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KPTI Overview

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$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
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Intellectia

Loading chart...

High
8.900
Open
8.900
VWAP
8.15
Vol
911.84K
Mkt Cap
160.51M
Low
7.660
Amount
7.43M
EV/EBITDA(TTM)
--
Total Shares
18.34M
EV
396.00M
EV/OCF(TTM)
--
P/S(TTM)
0.66
Karyopharm Therapeutics Inc. is a commercial-stage pharmaceutical company. The Company is engaged in the discovery, development and commercialization of drugs directed against nuclear export for the treatment of cancer and other diseases. It is developing and commercializing small molecule Selective Inhibitor of Nuclear Export (SINE) compounds that inhibit the nuclear export protein exportin 1 (XPO1). Its lead asset, XPOVIO (selinexor), is marketed in combination with bortezomib and dexamethasone for the treatment of adult patients with multiple myeloma who have received at least one prior therapy. The Company is engaged in evaluating selinexor in certain hematological and solid tumor malignancies, including endometrial cancer, mycosis fungoides (MF) and diffuse large B-cell lymphoma (DLBCL). The Company’s product candidate, eltanexor, is an oral SINE compound like selinexor, that selectively blocks the nuclear export protein XPO1.
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Events Timeline

(ET)
2026-02-12
07:40:00
Karyopharm Reports Q4 Revenue of $114.9M
select
2026-02-12
07:40:00
Expects Existing Liquidity to Fund Operations into Q2
select
2026-01-12 (ET)
2026-01-12
07:20:00
Karyopharm Sees FY25 Xpovio Net Product Revenue at $115M
select
2025-11-05 (ET)
2025-11-05
08:45:01
Significant Borrowing Rate Hikes Among Liquid Assets
select
2025-11-03 (ET)
2025-11-03
07:08:08
Karyopharm projects FY25 revenue between $140M and $155M, with consensus at $150.22M.
select
2025-11-03
07:06:28
Karyopharm Announces Q3 Earnings Per Share of $3.82, Exceeding Consensus Estimate of $3.25
select

News

Benzinga
6.5
03-10Benzinga
Wall Street Analysts Adjust Ratings on Key Stocks
  • Analyst Rating Changes: Top Wall Street analysts have adjusted their ratings on several stocks, including upgrades, downgrades, and initiations, reflecting varying market perspectives on these companies.
  • Market Dynamics: While specific stock names are not mentioned, changes in analyst ratings typically influence investor decisions and can lead to price volatility in the affected stocks.
  • Investor Focus: Investors considering purchasing MSTR stock should pay attention to the latest insights from analysts to make more informed investment choices.
  • Information Source: A complete view of all analyst rating changes can be found on Benzinga's analyst ratings page, providing a comprehensive market perspective.
Newsfilter
9.0
02-17Newsfilter
FDA's Accelerated Approval Framework Drives Cancer Treatment Advances
  • Clinical Survival Rate Improvement: A January 2026 analysis confirmed that drugs approved through the FDA's accelerated pathway improved progression-free survival in 65% of solid tumor indications, demonstrating significant clinical efficacy and driving clinical-stage oncology companies toward registration-directed study designs in high-unmet-need tumor types.
  • Fast Track Designation: Oncolytics Biotech's cancer treatment pelareorep received FDA Fast Track designation for KRAS-mutant microsatellite-stable metastatic colorectal cancer patients, achieving a 33% response rate in combination with standard chemotherapy, significantly higher than the 10% response rate with standard treatment, and a median survival of 27 months compared to 11.2 months with standard care.
  • Substantial Market Potential: The second-line treatment market for KRAS-mutant microsatellite-stable colorectal cancer patients is estimated to be between $3 billion and $5 billion annually, with Oncolytics Biotech planning a controlled study to compare standard care versus standard care plus pelareorep, further validating its therapeutic advantage in this high-demand area.
  • Team Expansion and Strategic Positioning: Oncolytics Biotech recently appointed two key executives to support its expansion plans, with CEO Jared Kelly emphasizing that the success of pelareorep in clinical trials will present significant market opportunities, particularly in cancer areas lacking effective treatment options.
seekingalpha
9.5
02-13seekingalpha
Karyopharm Therapeutics Q4 2025 Earnings Call Highlights
  • Financial Performance Review: Karyopharm reported net product revenue of $32.1 million in Q4 and $114.9 million for the full year, indicating sustained growth potential in oncology, with guidance for 2026 revenue between $130 million and $150 million, further solidifying its market position.
  • Clinical Trial Progress: Management confirmed that top-line data from the Phase III SENTRY trial will be shared in March, marking a critical milestone in the myelofibrosis space that could set new standards of care for future treatments.
  • Cost Control Measures: R&D expenses decreased by 17% year-over-year in Q4, while selling, general, and administrative expenses fell by 16%, demonstrating strict financial management that is expected to enhance future profitability.
  • Strategic Outlook: Management emphasized a continued focus on near-term value-creating milestones, with cash runway extending into the second quarter, indicating the company's ability to maintain flexible capital decisions ahead of clinical trial results.
NASDAQ.COM
2.0
02-12NASDAQ.COM
Karyopharm (KPTI) Q4 2025 Earnings Call Transcript
seekingalpha
9.5
02-12seekingalpha
Karyopharm Q4 Earnings Beat Expectations, 2026 Outlook Positive
  • Earnings Performance: Karyopharm reported a Q4 GAAP EPS of -$5.71, missing expectations by $3.67, although revenue of $34.08 million, up 11.7% year-over-year, beat estimates by $0.92 million, indicating resilience in revenue growth.
  • 2026 Revenue Outlook: The company anticipates total revenue for 2026 to range between $130 million and $150 million, with U.S. XPOVIO net product revenue expected to be between $115 million and $130 million, reflecting confidence in future product sales.
  • Expense Projections: Karyopharm expects R&D and selling, general, and administrative expenses to be between $230 million and $245 million, which will impact profitability but also highlights ongoing investments in R&D and marketing.
  • Liquidity Assurance: The company expects its existing liquidity, including cash, cash equivalents, and investments, to fund its operating plans into the second quarter of 2026, demonstrating financial stability and operational sustainability.
PRnewswire
9.5
02-12PRnewswire
Karyopharm Reports 2025 Financial Results and 2026 Outlook
  • 2025 Financial Performance: Karyopharm reported total revenue of $146 million for 2025, slightly up from 2024, primarily driven by $115 million in XPOVIO® product revenue, despite a net loss of $196 million, indicating challenges in profitability.
  • R&D Spending Adjustments: R&D expenses for 2025 were $125.6 million, a 12.3% decrease from 2024, reflecting cost control in clinical trial spending, although this may impact the pace of future product development.
  • Clinical Trial Progress: Karyopharm expects to release top-line data from the SENTRY trial in March 2026, which, if successful, could provide the first combination therapy for myelofibrosis patients, representing significant market potential and addressing unmet patient needs.
  • 2026 Financial Guidance: The company projects total revenue for 2026 to be between $130 million and $150 million, demonstrating continued confidence in XPOVIO's market performance despite facing intense competition and R&D risks.
Wall Street analysts forecast KPTI stock price to rise
6 Analyst Rating
Wall Street analysts forecast KPTI stock price to rise
5 Buy
1 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
6.00
Averages
13.83
High
21.00
Current: 0.000
sliders
Low
6.00
Averages
13.83
High
21.00
Rodman & Renshaw
initiated
$28
AI Analysis
2026-03-09
New
Reason
Rodman & Renshaw
Price Target
$28
AI Analysis
2026-03-09
New
initiated
Reason
Rodman & Renshaw initiated coverage of Karyopharm with a Buy rating and $28 price target. The firm is positive on selinexor's "differentiated" mechanism of action and "compelling" Phase 1 combination data in myelofibrosis. The drug's peak revenue opportunity of $800M-$850M in frontline myelofibrosis alone is "substantial" with additional upside from ongoing the multiple myeloma programs, the analyst tells investors in a research note.
Cantor Fitzgerald
Yanni Souroutzidis
Overweight
initiated
2026-02-05
Reason
Cantor Fitzgerald
Yanni Souroutzidis
Price Target
2026-02-05
initiated
Overweight
Reason
Cantor Fitzgerald analyst Yanni Souroutzidis initiated coverage of Karyopharm with an Overweight rating. The firm cites its probability-weighted scenarios from the company's Phase 3 SENTRY trial in myelofibrosis for the buy rating. It assigns a 70% probability of success. A "clean win" would reposition Karyopharm from "challenged MM player" to "frontline MF combo contender" which would result in significant upside for the shares, the analyst tells investors in a research note.
Unlock Full Analyst Thesis, Get the complete breakdown of rating reason for KPTI
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Valuation Metrics

The current forward P/E ratio for Karyopharm Therapeutics Inc (KPTI.O) is -1.00, compared to its 5-year average forward P/E of -2.05. For a more detailed relative valuation and DCF analysis to assess Karyopharm Therapeutics Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-2.05
Current PE
-1.00
Overvalued PE
-0.72
Undervalued PE
-3.37

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-2.16
Current EV/EBITDA
0.00
Overvalued EV/EBITDA
-0.34
Undervalued EV/EBITDA
-3.98

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
5Y Average PS
1.93
Current PS
0.86
Overvalued PS
3.53
Undervalued PS
0.34

Financials

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Whales Holding KPTI

A
Affinity Asset Advisors, LLC
Holding
KPTI
+1.08%
3M Return

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Frequently Asked Questions

What is Karyopharm Therapeutics Inc (KPTI) stock price today?

The current price of KPTI is 7.9 USD — it has decreased -9.71

What is Karyopharm Therapeutics Inc (KPTI)'s business?

Karyopharm Therapeutics Inc. is a commercial-stage pharmaceutical company. The Company is engaged in the discovery, development and commercialization of drugs directed against nuclear export for the treatment of cancer and other diseases. It is developing and commercializing small molecule Selective Inhibitor of Nuclear Export (SINE) compounds that inhibit the nuclear export protein exportin 1 (XPO1). Its lead asset, XPOVIO (selinexor), is marketed in combination with bortezomib and dexamethasone for the treatment of adult patients with multiple myeloma who have received at least one prior therapy. The Company is engaged in evaluating selinexor in certain hematological and solid tumor malignancies, including endometrial cancer, mycosis fungoides (MF) and diffuse large B-cell lymphoma (DLBCL). The Company’s product candidate, eltanexor, is an oral SINE compound like selinexor, that selectively blocks the nuclear export protein XPO1.

What is the price predicton of KPTI Stock?

Wall Street analysts forecast KPTI stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for KPTI is13.83 USD with a low forecast of 6.00 USD and a high forecast of 21.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Karyopharm Therapeutics Inc (KPTI)'s revenue for the last quarter?

Karyopharm Therapeutics Inc revenue for the last quarter amounts to 34.08M USD, increased 11.58

What is Karyopharm Therapeutics Inc (KPTI)'s earnings per share (EPS) for the last quarter?

Karyopharm Therapeutics Inc. EPS for the last quarter amounts to -5.68 USD, increased 54.77

How many employees does Karyopharm Therapeutics Inc (KPTI). have?

Karyopharm Therapeutics Inc (KPTI) has 228 emplpoyees as of March 12 2026.

What is Karyopharm Therapeutics Inc (KPTI) market cap?

Today KPTI has the market capitalization of 160.51M USD.