vTv Therapeutics Submits Phase 2 Study Protocol for Cadisegliatin in Type 2 Diabetes
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Dec 18 2025
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Source: Globenewswire
- Clinical Trial Launch: vTv Therapeutics has submitted a Phase 2 clinical study protocol, developed in collaboration with M42, to the Abu Dhabi Department of Health, aimed at evaluating the safety and efficacy of cadisegliatin as an adjunctive therapy to insulin, with approximately 300 type 2 diabetes patients expected to be enrolled over a 12-month period, marking a significant advancement in the drug's research.
- Multinational Trial Setup: The trial will take place in the UAE, Jordan, and Tunisia, with the first patient expected to be enrolled in Q1 2026, aiming to expand cadisegliatin's geographic footprint and enhance its competitiveness in the global market.
- Market Potential Assessment: Given the high prevalence of type 2 diabetes among UAE nationals, cadisegliatin is poised to play a crucial role in glucose management for millions of patients, indicating a broad market application potential.
- Funding Support and Regulatory Role: vTv serves as the regulatory sponsor while M42 provides funding, a collaborative model that not only reduces R&D costs but also accelerates the clinical trial process, further strengthening vTv's strategic position in the diabetes treatment landscape.
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Analyst Views on VTVT
Wall Street analysts forecast VTVT stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for VTVT is 51.33 USD with a low forecast of 40.00 USD and a high forecast of 67.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
3 Analyst Rating
3 Buy
0 Hold
0 Sell
Strong Buy
Current: 34.150
Low
40.00
Averages
51.33
High
67.00
Current: 34.150
Low
40.00
Averages
51.33
High
67.00
About VTVT
vTv Therapeutics Inc. is a clinical-stage biopharmaceutical company focused on the development of orally administered treatments for metabolic and inflammatory diseases. Its product pipeline includes TTP399, TTP273, HPP737 and HPP593. The lead product candidate, cadisegliatin (TTP399), is an orally administered, small-molecule, liver-selective glucokinase activator (GKA) that is a potential adjunctive therapy to insulin for the treatment of type 1 diabetes (T1D). HPP737 is an orally administered, non-central nervous system (non-CNS) penetrant phosphodiesterase type 4 (PDE4) inhibitor that addresses inflammatory diseases and offers the potential for an improved tolerability profile and efficacy over commercially available PDE4 inhibitors. TTP273 is an oral, small molecule, glucagon-like peptide 1 (GLP-1) receptor agonist being evaluated for the treatment of type 2 diabetes mellitus. Its product pipeline also includes Azeliragon and HPP3033.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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