecast of USD and a high forecast of USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Hoth Therapeutics Inc (HOTH)'s revenue for the last quarter?

Hoth Therapeutics Inc revenue for the last quarter amounts to -4.08M USD, increased 83.05

What is Hoth Therapeutics Inc (HOTH)'s earnings per share (EPS) for the last quarter?

Hoth Therapeutics Inc. EPS for the last quarter amounts to -2792672.00 USD, decreased

How many employees does Hoth Therapeutics Inc (HOTH). have?

Hoth Therapeutics Inc (HOTH) has 2 emplpoyees as of March 12 2026.

What is Hoth Therapeutics Inc (HOTH) market cap?

Today HOTH has the market capitalization of 17.69M USD.