Alnylam (ALNY) Rises 6.0%: Could This Signal More Upside Ahead?
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Sep 10 2025
0mins
Should l Buy ALNY?
Source: NASDAQ.COM
Alnylam Pharmaceuticals Stock Performance: Alnylam Pharmaceuticals (ALNY) shares rose 6% to $482.13, driven by strong sales of its drug Amvuttra, which saw an 89% year-over-year growth, generating $801.9 million in global sales. The company is expected to report a quarterly earnings increase of 378% year-over-year.
Earnings Estimate Revisions: The consensus EPS estimate for Alnylam has been revised 46.4% higher in the last 30 days, indicating a positive trend that often correlates with stock price appreciation. The stock currently holds a Zacks Rank of #3 (Hold).
Foghorn Therapeutics Overview: Foghorn Therapeutics (FHTX) experienced a 5.6% decline in its stock price, with a consensus EPS estimate change of +6.7% for the upcoming report, reflecting a year-over-year change of +12.9%. It currently has a Zacks Rank of #2 (Buy).
AI Investment Insights: The article discusses the potential for significant wealth creation in the next phase of AI, suggesting that early investors in emerging companies may benefit as the growth of current AI stocks levels off. Zacks' report highlights four under-the-radar companies poised for success in AI's next wave.
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Analyst Views on ALNY
Wall Street analysts forecast ALNY stock price to rise
17 Analyst Rating
14 Buy
3 Hold
0 Sell
Strong Buy
Current: 295.910
Low
351.00
Averages
479.53
High
580.00
Current: 295.910
Low
351.00
Averages
479.53
High
580.00
About ALNY
Alnylam Pharmaceuticals, Inc. is a commercial-stage biopharmaceutical company. The Company is engaged in discovering, developing, manufacturing and commercializing novel therapeutics based on ribonucleic acid interference (RNAi). Its marketed products include AMVUTTRA (vutrisiran) for the treatment of the polyneuropathy of hereditary transthyretin-mediated amyloidosis (hATTR) in adults ; ONPATTRO (patisiran) for the treatment of the polyneuropathy of hATTR amyloidosis in adults; GIVLAARI (givosiran) for the treatment of adults with acute hepatic porphyria; OXLUMO (lumasiran) for the treatment of primary hyperoxaluria type 1, and Leqvio (inclisiran), which is being developed and commercialized by its partner, Novartis AG, for the treatment of adults with hypercholesterolemia or mixed dyslipidemia. The Company’s clinical development programs include Cemdisiran, Zilebesiran, Elebsiran, Mivelsiran, ALN-6400, and ALN-HTT02. It is developing Cemdisiran to treat complement-mediated diseases.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
Alnylam to Present New Vutrisiran Data at Heart Failure 2026
- New Data Presentation: Alnylam Pharmaceuticals will present new data analyses for vutrisiran at the Heart Failure 2026 congress in Barcelona from May 9-12, 2026, further supporting its efficacy as a first-line treatment for patients with cardiomyopathy.
- Clinical Study Validation: The HELIOS-B study demonstrates vutrisiran's adaptability to patients with high disease burden, indicating its potential value in complex clinical scenarios, which may enhance treatment options for patients.
- Global Observational Study: Alnylam will also introduce the design of the DemonsTTRate study, aimed at evaluating the real-world use of vutrisiran, emphasizing the company's commitment to long-term efficacy and potentially providing critical data for future clinical practices.
- Safety Analysis: The congress will showcase a safety analysis of vutrisiran related to vitamin A, assessing adverse reactions in clinical trials and real-world datasets, ensuring patient safety and treatment effectiveness during administration.
See More
Alnylam Pharmaceuticals Q1 Results Exceed Expectations
- Performance Beat: Alnylam Pharmaceuticals reported Q1 revenue of $1.2 billion, exceeding forecasts by 4.5%, with earnings per share (EPS) at $1.51, 67% above expectations, indicating strong financial performance that boosts investor confidence.
- Future Growth Outlook: Analysts forecast revenues of $5.61 billion in 2026, reflecting a 31% increase from the past 12 months, with EPS expected to soar 86% to $7.51, showcasing a more bullish sentiment towards the company's earnings potential.
- Stable Price Target: Despite the improved earnings outlook, the consensus price target remains unchanged at $449, suggesting that the market does not anticipate significant long-term value creation, prompting investors to consider diverse valuation opinions.
- Industry Growth Comparison: Alnylam is projected to achieve an annualized growth rate of 43% by 2026, significantly outpacing the 21% growth forecast for similar companies, highlighting its competitive advantage and market potential in the biopharmaceutical sector.
See More
Alnylam Pharmaceuticals Q1 2026 Earnings Call Highlights
- Significant Revenue Growth: Alnylam reported over $1 billion in global net product revenues for Q1 2026, with TTR revenue reaching $910 million, indicating strong performance in the TTR market and supporting the achievement of the annual sales guidance of $4.4 billion to $4.7 billion.
- Strategic Collaboration Expansion: CEO Yvonne Greenstreet highlighted new partnerships aimed at enhancing TTR disease awareness and diagnosis, reflecting Alnylam's pursuit of global leadership under its 'Alnylam 2030' strategy, which focuses on sustainable innovation for business growth.
- Increased R&D Spending: CFO Jeffrey Poulton reported non-GAAP R&D expenses of $335 million, a 39% increase, indicating ongoing investment in research and development, while maintaining profitability, showcasing confidence in future product development.
- Market Dynamics Analysis: Management emphasized that despite challenges from German pricing adjustments and U.S. insurance reauthorizations, Q1 results were consistent with expectations, demonstrating the company's flexibility and adaptability in navigating market fluctuations.
See More
Alnylam Pharmaceuticals Q1 Earnings Exceed Expectations
- Strong Earnings Report: Alnylam Pharmaceuticals reported a Q1 non-GAAP EPS of $1.99, beating expectations by $0.52, which highlights the company's improved profitability and boosts investor confidence.
- Revenue Surge: The company achieved Q1 revenue of $1.17 billion, representing a 96.9% year-over-year increase and exceeding market expectations by $50 million, reflecting robust demand and sales performance for its products.
- Guidance Reaffirmation: Alnylam reiterated its 2026 financial guidance, projecting combined net product revenues between $4.9 billion and $5.3 billion, and total TTR net product revenues between $4.4 billion and $4.7 billion, indicating strong confidence in future growth.
- Market Strategy: Alnylam has made progress in transforming ATTR amyloidosis care and expanding its TTR franchise, demonstrating its strategic decision-making capabilities in innovative drug development and market expansion.
See More
Alnylam Pharmaceuticals Q1 Earnings Announcement Scheduled
- Earnings Release Date: Alnylam Pharmaceuticals is set to announce its Q1 2023 earnings on April 30 before market open, with consensus EPS estimate at $0.91 and revenue expected to reach $1.12 billion, reflecting an impressive 88.5% year-over-year growth, marking a critical performance indicator for the company.
- Performance Expectations: Over the past two years, Alnylam has beaten EPS and revenue estimates 63% of the time, indicating stability in managing market expectations, although recent revisions show 7 downward adjustments for EPS and 12 for revenue in the last three months.
- Market Reaction: Despite the optimistic outlook, analysts caution that Alnylam's current valuation may still appear overvalued, urging investors to carefully assess the balance between long-term growth potential and short-term performance volatility.
- Strategic Partnership Progress: Alnylam's research pact with Tenaya, valued at up to $1.1 billion, underscores the company's ongoing innovation in treating ATTR amyloidosis and its strategy to expand the TTR franchise, potentially supporting future revenue growth.
See More
ETF Analysis: FDG Implies 18.96% Upside Potential
- FDG ETF Potential: The American Century Focused Dynamic Growth ETF (FDG) has an implied analyst target price of $152.53 per unit, while trading at $128.22, indicating an 18.96% upside potential that reflects market optimism about the ETF's future performance.
- HubSpot Price Analysis: HubSpot Inc (HUBS) is currently priced at $214.69, with an analyst target of $336.16, suggesting a significant 56.58% upside, indicating analysts' positive outlook on its growth prospects.
- Reddit Investment Outlook: Reddit Inc (RDDT) trades at $152.96, with a target price of $223.03, representing a 45.81% potential increase, reflecting market confidence in its business outlook.
- Alnylam Growth Expectations: Alnylam Pharmaceuticals Inc (ALNY) is priced at $313.79, with an analyst target of $450.22, indicating a 43.48% upside, showcasing analysts' optimism regarding its future performance.
See More
Alnylam to Present New Vutrisiran Data at Heart Failure 2026
- New Data Presentation: Alnylam Pharmaceuticals will present new data analyses for vutrisiran at the Heart Failure 2026 congress in Barcelona from May 9-12, 2026, further supporting its efficacy as a first-line treatment for patients with cardiomyopathy.
- Clinical Study Validation: The HELIOS-B study demonstrates vutrisiran's adaptability to patients with high disease burden, indicating its potential value in complex clinical scenarios, which may enhance treatment options for patients.
- Global Observational Study: Alnylam will also introduce the design of the DemonsTTRate study, aimed at evaluating the real-world use of vutrisiran, emphasizing the company's commitment to long-term efficacy and potentially providing critical data for future clinical practices.
- Safety Analysis: The congress will showcase a safety analysis of vutrisiran related to vitamin A, assessing adverse reactions in clinical trials and real-world datasets, ensuring patient safety and treatment effectiveness during administration.
See More
Alnylam Pharmaceuticals Q1 Results Exceed Expectations
- Performance Beat: Alnylam Pharmaceuticals reported Q1 revenue of $1.2 billion, exceeding forecasts by 4.5%, with earnings per share (EPS) at $1.51, 67% above expectations, indicating strong financial performance that boosts investor confidence.
- Future Growth Outlook: Analysts forecast revenues of $5.61 billion in 2026, reflecting a 31% increase from the past 12 months, with EPS expected to soar 86% to $7.51, showcasing a more bullish sentiment towards the company's earnings potential.
- Stable Price Target: Despite the improved earnings outlook, the consensus price target remains unchanged at $449, suggesting that the market does not anticipate significant long-term value creation, prompting investors to consider diverse valuation opinions.
- Industry Growth Comparison: Alnylam is projected to achieve an annualized growth rate of 43% by 2026, significantly outpacing the 21% growth forecast for similar companies, highlighting its competitive advantage and market potential in the biopharmaceutical sector.
See More
Alnylam Pharmaceuticals Q1 2026 Earnings Call Highlights
- Significant Revenue Growth: Alnylam reported over $1 billion in global net product revenues for Q1 2026, with TTR revenue reaching $910 million, indicating strong performance in the TTR market and supporting the achievement of the annual sales guidance of $4.4 billion to $4.7 billion.
- Strategic Collaboration Expansion: CEO Yvonne Greenstreet highlighted new partnerships aimed at enhancing TTR disease awareness and diagnosis, reflecting Alnylam's pursuit of global leadership under its 'Alnylam 2030' strategy, which focuses on sustainable innovation for business growth.
- Increased R&D Spending: CFO Jeffrey Poulton reported non-GAAP R&D expenses of $335 million, a 39% increase, indicating ongoing investment in research and development, while maintaining profitability, showcasing confidence in future product development.
- Market Dynamics Analysis: Management emphasized that despite challenges from German pricing adjustments and U.S. insurance reauthorizations, Q1 results were consistent with expectations, demonstrating the company's flexibility and adaptability in navigating market fluctuations.
See More
Alnylam Pharmaceuticals Q1 Earnings Exceed Expectations
- Strong Earnings Report: Alnylam Pharmaceuticals reported a Q1 non-GAAP EPS of $1.99, beating expectations by $0.52, which highlights the company's improved profitability and boosts investor confidence.
- Revenue Surge: The company achieved Q1 revenue of $1.17 billion, representing a 96.9% year-over-year increase and exceeding market expectations by $50 million, reflecting robust demand and sales performance for its products.
- Guidance Reaffirmation: Alnylam reiterated its 2026 financial guidance, projecting combined net product revenues between $4.9 billion and $5.3 billion, and total TTR net product revenues between $4.4 billion and $4.7 billion, indicating strong confidence in future growth.
- Market Strategy: Alnylam has made progress in transforming ATTR amyloidosis care and expanding its TTR franchise, demonstrating its strategic decision-making capabilities in innovative drug development and market expansion.
See More
Alnylam Pharmaceuticals Q1 Earnings Announcement Scheduled
- Earnings Release Date: Alnylam Pharmaceuticals is set to announce its Q1 2023 earnings on April 30 before market open, with consensus EPS estimate at $0.91 and revenue expected to reach $1.12 billion, reflecting an impressive 88.5% year-over-year growth, marking a critical performance indicator for the company.
- Performance Expectations: Over the past two years, Alnylam has beaten EPS and revenue estimates 63% of the time, indicating stability in managing market expectations, although recent revisions show 7 downward adjustments for EPS and 12 for revenue in the last three months.
- Market Reaction: Despite the optimistic outlook, analysts caution that Alnylam's current valuation may still appear overvalued, urging investors to carefully assess the balance between long-term growth potential and short-term performance volatility.
- Strategic Partnership Progress: Alnylam's research pact with Tenaya, valued at up to $1.1 billion, underscores the company's ongoing innovation in treating ATTR amyloidosis and its strategy to expand the TTR franchise, potentially supporting future revenue growth.
See More
ETF Analysis: FDG Implies 18.96% Upside Potential
- FDG ETF Potential: The American Century Focused Dynamic Growth ETF (FDG) has an implied analyst target price of $152.53 per unit, while trading at $128.22, indicating an 18.96% upside potential that reflects market optimism about the ETF's future performance.
- HubSpot Price Analysis: HubSpot Inc (HUBS) is currently priced at $214.69, with an analyst target of $336.16, suggesting a significant 56.58% upside, indicating analysts' positive outlook on its growth prospects.
- Reddit Investment Outlook: Reddit Inc (RDDT) trades at $152.96, with a target price of $223.03, representing a 45.81% potential increase, reflecting market confidence in its business outlook.
- Alnylam Growth Expectations: Alnylam Pharmaceuticals Inc (ALNY) is priced at $313.79, with an analyst target of $450.22, indicating a 43.48% upside, showcasing analysts' optimism regarding its future performance.
See More
