Galmed announces significant findings from AM-001 study of Aramchol meglumine
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Nov 18 2025
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Study Results: Galmed Pharmaceuticals reported significant top-line results from the AM-001 Phase 1 Bioavailability Study of Aramchol meglumine, showing that its bioavailability (BA) is significantly higher than that of Aramchol free acid tablets.
Dosing Insights: The study indicated that the BA of 400mg and 200mg Aramchol meglumine granules was approximately 5-fold and 3-fold greater, respectively, compared to the 300 mg Aramchol free acid tablets.
Clinical Progress: Galmed has successfully advanced Aramchol through six clinical trials, including Phase 3, with a total of 661 patients enrolled, demonstrating its safety and efficacy in treating NASH.
Regulatory Pathway: To date, 82 healthy subjects have received Aramchol meglumine under a clinical trial application in the UK, as part of the IND 505(b)1 regulatory pathway.
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About GLMD
Galmed Pharmaceuticals Ltd. is an Israel-based biopharmaceutical company dedicated to the development of therapeutics for the treatment of liver diseases. The Company is focused its research and development efforts on addressing unmet medical needs in the field of liver health. The Company's flagship product is Aramchol, a first-in-class synthetic fatty acid-bile acid conjugate molecule. Aramchol is aimed to be effective in the treatment of non-alcoholic steatohepatitis (NASH) in patients who are overweight or obese and have prediabetes or type II diabetes mellitus. The Company's drug aims to be efficient treatment of NASH, a chronic liver disease characterized by fat accumulation, inflammation, and fibrosis, which can lead to cirrhosis and liver cancer if left untreated.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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