The Implied Analyst 12-Month Target For TMSL
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Aug 05 2025
0mins
Source: NASDAQ.COM
ETF Analysis: The T. Rowe Price Small - Mid Cap ETF (TMSL) has an implied analyst target price of $39.15, indicating a potential upside of 17.84% from its current trading price of $33.22.
Stock Performance Insights: Notable underlying holdings with significant upside include Alkermes plc (ALKS), monday.com Ltd (MNDY), and Skyward Specialty Insurance Group Inc (SKWD), each showing potential increases of 53.23%, 40.33%, and 26.20% respectively based on analyst targets.
Trade with 70% Backtested Accuracy
Stop guessing "Should I Buy ALKS?" and start using high-conviction signals backed by rigorous historical data.
Sign up today to access powerful investing tools and make smarter, data-driven decisions.
Analyst Views on ALKS
Wall Street analysts forecast ALKS stock price to rise
12 Analyst Rating
10 Buy
2 Hold
0 Sell
Strong Buy
Current: 44.090
Low
37.00
Averages
46.20
High
58.00
Current: 44.090
Low
37.00
Averages
46.20
High
58.00
About ALKS
Alkermes plc is an Ireland-based global biopharmaceutical company that seeks to develop medicines in the field of neuroscience. The Company has a portfolio of commercial products for the treatment of alcohol dependence, opioid dependence, schizophrenia, bipolar I disorder and narcolepsy. Its pipeline includes late-stage clinical candidates in development for narcolepsy and idiopathic hypersomnia, and orexin 2 receptor agonists in early clinical development for other neurological disorders, including attention-deficit hyperactivity disorder (ADHD) and fatigue associated with multiple sclerosis and Parkinson’s disease. The Company's pipeline includes Olanzapine and samidorphan, Alixorexton, ALKS 4510, ALKS 7290, and Valiloxybate. Its LUMRYZ (sodium oxybate) for extended-release oral suspension is a central nervous system depressant indicated for the treatment of cataplexy or excessive daytime sleepiness (EDS) in patients seven years of age and older with narcolepsy.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
Alkermes Receives Orphan Drug Designation for Alixorexton
- Orphan Drug Designation: Alkermes' alixorexton has received orphan drug designation from the FDA for idiopathic hypersomnia, marking a significant milestone in the drug development process that could expedite market access.
- European Commission Approval: The drug also received orphan drug designation from the European Commission for narcolepsy treatment, which will aid the company's expansion in the European market and enhance its international competitiveness.
- Clinical Trial Progress: Alkermes is currently enrolling patients in the phase 3 Brilliance Studies and completing the phase 2 Vibrance-3 study for alixorexton, with completion expected this year, which could lead to potential revenue growth for the company.
- Market Reaction: Alkermes shares are down 0.18% to $44.20 in pre-market trading on Nasdaq, reflecting a cautious market response to the drug development progress, which may impact investor confidence.
See More
Alkermes Receives FDA Orphan Drug Designation
- Orphan Drug Designation: The US FDA has granted orphan drug designation to Alkermes' alixorexton for idiopathic hypersomnia, highlighting the company's innovative potential in the sleep medicine sector.
- Drug Development Stage: Alixorexton is currently in phase 2 clinical trials as an oral orexin 2 receptor agonist, aimed at alleviating daytime sleepiness symptoms, which could introduce a new treatment option to the market.
- Market Demand Context: Idiopathic hypersomnia is characterized by difficulty waking up in the morning and extreme daytime sleepiness, and as awareness of sleep health increases, the successful development of this drug will meet the growing market demand.
- Strategic Company Implications: The FDA's orphan drug designation not only enhances Alkermes' reputation in the sleep medicine field but may also provide funding and market support for its future commercialization efforts, strengthening its competitive position in the CNS pharmaceutical market.
See More
Alkermes' Lumryz Achieves Key Trial Milestone for Sleep Disorder
- Trial Success: Alkermes announced that its sleep disorder therapy Lumryz met the primary goal in a late-stage trial for idiopathic hypersomnia, with patients showing statistically significant improvements in excessive daytime sleepiness, indicating strong market potential for the drug.
- Safety Profile Confirmed: The Revitalyz study reaffirmed Lumryz's safety profile consistent with prior data, with no new safety signals reported, which supports its future market rollout and mitigates regulatory risks.
- Future Plans: Alkermes intends to present the trial data at an upcoming medical event and plans to submit a supplemental new drug application by the end of 2026 to seek label expansion for Lumryz in the U.S., further enhancing its competitive position.
- Market Potential: With increasing demand for treatments for idiopathic hypersomnia, Alkermes' Lumryz is poised to play a significant role in the sleep medicine sector, driving future revenue growth and market share expansion for the company.
See More
Alkermes Q1 Earnings Announcement Scheduled
- Earnings Release Date: Alkermes is set to announce its Q1 earnings on May 5 before market open, with a consensus EPS estimate of -$0.04, reflecting a significant year-over-year decline of 130.8%, indicating potential profitability challenges for the company.
- Revenue Expectations: The anticipated revenue for Q1 is $361.38 million, representing a 17.9% year-over-year increase, suggesting that despite challenges, Alkermes may still exhibit revenue growth potential, possibly reflecting stable product demand.
- Historical Performance Review: Over the past year, Alkermes has only beaten EPS estimates 25% of the time while exceeding revenue estimates 75% of the time, indicating relative stability in revenue but a need for improvement in profitability.
- Estimate Revision Trends: In the last three months, EPS estimates have seen no upward or downward revisions, while revenue estimates experienced 10 upward and 6 downward revisions, indicating market divergence in expectations for the company's future revenue.
See More
Analysis of XBI ETF Trading Dynamics
- Price Range Fluctuation: The XBI ETF has a 52-week low of $66.66 and a high of $132.09, with the current trading price at $127.30, indicating significant volatility over the past year that may influence investor buying decisions.
- Technical Analysis Tool: Comparing the current share price to the 200-day moving average provides investors with deeper market trend insights, aiding in the formulation of more effective trading strategies to enhance investment returns.
- ETF Unit Trading Mechanism: ETFs trade like stocks, where investors buy and sell 'units' that can be created or destroyed based on demand, offering flexibility that makes ETFs an effective tool for portfolio management.
- Inflows and Outflows Monitoring: Weekly monitoring of changes in shares outstanding helps track notable inflows (new units created) or outflows (old units destroyed), which directly impacts the underlying holdings of the ETF and consequently affects overall market performance.
See More
Alkermes Shares Surge 15% Following Lilly-Centessa Deal
- Clinical Trial Progress: Alkermes' alixorexton demonstrated statistically significant improvements in wakefulness during mid-stage studies compared to placebo, indicating its potential in treating narcolepsy and attracting interest from large pharma companies.
- Positive Market Reaction: Following Eli Lilly's acquisition of Centessa, Alkermes shares surged 15%, reflecting market optimism regarding its prospects in the sleep disorder space, particularly with its developing orexin 2 receptor drug.
- Analyst Outlook: RBC Capital highlighted that the Lilly-Centessa deal underscores large pharma interest in the sleep sector, assigning Alkermes an 'Outperform' rating with a $45 price target, suggesting the stock is undervalued based on its orexin program alone.
- Retail Investor Sentiment Shift: On Stocktwits, retail sentiment around Alkermes stock shifted from 'neutral' to 'bullish' in the past 24 hours, with message volume increasing from 'low' to 'normal' levels, indicating rising interest in the stock.
See More
Alkermes Receives Orphan Drug Designation for Alixorexton
- Orphan Drug Designation: Alkermes' alixorexton has received orphan drug designation from the FDA for idiopathic hypersomnia, marking a significant milestone in the drug development process that could expedite market access.
- European Commission Approval: The drug also received orphan drug designation from the European Commission for narcolepsy treatment, which will aid the company's expansion in the European market and enhance its international competitiveness.
- Clinical Trial Progress: Alkermes is currently enrolling patients in the phase 3 Brilliance Studies and completing the phase 2 Vibrance-3 study for alixorexton, with completion expected this year, which could lead to potential revenue growth for the company.
- Market Reaction: Alkermes shares are down 0.18% to $44.20 in pre-market trading on Nasdaq, reflecting a cautious market response to the drug development progress, which may impact investor confidence.
See More
Alkermes Receives FDA Orphan Drug Designation
- Orphan Drug Designation: The US FDA has granted orphan drug designation to Alkermes' alixorexton for idiopathic hypersomnia, highlighting the company's innovative potential in the sleep medicine sector.
- Drug Development Stage: Alixorexton is currently in phase 2 clinical trials as an oral orexin 2 receptor agonist, aimed at alleviating daytime sleepiness symptoms, which could introduce a new treatment option to the market.
- Market Demand Context: Idiopathic hypersomnia is characterized by difficulty waking up in the morning and extreme daytime sleepiness, and as awareness of sleep health increases, the successful development of this drug will meet the growing market demand.
- Strategic Company Implications: The FDA's orphan drug designation not only enhances Alkermes' reputation in the sleep medicine field but may also provide funding and market support for its future commercialization efforts, strengthening its competitive position in the CNS pharmaceutical market.
See More
Alkermes' Lumryz Achieves Key Trial Milestone for Sleep Disorder
- Trial Success: Alkermes announced that its sleep disorder therapy Lumryz met the primary goal in a late-stage trial for idiopathic hypersomnia, with patients showing statistically significant improvements in excessive daytime sleepiness, indicating strong market potential for the drug.
- Safety Profile Confirmed: The Revitalyz study reaffirmed Lumryz's safety profile consistent with prior data, with no new safety signals reported, which supports its future market rollout and mitigates regulatory risks.
- Future Plans: Alkermes intends to present the trial data at an upcoming medical event and plans to submit a supplemental new drug application by the end of 2026 to seek label expansion for Lumryz in the U.S., further enhancing its competitive position.
- Market Potential: With increasing demand for treatments for idiopathic hypersomnia, Alkermes' Lumryz is poised to play a significant role in the sleep medicine sector, driving future revenue growth and market share expansion for the company.
See More
Alkermes Q1 Earnings Announcement Scheduled
- Earnings Release Date: Alkermes is set to announce its Q1 earnings on May 5 before market open, with a consensus EPS estimate of -$0.04, reflecting a significant year-over-year decline of 130.8%, indicating potential profitability challenges for the company.
- Revenue Expectations: The anticipated revenue for Q1 is $361.38 million, representing a 17.9% year-over-year increase, suggesting that despite challenges, Alkermes may still exhibit revenue growth potential, possibly reflecting stable product demand.
- Historical Performance Review: Over the past year, Alkermes has only beaten EPS estimates 25% of the time while exceeding revenue estimates 75% of the time, indicating relative stability in revenue but a need for improvement in profitability.
- Estimate Revision Trends: In the last three months, EPS estimates have seen no upward or downward revisions, while revenue estimates experienced 10 upward and 6 downward revisions, indicating market divergence in expectations for the company's future revenue.
See More
Analysis of XBI ETF Trading Dynamics
- Price Range Fluctuation: The XBI ETF has a 52-week low of $66.66 and a high of $132.09, with the current trading price at $127.30, indicating significant volatility over the past year that may influence investor buying decisions.
- Technical Analysis Tool: Comparing the current share price to the 200-day moving average provides investors with deeper market trend insights, aiding in the formulation of more effective trading strategies to enhance investment returns.
- ETF Unit Trading Mechanism: ETFs trade like stocks, where investors buy and sell 'units' that can be created or destroyed based on demand, offering flexibility that makes ETFs an effective tool for portfolio management.
- Inflows and Outflows Monitoring: Weekly monitoring of changes in shares outstanding helps track notable inflows (new units created) or outflows (old units destroyed), which directly impacts the underlying holdings of the ETF and consequently affects overall market performance.
See More
Alkermes Shares Surge 15% Following Lilly-Centessa Deal
- Clinical Trial Progress: Alkermes' alixorexton demonstrated statistically significant improvements in wakefulness during mid-stage studies compared to placebo, indicating its potential in treating narcolepsy and attracting interest from large pharma companies.
- Positive Market Reaction: Following Eli Lilly's acquisition of Centessa, Alkermes shares surged 15%, reflecting market optimism regarding its prospects in the sleep disorder space, particularly with its developing orexin 2 receptor drug.
- Analyst Outlook: RBC Capital highlighted that the Lilly-Centessa deal underscores large pharma interest in the sleep sector, assigning Alkermes an 'Outperform' rating with a $45 price target, suggesting the stock is undervalued based on its orexin program alone.
- Retail Investor Sentiment Shift: On Stocktwits, retail sentiment around Alkermes stock shifted from 'neutral' to 'bullish' in the past 24 hours, with message volume increasing from 'low' to 'normal' levels, indicating rising interest in the stock.
See More
