vTv Therapeutics Submits Phase 2 Trial Protocol for Cadisegliatin in Type 2 Diabetes
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Dec 18 2025
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Source: Newsfilter
- Clinical Trial Launch: vTv Therapeutics has submitted a Phase 2 clinical trial protocol in collaboration with M42 to the Abu Dhabi Department of Health, aimed at evaluating the safety and efficacy of cadisegliatin as an adjunct therapy to insulin, with approximately 300 type 2 diabetes patients expected to be enrolled over a 12-month period, demonstrating the company's ongoing commitment to diabetes treatment.
- Innovative Treatment Exploration: This study represents the longest investigation of cadisegliatin to date, utilizing a double-blind, randomized, placebo-controlled design where participants will be assigned to three groups receiving either 400 mg or 800 mg of cadisegliatin or a placebo, potentially offering new treatment options that could alter existing therapeutic paradigms.
- Geographic Expansion Potential: The trial will take place in the UAE, Jordan, and Tunisia, which is expected to broaden cadisegliatin's geographic footprint, particularly in the UAE where the prevalence of type 2 diabetes is among the highest globally, indicating significant market potential for the drug in this region.
- Strengthened Partnership: With vTv acting as the regulatory sponsor and M42 providing funding, this collaboration not only enhances the synergy between both parties in clinical research but also holds the promise of positively impacting millions of diabetes patients who struggle to maintain glycemic control.
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Analyst Views on VTVT
Wall Street analysts forecast VTVT stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for VTVT is 51.33 USD with a low forecast of 40.00 USD and a high forecast of 67.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
3 Analyst Rating
3 Buy
0 Hold
0 Sell
Strong Buy
Current: 34.150
Low
40.00
Averages
51.33
High
67.00
Current: 34.150
Low
40.00
Averages
51.33
High
67.00
About VTVT
vTv Therapeutics Inc. is a clinical-stage biopharmaceutical company focused on the development of orally administered treatments for metabolic and inflammatory diseases. Its product pipeline includes TTP399, TTP273, HPP737 and HPP593. The lead product candidate, cadisegliatin (TTP399), is an orally administered, small-molecule, liver-selective glucokinase activator (GKA) that is a potential adjunctive therapy to insulin for the treatment of type 1 diabetes (T1D). HPP737 is an orally administered, non-central nervous system (non-CNS) penetrant phosphodiesterase type 4 (PDE4) inhibitor that addresses inflammatory diseases and offers the potential for an improved tolerability profile and efficacy over commercially available PDE4 inhibitors. TTP273 is an oral, small molecule, glucagon-like peptide 1 (GLP-1) receptor agonist being evaluated for the treatment of type 2 diabetes mellitus. Its product pipeline also includes Azeliragon and HPP3033.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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