BioLineRx Announces Receipt of USPTO Notice of Allowance for Key Patent Covering GLIX1 for Treating a Broad Range of Cancer Types
Patent Approval: BioLineRx has received a Notice of Allowance from the USPTO for a patent covering the use of GLIX1 in treating cancers where cytidine deaminase (CDA) is not over-expressed, which applies to over 90% of cancer types.
Extended Patent Protection: The patent strengthens GLIX1's protection until 2040, with a potential five-year extension, allowing BioLineRx to expand its development of GLIX1 beyond glioblastoma into other cancer types.
Clinical Trials: BioLineRx plans to initiate a first-in-human study of GLIX1 in glioblastoma patients in early 2026 while also advancing pre-clinical studies in other cancer models.
Broader Patent Coverage: GLIX1 is supported by a comprehensive portfolio of patents, including its use in combination with PARP inhibitors for treating homologous recombination proficient cancers, with potential patent validity extending to at least 2044.
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Today's Options Volatility and Implied Earnings Changes - November 24, 2025
Earnings Reports Today: Major companies such as Agilent, Zoom Video Communications, and Semtech are set to report their earnings today, with expected significant stock movements based on options prices.
Options Activity Insights: Investors are closely monitoring options activity prior to earnings announcements, as it can provide insights into potential stock price movements following the reports.
Implied Moves Before Market Open: Companies like Bioline RX and Lexinfintech are expected to have substantial implied moves of +/- 187.69% and +/- 30.33%, respectively, before the market opens.
Implied Moves After Market Close: Other companies reporting after market close, including Agilent and Zoom, have implied moves ranging from +/- 8.20% to +/- 29.35%, indicating varying levels of expected volatility.
Options Volatility and Projected Earnings Changes for the Week of November 24 – November 26, 2025
Upcoming Earnings Reports: Major companies such as Alibaba, Nio, Zoom, Dell, and Li Auto are set to report their earnings this week.
Options Volatility: The article discusses how options volatility increases before earnings announcements due to uncertainty, leading to higher option premiums.
Volatility Crush: After earnings are announced, the uncertainty resolves, causing a significant decrease in option premiums, known as the volatility crush.
Expected Stock Moves: The expected stock price movements for various companies are provided, with percentages indicating potential volatility around their earnings announcements.