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ANRO Overview

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ET
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0.000(0.000%)
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ET
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Intellectia

Loading chart...

High
23.560
Open
20.720
VWAP
22.41
Vol
444.15K
Mkt Cap
716.08M
Low
20.630
Amount
9.96M
EV/EBITDA(TTM)
--
Total Shares
31.07M
EV
533.29M
EV/OCF(TTM)
--
P/S(TTM)
--
Alto Neuroscience, Inc. is a clinical-stage biopharmaceutical company focused on redefining psychiatry by leveraging neurobiology to develop personalized and effective treatment options. The Company's Precision Psychiatry Platform measures brain biomarkers by analyzing EEG activity, neurocognitive assessments, wearable data, and other factors to identify which patients are likely to respond to its product candidates. Its clinical-stage pipeline includes drug candidates in bipolar depression, major depressive disorder, treatment resistant depression (TRD), and schizophrenia, and other mental health conditions. Its product candidates include ALTO-100, ALTO-300, ALTO-207, ALTO-203, ALTO-101, ALTO-202, and ALTO-208. ALTO-100 is a first-in-class, oral small molecule believed to work through enhancing neural plasticity in the hippocampus, a brain region important for both cognition and mood. ALTO-203 is an oral small molecule histamine H3 receptor inverse agonist.
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Events Timeline

(ET)
2026-02-13
08:10:00
Alto Neuroscience Completes Patient Enrollment for ALTO-101 Clinical Trial
select
2026-01-14 (ET)
2026-01-14
07:40:00
Alto Neuroscience Secures U.S. Patent No. 12,521,374
select
2025-10-20 (ET)
2025-10-20
07:15:41
Alto Neuroscience to Offer 3.832 Million Shares at $5.91 in Private Placement
select

News

PRnewswire
8.5
02-26PRnewswire
Helus Pharma's Psychedelic Drug Achieves Phase 3 Success
  • Clinical Trial Breakthrough: Helus Pharma's SPL026 demonstrated significant efficacy in a randomized controlled trial for treatment-resistant depression, with a MADRS score difference of -7.35 (p=0.023) among 34 participants, providing clinical proof-of-concept that could shift regulatory and investor perspectives on psychedelic applications in psychiatry.
  • Production Quota Increase: The DEA raised the 2026 psilocybin production quota by 67%, creating larger market opportunities for companies like Helus Pharma and accelerating their research and development efforts in psychedelic therapies.
  • Strong Financial Backing: As of December 31, 2025, Helus Pharma reported $195.1 million in cash, ensuring continued advancement of its multi-asset clinical pipeline, particularly for key assets like HLP003 and HLP004.
  • Optimistic Future Outlook: HLP003 has shown a 100% response rate and 71% remission rate in two pivotal Phase 3 studies, with topline data expected in Q4 2026, further solidifying Helus Pharma's market position in depression treatment.
Newsfilter
8.5
02-26Newsfilter
Helus Pharma Achieves Breakthrough in Depression Treatment
  • Clinical Trial Success: Helus Pharma's SPL026 achieved significant results in a Phase 2 trial for treatment-resistant depression, with a mean MADRS difference of -7.35 (p=0.023) among 34 participants receiving a 21.5 mg dose, indicating strong efficacy and market potential for the drug.
  • FDA Breakthrough Therapy: Helus's HLP003 has received FDA Breakthrough Therapy designation and is undergoing two pivotal Phase 3 trials, with early data showing 100% response rates and 71% remission at 12 months, potentially offering new treatment options for depression and solidifying the company's position in the psychiatric drug market.
  • Strong Financial Backing: As of December 31, 2025, Helus Pharma reported $195.1 million in cash reserves, providing robust financial support for the continued advancement of its multi-asset clinical pipeline, ensuring the company can maintain its competitive edge in a rapidly evolving market.
  • Significant Market Potential: The World Health Organization estimates that depression and anxiety cost the global economy over $1 trillion annually in lost productivity, positioning Helus Pharma's innovative drugs to meet this substantial market demand and drive future growth and investment appeal.
Newsfilter
1.0
02-23Newsfilter
Alto Neuroscience to Participate in Upcoming Investor Conferences
  • Investor Conference Schedule: Alto Neuroscience will participate in the TD Cowen 46th Annual Healthcare Conference from March 2-5, 2026, with a fireside chat and one-on-one meetings scheduled for March 3 at 1:50 PM EST, which is expected to attract significant investor interest and enhance the company's visibility in the biopharmaceutical sector.
  • Biotech Summit Participation: Additionally, Alto will attend the Jefferies 2026 Biotech on the Beach Summit on March 10-11, 2026, conducting one-on-one investor meetings that will provide direct engagement opportunities with potential investors, further facilitating funding for its clinical-stage drug candidates.
  • Precision Psychiatry Platform: Alto's Precision Psychiatry Platform aims to better identify patients likely to respond to its drug candidates by analyzing brain biomarkers through EEG activity, neurocognitive assessments, and wearable data, which holds significant market potential for improving treatment outcomes.
  • Clinical Pipeline Overview: Alto's clinical-stage pipeline includes innovative drug candidates targeting depression, schizophrenia, and other mental health conditions, and as the company advances these projects, it is expected to create positive impacts on future market performance and shareholder value.
Newsfilter
9.0
02-13Newsfilter
Alto Completes Patient Enrollment for ALTO-101 Clinical Trial
  • Clinical Trial Enrollment Completed: Alto Neuroscience announced the successful enrollment of 83 patients across 13 clinical sites in the U.S. for its Phase 2 trial of ALTO-101, marking a significant step in developing a novel treatment for cognitive impairment associated with schizophrenia.
  • Innovative Drug Mechanism: ALTO-101 is a novel transdermal phosphodiesterase-4 (PDE4) inhibitor designed to mitigate gastrointestinal side effects commonly associated with oral medications, potentially offering the first effective pharmacological treatment for schizophrenia patients, addressing a significant unmet medical need.
  • Study Design and Objectives: The trial employs a randomized, double-blind, placebo-controlled crossover design to assess the effects of ALTO-101 on electroencephalography (EEG) measures, with topline data expected to guide future development decisions and anticipated to be reported by the end of Q1.
  • Scientific Rationale and Preliminary Findings: Baseline analyses indicated a significant association between reduced theta-band inter-trial coherence (ITC) and slower processing speed, supporting ALTO-101 as a potential biomarker for cognitive impairment in schizophrenia, thereby reinforcing the scientific rationale for the program.
NASDAQ.COM
2.0
01-28NASDAQ.COM
Healthcare Stocks Surge in After-Hours Trading
  • Acumen Pharmaceuticals Surge: Acumen Pharmaceuticals, Inc. (ABOS) advanced 8.09% in after-hours trading to close at $2.94, adding $0.22, indicating strong investor confidence in its growth prospects.
  • Fulgent Genetics Rise: Fulgent Genetics, Inc. (FLGT) rose 5.98% to $28.90 in after-hours trading, gaining $1.63, reflecting market optimism regarding its business outlook.
  • Fractyl Health Growth: Fractyl Health, Inc. (GUTS) climbed 5.19% to $2.23 after hours, up $0.11, suggesting that its potential in the biotech sector is being recognized by the market.
  • Coeptis Therapeutics Increase: Coeptis Therapeutics Holdings, Inc. (COEP) added 4.14% to finish at $13.85, gaining $0.55 in after-hours trading, demonstrating investor support for its strategic direction.
Globenewswire
7.0
01-20Globenewswire
Alto Neuroscience and Others Under Investigation for Shareholder Claims
  • Shareholder Lawsuit Investigation: Johnson Fistel, PLLP is investigating shareholder claims against Alto Neuroscience (NYSE: ANRO) and others, alleging breaches of fiduciary duty that could lead to corporate governance reforms and return of funds.
  • False Statements Allegations: Alto Neuroscience is accused of making false statements regarding the efficacy of its lead drug ALTO-100, resulting in investor losses when the truth was revealed, negatively impacting the company's reputation and stock price.
  • Anticompetitive Pricing Practices: Atkore Inc. (NYSE: ATKR) faces a securities class action lawsuit alleging executives failed to disclose anticompetitive pricing practices related to PVC pipe products, which may lead to legal risks and diminished shareholder trust.
  • Safety Risks Concealment: Fly-E Group (NASDAQ: FLYE) is accused of downplaying safety risks associated with its lithium battery technology in electric mobility products, leading to a stock price decline and harming investor interests, affecting the company's future growth prospects.
Wall Street analysts forecast ANRO stock price to rise
8 Analyst Rating
Wall Street analysts forecast ANRO stock price to rise
8 Buy
0 Hold
0 Sell
Strong Buy
Current: 0.000
sliders
Low
25.00
Averages
35.67
High
50.00
Current: 0.000
sliders
Low
25.00
Averages
35.67
High
50.00
BTIG
Thomas Shrader
Buy
maintain
$27 -> $28
AI Analysis
2026-02-17
Reason
BTIG
Thomas Shrader
Price Target
$27 -> $28
AI Analysis
2026-02-17
maintain
Buy
Reason
BTIG analyst Thomas Shrader raised the firm's price target on Alto Neuroscience to $28 from $27 and keeps a Buy rating on the shares. The firm cites the Alto approach to precision psychiatry being focused on optimizing patient selection to match a candidate drug's molecular mechanism to a specific disease-associated impairment in order to maximize treatment effects, further noting that the ALTO-101 trial in the cognitive impairment associated with schizophrenia, CIAS, seems an ideal test case, the analyst tells investors in a research note.
BTIG
Thomas Shrader
initiated
$27
2025-11-17
Reason
BTIG
Thomas Shrader
Price Target
$27
2025-11-17
initiated
Reason
BTIG analyst Thomas Shrader initiated coverage of Alto Neuroscience with a Buy rating and $27 price target. The company is focused on next-generation drugs in psychiatry, including major depressive disorder and treatment-resistant depression, the analyst tells investors in a research note. The firm says each of Alto's programs is supported by "innovative" biomarkers to define subgroups of patients most likely to respond to the specific mechanism of the drug. It sees "several near-term validating" data readouts for the company.
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Valuation Metrics

The current forward P/E ratio for Alto Neuroscience Inc (ANRO.N) is -7.16, compared to its 5-year average forward P/E of -3.25. For a more detailed relative valuation and DCF analysis to assess Alto Neuroscience Inc's fair value, Click here.

Forward PE

The forward P/E ratio is a valuation metric that divides a company's current stock price by its estimated future earnings per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PE
-3.25
Current PE
-7.16
Overvalued PE
-1.13
Undervalued PE
-5.36

Forward EV/EBITDA

The forward EV/EBITDA ratio is a valuation metric that divides a company's enterprise value (EV) by its estimated future earnings before interest, taxes, depreciation, and amortization (EBITDA) over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average EV/EBITDA
-0.20
Current EV/EBITDA
-4.18
Overvalued EV/EBITDA
0.98
Undervalued EV/EBITDA
-1.38

Forward PS

The forward P/S ratio is a valuation metric that divides a company's current stock price by its estimated future sales (or revenue) per share over the next 12 months.
StronglyUndervaluedUndervaluedFairOvervaluedStronglyOvervalueddotted line Image
N/A
5Y Average PS
0.00
Current PS
0.00
Overvalued PS
0.00
Undervalued PS
0.00

Financials

AI Analysis
Annual
Quarterly

Whales Holding ANRO

V
Vivo Capital, LLC
Holding
ANRO
+6.93%
3M Return
C
Commodore Capital LP
Holding
ANRO
+6.92%
3M Return
V
Vestal Point Capital, LP
Holding
ANRO
+6.42%
3M Return
P
Perceptive Advisors LLC
Holding
ANRO
+3.66%
3M Return
A
Armistice Capital LLC
Holding
ANRO
-6.08%
3M Return

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Frequently Asked Questions

What is Alto Neuroscience Inc (ANRO) stock price today?

The current price of ANRO is 23.05 USD — it has increased 10.39

What is Alto Neuroscience Inc (ANRO)'s business?

Alto Neuroscience, Inc. is a clinical-stage biopharmaceutical company focused on redefining psychiatry by leveraging neurobiology to develop personalized and effective treatment options. The Company's Precision Psychiatry Platform measures brain biomarkers by analyzing EEG activity, neurocognitive assessments, wearable data, and other factors to identify which patients are likely to respond to its product candidates. Its clinical-stage pipeline includes drug candidates in bipolar depression, major depressive disorder, treatment resistant depression (TRD), and schizophrenia, and other mental health conditions. Its product candidates include ALTO-100, ALTO-300, ALTO-207, ALTO-203, ALTO-101, ALTO-202, and ALTO-208. ALTO-100 is a first-in-class, oral small molecule believed to work through enhancing neural plasticity in the hippocampus, a brain region important for both cognition and mood. ALTO-203 is an oral small molecule histamine H3 receptor inverse agonist.

What is the price predicton of ANRO Stock?

Wall Street analysts forecast ANRO stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for ANRO is35.67 USD with a low forecast of 25.00 USD and a high forecast of 50.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.

What is Alto Neuroscience Inc (ANRO)'s revenue for the last quarter?

Alto Neuroscience Inc revenue for the last quarter amounts to 0.00 USD, decreased

What is Alto Neuroscience Inc (ANRO)'s earnings per share (EPS) for the last quarter?

Alto Neuroscience Inc. EPS for the last quarter amounts to -0.52 USD, decreased -16.13

How many employees does Alto Neuroscience Inc (ANRO). have?

Alto Neuroscience Inc (ANRO) has 76 emplpoyees as of March 12 2026.

What is Alto Neuroscience Inc (ANRO) market cap?

Today ANRO has the market capitalization of 716.08M USD.