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XENE Overview

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$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
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Intellectia

Loading chart...

High
58.855
Open
57.640
VWAP
58.31
Vol
724.09K
Mkt Cap
5.66B
Low
57.490
Amount
42.22M
EV/EBITDA(TTM)
--
Total Shares
96.64M
EV
5.03B
EV/OCF(TTM)
--
P/S(TTM)
609.83
Xenon Pharmaceuticals Inc. is a Canada-based neuroscience-focused biopharmaceutical company committed to discovering, developing, and commercializing therapeutics to improve the lives of people living with neurological and psychiatric disorders. The Company is advancing a novel product pipeline to address areas of high unmet medical need, including epilepsy and depression. Azetukalner, a novel, highly potent, selective Kv7 potassium channel opener, represents the advanced, clinically validated potassium channel modulator in late-stage clinical development for the treatment of multiple indications that include epilepsy, including focal onset seizures (FOS), and primary generalized tonic-clonic seizures (PGTCS), as well as neuropsychiatric disorders including major depressive disorder (MDD), and bipolar depression (BPD). The Company is evaluating multiple therapeutic candidates targeting Kv7, Nav1.7, and Nav1.1 across various indications.
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Events Timeline

(ET)
2026-04-19
20:50:00
Xenon Pharmaceuticals Presents Positive Data on Azetukalner at Neurology Annual Meeting
select
2026-03-11 (ET)
2026-03-11
06:00:00
Deal Size Increased to $650M in Common Stock
select

News

Newsfilter
8.5
04-19Newsfilter
AAN Meeting: Azetukalner Significantly Reduces Seizure Frequency in Epilepsy
  • Clinical Trial Results: In the X-TOLE2 study, the 25 mg group showed a 53.2% reduction in monthly seizure frequency, significantly outperforming the placebo group's 10.4%, highlighting Azetukalner's potential in treating refractory epilepsy.
  • Long-term Efficacy Data: In the ongoing X-TOLE OLE study, nearly 40% of participants achieved at least 12 months of seizure freedom over 48 months, indicating the drug's effectiveness and safety in long-term use.
  • Improved Patient Experience: Real-world data suggest that Azetukalner's no-titration requirement alleviates stress for both patients and physicians, simplifying epilepsy management and enhancing patients' quality of life and adherence to treatment.
  • Future Development Plans: Xenon aims to submit a New Drug Application to the FDA in Q3 2026, further advancing Azetukalner's market access to meet the urgent demand for new anti-seizure medications.
Yahoo Finance
8.5
04-19Yahoo Finance
Xenon Pharmaceuticals Reports Significant Efficacy of Azetukalner in Epilepsy Studies
  • Clinical Trial Results: The X-TOLE2 study demonstrated a 53.2% reduction in monthly seizure frequency for the 25 mg azetukalner group compared to a mere 10.4% for the placebo group, highlighting the drug's potential to transform treatment for refractory epilepsy.
  • Long-term Efficacy Data: In the ongoing 48-month open-label extension study, nearly 40% of participants achieved at least 12 months of seizure freedom, with 25% achieving 24 months, indicating azetukalner's effectiveness in long-term epilepsy management.
  • Improved Patient Experience: Real-world data suggest that azetukalner's no-titration feature alleviates stress for both patients and physicians, enhancing patient confidence and adherence, thereby simplifying the management of epilepsy with significant clinical implications.
  • Future Development Plans: Xenon aims to submit a New Drug Application to the FDA in Q3 2026, further advancing azetukalner towards market availability, which is expected to provide a more effective treatment option for epilepsy patients.
Newsfilter
1.0
04-15Newsfilter
Xenon Pharmaceuticals to Present at Four Investor Conferences
  • Investor Conference Schedule: Xenon Pharmaceuticals will present at four investor conferences in Q2 2026, including Bloom Burton & Co., Bank of America, RBC Capital Markets, and Jefferies, showcasing its latest advancements in neuroscience and potentially boosting investor confidence.
  • Presentation Dates and Locations: The company will present on April 22, May 14, May 19, and June 4, 2026, in Toronto, Las Vegas, and New York, enhancing investor engagement and demonstrating its clinical development and commercialization strategies.
  • Clinical Trial Progress: Xenon's lead molecule, azetukalner, is currently in Phase 3 trials for epilepsy, major depressive disorder, and bipolar depression, and successful advancement could significantly enhance the company's market position in the biopharmaceutical sector.
  • Diverse Product Pipeline: In addition to azetukalner, Xenon is advancing multiple early-stage potassium and sodium channel modulator programs, and successful outcomes from these projects will provide more treatment options, further solidifying its leadership in the neuroscience field.
Newsfilter
8.5
04-07Newsfilter
Xenon Pharmaceuticals Presents New Drug Study Results at AAN Meeting
  • Research Presentation: Xenon Pharmaceuticals will present five abstracts at the 2026 American Academy of Neurology Annual Meeting, including the latest results from the Phase 3 X-TOLE2 study of azetukalner for focal onset seizures, indicating the drug's potential in clinical applications.
  • Long-term Efficacy Data: The company will showcase 48-month long-term efficacy and safety data for azetukalner from the X-TOLE open-label extension study, providing crucial clinical evidence for the drug's continued use, which may enhance confidence among physicians and patients.
  • Real-World Data: Presentations will include real-world data on the burden of antiseizure medication (ASM) titration, highlighting the needs of patients and clinicians, which could drive the development of no-titration options to improve patient quality of life.
  • Exhibition Participation: Xenon will showcase its research findings at Booth #2330 during the conference, scheduled from April 19 to 22, 2026, in Chicago, which is expected to attract significant attention from industry participants regarding its new drug development progress.
Fool
5.0
03-27Fool
Xenon Pharmaceuticals CMO Sells Shares Amid RSU Vesting
  • Transaction Overview: Christopher John Kenney, CMO of Xenon Pharmaceuticals, sold 1,410 common shares for approximately $78,000 on March 13, 2026, indicating a shift in his ownership stake within the company.
  • Holding Percentage Change: The 16.63% of direct holdings sold in this transaction is higher than the 5.86% sold on March 24, 2023, but lower than the percentage held just days prior on March 10, 2026, reflecting dynamic management of his equity position.
  • Tax Compliance Transaction: This sale was executed under a sell-to-cover instruction tied to vested RSUs, indicating it was a routine transaction aimed at satisfying tax obligations rather than a discretionary reduction in exposure.
  • Financial and R&D Outlook: Despite generating only $7.5 million in revenue in 2025 and reporting a net loss of $345.9 million, the positive developments in its R&D pipeline and a nearly $750 million offering provide essential funding for future growth.
Fool
6.5
03-13Fool
Driehaus Capital Increases Stake in Xenon Pharmaceuticals
  • Increased Holdings: Driehaus Capital Management disclosed a purchase of 369,577 shares of Xenon Pharmaceuticals in Q4 2025, valued at approximately $15.52 million, indicating strong confidence in the company.
  • Market Value Growth: This acquisition raised Driehaus's stake in Xenon to 1.4%, with the total position value increasing to $36.03 million at quarter-end, reflecting positive market expectations for the company.
  • Clinical Advancements: Xenon's lead drug candidate, Azetukalner, demonstrated significant efficacy in Phase 3 trials for focal onset seizures, with a median seizure frequency reduction of 53.2% in high-dose patients, paving the way for future commercialization.
  • Funding Support: The company recently completed a $747.5 million public offering, significantly strengthening its financial position to support commercialization and pipeline expansion, with market response being positive as shares surged over 30% following the trial results.
Wall Street analysts forecast XENE stock price to rise
14 Analyst Rating
Wall Street analysts forecast XENE stock price to rise
14 Buy
0 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
44.00
Averages
54.09
High
62.00
Current: 0.000
sliders
Low
44.00
Averages
54.09
High
62.00
Wedbush
Outperform -> NULL
downgrade
$64 -> $63
AI Analysis
2026-03-16
Reason
Wedbush
Price Target
$64 -> $63
AI Analysis
2026-03-16
downgrade
Outperform -> NULL
Reason
Wedbush lowered the firm's price target on Xenon Pharmaceuticals to $63 from $64 and keeps an Outperform rating on the shares. Following completion of the upsized $748M secondary offering, the firm is incorporating the raise into its estimates.
Wedbush
Outperform
maintain
$47 -> $64
2026-03-10
Reason
Wedbush
Price Target
$47 -> $64
2026-03-10
maintain
Outperform
Reason
Wedbush raised the firm's price target on Xenon Pharmaceuticals to $64 from $47 and keeps an Outperform rating on the shares. The much-anticipated XTOLE2 Phase 3 data for azetukalner arrived with the trial meeting its primary endpoint for both doses, the firm notes. While Wedbush awaits more detailed data presentation at the AAN late-breaker, the median percent change in monthly seizure frequency appears compelling on a placebo-adjusted basis. Important to note, that over half of study participants received at least 3 anti-epileptic drugs indicating this is a challenging population to address.
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Valuation Metrics

The current forward P/E ratio for Xenon Pharmaceuticals Inc (XENE.O) is 0.00, compared to its 5-year average forward P/E of -12.17. For a more detailed relative valuation and DCF analysis to assess Xenon Pharmaceuticals Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-12.17
Current PE
0.00
Overvalued PE
-9.58
Undervalued PE
-14.76

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-7.02
Current EV/EBITDA
-1.51
Overvalued EV/EBITDA
-3.07
Undervalued EV/EBITDA
-10.98

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
2110.97
Current PS
77.95
Overvalued PS
5748.28
Undervalued PS
-1526.34

Financials

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Whales Holding XENE

A
Artal Group S.A.
Holding
XENE
+17.43%
3M Return
A
Avoro Capital Advisors LLC
Holding
XENE
+16.93%
3M Return
D
Driehaus Capital Management LLC
Holding
XENE
+16.88%
3M Return
V
Vestal Point Capital, LP
Holding
XENE
+12.65%
3M Return
D
Deerfield Management Company, L.P.
Holding
XENE
+9.10%
3M Return
S
Sofinnova Investment, Inc.
Holding
XENE
+6.49%
3M Return

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Frequently Asked Questions

What is Xenon Pharmaceuticals Inc (XENE) stock price today?

The current price of XENE is 58.59 USD — it has increased 1.52

What is Xenon Pharmaceuticals Inc (XENE)'s business?

Xenon Pharmaceuticals Inc. is a Canada-based neuroscience-focused biopharmaceutical company committed to discovering, developing, and commercializing therapeutics to improve the lives of people living with neurological and psychiatric disorders. The Company is advancing a novel product pipeline to address areas of high unmet medical need, including epilepsy and depression. Azetukalner, a novel, highly potent, selective Kv7 potassium channel opener, represents the advanced, clinically validated potassium channel modulator in late-stage clinical development for the treatment of multiple indications that include epilepsy, including focal onset seizures (FOS), and primary generalized tonic-clonic seizures (PGTCS), as well as neuropsychiatric disorders including major depressive disorder (MDD), and bipolar depression (BPD). The Company is evaluating multiple therapeutic candidates targeting Kv7, Nav1.7, and Nav1.1 across various indications.

What is the price predicton of XENE Stock?

Wall Street analysts forecast XENE stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for XENE is54.09 USD with a low forecast of 44.00 USD and a high forecast of 62.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Xenon Pharmaceuticals Inc (XENE)'s revenue for the last quarter?

Xenon Pharmaceuticals Inc revenue for the last quarter amounts to 0.00 USD, decreased

What is Xenon Pharmaceuticals Inc (XENE)'s earnings per share (EPS) for the last quarter?

Xenon Pharmaceuticals Inc. EPS for the last quarter amounts to -1.31 USD, increased 55.95

How many employees does Xenon Pharmaceuticals Inc (XENE). have?

Xenon Pharmaceuticals Inc (XENE) has 358 emplpoyees as of May 07 2026.

What is Xenon Pharmaceuticals Inc (XENE) market cap?

Today XENE has the market capitalization of 5.66B USD.