Biotech Stocks Surge in After-Hours Trading Following Trial News, Insider Purchases, and Conference Excitement
Biotech Stock Movements: Several small- and mid-cap biotech stocks experienced significant gains in after-hours trading on September 9, 2025, driven by clinical updates, insider buying, and upcoming investor conferences, with notable performances from Immutep, Nautilus Biotechnology, and Pliant Therapeutics.
Immutep's Clinical Trial Update: Immutep's shares rose 4.37% after announcing that data from its Phase II trial for eftilagimod alpha will be presented at the CTOS 2025 conference, focusing on a rare cancer with high unmet need.
Nautilus Biotechnology Insider Buying: Nautilus Biotechnology's stock surged 12.25% following CEO Sujal M. Patel's significant insider purchases, indicating confidence in the company's future, alongside participation in an upcoming investor conference.
Kura Oncology's Regulatory Milestones: Kura Oncology's shares increased 6.12% after presenting at the H.C. Wainwright conference, highlighting key developments and upcoming regulatory milestones for its menin inhibitor targeting acute myeloid leukemia.
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Immutep's First LAG-3 Antibody Trial Shows Positive Phase I Results
- Clinical Trial Progress: Immutep's IMP761 has completed the 2.5 and 7 mg/kg dosing levels in a Phase I trial with healthy participants, demonstrating positive safety and efficacy data without serious adverse reactions, indicating its potential in treating autoimmune diseases.
- Immunosuppressive Effects: The drug exhibited dose-dependent immunosuppressive effects, achieving significant and long-lasting inhibition of T-cell-mediated intradermal reactions to a strong foreign antigen on days 2, 9, and 23, potentially offering new treatment avenues for conditions like rheumatoid arthritis.
- Market Opportunity: As a therapeutic target for autoimmune diseases, LAG-3 positions IMP761 to address large markets, including Type 1 diabetes and multiple sclerosis, which could translate into multi-billion dollar opportunities for the company.
- Future Outlook: Immutep plans to continue the trial as scheduled, with additional updates expected in the first half of 2026, further enhancing market interest and investor confidence in this promising program.
ASX Penny Stocks Highlight: DUG Technology Featured Among Three Key Selections
Market Overview: Australian shares are facing challenges due to global tech sector declines, prompting investors to consider penny stocks, which may offer surprising value and stability despite their smaller size.
DUG Technology Ltd: This technology company, with a market cap of A$281.66 million, has shown improvement in financial health, reducing losses significantly over the past five years, and has potential for future growth despite current profitability challenges.
Immutep Limited: A biotechnology firm focused on immunotherapies, Immutep has a market cap of A$552.65 million and is well-positioned financially, with a strong cash position supporting ongoing clinical trials, despite being pre-revenue.
Wagners Holding Company: With a market cap of A$719.01 million, Wagners has demonstrated robust financial health and significant earnings growth, supported by its inclusion in the S&P/ASX Emerging Companies Index, although it faces challenges with long-term liabilities.
