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APLS logo

APLS Overview

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$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
OverviewStock Price PredictionTechnicalValuationFinancialsEarningsShould I BuyNews & Events
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Intellectia

Loading chart...

High
20.010
Open
19.890
VWAP
19.69
Vol
1.33M
Mkt Cap
2.51B
Low
19.410
Amount
26.25M
EV/EBITDA(TTM)
43.87
Total Shares
127.83M
EV
2.50B
EV/OCF(TTM)
55.15
P/S(TTM)
2.49
Apellis Pharmaceuticals, Inc. is a commercial-stage biopharmaceutical company. The Company is focused on the discovery, development and commercialization of novel therapeutic compounds to treat diseases with high unmet needs through the inhibition of the complement system. SYFOVRE (pegcetacoplan injection) is the Company’s approved treatment for geographic atrophy secondary to age-related macular degeneration (GA). Its EMPAVELI (pegcetacoplan) is for the treatment of paroxysmal nocturnal hemoglobinuria (PNH). Its Aspaveli (pegcetacoplan) for the treatment of adults with PNH who are anemic after treatment with a C5 inhibitor for at least three months. Systemic pegcetacoplan has also been approved for the treatment of PNH in Japan, Saudi Arabia, Australia, the United Kingdom and other jurisdictions. Systemic pegcetacoplan is marketed under the trade name EMPAVELI in the United States, Saudi Arabia and Australia and Aspaveli in the European Union, Japan and the United Kingdom.
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Events Timeline

(ET)
2026-03-02
07:10:00
Apellis Pharmaceuticals Appoints Mikael Dolsten to Board of Directors
select
2026-02-24 (ET)
2026-02-24
07:30:00
Apellis Reports Q4 Revenue of $199.913M, Exceeds Consensus
select
2026-02-09 (ET)
2026-02-09
06:20:00
VNET Short Interest Rises to 23.5%
select
2026-01-27 (ET)
2026-01-27
19:40:00
S&P 500 Rises for Fifth Consecutive Day, Tech Stocks Lead
select

News

NASDAQ.COM
2.0
02-25NASDAQ.COM
Apellis (APLS) Q4 2025 Earnings Call Transcript
seekingalpha
9.5
02-24seekingalpha
Apellis Pharmaceuticals Reports Q4 2025 Financial Results
  • Financial Overview: Apellis Pharmaceuticals reported a net loss of $58.9 million for Q4 2025, an increase from a $36.4 million loss in the same period of 2024, indicating ongoing challenges in achieving profitability.
  • Revenue Performance: The company generated $199.9 million in revenue, a 5.9% year-over-year decline, although it beat market expectations by $0.46 million, reflecting a struggle with sales growth.
  • Cash Position: As of December 31, 2025, Apellis had $466 million in cash and cash equivalents, which is projected to be sufficient to fund operations until profitability, demonstrating financial stability.
  • Market Index Inclusion: Apellis Pharmaceuticals will be included in the S&P SmallCap 600 index, marking an increase in its recognition in the capital markets and potentially attracting more investor interest.
seekingalpha
9.5
02-23seekingalpha
Apellis Pharmaceuticals Set to Announce Q4 Earnings on February 24
  • Earnings Announcement: Apellis Pharmaceuticals is set to release its Q4 2023 earnings report on February 24 before market open, with consensus EPS estimates at -$0.39, reflecting a 34.5% year-over-year decline, indicating significant profitability challenges for the company.
  • Revenue Decline: The anticipated revenue for Q4 is $199.44 million, representing a 6.1% year-over-year decrease, which highlights the competitive pressures the company faces and could impact investor confidence moving forward.
  • Estimate Revision Trends: Over the past three months, EPS estimates have seen one upward revision and three downward adjustments, while revenue estimates have experienced six upward revisions and five downward changes, indicating analyst divergence on the company's performance and potential stock price volatility.
  • Market Index Inclusion: Apellis Pharmaceuticals will join TTM Technologies and Dutch Bros in the S&P 400 Index, while Amneal and Apellis will be part of the S&P SmallCap 600, which may enhance its market visibility and investment appeal.
Benzinga
4.0
01-28Benzinga
Wall Street Analysts Adjust Ratings
  • Analyst Rating Changes: Top Wall Street analysts have adjusted their ratings on several stocks, including upgrades, downgrades, and initiations, reflecting varying market perspectives on these companies.
  • Market Dynamics Observation: While specific stock names are not mentioned, changes in analyst ratings typically influence investor decisions, potentially leading to price volatility in the affected stocks.
  • Investor Attention: Investors considering buying OKLO stock should pay attention to analysts' opinions to make more informed investment decisions, especially amid increasing market uncertainty.
  • Impact of Rating Changes: Analyst rating adjustments not only affect short-term market sentiment but may also have profound implications for the long-term stock performance of the companies involved, necessitating close monitoring of subsequent developments.
Benzinga
8.5
01-21Benzinga
Apellis Pharmaceuticals' Empaveli Approved, Projected $508 Million Sales by 2033
  • Market Potential Unveiled: Apellis Pharmaceuticals' Empaveli received FDA approval in 2025 as the first treatment for C3 glomerulopathy, which is expected to significantly enhance the company's revenue outlook over the coming years.
  • Early Commercial Performance: In Q3, Empaveli generated $27 million in U.S. net product revenue, with 267 new patient start forms recorded since its late July approval, indicating a 5% market penetration and strong acceptance.
  • Competitive Advantage: The broader label of Empaveli is driving early uptake, with management asserting its efficacy surpasses Novartis' Fabhalta, projecting peak U.S. sales of $508 million by 2033, which could further elevate the company's valuation.
  • Future Catalysts: Analysts noted that the anticipated filing for Syfovre's prefilled syringe in the first half of 2026 could lead to market share expansion and overall market growth, with potential impacts expected in 2027.
seekingalpha
6.0
01-21seekingalpha
Bank of America Upgrades Apellis Pharmaceuticals to Buy, Highlights Strong Empaveli Launch
  • Strong Market Performance: Since receiving FDA approval for Empaveli in July for C3 glomerulopathy, Apellis has recorded 267 new patient start forms, indicating robust market demand and product acceptance.
  • Payer Progress: Management reports no full denials to date, suggesting that Empaveli's broader label and superior efficacy compared to Novartis' Fabhalta have facilitated rapid market penetration.
  • EU Approval Boost: Apellis' partner Sobi recently received EU approval for the drug against C3G and IC-MPGN, further enhancing Empaveli's competitive position in international markets.
  • Growth Potential: With the price target unchanged at $28 per share, analysts believe there is room for continued upside as momentum builds in the coming quarters.
Wall Street analysts forecast APLS stock price to rise
14 Analyst Rating
Wall Street analysts forecast APLS stock price to rise
9 Buy
5 Hold
0 Sell
Moderate Buy
Current: 0.000
sliders
Low
19.00
Averages
31.69
High
48.00
Current: 0.000
sliders
Low
19.00
Averages
31.69
High
48.00
Mizuho
Graig Suvannavejh
Neutral
maintain
$19 -> $20
AI Analysis
2026-03-05
Reason
Mizuho
Graig Suvannavejh
Price Target
$19 -> $20
AI Analysis
2026-03-05
maintain
Neutral
Reason
Mizuho analyst Graig Suvannavejh raised the firm's price target on Apellis to $20 from $19 and keeps a Neutral rating on the shares post the Q4 report. the company is seeing good momentum with Empaveli, the analyst tells investors in a research note.
JPMorgan
Anupam Rama
maintain
$36 -> $37
2026-03-05
Reason
JPMorgan
Anupam Rama
Price Target
$36 -> $37
2026-03-05
maintain
Reason
JPMorgan analyst Anupam Rama raised the firm's price target on Apellis to $37 from $36 and keeps an Overweight rating on the shares. The firm's survey of 23 nephrologists shows Empaveli is well positioned for "meaningful" share gain.
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Valuation Metrics

The current forward P/E ratio for Apellis Pharmaceuticals Inc (APLS.O) is -17.57, compared to its 5-year average forward P/E of -27.04. For a more detailed relative valuation and DCF analysis to assess Apellis Pharmaceuticals Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-27.04
Current PE
-17.57
Overvalued PE
7.28
Undervalued PE
-61.36

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-20.19
Current EV/EBITDA
-22.68
Overvalued EV/EBITDA
111.62
Undervalued EV/EBITDA
-152.00

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
27.47
Current PS
3.98
Overvalued PS
60.29
Undervalued PS
-5.34

Financials

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Quarterly

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Whales Holding APLS

A
Artal Group S.A.
Holding
APLS
+7.70%
3M Return
K
Kynam Capital Management, LP
Holding
APLS
+6.22%
3M Return
S
Suvretta Capital Management, LLC
Holding
APLS
+0.12%
3M Return
O
OrbiMed Advisors LLC
Holding
APLS
-2.05%
3M Return
A
Avoro Capital Advisors LLC
Holding
APLS
-2.32%
3M Return
D
Deep Track Capital, LP
Holding
APLS
-5.04%
3M Return

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Frequently Asked Questions

What is Apellis Pharmaceuticals Inc (APLS) stock price today?

The current price of APLS is 19.64 USD — it has decreased -1.75

What is Apellis Pharmaceuticals Inc (APLS)'s business?

Apellis Pharmaceuticals, Inc. is a commercial-stage biopharmaceutical company. The Company is focused on the discovery, development and commercialization of novel therapeutic compounds to treat diseases with high unmet needs through the inhibition of the complement system. SYFOVRE (pegcetacoplan injection) is the Company’s approved treatment for geographic atrophy secondary to age-related macular degeneration (GA). Its EMPAVELI (pegcetacoplan) is for the treatment of paroxysmal nocturnal hemoglobinuria (PNH). Its Aspaveli (pegcetacoplan) for the treatment of adults with PNH who are anemic after treatment with a C5 inhibitor for at least three months. Systemic pegcetacoplan has also been approved for the treatment of PNH in Japan, Saudi Arabia, Australia, the United Kingdom and other jurisdictions. Systemic pegcetacoplan is marketed under the trade name EMPAVELI in the United States, Saudi Arabia and Australia and Aspaveli in the European Union, Japan and the United Kingdom.

What is the price predicton of APLS Stock?

Wall Street analysts forecast APLS stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for APLS is31.69 USD with a low forecast of 19.00 USD and a high forecast of 48.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Apellis Pharmaceuticals Inc (APLS)'s revenue for the last quarter?

Apellis Pharmaceuticals Inc revenue for the last quarter amounts to 199.91M USD, decreased -5.94

What is Apellis Pharmaceuticals Inc (APLS)'s earnings per share (EPS) for the last quarter?

Apellis Pharmaceuticals Inc. EPS for the last quarter amounts to -0.47 USD, increased 62.07

How many employees does Apellis Pharmaceuticals Inc (APLS). have?

Apellis Pharmaceuticals Inc (APLS) has 733 emplpoyees as of March 11 2026.

What is Apellis Pharmaceuticals Inc (APLS) market cap?

Today APLS has the market capitalization of 2.51B USD.