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HOTH Overview

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0.000(0.000%)
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0.000(0.000%)Aft-market
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0.000
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ET
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Intellectia

Loading chart...

High
0.750
Open
0.699
VWAP
0.73
Vol
1.06M
Mkt Cap
14.23M
Low
0.695
Amount
776.50K
EV/EBITDA(TTM)
--
Total Shares
19.13M
EV
7.98M
EV/OCF(TTM)
--
P/S(TTM)
--
Hoth Therapeutics, Inc. is a clinical-stage biopharmaceutical company focused on developing new generation therapies for unmet medical needs. The Company is focused on developing a topical formulation for treating side effects from drugs used for the treatment of cancer (HT-001); a treatment for mast-cell derived cancers and anaphylaxis (HT-KIT), and a treatment and/or prevention for Alzheimer's or other neuroinflammatory diseases (HT-ALZ). The Company also has assets being developed for atopic dermatitis (also known as eczema) (BioLexa); a treatment for asthma and allergies using inhalational administration (HT-004), and a treatment for obesity, and obesity-related diseases and conditions (HT-VA).
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Events Timeline

(ET)
2026-04-14
07:10:00
Hoth Therapeutics Announces Positive Data from HT-VA Study
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2026-04-13 (ET)
2026-04-13
17:30:00
Hoth Therapeutics Announces Positive Data from HT-VA Study
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2026-04-13
17:30:00
Hoth Therapeutics Shares Up 52% to $0.78 After HT-VA Data
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2026-04-01 (ET)
2026-04-01
14:00:00
Hoth Therapeutics to Offer 2.86M Shares at $0.70 Each
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2026-04-01
08:20:00
Hoth Therapeutics Reports Positive Clinical Results for HT-001
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2026-03-31 (ET)
2026-03-31
08:10:00
Hoth Therapeutics Secures Chinese Patent Valid Until 2039
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2026-03-24 (ET)
2026-03-24
08:30:00
Hoth Therapeutics Reports Positive Clinical Data for HT-001
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2026-03-10 (ET)
2026-03-10
08:20:00
Hoth Therapeutics Announces New Female-Specific Metabolic Disease Study Results
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2026-02-24 (ET)
2026-02-24
16:30:00
Hoth Therapeutics Expands CLEER-001 Clinical Trial
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2026-02-12 (ET)
2026-02-12
08:40:00
Hoth Therapeutics Receives Patent Allowance for Allergy Treatment
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News

NASDAQ.COM
8.5
04-14NASDAQ.COM
Hoth Therapeutics Shares Surge 55% on Positive HT-VA Study Results
  • Significant Study Results: Hoth Therapeutics' HT-VA study demonstrated that GDNF can directly reprogram liver fat metabolism at the genetic level in diet-induced obesity and metabolic-associated fatty liver disease, significantly decreasing Srebf1 expression while increasing Ppara expression, highlighting its crucial role in fat metabolism.
  • Strong Market Performance: Following the announcement of the study results, HOTH shares surged over 55% in pre-market trading, rising by $0.80 to a 58.23% increase, reflecting strong market confidence and anticipation for the new therapy.
  • Future Development Plans: Hoth plans to advance HT-VA findings into additional preclinical validation studies and evaluate clinical development pathways for metabolic and liver diseases, indicating the company's ongoing commitment and strategic positioning in new therapies.
  • Diverse R&D Pipeline: In addition to HT-VA, Hoth is also developing HT-001, HT-KIT, and HT-ALZ targeting skin reactions in cancer patients, mast cell-driven disorders, and Alzheimer's disease, showcasing its broad portfolio and potential in the biopharmaceutical sector.
stocktwits
7.0
04-14stocktwits
REPL Faces Pressure After FDA Issues Second Complete Response Letter
  • Regulatory Pressure on REPL: REPL's stock plummeted 64% after the FDA issued a second Complete Response Letter (CRL) for its lead drug RP1 in combination with nivolumab for anti-PD-1-failed melanoma, highlighting a lack of alignment with the FDA and prompting widespread analyst downgrades across Wall Street.
  • HOTH Financing Impact: HOTH's stock declined 1% following the announcement of a $2 million stock offering priced at $0.70 per share, overshadowing positive pipeline updates for its HT-001 therapy, which showed significant efficacy in treating skin toxicities, indicating market concerns over dilution.
  • ONCO's Stock Slide: ONCO's shares fell 27% after implementing a 1-for-5 reverse stock split to comply with Nasdaq's minimum bid price requirement, despite ongoing efforts to acquire Realbotix in an all-stock deal, reflecting investor anxiety over compliance pressures.
  • Retail Investor Sentiment: Retail sentiment on Stocktwits showed REPL as 'bearish' while HOTH and ONCO were 'extremely bullish', indicating a divergence in market sentiment despite all three stocks underperforming the broader XLV ETF over the past year, with declines of 77%, 36%, and 97% respectively.
stocktwits
9.0
04-14stocktwits
HT-VA Drug Outperforms Novo Nordisk in Key Metabolic Markers
  • Clinical Trial Results: Hoth Therapeutics' HT-VA drug has outperformed Novo Nordisk's blockbuster semaglutide in key gene expression markers, indicating significant advantages in liver fat regulation and potential as a new therapy for metabolic-associated fatty liver disease and obesity.
  • Gene Expression Improvement: The drug demonstrated statistically significant reductions in fat production genes and increased fat metabolism during preclinical trials, suggesting that HT-VA fundamentally reprograms the body's fat production and metabolism mechanisms, which is clinically significant.
  • Stock Price Reaction: Hoth Therapeutics' shares surged 70% in after-hours trading on Monday, reflecting strong investor confidence in the drug's potential, despite a 38% decline in stock value over the past 12 months.
  • Future Development Plans: The company aims to advance HT-VA into further preclinical validation studies and evaluate clinical development pathways for metabolic and liver diseases while exploring strategic partnerships to accelerate the development process.
PRnewswire
2.0
04-13PRnewswire
GDNF Shows Promise as Next-Gen Therapy for MAFLD and Obesity
  • Significant Findings: Hoth Therapeutics' HT-VA study revealed that GDNF significantly reduces the expression of the fat production gene Srebf1 while increasing the activity of the fat metabolism gene Pparα, indicating its potential in treating metabolic-associated fatty liver disease (MAFLD) and obesity.
  • Innovative Mechanism: Unlike existing therapies that primarily focus on weight loss, GDNF directly targets the biological mechanisms of liver fat metabolism by shutting down fat production and activating fat metabolism, offering a potentially disease-modifying therapeutic approach with significant clinical implications.
  • Strategic Milestone: CEO Robb Knie noted that the HT-VA study represents a major expansion for Hoth into high-value metabolic indications, emphasizing GDNF's ability to fundamentally reprogram fat metabolism, which could alter the existing treatment landscape.
  • Future Plans: Hoth Therapeutics plans to advance the clinical development of GDNF, aiming to provide innovative treatment options for MAFLD and related metabolic disorders, thereby enhancing patient quality of life.
Newsfilter
8.5
04-13Newsfilter
GDNF Shows Promise as Next-Gen Therapy for MAFLD and Obesity
  • Significant Gene Expression Improvement: Hoth Therapeutics' HT-VA study demonstrates that GDNF treatment significantly reduces the expression of Srebf1, a gene linked to fat production in the liver, while enhancing the activity of Pparα, a key regulator of fat metabolism, thereby directly reprogramming liver fat metabolism and indicating its potential application in MAFLD and obesity treatment.
  • Differentiation from Existing Therapies: GDNF outperformed current GLP-1 therapies in key gene expression markers, focusing not just on weight loss but directly targeting the biological mechanisms of fat accumulation in the liver, showcasing its potential as a first-in-class metabolic reprogramming therapy.
  • Market Entry Strategy: The study results lay the groundwork for Hoth Therapeutics' entry into the MAFLD and obesity markets, indicating the company's strategic expansion into high-value metabolic indications that could reshape existing treatment paradigms.
  • Next Steps for Development: Hoth plans to advance HT-VA findings into additional preclinical validation studies, evaluate clinical development pathways for metabolic and liver diseases, and explore strategic partnerships to accelerate the development process.
PRnewswire
8.5
04-02PRnewswire
Hoth Therapeutics Closes Registered Direct Offering
  • Offering Size: Hoth Therapeutics successfully closed a registered direct offering of 2,857,144 shares of common stock at an offering price of $0.70 per share, which is expected to generate approximately $2 million in gross proceeds, enhancing the company's liquidity to support future R&D activities.
  • Placement Details: In conjunction with this offering, the company issued unregistered warrants to purchase up to 2,857,144 shares of common stock at an exercise price of $0.85 per share, which is anticipated to provide additional funding support and further strengthen its capital structure.
  • Use of Proceeds: Hoth Therapeutics indicated that the net proceeds will be utilized for general corporate purposes, including working capital, which will help the company maintain competitiveness in clinical-stage biopharmaceutical development and drive innovation.
  • Compliance Statement: The offering complies with Section 4(a)(2) of the Securities Act of 1933, ensuring that the issuance of unregistered warrants and related shares adheres to applicable laws and regulations, thereby mitigating legal risks associated with the financing.

Valuation Metrics

The current forward P/E ratio for Hoth Therapeutics Inc (HOTH.O) is 0.00, compared to its 5-year average forward P/E of -1.48. For a more detailed relative valuation and DCF analysis to assess Hoth Therapeutics Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-1.48
Current PE
0.00
Overvalued PE
-0.71
Undervalued PE
-2.24

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
0.44
Current EV/EBITDA
0.00
Overvalued EV/EBITDA
2.70
Undervalued EV/EBITDA
-1.82

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
0.00
Current PS
0.00
Overvalued PS
0.00
Undervalued PS
0.00

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Frequently Asked Questions

What is Hoth Therapeutics Inc (HOTH) stock price today?

The current price of HOTH is 0.7439 USD — it has increased 1.92

What is Hoth Therapeutics Inc (HOTH)'s business?

Hoth Therapeutics, Inc. is a clinical-stage biopharmaceutical company focused on developing new generation therapies for unmet medical needs. The Company is focused on developing a topical formulation for treating side effects from drugs used for the treatment of cancer (HT-001); a treatment for mast-cell derived cancers and anaphylaxis (HT-KIT), and a treatment and/or prevention for Alzheimer's or other neuroinflammatory diseases (HT-ALZ). The Company also has assets being developed for atopic dermatitis (also known as eczema) (BioLexa); a treatment for asthma and allergies using inhalational administration (HT-004), and a treatment for obesity, and obesity-related diseases and conditions (HT-VA).

What is the price predicton of HOTH Stock?

Wall Street analysts forecast HOTH stock price to fall over the next 12 months. According to Wall Street analysts, the average 1-year price target for HOTH is USD with a low forecast of USD and a high forecast of USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Hoth Therapeutics Inc (HOTH)'s revenue for the last quarter?

Hoth Therapeutics Inc revenue for the last quarter amounts to -2.60M USD, increased 9.31

What is Hoth Therapeutics Inc (HOTH)'s earnings per share (EPS) for the last quarter?

Hoth Therapeutics Inc. EPS for the last quarter amounts to -2150385.00 USD, decreased

How many employees does Hoth Therapeutics Inc (HOTH). have?

Hoth Therapeutics Inc (HOTH) has 2 emplpoyees as of April 21 2026.

What is Hoth Therapeutics Inc (HOTH) market cap?

Today HOTH has the market capitalization of 14.23M USD.