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APLS Overview

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$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
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Intellectia

Loading chart...

High
40.450
Open
40.400
VWAP
40.33
Vol
45.59M
Mkt Cap
2.18B
Low
40.250
Amount
1.84B
EV/EBITDA(TTM)
38.15
Total Shares
127.83M
EV
2.17B
EV/OCF(TTM)
47.96
P/S(TTM)
2.16
Apellis Pharmaceuticals, Inc. is a commercial-stage biopharmaceutical company. The Company is focused on the discovery, development and commercialization of novel therapeutic compounds to treat diseases with high unmet needs through the inhibition of the complement system. SYFOVRE (pegcetacoplan injection) is the Company’s approved treatment for geographic atrophy secondary to age-related macular degeneration (GA). Its EMPAVELI (pegcetacoplan) is for the treatment of paroxysmal nocturnal hemoglobinuria (PNH). Its Aspaveli (pegcetacoplan) for the treatment of adults with PNH who are anemic after treatment with a C5 inhibitor for at least three months. Systemic pegcetacoplan has also been approved for the treatment of PNH in Japan, Saudi Arabia, Australia, the United Kingdom and other jurisdictions. Systemic pegcetacoplan is marketed under the trade name EMPAVELI in the United States, Saudi Arabia and Australia and Aspaveli in the European Union, Japan and the United Kingdom.
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Events Timeline

(ET)
2026-03-31
10:10:00
New
Apellis Stock Rises 136% to $40.34
select
2026-03-31
09:00:00
New
Stock Futures Rise as S&P 500 and Nasdaq Face Correction
select
2026-03-31
07:10:00
Biogen to Acquire Apellis for $41 per Share
select
2026-03-31
07:00:00
Biogen to Acquire Apellis for $41.00 per Share
select

News

NASDAQ.COM
8.5
14:03 PMNASDAQ.COM
PinnedBiogen Acquires Apellis to Strengthen Immunology Position
  • Acquisition Details: Biogen has agreed to acquire Apellis for $41 per share in cash, valuing the deal at approximately $5.6 billion, which is expected to enhance Biogen's market position in immunology and rare diseases while providing immediate revenue.
  • Expanded Drug Portfolio: The acquisition adds two commercial medicines, EMPAVELI and SYFOVRE, to Biogen's portfolio, with projected combined net sales of $689 million by 2025 and a mid-to-high teens growth rate through at least 2028, significantly improving the company's long-term growth outlook.
  • Significant Clinical Outcomes: EMPAVELI is the only FDA-approved treatment for C3G, demonstrating a 68% reduction in proteinuria in the VALIANT study, while SYFOVRE has shown substantial reductions in GA lesion growth in the OAKS and DERBY studies, further solidifying Biogen's expansion in nephrology.
  • Future Outlook and Employee Integration: Biogen expects to integrate a significant portion of Apellis employees post-transaction, with plans to close the deal in Q2 2026, further enhancing the company's capabilities in treating kidney diseases with the anticipated launch of Felzartamab.
seekingalpha
8.5
12:12 PMseekingalpha
Apellis Pharmaceuticals Acquired by Biogen for $5.6 Billion
  • Acquisition Details: Apellis Pharmaceuticals has agreed to be acquired by Biogen for $41 per share, totaling $5.6 billion, with the deal expected to close in Q2 2026, reflecting Biogen's strong interest and confidence in the market.
  • Shareholder Value Enhancement: The transaction offers Apellis shareholders $41 in cash per share, representing an 86% premium over its 90-day volume-weighted average stock price, while also providing a nontransferable contingent value right worth $2 per share tied to Syfovre's net sales, further enhancing investment appeal.
  • Product Portfolio Expansion: The acquisition will add Apellis' Empaveli and Syfovre to Biogen's portfolio, which generated $689 million in revenue last year, expected to strengthen Biogen's competitive position in the ophthalmic drug market.
  • Financial Outlook Improvement: Biogen plans to fund the acquisition through a mix of cash and debt, anticipating an increase in its non-GAAP diluted EPS in 2027 and a compounded annual growth rate through 2030, indicating a positive impact on its long-term financial health.
stocktwits
8.5
12:10 PMstocktwits
Biogen Acquires Apellis Pharmaceuticals for $5.6 Billion
  • Acquisition Announcement: Biogen has agreed to acquire Apellis Pharmaceuticals for $5.6 billion, resulting in a 140% surge in Apellis' shares during Tuesday's pre-market trading, indicating strong market enthusiasm and a significant boost to Biogen's position in the rare disease treatment sector.
  • Retail Sentiment: Following the acquisition news, retail sentiment around Apellis on Stocktwits trended bullish with high message volumes, reflecting investor optimism about the company's future prospects, which could further drive up its stock price.
  • Business Expansion: This acquisition will enhance Biogen's rare disease treatment portfolio and accelerate its expansion into nephrology, signaling a strategic shift towards high-growth areas to capture increasing market demand.
  • Investor Attention: As the acquisition progresses, market focus on Apellis has intensified, with investors likely to closely monitor the integration process and its impact on Biogen's overall performance, suggesting potential future stock price volatility.
NASDAQ.COM
8.5
12:03 PMNASDAQ.COM
Biogen to Acquire Apellis for $5.6 Billion
  • Acquisition Agreement: Biogen has entered into a definitive agreement to acquire all outstanding shares of Apellis Pharmaceuticals for $41.00 per share in cash, totaling approximately $5.6 billion, reflecting Biogen's strong confidence in Apellis's future growth potential.
  • Additional Payment Structure: Apellis shareholders will receive a nontransferable CVR entitling them to two payments of $2 per share, contingent on meeting specific global net sales thresholds, which not only enhances shareholder potential returns but also incentivizes Apellis's performance.
  • Earnings Outlook Improvement: The acquisition is expected to significantly boost Biogen's non-GAAP EPS starting in 2027, with a compounded annual growth rate enhancing the company's profitability through the end of the decade, indicating a positive outlook for Biogen's future financial performance.
  • Positive Market Reaction: In pre-market trading on Nasdaq, Apellis shares surged 140.5% to $41.10, indicating a favorable market response to the acquisition, which may further strengthen Biogen's market position.
Fool
8.5
03-22Fool
RTW Investments Acquires Stake in Apellis Pharmaceuticals
  • New Investment Position: RTW Investments initiated a new stake in Apellis Pharmaceuticals during Q4 2026 by acquiring 7,666,764 shares valued at $192.59 million, reflecting a strategic confidence in the company.
  • Asset Allocation Insight: As of December 31, 2025, Apellis accounted for 1.93% of RTW's 13F reportable AUM, indicating its growing significance within the investment portfolio.
  • Market Performance Review: Despite a 29% decline in Apellis's stock price over the past year, currently priced at $17.21, the company generated approximately $689 million in product revenue last year, demonstrating strong demand in the rare disease market.
  • Strategic Investment Shift: RTW's portfolio is heavily weighted towards high-growth biotech firms, and the addition of Apellis is viewed as a calculated pivot towards more stable revenue streams, potentially offering investors a better risk-reward profile.
NASDAQ.COM
8.5
03-22NASDAQ.COM
RTW Investments Acquires Stake in Apellis Pharmaceuticals
  • New Investment Position: RTW Investments established a new position in Apellis Pharmaceuticals by acquiring 7,666,764 shares in Q4 2026, valued at $192.59 million, reflecting confidence in the company despite its 1.93% portfolio allocation.
  • Revenue Growth Potential: Apellis generated approximately $689 million in product revenue last year, with its flagship therapy contributing about $587 million, indicating strong demand and expanding market share in the rare disease sector.
  • Portfolio Diversification: RTW's portfolio is heavily weighted towards high-growth biotech firms like Madrigal and Insmed, while the sub-2% stake in Apellis suggests a strategic pivot towards more stable revenue streams without sacrificing upside potential.
  • Market Competitive Advantage: Apellis focuses on innovative therapies for complement-driven diseases, leveraging a robust pipeline and strategic collaborations to enhance its competitive position in the rare disease and specialty therapeutics market, despite its stock performance falling short of expectations.
Wall Street analysts forecast APLS stock price to rise
14 Analyst Rating
Wall Street analysts forecast APLS stock price to rise
9 Buy
5 Hold
0 Sell
Moderate Buy
Current: 0.000
sliders
Low
19.00
Averages
31.69
High
48.00
Current: 0.000
sliders
Low
19.00
Averages
31.69
High
48.00
Cantor Fitzgerald
Steve Seedhouse
Overweight
downgrade
$35 -> $31
AI Analysis
2026-03-18
Reason
Cantor Fitzgerald
Steve Seedhouse
Price Target
$35 -> $31
AI Analysis
2026-03-18
downgrade
Overweight
Reason
Cantor Fitzgerald analyst Steve Seedhouse lowered the firm's price target on Apellis to $31 from $35 and keeps an Overweight rating on the shares. The firm updated its model following the Q4 earnings report, including pruning estimates for both Syfovre and Empaveli, the analyst tells investors in a research note.
Roth Capital
Adam Walsh
initiated
$31
2026-03-13
Reason
Roth Capital
Adam Walsh
Price Target
$31
2026-03-13
initiated
Reason
Roth Capital analyst Adam Walsh initiated coverage of Apellis with a Buy rating and $31 price target. The firm sees strong underlying demand for Syfovre. A positive key opinion leader outlook supports a revenue inflection in fiscal 2027, the analyst tells investors in a research note. Roth believes investors are the company's pipeline for free at current share levels.
Unlock Full Analyst Thesis, Get the complete breakdown of rating reason for APLS
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Valuation Metrics

The current forward P/E ratio for Apellis Pharmaceuticals Inc (APLS.O) is -17.57, compared to its 5-year average forward P/E of -27.30. For a more detailed relative valuation and DCF analysis to assess Apellis Pharmaceuticals Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-27.30
Current PE
-17.57
Overvalued PE
7.14
Undervalued PE
-61.74

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-20.37
Current EV/EBITDA
-22.68
Overvalued EV/EBITDA
112.21
Undervalued EV/EBITDA
-152.94

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
5Y Average PS
25.02
Current PS
3.98
Overvalued PS
48.87
Undervalued PS
1.17

Financials

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Whales Holding APLS

A
Artal Group S.A.
Holding
APLS
+1.99%
3M Return
K
Kynam Capital Management, LP
Holding
APLS
-2.15%
3M Return
A
Avoro Capital Advisors LLC
Holding
APLS
-4.17%
3M Return
O
OrbiMed Advisors LLC
Holding
APLS
-5.14%
3M Return
R
RTW Investments, LP
Holding
APLS
-10.24%
3M Return
S
Suvretta Capital Management, LLC
Holding
APLS
-12.21%
3M Return

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Frequently Asked Questions

What is Apellis Pharmaceuticals Inc (APLS) stock price today?

The current price of APLS is 40.29 USD — it has increased 135.75

What is Apellis Pharmaceuticals Inc (APLS)'s business?

Apellis Pharmaceuticals, Inc. is a commercial-stage biopharmaceutical company. The Company is focused on the discovery, development and commercialization of novel therapeutic compounds to treat diseases with high unmet needs through the inhibition of the complement system. SYFOVRE (pegcetacoplan injection) is the Company’s approved treatment for geographic atrophy secondary to age-related macular degeneration (GA). Its EMPAVELI (pegcetacoplan) is for the treatment of paroxysmal nocturnal hemoglobinuria (PNH). Its Aspaveli (pegcetacoplan) for the treatment of adults with PNH who are anemic after treatment with a C5 inhibitor for at least three months. Systemic pegcetacoplan has also been approved for the treatment of PNH in Japan, Saudi Arabia, Australia, the United Kingdom and other jurisdictions. Systemic pegcetacoplan is marketed under the trade name EMPAVELI in the United States, Saudi Arabia and Australia and Aspaveli in the European Union, Japan and the United Kingdom.

What is the price predicton of APLS Stock?

Wall Street analysts forecast APLS stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for APLS is31.69 USD with a low forecast of 19.00 USD and a high forecast of 48.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Apellis Pharmaceuticals Inc (APLS)'s revenue for the last quarter?

Apellis Pharmaceuticals Inc revenue for the last quarter amounts to 199.91M USD, decreased -5.94

What is Apellis Pharmaceuticals Inc (APLS)'s earnings per share (EPS) for the last quarter?

Apellis Pharmaceuticals Inc. EPS for the last quarter amounts to -0.47 USD, increased 62.07

How many employees does Apellis Pharmaceuticals Inc (APLS). have?

Apellis Pharmaceuticals Inc (APLS) has 733 emplpoyees as of March 31 2026.

What is Apellis Pharmaceuticals Inc (APLS) market cap?

Today APLS has the market capitalization of 2.18B USD.