Intellia Halts Major Trial Following Severe Liver Incident, Shares Plummet
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Oct 27 2025
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Source: Benzinga
Trial Pause: Intellia Therapeutics has paused patient dosing and screening in its Phase 3 MAGNITUDE trials for its CRISPR therapy, nexiguran ziclumeran (nex-z), due to a serious liver-related adverse event in a participant.
Patient Safety Commitment: The company is working with regulators and medical experts to assess the incident, emphasizing its commitment to patient safety and planning to safely resume enrollment.
Promising Phase 1 Results: Long-term follow-up data from a Phase 1 trial showed significant reductions in transthyretin protein levels and improvements in neuropathy scores among patients treated with nex-z.
Market Impact: Following the announcement of the trial pause, Intellia's shares fell by over 43%, reflecting investor concerns about the implications for the ongoing MAGNITUDE trials.
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Analyst Views on CRSP
Wall Street analysts forecast CRSP stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for CRSP is 68.88 USD with a low forecast of 40.00 USD and a high forecast of 105.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
18 Analyst Rating
11 Buy
7 Hold
0 Sell
Moderate Buy
Current: 53.690
Low
40.00
Averages
68.88
High
105.00
Current: 53.690
Low
40.00
Averages
68.88
High
105.00
About CRSP
CRISPR Therapeutics AG is a Switzerland-based gene editing company focused on the development of CRISPR/Cas9-based therapeutics. CRISPR/Cas9 stands for Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) and is a technology for gene editing, the process of precisely altering specific sequences of genomic DNA. The Company aims to apply this technology to disrupt, delete, correct and insert genes to treat genetically-defined diseases and to engineer advanced cellular therapies. The Company has acquired the rights to the intellectual property (IP) encompassing CRISPR/Cas9 and related technologies and is also involved in its own IP research and additional in-licensing efforts. The Company product development and partnership strategies are designed to exploit the full potential of the CRISPR/Cas9 platform while maximizing the probability of successfully developing their product candidates.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
CRISPR Therapeutics: A Promising Biotech Investment
- Gene Editing Potential: CRISPR Therapeutics focuses on developing therapies for hard-to-treat diseases, with CTX211 aiming to restore insulin production in Type 1 diabetes patients, which could significantly enhance patient quality of life and open new market opportunities.
- Anticoagulant Innovation: SRSD107 is designed to address the side effects of existing anticoagulants, and if successful, it could provide a safer treatment option for 40 million high-risk patients, potentially transforming the anticoagulant market landscape.
- Cholesterol Management: The development of CTX310 aims to lower LDL cholesterol and triglycerides, targeting a vast market of 40 million patients; if it can achieve one-time treatment, it will greatly enhance patient compliance and reduce long-term healthcare costs.
- Market Risk Consideration: While CRISPR Therapeutics presents high return potential, clinical and regulatory risks could impact stock prices, necessitating careful evaluation of market acceptance and associated costs of its gene-editing therapies by investors.
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Wall Street Focuses on Earnings and Commodity Prices
- Earnings Impact: Meta's strong sales forecast and $100 billion AI investment plan drove its stock up in after-hours trading, while Microsoft fell due to slowing cloud growth and soft margin guidance, indicating a divergence in market sentiment towards tech stocks.
- Commodity Market Fluctuations: Gold prices nearing $5600 and silver surpassing $120 reflect investors' demand for safe-haven assets amid economic uncertainty, simultaneously boosting trading volumes in related ETFs like GLD and SLV.
- Market Sentiment: Despite Nasdaq and S&P 500 futures rising by 0.4% and 0.3% respectively, retail sentiment towards SPY and QQQ remains extremely bearish, suggesting ongoing investor concerns about market outlook.
- Upcoming Earnings Reports: Investors are keenly awaiting Apple's earnings report, particularly for insights on iPhone demand and AI roadmap updates, while Western Digital and SanDisk are also set to report today, potentially impacting the data storage sector.
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