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ATHE Overview

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Intellectia

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High
5.000
Open
4.960
VWAP
4.97
Vol
11.26K
Mkt Cap
93.17M
Low
4.960
Amount
55.98K
EV/EBITDA(TTM)
--
Total Shares
18.13M
EV
77.05M
EV/OCF(TTM)
--
P/S(TTM)
84.79
Alterity Therapeutics Limited is an Australia-based clinical-stage biotechnology company. The Company is focused on developing disease modifying treatments for neurodegenerative diseases. The Company's lead asset, ATH434, is to treat various Parkinsonian disorders. ATH434 is an oral agent designed to inhibit the aggregation of pathological proteins implicated in neurodegeneration. It has the potential to treat Parkinson's disease, as well as various Parkinsonian disorders, such as Multiple System Atrophy (MSA). The Company also has a drug discovery platform generating patentable chemical compounds to intercede in disease processes. Its lead asset, ATH434, is in a randomized, double blind, placebo-controlled Phase II clinical trial in participants with MSA. The Company is also conducting various nonclinical studies with ATH434 for use in Parkinson’s disease based on imaging of brain iron, preservation of neurons, and improvements in motor performance.
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Events Timeline

(ET)
2026-05-11
07:40:00
Alterity Therapeutics Publishes MSA Study Results
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2026-04-27 (ET)
2026-04-27
07:40:00
Alterity Therapeutics Receives FDA Feedback, Advances ATH434 Phase 3 Development
select
2026-04-22 (ET)
2026-04-22
07:40:00
Alterity Therapeutics Presents ATH434 Clinical Data
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2026-04-17 (ET)
2026-04-17
07:40:00
Alterity Therapeutics Appoints Ann Cunningham as Independent Director
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2026-03-30 (ET)
2026-03-30
07:40:00
Alterity Therapeutics Receives FDA Feedback to Advance ATH434 Phase 3 Development
select
2026-03-04 (ET)
2026-03-04
07:30:00
Alterity Therapeutics Appoints Daniel Claassen as Chief Medical Advisor
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News

NASDAQ.COM
9.0
06-10NASDAQ.COM
Alterity Aligns with FDA on Phase 3 Trial for ATH434 in MSA Treatment
  • FDA Alignment: Alterity Therapeutics achieved alignment with the FDA during the End-of-Phase 2 meeting, confirming the design for the Phase 3 trial of ATH434, which is a significant milestone in the treatment of multiple system atrophy (MSA).
  • Clinical Trial Design: The FDA agreed to use the Unified Multiple System Atrophy Rating Scale (UMSARS Part I) as the primary endpoint, evaluating multiple symptoms in patients, which ensures the trial's efficacy and scientific rigor, enhancing ATH434's clinical prospects.
  • Dosage Approval: Based on Phase 2 trial results, the FDA approved a dosing regimen of 50 mg of ATH434 administered twice daily, demonstrating a significant 48% slowing of disease progression in treated patients, which boosts investor confidence in the drug's potential.
  • Positive Market Reaction: Following the announcement, Alterity's shares rose by 10% to close at $4.29, reflecting market optimism regarding the upcoming Phase 3 trial and potentially providing the company with greater financing opportunities and market recognition.
seekingalpha
9.0
06-09seekingalpha
Alterity and FDA Finalize Phase 3 Agreement for ATH434
  • Phase 3 Agreement Reached: Alterity Therapeutics has finalized an agreement with the FDA regarding the Phase 3 program for ATH434, its candidate for the rare neurodegenerative disorder multiple system atrophy, covering study population, treatment duration, and primary endpoint, marking a significant milestone in clinical development.
  • Patient Recruitment Plan: The trial aims to enroll approximately 200 patients in a placebo-controlled design, intended to validate the efficacy of ATH434 and further enhance its market potential in the neurodegenerative disease sector.
  • Efficacy Data Review: In Phase 2 trials, the proposed dose of 50 mg twice daily resulted in 48% of patients experiencing slowed disease progression compared to placebo, demonstrating significant efficacy and providing strong support for the upcoming Phase 3 trial.
  • Market Reaction: Despite the notable clinical progress, Alterity's shares fell approximately 13% in premarket trading on Tuesday, reflecting market caution regarding its long-term prospects, which may impact future financing and development plans.
Newsfilter
8.5
06-09Newsfilter
Alterity Secures Key FDA Agreement for Phase 3 Trial
  • Successful FDA Meeting: Alterity Therapeutics achieved a successful End-of-Phase 2 meeting with the FDA, aligning on critical elements of the Phase 3 trial design for ATH434 in Multiple System Atrophy (MSA), marking a significant step towards a New Drug Application.
  • Significant Efficacy: In the Phase 2 study, ATH434 demonstrated clinically and statistically significant efficacy at a 50mg dose, achieving a 48% slowing of disease progression compared to placebo, laying a solid foundation for the upcoming Phase 3 trial.
  • Approved Trial Design: The FDA agreed on the 11-item UMSARS Part I as the primary endpoint and endorsed the selection of key secondary endpoints, reflecting confidence in ATH434's potential in treating MSA and supporting future drug applications.
  • Future Outlook: Alterity plans to initiate the Phase 3 trial by the end of 2026, aiming to enroll approximately 200 patients, with the successful EOP2 meeting results significantly reducing uncertainty around trial design and providing robust support for the company's strategic development in neurodegenerative diseases.
Newsfilter
8.5
05-19Newsfilter
Alterity Achieves Significant Progress in MSA Research
  • Clinical Trial Progress: Alterity's ATH434 demonstrated significant slowing of disease progression in the Phase 2 trial for MSA, with the 50 mg BID group showing a notable decline of 4.0 points (p=0.035), indicating its potential as the first disease-modifying treatment, which could transform the therapeutic landscape for MSA patients.
  • Biomarker Application: New research utilizing Quantitative Susceptibility Mapping (QSM) technology can detect iron accumulation in the early stages of MSA and track its changes over time, providing a novel approach for early diagnosis and trial enrichment that could significantly enhance clinical trial efficiency.
  • Phase 3 Planning: Alterity is on track to hold an FDA meeting in mid-2026 to confirm the pathway for ATH434 to enter Phase 3 clinical trials, further advancing its development in the MSA field, reflecting the company's confidence and strategic positioning for future market opportunities.
  • Multi-Center Trial Potential: By employing standardized QSM technology, Alterity can deliver highly comparable results in multi-center trials, which not only enhances the scientific rigor of clinical studies but may also attract increased investor interest in its research and development progress.
Newsfilter
9.0
05-11Newsfilter
Alterity Publishes Study on MSA Imaging Biomarker
  • Significant Findings: A peer-reviewed study published by Alterity Therapeutics demonstrates that quantitative susceptibility mapping (QSM) MRI can detect disease-specific iron accumulation in patients with Multiple System Atrophy (MSA), correlating with clinical severity and supporting earlier diagnosis and assessment of iron-modulating therapies.
  • Clinical Application Potential: Utilizing data from Alterity's Biomarkers of Progression in Multiple System Atrophy (bioMUSE) study, the research analyzed high-resolution MRI data from 10 MSA patients, revealing significantly higher iron content in the lentiform nucleus compared to healthy controls and Parkinson's disease patients, with a positive correlation to UMSARS scores.
  • Technology Validation: The study indicates that QSM distinguishes MSA from Parkinson's disease with moderate-to-good accuracy (AUC = 0.76–0.79), providing objective evidence for the application of Alterity's ATH434 drug in clinical trials and enhancing diagnostic accuracy.
  • Future Development Direction: Alterity plans to hold a Phase 2 meeting with the FDA in mid-2026 to advance the Phase 3 clinical trial of ATH434, aiming to provide effective treatment options for MSA patients and furthering the company's strategic positioning in the neurodegenerative disease sector.
Newsfilter
8.5
04-27Newsfilter
Alterity Receives Positive FDA Feedback, Advancing ATH434 Phase 3 Development
  • Positive FDA Feedback: Alterity Therapeutics received positive feedback during a Type C meeting with the FDA, confirming alignment on the chemistry, manufacturing, and control (CMC) elements of its Phase 3 development program for Multiple System Atrophy (MSA), marking a significant advancement in the company's pivotal clinical trial preparations.
  • Phase 3 Trial Readiness: The FDA endorsed Alterity's plans for the manufacturing and testing of ATH434, laying the groundwork for its Phase 3 trial, which, if approved, could facilitate commercialization, demonstrating the company's confidence and commitment to developing disease-modifying therapies.
  • Clinical Trial Progress: ATH434 has shown clinically meaningful efficacy in a randomized, double-blind, placebo-controlled Phase 2 trial, and positive data from an open-label Phase 2 trial further enhances its market potential in the treatment of MSA.
  • Future Planning: Alterity is set to hold an End-of-Phase 2 meeting with the FDA in mid-2026 to ensure the smooth initiation of the Phase 3 trial, indicating a clear strategic vision and ongoing regulatory compliance in its future clinical development.

Valuation Metrics

The current forward P/E ratio for Alterity Therapeutics Ltd (ATHE.O) is 0.00, compared to its 5-year average forward P/E of -20.85. For a more detailed relative valuation and DCF analysis to assess Alterity Therapeutics Ltd's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-20.85
Current PE
0.00
Overvalued PE
85.49
Undervalued PE
-127.19

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-1.17
Current EV/EBITDA
-5.27
Overvalued EV/EBITDA
0.88
Undervalued EV/EBITDA
-3.22

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
12.54
Current PS
49.95
Overvalued PS
27.92
Undervalued PS
-2.84

Financials

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Frequently Asked Questions

What is Alterity Therapeutics Ltd (ATHE) stock price today?

The current price of ATHE is 4.96 USD — it has decreased -3.5

What is Alterity Therapeutics Ltd (ATHE)'s business?

Alterity Therapeutics Limited is an Australia-based clinical-stage biotechnology company. The Company is focused on developing disease modifying treatments for neurodegenerative diseases. The Company's lead asset, ATH434, is to treat various Parkinsonian disorders. ATH434 is an oral agent designed to inhibit the aggregation of pathological proteins implicated in neurodegeneration. It has the potential to treat Parkinson's disease, as well as various Parkinsonian disorders, such as Multiple System Atrophy (MSA). The Company also has a drug discovery platform generating patentable chemical compounds to intercede in disease processes. Its lead asset, ATH434, is in a randomized, double blind, placebo-controlled Phase II clinical trial in participants with MSA. The Company is also conducting various nonclinical studies with ATH434 for use in Parkinson’s disease based on imaging of brain iron, preservation of neurons, and improvements in motor performance.

What is the price predicton of ATHE Stock?

Wall Street analysts forecast ATHE stock price to fall over the next 12 months. According to Wall Street analysts, the average 1-year price target for ATHE is USD with a low forecast of USD and a high forecast of USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Alterity Therapeutics Ltd (ATHE)'s revenue for the last quarter?

Alterity Therapeutics Ltd revenue for the last quarter amounts to NaN USD, decreased

What is Alterity Therapeutics Ltd (ATHE)'s earnings per share (EPS) for the last quarter?

Alterity Therapeutics Ltd. EPS for the last quarter amounts to USD, decreased

How many employees does Alterity Therapeutics Ltd (ATHE). have?

Alterity Therapeutics Ltd (ATHE) has 9 emplpoyees as of June 18 2026.

What is Alterity Therapeutics Ltd (ATHE) market cap?

Today ATHE has the market capitalization of 93.17M USD.