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KPTI Overview

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0.000(0.000%)
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0.000(0.000%)Aft-market
ET
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0.000
0.000(0.000%)
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0.000(0.000%)Aft-market
ET
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Intellectia

Loading chart...

High
9.460
Open
9.120
VWAP
9.17
Vol
290.71K
Mkt Cap
206.23M
Low
8.940
Amount
2.67M
EV/EBITDA(TTM)
--
Total Shares
22.66M
EV
412.11M
EV/OCF(TTM)
--
P/S(TTM)
0.86
Karyopharm Therapeutics Inc. is a commercial-stage pharmaceutical company. The Company is engaged in the discovery, development and commercialization of drugs directed against nuclear export for the treatment of cancer. It is developing and commercializing novel, small molecule XPO1 inhibitor compounds that inhibit the nuclear export protein exportin 1 (XPO1). Its lead asset, XPOVIO (selinexor), is marketed in combination with bortezomib and dexamethasone for the treatment of adult patients with multiple myeloma who have received at least one prior therapy. XPOVIO is also marketed for treatment of adult patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL). The Company is engaged in evaluating selinexor in certain hematological and solid tumor malignancies, including myelofibrosis, endometrial cancer and multiple myeloma. The Company’s product candidate, eltanexor, is an oral SINE compound like selinexor, that selectively blocks the nuclear export protein XPO1.
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Events Timeline

(ET)
2026-05-14
07:40:00
Karyopharm Reports Q1 Revenue of $35.1M, Exceeding Expectations
select
2026-05-14
07:40:00
Karyopharm Sees 2026 Revenue of $130M-$150M
select
2026-05-04 (ET)
2026-05-04
16:50:00
Karyopharm Files to Sell 8.84M Shares of Common Stock
select
2026-05-04
16:40:00
Karyopharm Files $400M Mixed Securities Shelf
select

News

Newsfilter
1.0
11:43 AMNewsfilter
Karyopharm to Host Conference Call on SENTRY Trial Results
  • Conference Call Scheduled: Karyopharm Therapeutics will host a conference call on June 2, 2026, at 2:00 p.m. ET to discuss the results of the SENTRY trial, which is expected to attract attention from investors and healthcare professionals, thereby enhancing the company's visibility in cancer treatment.
  • Expert Participation: The call will feature Dr. John Mascarenhas, the principal investigator of the SENTRY trial, who will share insights from his oral presentation at the 2026 American Society of Clinical Oncology Annual Meeting, reinforcing investor confidence in the company's future developments in hematologic cancer therapies.
  • Product Background: Karyopharm's lead product, XPOVIO® (selinexor), is the first-in-class exportin 1 inhibitor approved in the U.S. for relapsed or refractory multiple myeloma and has been approved in over 50 countries, showcasing its broad market potential globally.
  • Future Development Directions: The company is exploring the potential of XPO1 inhibition across various hematologic malignancies and solid tumors, particularly in TP53 wild-type endometrial cancer, indicating Karyopharm's commitment to addressing unmet medical needs through innovative drug development.
PRnewswire
1.0
05-28PRnewswire
Karyopharm to Speak at 2026 Jefferies Global Healthcare Conference
  • Management Participation: Karyopharm Therapeutics' senior management team will participate in a fireside chat at the 2026 Jefferies Global Healthcare Conference on June 4, 2026, in New York, showcasing the company's innovative advancements in cancer therapies.
  • Live Webcast Available: The fireside chat will be accessible via a live webcast on the company's website under the 'Investors & Media' section, allowing investors to engage with the company's updates and access a replay post-event.
  • Leading Therapeutic Solution: Karyopharm's lead therapy, XPOVIO® (selinexor), is the first-in-class export inhibitor approved in the U.S. for relapsed or refractory multiple myeloma and in over 50 countries, highlighting its global market potential.
  • Research and Development Opportunities: The company is exploring XPO1 inhibition across various hematologic and solid tumors, including myelofibrosis and TP53 wild-type endometrial cancer, indicating its ongoing innovation and expansion potential in cancer treatment.
seekingalpha
9.5
05-14seekingalpha
Karyopharm Therapeutics Q1 2026 Earnings Call Insights
  • Clinical Trial Progress: Karyopharm reported top-line results from the Phase III SENTRY trial in Q1, with a spleen response rate of 50% for the combination therapy, significantly higher than the 28% for ruxolitinib alone, providing robust data to enhance the company's competitive position in the myelofibrosis market.
  • Financial Performance Boost: Total revenue for the first quarter reached $35.1 million, up from $30 million in the prior year, primarily driven by an increase in U.S. XPOVIO net product revenue from $21.1 million to $29.2 million, indicating strong sales performance.
  • Future Outlook: The company expects total revenue in the range of $130 million to $150 million for 2026, while anticipating combined R&D and SG&A expenses between $230 million and $245 million, reflecting ongoing investments in R&D to drive future growth.
  • Liquidity Position: Karyopharm ended the quarter with $91.2 million in cash and cash equivalents, including approximately $50 million raised this quarter, ensuring operational flexibility through upcoming clinical and regulatory catalysts.
seekingalpha
9.5
05-14seekingalpha
Karyopharm Q1 Earnings Beat Expectations
  • Earnings Highlights: Karyopharm Therapeutics reported a Q1 GAAP EPS of -$1.24, beating expectations by $0.25, with revenue of $35.07 million reflecting a 16.8% year-over-year increase, surpassing estimates by $3.67 million, indicating strong performance in revenue growth.
  • Product Revenue Analysis: For the quarter ended March 31, 2026, U.S. net product revenue reached $29.2 million, up from $21.1 million in the same quarter of 2025, although demand for XPOVIO decreased due to new competitive entrants, highlighting challenges in market competition.
  • Royalty Revenue Growth: Royalty revenue increased to $1.9 million in Q1 2026 compared to $1.7 million in Q1 2025, indicating that selinexor's approval in over 50 ex-U.S. countries and territories has strengthened the company's international market position.
  • Cash Flow Status: As of March 31, 2026, the company reported total cash, cash equivalents, and restricted cash of $91.2 million, including approximately $50 million raised from private placements and open market sales, a significant increase from $64.1 million as of December 31, 2025, demonstrating positive progress in fundraising efforts.
PRnewswire
9.5
05-14PRnewswire
Karyopharm Reports Q1 2026 Financial Results and Clinical Progress
  • Clinical Trial Progress: Karyopharm has completed enrollment in the Phase 3 XPORT-EC-042 trial for endometrial cancer, with topline data expected in mid-2026, which will establish a foundation for further advancements in cancer treatment.
  • Improved Financial Performance: Total revenue for Q1 2026 was $35.1 million, a 17% increase from $30 million in Q1 2025, with net product revenue from XPOVIO at $29.2 million, indicating strong market performance and increased product demand.
  • Annual Revenue Guidance Reaffirmed: The company reaffirmed its total revenue guidance for 2026 at $130 million to $150 million, including net product revenue guidance for XPOVIO at $115 million to $130 million, reflecting management's confidence in future performance and market potential.
  • Operational Efficiency Improvement: The operating loss for Q1 was $26.8 million, a 20% improvement from $33.3 million in Q1 2025, demonstrating positive progress in cost management and operational efficiency, which enhances financial stability.
seekingalpha
9.5
05-13seekingalpha
Karyopharm Therapeutics Set to Announce Q1 Earnings Results
  • Earnings Announcement: Karyopharm Therapeutics (KPTI) is set to release its Q1 2023 earnings report on May 14 before market open, with consensus EPS estimated at -$1.49 and revenue expected to reach $31.4 million, reflecting a 4.6% year-over-year increase.
  • Earnings Estimate Changes: Over the last three months, EPS estimates have seen one upward revision with no downward adjustments, while revenue estimates have faced three downward revisions, indicating a cautious market outlook on the company's performance.
  • Clinical Trial Progress: Karyopharm has achieved positive top-line results from its Phase III SENTRY trial in myelofibrosis, which is expected to support label expansion for Xpovio, potentially opening new revenue streams for the company in the future.
  • Funding Activity: The company recently raised $30 million through private financing, resulting in an 18% stock price increase, reflecting market confidence in its growth potential, particularly in drug development and market expansion.
Wall Street analysts forecast KPTI stock price to rise
6 Analyst Rating
Wall Street analysts forecast KPTI stock price to rise
5 Buy
1 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
6.00
Averages
13.83
High
21.00
Current: 0.000
sliders
Low
6.00
Averages
13.83
High
21.00
H.C. Wainwright
H.C. Wainwright
Buy
maintain
$8 -> $13
AI Analysis
2026-05-06
Reason
H.C. Wainwright
H.C. Wainwright
Price Target
$8 -> $13
AI Analysis
2026-05-06
maintain
Buy
Reason
H.C. Wainwright raised the firm's price target on Karyopharm to $13 from $8 and keeps a Buy rating on the shares. The firm sees a greater probability of approval for Xpovio in endometrial cancer. Exploratory subgroup analysis from the Phase 3 SIENDO trial showed that Xpovio maintenance therapy resulted in a 65% reduction in the risk of progression or death, the analyst tells investors in a research note.
Piper Sandler
NULL
to
Overweight
maintain
$8 -> $16
2026-04-27
Reason
Piper Sandler
Price Target
$8 -> $16
2026-04-27
maintain
NULL
to
Overweight
Reason
Piper Sandler raised the firm's price target on Karyopharm to $16 from $8 and keeps an Overweight rating on the shares. The firm notes Karyopharm will report Phase III XPORT-EC-042 data on selinexor in TP53 wild-type advanced/recurrent endometrial cancer in mid-2026.
Unlock Full Analyst Thesis, Get the complete breakdown of rating reason for KPTI
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Valuation Metrics

The current forward P/E ratio for Karyopharm Therapeutics Inc (KPTI.O) is 0.00, compared to its 5-year average forward P/E of -1.96. For a more detailed relative valuation and DCF analysis to assess Karyopharm Therapeutics Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-1.96
Current PE
0.00
Overvalued PE
-0.67
Undervalued PE
-3.24

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-2.20
Current EV/EBITDA
-2.98
Overvalued EV/EBITDA
-0.40
Undervalued EV/EBITDA
-3.99

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
5Y Average PS
1.71
Current PS
1.33
Overvalued PS
3.11
Undervalued PS
0.31

Financials

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Whales Holding KPTI

A
Affinity Asset Advisors, LLC
Holding
KPTI
+7.94%
3M Return

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Frequently Asked Questions

What is Karyopharm Therapeutics Inc (KPTI) stock price today?

The current price of KPTI is 9.1 USD — it has decreased -0.11

What is Karyopharm Therapeutics Inc (KPTI)'s business?

Karyopharm Therapeutics Inc. is a commercial-stage pharmaceutical company. The Company is engaged in the discovery, development and commercialization of drugs directed against nuclear export for the treatment of cancer. It is developing and commercializing novel, small molecule XPO1 inhibitor compounds that inhibit the nuclear export protein exportin 1 (XPO1). Its lead asset, XPOVIO (selinexor), is marketed in combination with bortezomib and dexamethasone for the treatment of adult patients with multiple myeloma who have received at least one prior therapy. XPOVIO is also marketed for treatment of adult patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL). The Company is engaged in evaluating selinexor in certain hematological and solid tumor malignancies, including myelofibrosis, endometrial cancer and multiple myeloma. The Company’s product candidate, eltanexor, is an oral SINE compound like selinexor, that selectively blocks the nuclear export protein XPO1.

What is the price predicton of KPTI Stock?

Wall Street analysts forecast KPTI stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for KPTI is13.83 USD with a low forecast of 6.00 USD and a high forecast of 21.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Karyopharm Therapeutics Inc (KPTI)'s revenue for the last quarter?

Karyopharm Therapeutics Inc revenue for the last quarter amounts to 35.07M USD, increased 16.83

What is Karyopharm Therapeutics Inc (KPTI)'s earnings per share (EPS) for the last quarter?

Karyopharm Therapeutics Inc. EPS for the last quarter amounts to -1.02 USD, decreased -63.18

How many employees does Karyopharm Therapeutics Inc (KPTI). have?

Karyopharm Therapeutics Inc (KPTI) has 228 emplpoyees as of June 01 2026.

What is Karyopharm Therapeutics Inc (KPTI) market cap?

Today KPTI has the market capitalization of 206.23M USD.