Loading...

Intellectia LogoIntellectia
AI Trading Bot
Features
Markets
News
Resources
Pricing
Get Started
  1. Home
  2. Stock
  3. KPTI
KPTI logo

KPTI Overview

-
$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
OverviewStock Price PredictionTechnicalValuationFinancialsEarningsShould I BuyNews & Events
an image of Intellectia Logoan image of Intellectia

Most Trusted AI Platform for Winning Trades

TwitterYoutubeQuoraDiscordLinkedinTelegram

Copyright © 2026 Intellectia.AI. All Rights Reserved.

Company

  • Home
  • Contact
  • About Us
  • Press
  • Privacy
  • Terms of Service
  • Service Terms of Use

Resources

  • Blog
  • Tutorial
  • Help Center
  • Affiliate Program

Markets

  • Market Analysis
  • Crypto
  • Featured Screeners
  • AI Earnings Calendar
  • Market Movers
  • Stock Monitor
  • Economic Calendar
  • All US Stocks
  • All Cryptos

Tools

  • Dividend Calculator
  • Dividend Yield Calculator
  • Options Profit Calculator

Features

  • QuantAI Alpha Pick
  • SwingMax Portfolio
  • Swing Trading
  • AI Stock Picker
  • Whales Auto Tracker
  • Daytrading Center
  • Patterns Detection
  • AI Screener
  • Financial AI Agent
  • Backtesting Playground
  • AI Earnings Prediction
  • Stock Monitor
  • Technical Analysis

News

  • Overview
  • Top News
  • Daily Market Brief
  • Earnings Analysis
  • Newswire
  • Stock News
  • Crypto News
  • Institution News
  • Congress News
  • Monitor News

Compare

  • TradingView
  • SeekingAlpha
Intellectia

Loading chart...

High
5.860
Open
5.610
VWAP
5.69
Vol
587.68K
Mkt Cap
125.57M
Low
5.390
Amount
3.34M
EV/EBITDA(TTM)
--
Total Shares
22.54M
EV
361.06M
EV/OCF(TTM)
--
P/S(TTM)
0.42
Karyopharm Therapeutics Inc. is a commercial-stage pharmaceutical company. The Company is engaged in the discovery, development and commercialization of drugs directed against nuclear export for the treatment of cancer. It is developing and commercializing novel, small molecule XPO1 inhibitor compounds that inhibit the nuclear export protein exportin 1 (XPO1). Its lead asset, XPOVIO (selinexor), is marketed in combination with bortezomib and dexamethasone for the treatment of adult patients with multiple myeloma who have received at least one prior therapy. XPOVIO is also marketed for treatment of adult patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL). The Company is engaged in evaluating selinexor in certain hematological and solid tumor malignancies, including myelofibrosis, endometrial cancer and multiple myeloma. The Company’s product candidate, eltanexor, is an oral SINE compound like selinexor, that selectively blocks the nuclear export protein XPO1.
Show More

Events Timeline

(ET)
2026-03-24
07:40:00
Shares Up 23% to $8.23 in Pre-Market Trading
select
2026-03-24
07:10:00
Karyopharm Enters $30M Private Placement Agreement with RA Capital
select
2026-03-24
07:10:00
Karyopharm Reports Positive Results from SENTRY Trial
select
2026-02-12 (ET)
2026-02-12
07:40:00
Expects Existing Liquidity to Fund Operations into Q2
select
2026-02-12
07:40:00
Karyopharm Reports Q4 Revenue of $114.9M
select

News

NASDAQ.COM
8.5
03-27NASDAQ.COM
Biotech Landscape Update: Regulatory Approvals and Mergers
  • Anavex Drug Withdrawal: Anavex Life Sciences Corp. (AVXL) withdrew its EU marketing application for Alzheimer's drug Blarcamesine after the EMA's CHMP indicated it could not issue a positive opinion, marking a significant setback for the company's lead candidate despite continued support from patient groups.
  • Quoin FDA Alignment: Quoin Pharmaceuticals Ltd. (QNRX) received positive feedback from the FDA confirming that a single Phase 3 trial may suffice for U.S. approval of QRX003 for Netherton Syndrome, with plans to initiate Phase 3 in 2026 and potentially file an NDA in 2027.
  • Corcept Drug Approval: Corcept Therapeutics Inc. (CORT) secured FDA approval for Lifyorli combined with nab-paclitaxel to treat platinum-resistant ovarian cancer, based on Phase 3 ROSELLA trial results involving 381 patients, marking the first FDA-approved selective glucocorticoid receptor antagonist.
  • Merck Acquires Terns: Merck (MRK) announced a definitive agreement to acquire Terns Pharmaceuticals for $53.00 per share, totaling approximately $6.7 billion, which is expected to enhance Merck's presence in hematology, with the transaction anticipated to close in Q2 2026.
stocktwits
9.0
03-24stocktwits
KPTI Shares Drop in Pre-Market Trading Despite Karyopharm's Myelofibrosis Treatment Achieving Key Goal — Retail Investors Skeptical of FDA Approval
  • Phase 3 Trial Results: Karyopharm's Phase 3 SENTRY trial showed that 50% of patients treated with selinexor combined with ruxolitinib achieved significant spleen volume reduction, compared to 28% with ruxolitinib alone, indicating promising efficacy for treating myelofibrosis.

  • Private Placement Announcement: Karyopharm announced a private placement deal with RA Capital Management to raise approximately $30 million, which is expected to support operations and planned clinical trials into the third quarter of 2026.

  • Stock Performance: Following the positive trial results, Karyopharm's stock initially gained but later reversed to a 13% decline in pre-market trading, reflecting mixed sentiment among investors regarding the FDA's potential approval of the drug.

  • Future Plans: The company plans to meet with the FDA to discuss next steps, including the possibility of filing a supplemental new drug application (sNDA) based on the trial data, which they believe could significantly improve clinical outcomes for patients.

seekingalpha
8.5
03-24seekingalpha
Karyopharm Seeks Label Expansion for Xpovio After Positive Trial Results
  • Clinical Trial Success: Karyopharm Therapeutics announced that its lead asset, selinexor, succeeded in a late-stage trial for myelofibrosis, with over 35% of patients showing significant spleen volume reduction, indicating treatment efficacy.
  • Safety Assessment: The SENTRY trial demonstrated that the combination of selinexor and JAK inhibitor ruxolitinib had a manageable safety and tolerability profile, although 15% of patients discontinued treatment due to adverse events, with no new safety signals identified.
  • FDA Meeting Plans: Karyopharm plans to meet with the FDA to discuss the trial results and anticipates filing a supplemental new drug application for selinexor in myelofibrosis, which could further advance its market entry.
  • Positive Stock Reaction: Following the announcement, Karyopharm's shares surged approximately 14%, and the company also revealed a $30 million private placement with RA Capital Management, enhancing its financial strength to support ongoing research and development.
seekingalpha
8.5
03-24seekingalpha
Karyopharm Therapeutics Secures $30M Private Placement
  • Funding Size: Karyopharm Therapeutics announced a $30 million private placement with RA Capital, with an additional ~$44 million expected if accompanying warrants are fully exercised, indicating strong market confidence in its future growth.
  • Share Sale Details: The private placement involves the sale of approximately 1.03 million shares at $6.785 each, along with about 3.39 million pre-funded warrants priced at $6.7849 each, providing substantial funding to support the company's clinical trial activities.
  • Use of Proceeds: The proceeds will be allocated for general corporate purposes, particularly to support ongoing and planned clinical trial activities, which will aid in advancing its research and development efforts and enhance market competitiveness.
  • Stock Price Reaction: Following the announcement of the private placement, Karyopharm's stock price jumped approximately 18% to $7.81 during pre-market trading on Tuesday, reflecting investor optimism regarding the company's future prospects.
PRnewswire
2.0
03-24PRnewswire
Karyopharm Reports Significant Results from SENTRY Trial for Myelofibrosis
  • Significant Efficacy: Karyopharm's SENTRY trial demonstrated that the combination of 60 mg selinexor with ruxolitinib significantly increased the proportion of patients achieving a spleen volume reduction of 35% or more, indicating important clinical relevance in treating myelofibrosis.
  • Survival Signal: The combination therapy showed a greater than 50% reduction in the risk of death at 24 weeks, suggesting its potential to improve overall survival rates for patients, which may provide new directions for future treatments.
  • Good Safety Profile: No new safety signals were identified in the combination treatment group, and the adverse event rates were consistent with the known safety profiles of selinexor and ruxolitinib used individually, indicating good tolerability.
  • Next Steps: Karyopharm plans to meet with the FDA to discuss the totality of the data and its supplemental new drug application, with expectations to submit relevant data in the second half of 2026 to further advance the clinical application of selinexor.
PRnewswire
8.5
03-24PRnewswire
Karyopharm Secures $30 Million in Private Placement Financing
  • Financing Agreement: Karyopharm Therapeutics has entered into a securities purchase agreement with RA Capital Management, expected to yield approximately $30 million in gross proceeds, with potential total proceeds of about $44 million if accompanying warrants are fully exercised, enhancing the company's liquidity for future growth.
  • Share Sale Details: In this private placement, the company will sell 1,030,354 shares of common stock at $6.785 per share and 3,391,164 pre-funded warrants at $6.7849 each, with the transaction expected to close around March 26, 2026.
  • Planned Use of Funds: Karyopharm intends to utilize the proceeds from the private placement for general corporate purposes, including supporting ongoing and planned clinical trial activities, ensuring sufficient funding for the company's operational plans moving forward.
  • Market Compliance: The financing is priced at-the-market under Nasdaq rules, and the securities sold are not registered under the Securities Act of 1933, ensuring compliance while executing capital operations.
Wall Street analysts forecast KPTI stock price to rise
6 Analyst Rating
Wall Street analysts forecast KPTI stock price to rise
5 Buy
1 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
6.00
Averages
13.83
High
21.00
Current: 0.000
sliders
Low
6.00
Averages
13.83
High
21.00
Piper Sandler
Overweight
downgrade
$12 -> $8
AI Analysis
2026-03-30
New
Reason
Piper Sandler
Price Target
$12 -> $8
AI Analysis
2026-03-30
New
downgrade
Overweight
Reason
Piper Sandler lowered the firm's price target on Karyopharm to $8 from $12 and keeps an Overweight rating on the shares. Phase III SENTRY data in myelofibrosis met the first co-primary endpoint. However, it missed the second co-primary endpoint, the firm notes. Importantly, seli-rux showed a significant overall survival benefit with 4.7% deaths vs. 10.2% on ruxolitinib at about 12-month follow-up. Karyopharm plans to meet with FDA to discuss potential sNDA submission for seli-rux in myelofibrosis. While seli-rux miss on Abs-TSS introduces some uncertainty into the likelihood of approval in myelofibrosis, Piper believes the rapid and profound SVR-35 reduction coupled with the OS benefit could be used to gain approval.
Baird
Outperform -> NULL
downgrade
$21 -> $15
2026-03-25
Reason
Baird
Price Target
$21 -> $15
2026-03-25
downgrade
Outperform -> NULL
Reason
Baird lowered the firm's price target on Karyopharm to $15 from $21 and keeps an Outperform rating on the shares. The firm updated its model following mixed Ph 3 Sentry data which may still have a possible path forward in MF.
Unlock Full Analyst Thesis, Get the complete breakdown of rating reason for KPTI
Unlock Now

Valuation Metrics

The current forward P/E ratio for Karyopharm Therapeutics Inc (KPTI.O) is 0.00, compared to its 5-year average forward P/E of -2.02. For a more detailed relative valuation and DCF analysis to assess Karyopharm Therapeutics Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-2.02
Current PE
0.00
Overvalued PE
-0.71
Undervalued PE
-3.33

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-2.21
Current EV/EBITDA
-3.37
Overvalued EV/EBITDA
-0.40
Undervalued EV/EBITDA
-4.01

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
5Y Average PS
1.83
Current PS
0.75
Overvalued PS
3.34
Undervalued PS
0.32

Financials

AI Analysis
Annual
Quarterly

Related Community Screener

low float high volume medical stock
Intellectia · 22 candidates
Sector: Healthcare, Healthcare Services & Equipment, Pharmaceuticals & Medical ResearchVolume: >= 1,000,000List Exchange: XNYS, XNAS, XASEFloating Shares: <= 30,000,000
Ticker
Name
Market Cap$
top bottom
AKAN logo
AKAN
Akanda Corp
1.66M
IBIO logo
IBIO
iBio Inc
60.11M
BIAF logo
BIAF
bioAffinity Technologies Inc
21.32M
AZTR logo
AZTR
Azitra Inc
3.82M
KPTI logo
KPTI
Karyopharm Therapeutics Inc
109.27M
SNGX logo
SNGX
Soligenix Inc
12.20M
low float medical tech stock
Intellectia · 68 candidates
Market Cap: 50.00M - 5.00BSector: Healthcare, Healthcare Services & Equipment, Pharmaceuticals & Medical ResearchRegion: USPrice: $1.00 - $50.00Beta: ModerateRisk, HighRisk, LowRisk, NegativeBetaList Exchange: XNYS, XNAS, XASEMonthly Average Dollar Volume: >= 300,000Floating Shares: <= 20,000,000
Ticker
Name
Market Cap$
top bottom
XLO logo
XLO
Xilio Therapeutics Inc
50.19M
LPCN logo
LPCN
Lipocine Inc
54.02M
LFVN logo
LFVN
LifeVantage Corp
54.88M
CLNN logo
CLNN
Clene Inc
63.49M
OM logo
OM
Outset Medical Inc
64.46M
ACET logo
ACET
Adicet Bio Inc
64.58M
What stock can I profit day trading $46
Intellectia · 8 candidates
Region: USPrice: $2.00 - $10.00Price Change Pct: $3.00 - $15.00Relative Vol: >= 1.50Beta: HighRiskList Exchange: XNYS, XNAS, XASEMonthly Average Dollar Volume: >= 2,000,000
Ticker
Name
Market Cap$
top bottom
MARA logo
MARA
MARA Holdings Inc
3.26B
HTZ logo
HTZ
Hertz Global Holdings Inc
1.49B
KPTI logo
KPTI
Karyopharm Therapeutics Inc
109.27M
AVXL logo
AVXL
Anavex Life Sciences Corp
266.89M
PAYS logo
PAYS
Paysign Inc
294.14M
MBOT logo
MBOT
Microbot Medical Inc
175.95M
high volume low float stocks today
Intellectia · 31 candidates
Market Cap: 50.00M - 5.00BRegion: USPrice: $1.00 - $50.00Volume: >= 1,000,000Relative Vol: >= 2Floating Shares: <= 30,000,000
Ticker
Name
Market Cap$
top bottom
BATL logo
BATL
Battalion Oil Corp
95.48M
PAYS logo
PAYS
Paysign Inc
283.70M
FUBO logo
FUBO
FuboTV Inc
1.18B
SLND logo
SLND
Southland Holdings Inc
71.43M
KSCP logo
KSCP
Knightscope Inc
77.31M
AGRO logo
AGRO
Adecoagro SA
2.10B
high volume low float stocks
Intellectia · 69 candidates
Region: USVolume: >= 1,000,000Floating Shares: <= 30,000,000
Ticker
Name
Market Cap$
top bottom
PAVS logo
PAVS
Paranovus Entertainment Technology Ltd
1.28M
HKIT logo
HKIT
Hitek Global Inc
2.10M
WNW logo
WNW
Meiwu Technology Co Ltd
2.04M
ASNS logo
ASNS
Actelis Networks Inc
10.05M
UGRO logo
UGRO
urban-gro Inc
5.28M
RAYA logo
RAYA
Erayak Power Solution Group Inc
370.63K
possible longs in short term
Intellectia · 53 candidates
Region: USList Exchange: XNYS, XNAS, XASEMoving Average Relationship: PriceAboveMA20Week Price Change Pct: >= $10.00Floating Shares: <= 20,000,000
Ticker
Name
Market Cap$
top bottom
NKTR logo
NKTR
Nektar Therapeutics
1.44B
PHGE logo
PHGE
Biomx Inc
9.77M
ESOA logo
ESOA
Energy Services Of America Corp
231.56M
WORX logo
WORX
Scworx Corp
4.00M
SIF logo
SIF
SIFCO Industries Inc
54.64M
KPTI logo
KPTI
Karyopharm Therapeutics Inc
163.69M
what stocks tomorrow are gonna be volatile
Intellectia · 11 candidates
Price Change Pct: >= $5.00Beta: HighRiskOption Iv Rank: >= 40
Ticker
Name
Market Cap$
top bottom
GNRC logo
GNRC
Generac Holdings Inc
12.61B
ENTX logo
ENTX
Entera Bio Ltd
75.21M
KPTI logo
KPTI
Karyopharm Therapeutics Inc
134.95M
OTLK logo
OTLK
Outlook Therapeutics Inc
34.51M
PRTS logo
PRTS
Carparts.Com Inc
41.60M
AXTI logo
AXTI
AXT Inc
1.48B

Whales Holding KPTI

A
Affinity Asset Advisors, LLC
Holding
KPTI
+4.08%
3M Return

Trading Trends

    Insider
    Hedge Fund
    Congress Trading

People Also Watch

Frequently Asked Questions

What is Karyopharm Therapeutics Inc (KPTI) stock price today?

The current price of KPTI is 5.82 USD — it has increased 4.49

What is Karyopharm Therapeutics Inc (KPTI)'s business?

Karyopharm Therapeutics Inc. is a commercial-stage pharmaceutical company. The Company is engaged in the discovery, development and commercialization of drugs directed against nuclear export for the treatment of cancer. It is developing and commercializing novel, small molecule XPO1 inhibitor compounds that inhibit the nuclear export protein exportin 1 (XPO1). Its lead asset, XPOVIO (selinexor), is marketed in combination with bortezomib and dexamethasone for the treatment of adult patients with multiple myeloma who have received at least one prior therapy. XPOVIO is also marketed for treatment of adult patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL). The Company is engaged in evaluating selinexor in certain hematological and solid tumor malignancies, including myelofibrosis, endometrial cancer and multiple myeloma. The Company’s product candidate, eltanexor, is an oral SINE compound like selinexor, that selectively blocks the nuclear export protein XPO1.

What is the price predicton of KPTI Stock?

Wall Street analysts forecast KPTI stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for KPTI is13.83 USD with a low forecast of 6.00 USD and a high forecast of 21.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Karyopharm Therapeutics Inc (KPTI)'s revenue for the last quarter?

Karyopharm Therapeutics Inc revenue for the last quarter amounts to 34.08M USD, increased 11.58

What is Karyopharm Therapeutics Inc (KPTI)'s earnings per share (EPS) for the last quarter?

Karyopharm Therapeutics Inc. EPS for the last quarter amounts to -5.68 USD, increased 54.77

How many employees does Karyopharm Therapeutics Inc (KPTI). have?

Karyopharm Therapeutics Inc (KPTI) has 228 emplpoyees as of April 02 2026.

What is Karyopharm Therapeutics Inc (KPTI) market cap?

Today KPTI has the market capitalization of 125.57M USD.