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HOTH Overview

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Intellectia

Loading chart...

High
0.850
Open
0.785
VWAP
0.83
Vol
118.37K
Mkt Cap
13.66M
Low
0.785
Amount
97.68K
EV/EBITDA(TTM)
--
Total Shares
16.26M
EV
7.41M
EV/OCF(TTM)
--
P/S(TTM)
--
Hoth Therapeutics, Inc. is a clinical-stage biopharmaceutical company focused on developing new generation therapies for unmet medical needs. The Company is focused on developing a topical formulation for treating side effects from drugs used for the treatment of cancer (HT-001); a treatment for mast-cell derived cancers and anaphylaxis (HT-KIT), and a treatment and/or prevention for Alzheimer's or other neuroinflammatory diseases (HT-ALZ). The Company also has assets being developed for atopic dermatitis (also known as eczema) (BioLexa); a treatment for asthma and allergies using inhalational administration (HT-004), and a treatment for obesity, and obesity-related diseases and conditions (HT-VA).
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Events Timeline

(ET)
2026-03-31
08:10:00
Hoth Therapeutics Secures Chinese Patent Valid Until 2039
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2026-03-24 (ET)
2026-03-24
08:30:00
Hoth Therapeutics Reports Positive Clinical Data for HT-001
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2026-03-10 (ET)
2026-03-10
08:20:00
Hoth Therapeutics Announces New Female-Specific Metabolic Disease Study Results
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2026-02-24 (ET)
2026-02-24
16:30:00
Hoth Therapeutics Expands CLEER-001 Clinical Trial
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2026-02-12 (ET)
2026-02-12
08:40:00
Hoth Therapeutics Receives Patent Allowance for Allergy Treatment
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2026-02-10 (ET)
2026-02-10
08:40:00
Hoth Therapeutics Releases Compelling GDNF Preclinical Data Showing Significant Weight Loss Effects
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2026-01-22 (ET)
2026-01-22
08:30:00
Hoth Therapeutics Reports Positive Interim Results from CLEER-001 Trial
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2026-01-21 (ET)
2026-01-21
08:20:00
Hoth Therapeutics Secures Key Patent for HT-KIT
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2026-01-15 (ET)
2026-01-15
08:20:00
Hoth Therapeutics Achieves EU Regulatory Approval for HT-001 Clinical Program
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News

PRnewswire
3.5
03-26PRnewswire
Hoth Therapeutics Launches AI Drug Development Platform OpenClaw™
  • AI-Driven Drug Discovery: Hoth Therapeutics' launch of the OpenClaw™ platform integrates clinical and preclinical data in real-time, accelerating the drug discovery process and is expected to significantly enhance development efficiency and success probability, thereby boosting the company's competitiveness in the biopharmaceutical sector.
  • Modular Design Advantage: The modular design of OpenClaw™ allows seamless deployment across multiple indications, including dermatology, oncology, and inflammatory diseases, standardizing workflows and increasing reproducibility, which further enhances Hoth's R&D capabilities across various therapeutic areas.
  • Strategic Shift: The launch of this platform marks a strategic shift for Hoth at the intersection of biotechnology and artificial intelligence, leveraging advanced analytics to drive innovation and pipeline expansion, thereby strengthening the company's position in the rapidly evolving biopharmaceutical market.
  • CEO Outlook: Hoth's CEO Robb Knie stated that OpenClaw™ will enhance the company's decision-making capabilities and data value extraction, marking the entry into a new phase of execution, with expectations to accelerate product development and market responsiveness.
Newsfilter
3.5
03-26Newsfilter
Hoth Therapeutics Launches AI Drug Development Platform OpenClaw™
  • Strategic Shift: Hoth Therapeutics has launched OpenClaw™, an advanced AI computational platform designed to accelerate drug discovery and enhance data-driven decision-making, unlocking greater value across its therapeutic pipeline.
  • Efficiency Gains: The platform integrates clinical and preclinical datasets in real time, which is expected to significantly enhance research execution speed and efficiency, thereby improving the probability of technical success.
  • Modular Design: OpenClaw™ features a modular design that allows seamless deployment across dermatology, oncology, and inflammatory disease programs, standardizing workflows and increasing reproducibility at scale, thereby enhancing the company's competitiveness across multiple indications.
  • Growth Potential: With the deployment of OpenClaw™, Hoth strengthens its positioning at the intersection of biotechnology and artificial intelligence, leveraging advanced analytics to drive innovation and pipeline expansion, marking a new phase of execution for the company.
PRnewswire
9.0
03-24PRnewswire
Hoth Therapeutics Reports Positive Data for HT-001
  • Increased Drug Exposure: HT-001 demonstrated a ~77% increase in systemic drug exposure following repeat dosing, indicating its ability to maintain effective drug concentrations during treatment, which may enhance clinical outcomes and improve patient experience.
  • Safety and Tolerability: The clinical trial results showed a favorable safety profile for HT-001, with no serious adverse events reported, supporting its potential as a novel therapeutic option, especially given that systemic absorption levels remained extremely low at below 0.2% compared to FDA-approved oral formulations.
  • Pharmacokinetic Analysis: On Day 42, the mean AUC₀–₂₄ for HT-001 increased from 45.61 h•ng/mL on Day 1 to 80.60 h•ng/mL, demonstrating sustained accumulation of the drug in the body, further validating its dose-dependent pharmacokinetics and clinical efficacy.
  • Clinical Activity: Subjects treated with HT-001 exhibited significant reductions in symptom severity, with this improvement remaining stable throughout the treatment period, indicating the potential value and market prospects of HT-001 in clinical applications.
Newsfilter
9.0
03-24Newsfilter
Hoth Therapeutics Reports Positive Data for HT-001
  • Increased Drug Exposure: HT-001 shows a ~77% increase in systemic drug exposure after repeat dosing, indicating minimal systemic absorption compared to FDA-approved oral formulations, which supports the company's dosing strategy in drug development.
  • Favorable Safety Profile: The clinical trial reported no serious adverse events (0%) and no dose-limiting toxicities, demonstrating good tolerability and enhancing the drug's competitive position in the market.
  • Significant Clinical Efficacy: Treated subjects exhibited meaningful reductions in symptom severity with sustained responses throughout the treatment period, suggesting that the drug's clinical activity aligns with its pharmacokinetic profile, potentially leading to improved clinical outcomes.
  • Sustained Response Support: The pharmacokinetic analysis on Day 42 showed an increase in mean AUC₀–₂₄ from 45.61 h•ng/mL on Day 1 to 80.60 h•ng/mL, demonstrating consistent drug accumulation and further supporting the clinical advancement and dose optimization of HT-001.
PRnewswire
8.5
03-10PRnewswire
Hoth Therapeutics Advances GDNF for Metabolic Dysfunction
  • Cholesterol Restoration: GDNF treatment in western diet-fed female mice restored cholesterol levels to control diet ranges, indicating its effectiveness in improving metabolic dysfunction models associated with obesity, thus offering new hope for treating obesity-related metabolic diseases.
  • Triglyceride Level Comparison: Compared to female mice treated with Semaglutide, those treated with GDNF maintained lower triglyceride levels, demonstrating a more favorable lipid profile, which could provide critical insights for developing new therapeutic options.
  • Hepatic Autophagy Preservation: GDNF treatment showed protective effects on liver autophagy markers, maintaining normal cellular recycling pathways, while Semaglutide led to p62 accumulation, suggesting GDNF's potential advantage in preserving liver cellular homeostasis.
  • Molecular Signaling Characteristics: GDNF treatment did not significantly alter AKT signaling, while Semaglutide increased AKT phosphorylation, highlighting significant differences in molecular mechanisms between the two treatments, paving the way for future research directions.
PRnewswire
8.5
03-04PRnewswire
Hoth Therapeutics Integrates AI for IND Preparation and Phase 1 Progression
  • AI Integration: Hoth Therapeutics has announced the integration of OpenAI's API into the HT-KIT development workflow to support IND preparation for rare KIT-driven cancers, enhancing data analysis and molecular modeling efficiency, thereby accelerating preclinical research progress.
  • IND Strategy Advancement: CEO Robb Knie stated that the application of AI not only optimizes the HT-KIT development process but also prepares necessary regulatory documentation for the upcoming IND submission, marking a significant step towards Phase 1 clinical trials.
  • Patient-Centric R&D: Hoth Therapeutics is dedicated to developing innovative therapies, leveraging AI technology to improve patient quality of life, indicating the company's crucial role in early-stage drug development, which may attract more investor interest.
  • Market Potential Outlook: With the increasing demand for treatments for rare cancers, Hoth's AI integration strategy not only enhances R&D efficiency but also positions the company favorably in the future market, driving long-term growth.

Valuation Metrics

The current forward P/E ratio for Hoth Therapeutics Inc (HOTH.O) is -2.04, compared to its 5-year average forward P/E of -1.49. For a more detailed relative valuation and DCF analysis to assess Hoth Therapeutics Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-1.49
Current PE
-2.04
Overvalued PE
-0.72
Undervalued PE
-2.26

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
0.39
Current EV/EBITDA
0.00
Overvalued EV/EBITDA
2.68
Undervalued EV/EBITDA
-1.90

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
0.00
Current PS
0.00
Overvalued PS
0.00
Undervalued PS
0.00

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Frequently Asked Questions

What is Hoth Therapeutics Inc (HOTH) stock price today?

The current price of HOTH is 0.8403 USD — it has increased 9.09

What is Hoth Therapeutics Inc (HOTH)'s business?

Hoth Therapeutics, Inc. is a clinical-stage biopharmaceutical company focused on developing new generation therapies for unmet medical needs. The Company is focused on developing a topical formulation for treating side effects from drugs used for the treatment of cancer (HT-001); a treatment for mast-cell derived cancers and anaphylaxis (HT-KIT), and a treatment and/or prevention for Alzheimer's or other neuroinflammatory diseases (HT-ALZ). The Company also has assets being developed for atopic dermatitis (also known as eczema) (BioLexa); a treatment for asthma and allergies using inhalational administration (HT-004), and a treatment for obesity, and obesity-related diseases and conditions (HT-VA).

What is the price predicton of HOTH Stock?

Wall Street analysts forecast HOTH stock price to fall over the next 12 months. According to Wall Street analysts, the average 1-year price target for HOTH is USD with a low forecast of USD and a high forecast of USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Hoth Therapeutics Inc (HOTH)'s revenue for the last quarter?

Hoth Therapeutics Inc revenue for the last quarter amounts to -2.60M USD, increased 9.31

What is Hoth Therapeutics Inc (HOTH)'s earnings per share (EPS) for the last quarter?

Hoth Therapeutics Inc. EPS for the last quarter amounts to -2150385.00 USD, decreased

How many employees does Hoth Therapeutics Inc (HOTH). have?

Hoth Therapeutics Inc (HOTH) has 2 emplpoyees as of April 01 2026.

What is Hoth Therapeutics Inc (HOTH) market cap?

Today HOTH has the market capitalization of 13.66M USD.