Acrivon Updates ACR-368 Phase 2 Data, Reports 39% ORR in Endometrial Cancer
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Jan 08 2026
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Source: Benzinga
- Clinical Trial Progress: In the ACR-368 Phase 2b registrational trial for endometrial cancer, the overall response rate (ORR) was reported at 39%, with a notable 44% ORR in patients with more than two prior therapies, indicating the drug's potential in refractory cases.
- Targeted Strategy: Following the analysis of response rates in serous endometrial cancer patients, Arm 3 of the trial will focus exclusively on subjects with ≤2 prior treatments, aiming to enhance the trial's effectiveness and specificity.
- New Drug Development Update: Initial clinical data from ACR-2316 shows a tumor shrinkage rate of 45% in patients with small cell lung cancer and squamous non-small cell lung cancer at doses of 120 mg and above, providing a positive clinical basis for future treatment regimens.
- Financial Overview: As of December 31, 2025, Acrivon reported approximately $119 million in cash and cash equivalents, expected to fund operations and capital expenditures into the second quarter of 2027, ensuring continued investment in R&D.
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Analyst Views on ACRV
Wall Street analysts forecast ACRV stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for ACRV is 10.50 USD with a low forecast of 7.00 USD and a high forecast of 19.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
6 Analyst Rating
5 Buy
1 Hold
0 Sell
Strong Buy
Current: 1.890
Low
7.00
Averages
10.50
High
19.00
Current: 1.890
Low
7.00
Averages
10.50
High
19.00
About ACRV
Acrivon Therapeutics, Inc. is a clinical-stage biopharmaceutical company developing precision oncology medicines. It uses its precision Generative Phosphoproteomics platform, Acrivon Predictive Precision Proteomics (AP3), to develop its pipeline of oncology drug candidates. Its lead candidate, ACR-368, is a selective small molecule inhibitor which targets CHK1 and CHK2 at sub single-digit nM and single-digit nM potency in intact cells, respectively, in a registrational Phase II trial across multiple solid tumor types. Using its AP3 platform, it has developed a predictive OncoSignature test for ACR-368, called ACR-368 OncoSignature, that can predict patient response to ACR-368 monotherapy and therefore improve the clinical overall response rate (ORR) and has the potential to enable drug development. Its preclinical program, ACR-2316, is advancing in investigational new drug-enabling studies. It is a novel, dual WEE1 and PKMYT1 inhibitor small molecule development candidate.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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