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KPTI Overview

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ET
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0.000
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ET
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Intellectia

Loading chart...

High
9.735
Open
9.600
VWAP
9.22
Vol
492.12K
Mkt Cap
204.42M
Low
8.900
Amount
4.54M
EV/EBITDA(TTM)
--
Total Shares
22.66M
EV
410.30M
EV/OCF(TTM)
--
P/S(TTM)
0.85
Karyopharm Therapeutics Inc. is a commercial-stage pharmaceutical company. The Company is engaged in the discovery, development and commercialization of drugs directed against nuclear export for the treatment of cancer. It is developing and commercializing novel, small molecule XPO1 inhibitor compounds that inhibit the nuclear export protein exportin 1 (XPO1). Its lead asset, XPOVIO (selinexor), is marketed in combination with bortezomib and dexamethasone for the treatment of adult patients with multiple myeloma who have received at least one prior therapy. XPOVIO is also marketed for treatment of adult patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL). The Company is engaged in evaluating selinexor in certain hematological and solid tumor malignancies, including myelofibrosis, endometrial cancer and multiple myeloma. The Company’s product candidate, eltanexor, is an oral SINE compound like selinexor, that selectively blocks the nuclear export protein XPO1.
Show More

Events Timeline

(ET)
2026-06-02
09:10:00
Karyopharm Presents SENTRY Trial Results at ASCO Annual Meeting
select
2026-05-14 (ET)
2026-05-14
07:40:00
Karyopharm Reports Q1 Revenue of $35.1M, Exceeding Expectations
select
2026-05-14
07:40:00
Karyopharm Sees 2026 Revenue of $130M-$150M
select
2026-05-04 (ET)
2026-05-04
16:50:00
Karyopharm Files to Sell 8.84M Shares of Common Stock
select
2026-05-04
16:40:00
Karyopharm Files $400M Mixed Securities Shelf
select

News

Yahoo Finance
2.0
06-14Yahoo Finance
Combination Therapy Shows Significant Spleen Volume Reduction in Myelofibrosis
  • Clinical Trial Results: The SENTRY trial demonstrated that the combination of selinexor and ruxolitinib achieved a spleen volume reduction rate (SVR35) of 49.8% at week 24, significantly higher than the control group's 28%, indicating substantial clinical efficacy in myelofibrosis patients.
  • Survival Signal: Although the data is immature, preliminary analysis suggests that the selinexor combination therapy reduces the risk of death by over 50% (HR 0.43) compared to ruxolitinib alone, providing potential survival benefits for patients, which is clinically significant.
  • Symptom Improvement: The combination therapy showed a comparable improvement in Absolute Total Symptom Score (Abs-TSS) to ruxolitinib alone, although the difference was not statistically significant, indicating the combination's potential in symptom management.
  • Safety and Tolerability: The combination demonstrated a manageable safety and tolerability profile consistent with the known characteristics of selinexor and ruxolitinib individually, with no new safety signals observed, enhancing its clinical applicability.
PRnewswire
1.0
06-03PRnewswire
Karyopharm to Participate in Virtual Fireside Chat
  • Virtual Meeting Announcement: Karyopharm Therapeutics will participate in a virtual fireside chat hosted by Cantor on June 8, 2026, at 12:00 PM ET, featuring the company's senior management team and renowned gynecologic oncologist Dr. Robert Coleman, aimed at showcasing the company's latest developments to institutional investors.
  • XPOVIO Treatment Progress: Karyopharm's lead therapy, XPOVIO (selinexor), is the first export inhibitor approved in the U.S. for relapsed or refractory multiple myeloma and has been approved in over 50 countries, demonstrating its broad market potential globally.
  • Clinical Trial Updates: The company is advancing XPOVIO's applications in hematologic and solid tumors, including myelofibrosis and TP53 wild-type endometrial cancer, indicating Karyopharm's ongoing innovation and research capabilities in cancer treatment.
  • Commercial Infrastructure: Headquartered in Newton, Massachusetts, Karyopharm has an efficient and scalable commercial infrastructure designed to provide novel therapeutic options for cancer patients, further solidifying its leadership position in the biopharmaceutical industry.
Newsfilter
1.0
06-03Newsfilter
Karyopharm to Participate in Virtual Investor Fireside Chat
  • Virtual Meeting Announcement: Karyopharm Therapeutics will participate in a virtual investor fireside chat hosted by Cantor on June 8, 2026, at 12:00 p.m. ET, featuring the company's senior management team and renowned gynecologic oncologist Dr. Robert Coleman, aiming to engage institutional investors.
  • XPOVIO Drug Overview: Karyopharm's lead therapy, XPOVIO (selinexor), is the first-in-class exportin 1 inhibitor approved in the U.S. for relapsed or refractory multiple myeloma, with approvals in over 50 countries, highlighting its significant global market potential.
  • Clinical Trial Developments: The company is advancing XPOVIO's applications in hematologic and solid tumors, including evaluations for myelofibrosis and TP53 wild-type endometrial cancer, indicating its ongoing innovation in cancer treatment.
  • Commercial Infrastructure: Headquartered in Newton, Massachusetts, Karyopharm has established an efficient and scalable commercial infrastructure to deliver novel therapeutic options to cancer patients, further solidifying its leadership position in the oncology market.
PRnewswire
8.5
06-02PRnewswire
Karyopharm's SENTRY Trial Data to be Presented at EHA Congress
  • Clinical Trial Results: Karyopharm's new data from the SENTRY trial will be presented at the 2026 European Hematology Association Congress, showcasing the significant effects of selinexor combined with ruxolitinib on spleen volume reduction, which may predict improved overall survival for patients.
  • Key Data Analysis: New findings indicate that achieving a 35% spleen volume reduction (SVR35) in the Phase 1 portion of the SENTRY trial may correlate with better survival outcomes, further supporting the clinical application potential of this combination therapy.
  • Innovative Mechanism of Action: As the first-in-class exportin inhibitor, selinexor demonstrates a distinct mechanism of action compared to JAK inhibitors, potentially offering new treatment options for myelofibrosis patients and addressing the urgent market need for novel therapies.
  • Broad Market Potential: Karyopharm's research shows that the combination of selinexor and ruxolitinib nearly doubles the proportion of patients achieving SVR35 by week 12, indicating strong competitive positioning and potential economic benefits in the future market.
Newsfilter
9.0
06-02Newsfilter
Karyopharm Presents SENTRY Trial Results at EHA Congress
  • Clinical Trial Results: Karyopharm's SENTRY trial results indicate that the combination of selinexor and ruxolitinib can achieve a 35% spleen volume reduction (SVR35), which may predict overall survival for patients, highlighting the significant potential of this combination in treating myelofibrosis.
  • EHA Congress Recognition: This study has been selected as one of the six best abstracts by the European Hematology Association (EHA) Scientific Program Committee, and will be presented orally on June 14, 2026, in Stockholm, enhancing Karyopharm's reputation in the academic community.
  • Patient Benefits: The research shows that the combination of selinexor and ruxolitinib nearly doubles the proportion of patients achieving SVR35 by week 12, demonstrating the potential of this treatment regimen to improve patient symptoms and extend survival, addressing the urgent need for new therapies.
  • Future Outlook: Karyopharm plans to continue advancing selinexor's applications in various cancers, particularly in myelofibrosis and TP53 wild-type endometrial cancer, showcasing the company's strategic positioning in the field of innovative therapies.
PRnewswire
5.0
06-01PRnewswire
Karyopharm Grants Restricted Stock Units to New Employee
  • Employee Incentive Plan: Karyopharm Therapeutics granted 1,200 restricted stock units (RSUs) to a newly hired employee on May 31, 2026, as part of its strategy to attract and retain talent, in compliance with Nasdaq Listing Rule 5635(c)(4).
  • Vesting Schedule: The RSU award will vest over three years, with 33 1/3% of the shares vesting annually, ensuring the employee's continued contribution to the company, thereby enhancing loyalty and motivation among staff.
  • Company Overview: Karyopharm is a commercial-stage pharmaceutical company focused on developing cancer therapies, with its lead product XPOVIO® being the first export inhibitor approved in the U.S. and over 50 countries, showcasing its innovative capabilities in cancer treatment.
  • Future Development Potential: Karyopharm is exploring the application of XPO1 inhibition in various cancers, including myelofibrosis and TP53 wild-type endometrial cancer, indicating the company's commitment to advancing cancer treatment through next-generation compounds.
Wall Street analysts forecast KPTI stock price to rise
6 Analyst Rating
Wall Street analysts forecast KPTI stock price to rise
5 Buy
1 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
6.00
Averages
13.83
High
21.00
Current: 0.000
sliders
Low
6.00
Averages
13.83
High
21.00
H.C. Wainwright
H.C. Wainwright
Buy
maintain
$8 -> $13
AI Analysis
2026-05-06
Reason
H.C. Wainwright
H.C. Wainwright
Price Target
$8 -> $13
AI Analysis
2026-05-06
maintain
Buy
Reason
H.C. Wainwright raised the firm's price target on Karyopharm to $13 from $8 and keeps a Buy rating on the shares. The firm sees a greater probability of approval for Xpovio in endometrial cancer. Exploratory subgroup analysis from the Phase 3 SIENDO trial showed that Xpovio maintenance therapy resulted in a 65% reduction in the risk of progression or death, the analyst tells investors in a research note.
Piper Sandler
NULL
to
Overweight
maintain
$8 -> $16
2026-04-27
Reason
Piper Sandler
Price Target
$8 -> $16
2026-04-27
maintain
NULL
to
Overweight
Reason
Piper Sandler raised the firm's price target on Karyopharm to $16 from $8 and keeps an Overweight rating on the shares. The firm notes Karyopharm will report Phase III XPORT-EC-042 data on selinexor in TP53 wild-type advanced/recurrent endometrial cancer in mid-2026.
Unlock Full Analyst Thesis, Get the complete breakdown of rating reason for KPTI
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Valuation Metrics

The current forward P/E ratio for Karyopharm Therapeutics Inc (KPTI.O) is 0.00, compared to its 5-year average forward P/E of -1.93. For a more detailed relative valuation and DCF analysis to assess Karyopharm Therapeutics Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-1.93
Current PE
0.00
Overvalued PE
-0.66
Undervalued PE
-3.21

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-2.18
Current EV/EBITDA
-2.97
Overvalued EV/EBITDA
-0.40
Undervalued EV/EBITDA
-3.96

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
5Y Average PS
1.66
Current PS
1.32
Overvalued PS
3.01
Undervalued PS
0.31

Financials

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Whales Holding KPTI

A
Affinity Asset Advisors, LLC
Holding
KPTI
+6.76%
3M Return

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Frequently Asked Questions

What is Karyopharm Therapeutics Inc (KPTI) stock price today?

The current price of KPTI is 9.02 USD — it has decreased -4.04

What is Karyopharm Therapeutics Inc (KPTI)'s business?

Karyopharm Therapeutics Inc. is a commercial-stage pharmaceutical company. The Company is engaged in the discovery, development and commercialization of drugs directed against nuclear export for the treatment of cancer. It is developing and commercializing novel, small molecule XPO1 inhibitor compounds that inhibit the nuclear export protein exportin 1 (XPO1). Its lead asset, XPOVIO (selinexor), is marketed in combination with bortezomib and dexamethasone for the treatment of adult patients with multiple myeloma who have received at least one prior therapy. XPOVIO is also marketed for treatment of adult patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL). The Company is engaged in evaluating selinexor in certain hematological and solid tumor malignancies, including myelofibrosis, endometrial cancer and multiple myeloma. The Company’s product candidate, eltanexor, is an oral SINE compound like selinexor, that selectively blocks the nuclear export protein XPO1.

What is the price predicton of KPTI Stock?

Wall Street analysts forecast KPTI stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for KPTI is13.83 USD with a low forecast of 6.00 USD and a high forecast of 21.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Karyopharm Therapeutics Inc (KPTI)'s revenue for the last quarter?

Karyopharm Therapeutics Inc revenue for the last quarter amounts to 35.07M USD, increased 16.83

What is Karyopharm Therapeutics Inc (KPTI)'s earnings per share (EPS) for the last quarter?

Karyopharm Therapeutics Inc. EPS for the last quarter amounts to -1.02 USD, decreased -63.18

How many employees does Karyopharm Therapeutics Inc (KPTI). have?

Karyopharm Therapeutics Inc (KPTI) has 228 emplpoyees as of June 21 2026.

What is Karyopharm Therapeutics Inc (KPTI) market cap?

Today KPTI has the market capitalization of 204.42M USD.