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ANRO Overview

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ET
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ET
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Intellectia

Loading chart...

High
23.047
Open
20.350
VWAP
21.84
Vol
744.20K
Mkt Cap
718.14M
Low
20.000
Amount
16.25M
EV/EBITDA(TTM)
--
Total Shares
31.95M
EV
480.77M
EV/OCF(TTM)
--
P/S(TTM)
--
Alto Neuroscience, Inc. is a clinical-stage biopharmaceutical company focused on redefining psychiatry by leveraging neurobiology to develop personalized and effective treatment options. The Company's Precision Psychiatry Platform measures brain biomarkers by analyzing EEG activity, neurocognitive assessments, wearable data, and other factors to identify which patients are likely to respond to its product candidates. Its clinical-stage pipeline includes drug candidates in bipolar depression, major depressive disorder, treatment resistant depression (TRD), and schizophrenia, and other mental health conditions. Its product candidates include ALTO-100, ALTO-300, ALTO-207, ALTO-203, ALTO-101, ALTO-202, and ALTO-208. ALTO-100 is a first-in-class, oral small molecule believed to work through enhancing neural plasticity in the hippocampus, a brain region important for both cognition and mood. ALTO-203 is an oral small molecule histamine H3 receptor inverse agonist.
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Events Timeline

(ET)
2026-03-16
07:30:00
Alto Neuroscience Signs $120M Private Placement Financing Agreement
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2026-03-16
06:20:00
Alto Neuroscience Cash Balance Reaches $177 Million, Prepares for ALTO-207 Pivotal Trial
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2026-03-16
06:10:00
Company Cash Balance Expected to Support Operations into 2028
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2026-02-13 (ET)
2026-02-13
08:10:00
Alto Neuroscience Completes Patient Enrollment for ALTO-101 Clinical Trial
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2026-01-14 (ET)
2026-01-14
07:40:00
Alto Neuroscience Secures U.S. Patent No. 12,521,374
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News

seekingalpha
8.5
03-16seekingalpha
Alto Neuroscience Secures $120 Million PIPE Financing for ALTO-207 Development
  • Financing Size: Alto Neuroscience has announced a PIPE agreement to raise approximately $120 million, primarily aimed at developing ALTO-207 for treatment-resistant depression, which is expected to significantly enhance the company's R&D capabilities.
  • Clinical Trial Plans: The funds will support a Phase 2b study of ALTO-207 expected to start in the first half of 2026, while also preparing for a Phase 3 study set to begin in early 2027, with positive results potentially leading to a New Drug Application submission.
  • Funding Utilization: By February 28, 2026, the company's estimated cash and cash equivalents are projected to be around $275 million, providing ample financial backing for subsequent clinical trials and NDA submissions, thereby enhancing market competitiveness.
  • Stock Issuance Details: Alto plans to offer 2.9 million shares of common stock at $20 each, along with 3.1 million pre-funded warrants at $19.9999 each, which will be immediately exercisable and have no expiration date, increasing investor participation interest.
Newsfilter
8.5
03-16Newsfilter
Alto Secures $120 Million Financing to Advance ALTO-207 Development
  • Significant Financing: Alto Neuroscience successfully raised approximately $120 million through a PIPE financing agreement, which will be utilized for the development of ALTO-207, particularly in a Phase 3 clinical trial for treatment-resistant depression, significantly enhancing the company's competitiveness in the psychiatric drug market.
  • Clinical Trial Timeline: The company plans to initiate a Phase 2b study of ALTO-207 in the first half of 2026 and expects to enter Phase 3 trials in early 2027, with this timeline paving the way for a potential New Drug Application, addressing the urgent market need for new therapies.
  • Investor Confidence: The financing is led by Commodore Capital and includes participation from multiple biotech investors, reflecting growing market confidence in Alto's precision neuroscience strategy, which is expected to bolster the company's reputation and attractiveness in the industry.
  • Clear Use of Proceeds: In addition to supporting the clinical development of ALTO-207, the proceeds will also fund general corporate purposes, with the company estimating cash and cash equivalents to reach approximately $275 million by February 28, 2026, ensuring liquidity for the coming years.
seekingalpha
9.5
03-16seekingalpha
Alto Neuroscience Reports FY EPS Beat and Strong Cash Position
  • Earnings Performance: Alto Neuroscience reported a FY GAAP EPS of -$2.19, beating expectations by $0.06, indicating an improvement in financial performance despite still being in a loss position.
  • Cash Reserve Increase: As of December 31, 2025, the company had approximately $177 million in cash, cash equivalents, and restricted cash, up from about $169 million as of December 31, 2024, reflecting robust financial management.
  • Operational Support Capability: The company expects its cash balance to sustain operations into 2028, providing investor confidence and indicating financial stability for the coming years.
  • Market Attention: Alto Neuroscience's financial data has garnered market attention, with Seeking Alpha's Quant Rating offering additional analytical perspectives for investors, potentially influencing future investment decisions.
Newsfilter
8.5
03-16Newsfilter
Alto Acquires ALTO-207 to Address Treatment-Resistant Depression
  • Acquisition of ALTO-207: In June 2025, Alto acquired ALTO-207, targeting treatment-resistant depression (TRD) with a combination of a dopamine agonist and an antiemetic, with a pivotal Phase 2b trial expected to start in the first half of 2026, potentially offering new treatment options for millions of patients.
  • PAX-D Study Validation: The independent PAX-D study demonstrated an effect size of 0.87 for ALTO-207's core mechanism in TRD patients, significantly surpassing current standard treatments, indicating the drug's potential to transform clinical treatment paradigms.
  • Strong Financial Foundation: As of December 31, 2025, Alto reported a cash balance of $177 million, expected to fund operations into 2028 while covering four key data readouts, thereby enhancing investor confidence in the company's future.
  • ALTO-101 Fast Track: ALTO-101 received FDA Fast Track designation, with topline data from the Phase 2 proof-of-concept trial anticipated around the end of Q1 2026, further advancing Alto's innovative efforts in the field of psychiatry.
Newsfilter
1.0
03-13Newsfilter
Alto Neuroscience to Participate in Virtual Forum
  • Management Participation: Alto Neuroscience's management team will participate in the Stifel 2026 Virtual CNS Forum on March 17, 2026, at 12:00 PM ET, showcasing its innovative advancements in psychiatry, aimed at enhancing the company's visibility and credibility among investors.
  • Live Webcast Availability: The presentation will be accessible via a live webcast on Alto's investor relations website, with a replay available afterward, ensuring that investors unable to attend in real-time can still access key information, thereby enhancing transparency and investor relations.
  • Precision Psychiatry Platform: Alto's Precision Psychiatry Platform leverages brain biomarkers by analyzing EEG activity, neurocognitive assessments, and wearable data to provide personalized and effective treatment options for psychiatric disorders, demonstrating the company's foresight and technological edge in mental health.
  • Diverse Clinical Pipeline: Alto's clinical-stage pipeline includes novel drug candidates targeting depression, schizophrenia, and other mental health conditions, reflecting the company's commitment to developing innovative treatment solutions and potential market opportunities.
PRnewswire
8.5
02-26PRnewswire
Helus Pharma's Psychedelic Drug Achieves Phase 3 Success
  • Clinical Trial Breakthrough: Helus Pharma's SPL026 demonstrated significant efficacy in a randomized controlled trial for treatment-resistant depression, with a MADRS score difference of -7.35 (p=0.023) among 34 participants, providing clinical proof-of-concept that could shift regulatory and investor perspectives on psychedelic applications in psychiatry.
  • Production Quota Increase: The DEA raised the 2026 psilocybin production quota by 67%, creating larger market opportunities for companies like Helus Pharma and accelerating their research and development efforts in psychedelic therapies.
  • Strong Financial Backing: As of December 31, 2025, Helus Pharma reported $195.1 million in cash, ensuring continued advancement of its multi-asset clinical pipeline, particularly for key assets like HLP003 and HLP004.
  • Optimistic Future Outlook: HLP003 has shown a 100% response rate and 71% remission rate in two pivotal Phase 3 studies, with topline data expected in Q4 2026, further solidifying Helus Pharma's market position in depression treatment.
Wall Street analysts forecast ANRO stock price to rise
8 Analyst Rating
Wall Street analysts forecast ANRO stock price to rise
8 Buy
0 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
25.00
Averages
35.67
High
50.00
Current: 0.000
sliders
Low
25.00
Averages
35.67
High
50.00
Baird
Brian Skorney
maintain
$22 -> $41
AI Analysis
2026-03-18
Reason
Baird
Brian Skorney
Price Target
$22 -> $41
AI Analysis
2026-03-18
maintain
Reason
Baird analyst Brian Skorney raised the firm's price target on Alto Neuroscience to $41 from $22 and keeps an Outperform rating on the shares. The firm updated its model ahead of multiple catalysts.
Wedbush
Laura Chico
Neutral
maintain
$13 -> $22
2026-03-17
Reason
Wedbush
Laura Chico
Price Target
$13 -> $22
2026-03-17
maintain
Neutral
Reason
Wedbush analyst Laura Chico raised the firm's price target on Alto Neuroscience to $22 from $13 and keeps a Neutral rating on the shares. Most notable in Q4 results, the company completed a $120M private placement which extends cash runway through 2029. Proceeds will help fund the ALTO-207 Phase 2b study in treatment-resistant depression.
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Valuation Metrics

The current forward P/E ratio for Alto Neuroscience Inc (ANRO.N) is 0.00, compared to its 5-year average forward P/E of -3.24. For a more detailed relative valuation and DCF analysis to assess Alto Neuroscience Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-3.24
Current PE
0.00
Overvalued PE
-1.13
Undervalued PE
-5.34

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-0.19
Current EV/EBITDA
0.00
Overvalued EV/EBITDA
0.97
Undervalued EV/EBITDA
-1.36

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
0.00
Current PS
0.00
Overvalued PS
0.00
Undervalued PS
0.00

Financials

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Whales Holding ANRO

C
Commodore Capital LP
Holding
ANRO
+22.71%
3M Return
V
Vivo Capital, LLC
Holding
ANRO
+14.23%
3M Return
P
Perceptive Advisors LLC
Holding
ANRO
+8.68%
3M Return
V
Vestal Point Capital, LP
Holding
ANRO
+6.42%
3M Return
A
Armistice Capital LLC
Holding
ANRO
-5.93%
3M Return

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Frequently Asked Questions

What is Alto Neuroscience Inc (ANRO) stock price today?

The current price of ANRO is 22.48 USD — it has increased 12.51

What is Alto Neuroscience Inc (ANRO)'s business?

Alto Neuroscience, Inc. is a clinical-stage biopharmaceutical company focused on redefining psychiatry by leveraging neurobiology to develop personalized and effective treatment options. The Company's Precision Psychiatry Platform measures brain biomarkers by analyzing EEG activity, neurocognitive assessments, wearable data, and other factors to identify which patients are likely to respond to its product candidates. Its clinical-stage pipeline includes drug candidates in bipolar depression, major depressive disorder, treatment resistant depression (TRD), and schizophrenia, and other mental health conditions. Its product candidates include ALTO-100, ALTO-300, ALTO-207, ALTO-203, ALTO-101, ALTO-202, and ALTO-208. ALTO-100 is a first-in-class, oral small molecule believed to work through enhancing neural plasticity in the hippocampus, a brain region important for both cognition and mood. ALTO-203 is an oral small molecule histamine H3 receptor inverse agonist.

What is the price predicton of ANRO Stock?

Wall Street analysts forecast ANRO stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for ANRO is35.67 USD with a low forecast of 25.00 USD and a high forecast of 50.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Alto Neuroscience Inc (ANRO)'s revenue for the last quarter?

Alto Neuroscience Inc revenue for the last quarter amounts to 0.00 USD, decreased

What is Alto Neuroscience Inc (ANRO)'s earnings per share (EPS) for the last quarter?

Alto Neuroscience Inc. EPS for the last quarter amounts to -0.47 USD, decreased -17.54

How many employees does Alto Neuroscience Inc (ANRO). have?

Alto Neuroscience Inc (ANRO) has 68 emplpoyees as of April 01 2026.

What is Alto Neuroscience Inc (ANRO) market cap?

Today ANRO has the market capitalization of 718.14M USD.