Biohaven's BHV-7000 Fails Phase 2 Depression Trial, Shares Drop 15.45%
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Dec 26 2025
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Source: Benzinga
- Clinical Trial Outcome: Biohaven Ltd.'s BHV-7000 failed to meet its primary endpoint in a Phase 2 trial for major depressive disorder, although favorable trends were noted in some severely depressed subgroups, which may impact future R&D directions.
- Safety Assessment: While BHV-7000 was mostly safe with mild to moderate adverse events largely resolving spontaneously, the lack of significant efficacy signals raises investor concerns about its market prospects.
- Resource Reallocation: The company has decided against further psychiatric clinical trials, opting instead to focus resources on key priority areas such as immunology, obesity, and epilepsy, indicating a strategic shift in focus.
- Market Reaction: Biohaven's shares fell 15.45% to $9.14 in premarket trading on Friday, reflecting negative market sentiment regarding the trial results, with analysts remaining cautious about future regulatory clarity and data outcomes.
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Analyst Views on BHVN
Wall Street analysts forecast BHVN stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for BHVN is 15.09 USD with a low forecast of 9.00 USD and a high forecast of 30.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
14 Analyst Rating
8 Buy
6 Hold
0 Sell
Moderate Buy
Current: 12.100
Low
9.00
Averages
15.09
High
30.00
Current: 12.100
Low
9.00
Averages
15.09
High
30.00
About BHVN
Biohaven Ltd. is a biopharmaceutical company focused on the discovery, development and commercialization of treatments in key therapeutic areas, including immunology, neuroscience, and oncology. It is advancing its portfolio of therapeutics, leveraging its drug development experience and multiple proprietary drug development platforms. Its clinical and preclinical programs include Kv7 ion channel modulation for epilepsy and mood disorders; extracellular protein degradation for immunological diseases; TRPM3 antagonism for migraine and neuropathic pain; TYK2/JAK1 inhibition for neuroinflammatory disorders; glutamate modulation for obsessive-compulsive disorder (OCD) and spinocerebellar ataxia (SCA); myostatin inhibition for neuromuscular and metabolic diseases, including spinal muscular atrophy (SMA) and obesity; antibody recruiting bispecific molecules; and antibody drug conjugates for cancer. Its advanced product candidate from its glutamate receptor antagonist platform is troriluzole.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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RBC Upgrades Biohaven to Outperform on Positive Drug Data, $22 Price Target Implies 74% Upside
- Rating Upgrade: RBC Capital Markets upgraded Biohaven from sector perform to outperform, with analyst Timashev noting that new data has reduced uncertainty around the company's epilepsy drug, setting a price target of $22, implying a 74% upside.
- Data Support: Recent January data indicates that Biohaven's Kv7 drug shows activity in the central nervous system, alleviating investors' worst-case concerns ahead of upcoming late-stage trials, thus boosting market confidence.
- Market Potential: Timashev believes the Kv7 modulator may demonstrate a better safety profile than competitors and has the potential to be a fast follower in a market that can support multiple branded drugs, enhancing Biohaven's competitive edge.
- Financial Outlook: While Biohaven still carries a relatively high risk profile, the analyst highlights that the improved financial position and discount relative to the platform's opportunity create an attractive setup for catalysts in 2H26, with successful clinical trials potentially pushing the stock price to $30, indicating nearly 137% upside.
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