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ANRO Overview

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$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
$
0.000
0.000(0.000%)
At close
0.000(0.000%)Aft-market
ET
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Intellectia

Loading chart...

High
27.590
Open
27.590
VWAP
26.98
Vol
334.88K
Mkt Cap
873.07M
Low
26.010
Amount
9.03M
EV/EBITDA(TTM)
--
Total Shares
31.95M
EV
715.57M
EV/OCF(TTM)
--
P/S(TTM)
--
Alto Neuroscience, Inc. is a clinical-stage biopharmaceutical company focused on redefining psychiatry by leveraging neurobiology to develop personalized and effective treatment options. The Company's Precision Psychiatry Platform measures brain biomarkers by analyzing EEG activity, neurocognitive assessments, wearable data, and other factors to identify which patients are likely to respond to its product candidates. Its clinical-stage pipeline includes drug candidates in bipolar depression, major depressive disorder, treatment resistant depression (TRD), and schizophrenia, and other mental health conditions. Its product candidates include ALTO-100, ALTO-300, ALTO-207, ALTO-203, ALTO-101, ALTO-202, and ALTO-208. ALTO-100 is a first-in-class, oral small molecule believed to work through enhancing neural plasticity in the hippocampus, a brain region important for both cognition and mood. ALTO-203 is an oral small molecule histamine H3 receptor inverse agonist.
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Events Timeline

(ET)
2026-04-21
08:30:00
New
Alto Neuroscience Initiates Phase 2b Trial of ALTO-207
select
2026-04-10 (ET)
2026-04-10
16:10:00
Alto Neuroscience Files to Sell 6M Shares of Common Stock
select
2026-04-02 (ET)
2026-04-02
09:00:00
Stock Futures Lower Across the Board as Geopolitical Tensions Escalate
select
2026-04-01 (ET)
2026-04-01
19:30:00
Nasdaq Rises 1.2% as Energy Sector Struggles
select
2026-04-01
16:40:00
Alto Neuroscience ALTO-101 Clinical Trial Results Not Statistically Significant
select

News

NASDAQ.COM
4.5
04-02NASDAQ.COM
US Stocks Close Mixed Amid Oil Surge and Economic Data
  • Market Fluctuations: The S&P 500 Index closed up 0.11%, while the Dow Jones Industrial Average fell 0.13%, and the Nasdaq 100 Index rose 0.11%, reflecting volatility influenced by surging oil prices and economic data.
  • Positive Economic Data: Weekly initial unemployment claims unexpectedly fell by 9,000 to 202,000, indicating a stronger labor market than the anticipated increase to 212,000, which could impact the Fed's interest rate policy.
  • Impact of Oil Surge: Crude oil prices soared over 11% due to President Trump's tougher stance on Iran, leading to sharp declines in airline and cruise line stocks, with United Airlines and Carnival both down more than 3%.
  • Corporate Developments: SBA Communications surged over 18% as it explores potential acquisition options, while Globalstar rose over 13% amid reports of Amazon's interest in acquiring the company, highlighting market focus on M&A activity.
stocktwits
9.5
04-02stocktwits
Analysis of ALTO-101 Clinical Trial Failure Impact
  • ALTO-101 Trial Failure: Alto Neuroscience's ALTO-101 failed to meet key goals in its Phase 2 study, resulting in a 7% drop in stock price on Thursday, indicating weakened market confidence in its schizophrenia treatment and potential impacts on future funding capabilities.
  • Analyst Target Adjustments: Baird lowered Alto's price target from $41 to $38 while maintaining an 'Outperform' rating, emphasizing that the depression pipeline remains a key driver of the company's valuation, reflecting a reassessment of its potential value in the market.
  • Cash Reserves Support: H.C. Wainwright highlighted Alto's strong cash position of $275 million, which supports its other R&D projects despite the failure of ALTO-101, maintaining a 'Buy' rating and a $50 price target, demonstrating confidence in the company's long-term prospects.
  • Retail Sentiment Shift: Despite the stock's decline, retail investor sentiment on Stocktwits shifted from 'neutral' to 'bullish', indicating optimism about Alto's future potential, with the stock gaining over 20% year-to-date.
NASDAQ.COM
4.5
04-02NASDAQ.COM
Stock Markets Pressured by Soaring Oil Prices
  • Oil Price Surge Pressures Markets: Stock indexes are under pressure as crude oil prices soar over 8% following President Trump's aggressive stance on Iran, leading to a 0.06% drop in the S&P 500, a 0.23% decline in the Dow, and a 0.20% fall in the Nasdaq 100, indicating heightened inflation concerns among investors.
  • Unexpected Jobless Claims Drop: Despite market pressures, initial jobless claims fell by 9,000 to 202,000, indicating a stronger labor market than anticipated, which may provide some support for stocks and alleviate investor fears of an economic slowdown.
  • Divergent Energy Sector Performance: Energy producers like Diamondback Energy rose over 2% due to soaring WTI prices, while airline stocks such as American Airlines and Carnival fell more than 4% as rising fuel costs cut into profits, highlighting a clear divergence across sectors.
  • Tech Stocks Decline: Chipmakers and AI infrastructure stocks retreated, with ARM Holdings leading the Nasdaq 100 down over 5%, reflecting waning confidence in tech stocks and potentially impacting future investment decisions.
NASDAQ.COM
4.5
04-02NASDAQ.COM
US Stocks Plummet as Oil Prices Surge
  • Oil Price Surge: Crude oil prices soared over 13% as President Trump took a tougher stance on Iran, reaching a 3.5-week high, which not only heightened inflation fears but also pushed bond yields higher, with the 10-year T-note yield rising by 2 basis points to 4.34%.
  • Unemployment Claims Drop: Weekly initial unemployment claims unexpectedly fell by 9,000 to 202,000, indicating a stronger labor market than the anticipated increase to 212,000, which could provide support for the stock market amid rising inflation concerns.
  • Global Market Decline: Overseas stock markets are lower, with the Euro Stoxx 50 down 2.25%, China's Shanghai Composite down 0.74%, and Japan's Nikkei 225 sharply falling 2.38% from a two-week high, reflecting global economic uncertainty and investor caution.
  • Airline Stocks Plummet: Airline stocks are sharply lower as crude oil prices surged over 10%, raising fuel costs; United Airlines and American Airlines Group both fell more than 6%, highlighting the direct impact of rising oil prices on airline profitability.
stocktwits
9.0
04-01stocktwits
Alto Neuroscience's Schizophrenia Drug Fails Mid-Stage Study
  • Clinical Trial Failure: Alto Neuroscience's experimental drug ALTO-101 failed to achieve statistical significance on primary electroencephalography and cognitive endpoints in a mid-stage study for schizophrenia, leading the company to discontinue its independent development.
  • Shift in Research Focus: Following the disappointing results for ALTO-101 in treating cognitive impairment associated with schizophrenia, the company plans to redirect its efforts towards other research programs, which may impact its future market positioning and investor confidence.
  • Increased Investor Attention: After the trial results were announced, ANRO shares attracted heightened investor focus, reflecting market concerns about the company's future direction and expectations for its other projects.
  • Market Reaction Analysis: The failure of the clinical trial may lead to short-term volatility in ANRO stock, prompting investors to closely monitor the company's subsequent research developments and strategic adjustments.
Newsfilter
9.0
04-01Newsfilter
ALTO-101 Clinical Trial Results Update
  • Clinical Trial Results: ALTO-101 did not achieve statistical significance on primary endpoints in its Phase 2 trial for cognitive impairment associated with schizophrenia, although near-significant improvements were observed in certain EEG measures (p=0.052), indicating potential efficacy in specific subpopulations.
  • Priority Shift: The company has decided not to independently advance ALTO-101 and will instead prioritize resources towards ALTO-207, which is on track to initiate a Phase 2b clinical trial in the first half of 2026, targeting treatment-resistant depression.
  • New Formulation Development: Alto has developed a modified-release oral formulation of ALTO-101 that demonstrates improved pharmacokinetic and tolerability profiles compared to the immediate-release version, with plans to explore partnership opportunities to drive further development of this formulation.
  • Strong Financial Position: Alto currently holds $275 million in cash, supporting the advancement of multiple clinical programs, particularly ALTO-207, which is considered one of the most promising mechanisms in psychiatry.
Wall Street analysts forecast ANRO stock price to rise
8 Analyst Rating
Wall Street analysts forecast ANRO stock price to rise
8 Buy
0 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
25.00
Averages
35.67
High
50.00
Current: 0.000
sliders
Low
25.00
Averages
35.67
High
50.00
H.C. Wainwright
H.C. Wainwright
Buy
maintain
$50
AI Analysis
2026-04-02
Reason
H.C. Wainwright
H.C. Wainwright
Price Target
$50
AI Analysis
2026-04-02
maintain
Buy
Reason
While Alto Neuroscience's ALTO-101 failed to meet its Phase 2 primary endpoints in cognitive impairment associated with schizophrenia, the outcome does not alter H.C. Wainwright's broader thesis, as no prior value had been assigned to the program and it will not be advanced independently, the analyst tells investors in a research note. Focus shifts to a catalyst-rich 2026, including ALTO-207 in treatment-resistant depression, ALTO-300 in major depressive disorder, and ALTO-100 in bipolar depression, with $275M in cash supporting execution across a robust precision neuropsychiatry pipeline, the firm says. H.C. Wainwright reiterates a Buy rating and $50 price target on the shares.
Baird
Brian Skorney
Outperform
to
NULL
downgrade
$41 -> $38
2026-04-02
Reason
Baird
Brian Skorney
Price Target
$41 -> $38
2026-04-02
downgrade
Outperform
to
NULL
Reason
Baird analyst Brian Skorney lowered the firm's price target on Alto Neuroscience to $38 from $41 and keeps an Outperform rating on the shares. The firm views the Phase 2 proof-of-concept trial failture evaluating ALTO-101 for the treatment of cognitive impairment associated with schizophrenia as a "bit disappointing." Schizophrenia indications are notoriously challenging so expectations were "relatively muted" into the readout, the analyst tells investors in a research note. Baird continues to see the multiple opportunities for Alto in depression as the more crucial valuation driver. The stock in premarket trading is down 11%, or $2.51, to $20.90.
Unlock Full Analyst Thesis, Get the complete breakdown of rating reason for ANRO
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Valuation Metrics

The current forward P/E ratio for Alto Neuroscience Inc (ANRO.N) is 0.00, compared to its 5-year average forward P/E of -3.24. For a more detailed relative valuation and DCF analysis to assess Alto Neuroscience Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-3.24
Current PE
0.00
Overvalued PE
-1.13
Undervalued PE
-5.34

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-0.19
Current EV/EBITDA
0.00
Overvalued EV/EBITDA
0.97
Undervalued EV/EBITDA
-1.36

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
0.00
Current PS
0.00
Overvalued PS
0.00
Undervalued PS
0.00

Financials

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Whales Holding ANRO

C
Commodore Capital LP
Holding
ANRO
+32.74%
3M Return
V
Vivo Capital, LLC
Holding
ANRO
+17.88%
3M Return
P
Perceptive Advisors LLC
Holding
ANRO
+14.76%
3M Return
V
Vestal Point Capital, LP
Holding
ANRO
+12.47%
3M Return
A
Armistice Capital LLC
Holding
ANRO
+4.77%
3M Return

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Frequently Asked Questions

What is Alto Neuroscience Inc (ANRO) stock price today?

The current price of ANRO is 27.33 USD — it has decreased -1.41

What is Alto Neuroscience Inc (ANRO)'s business?

Alto Neuroscience, Inc. is a clinical-stage biopharmaceutical company focused on redefining psychiatry by leveraging neurobiology to develop personalized and effective treatment options. The Company's Precision Psychiatry Platform measures brain biomarkers by analyzing EEG activity, neurocognitive assessments, wearable data, and other factors to identify which patients are likely to respond to its product candidates. Its clinical-stage pipeline includes drug candidates in bipolar depression, major depressive disorder, treatment resistant depression (TRD), and schizophrenia, and other mental health conditions. Its product candidates include ALTO-100, ALTO-300, ALTO-207, ALTO-203, ALTO-101, ALTO-202, and ALTO-208. ALTO-100 is a first-in-class, oral small molecule believed to work through enhancing neural plasticity in the hippocampus, a brain region important for both cognition and mood. ALTO-203 is an oral small molecule histamine H3 receptor inverse agonist.

What is the price predicton of ANRO Stock?

Wall Street analysts forecast ANRO stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for ANRO is35.67 USD with a low forecast of 25.00 USD and a high forecast of 50.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Alto Neuroscience Inc (ANRO)'s revenue for the last quarter?

Alto Neuroscience Inc revenue for the last quarter amounts to 0.00 USD, decreased

What is Alto Neuroscience Inc (ANRO)'s earnings per share (EPS) for the last quarter?

Alto Neuroscience Inc. EPS for the last quarter amounts to -0.47 USD, decreased -17.54

How many employees does Alto Neuroscience Inc (ANRO). have?

Alto Neuroscience Inc (ANRO) has 68 emplpoyees as of April 21 2026.

What is Alto Neuroscience Inc (ANRO) market cap?

Today ANRO has the market capitalization of 873.07M USD.