Alto Neuroscience Secures Patent for ALTO-207, Protecting Key Treatment Method Until Mid-2040s
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Jan 14 2026
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Source: Newsfilter
- Patent Protection Extended: Alto Neuroscience announced the issuance of U.S. Patent Number 12,521,374 covering methods for treating depression with ALTO-207, expected to provide protection into the mid-2040s, thus offering the company a long-term commercial opportunity in the treatment of treatment-resistant depression.
- Innovative Combination Therapy: ALTO-207 combines pramipexole and ondansetron to mitigate side effects associated with pramipexole, enabling patients to achieve higher doses for more significant antidepressant effects, addressing the urgent market demand for new therapies.
- Clinical Trial Success: In a randomized, placebo-controlled Phase 2a trial involving 32 patients with depression, ALTO-207 demonstrated significant efficacy, with patients reaching a mean dose of 4.1mg per day and an adverse event rate similar to placebo, indicating good tolerability.
- Strategic Value Enhancement: CEO Amit Etkin emphasized that a robust intellectual property foundation is critical for advancing precision treatments, and this patent issuance not only reflects the novelty of ALTO-207 but also strengthens the company's competitive position in the mental health market.
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Analyst Views on ANRO
Wall Street analysts forecast ANRO stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for ANRO is 32.86 USD with a low forecast of 16.00 USD and a high forecast of 50.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
9 Analyst Rating
9 Buy
0 Hold
0 Sell
Strong Buy
Current: 15.330
Low
16.00
Averages
32.86
High
50.00
Current: 15.330
Low
16.00
Averages
32.86
High
50.00
About ANRO
Alto Neuroscience, Inc. is a clinical-stage biopharmaceutical company focused on redefining psychiatry by leveraging neurobiology to develop personalized and effective treatment options. The Company's Precision Psychiatry Platform measures brain biomarkers by analyzing EEG activity, neurocognitive assessments, wearable data, and other factors to identify which patients are likely to respond to its product candidates. Its clinical-stage pipeline includes drug candidates in bipolar depression, major depressive disorder, treatment resistant depression (TRD), and schizophrenia, and other mental health conditions. Its product candidates include ALTO-100, ALTO-300, ALTO-207, ALTO-203, ALTO-101, ALTO-202, and ALTO-208. ALTO-100 is a first-in-class, oral small molecule believed to work through enhancing neural plasticity in the hippocampus, a brain region important for both cognition and mood. ALTO-203 is an oral small molecule histamine H3 receptor inverse agonist.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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Alto Neuroscience and Others Under Investigation for Shareholder Claims
- Shareholder Lawsuit Investigation: Johnson Fistel, PLLP is investigating shareholder claims against Alto Neuroscience (NYSE: ANRO) and others, alleging breaches of fiduciary duty that could lead to corporate governance reforms and return of funds.
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