Compass Pathways Achieves Significant Success in COMP360 Trials
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Jun 23 2025
0mins
Should l Buy CMPS?
Compass Pathways PLC's stock surged by 17.90% in pre-market trading, crossing above the 5-day SMA, following the announcement of significant success in its COMP360 Phase 3 trials.
The company reported a highly statistically significant reduction in MADRS scores in both Phase 3 trials of COMP360, a treatment for treatment-resistant depression (TRD). The results indicated a mean difference of -3.8 (p<0.001), showcasing the drug's efficacy. Additionally, Compass has requested a meeting with the FDA to discuss a rolling submission for a New Drug Application (NDA) expected to be completed in Q4 2024, paving the way for market launch.
These promising trial results not only highlight the potential of COMP360 as a new treatment option but also position Compass Pathways favorably in the mental health treatment landscape, potentially attracting more investor interest.
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Analyst Views on CMPS
Wall Street analysts forecast CMPS stock price to rise
7 Analyst Rating
6 Buy
1 Hold
0 Sell
Strong Buy
Current: 8.450
Low
8.00
Averages
18.43
High
40.00
Current: 8.450
Low
8.00
Averages
18.43
High
40.00
About CMPS
Compass Pathways plc is a United Kingdom-based biotechnology company dedicated to accelerating patient access to evidence-based innovation in mental health. The Company is engaged in treating mental health conditions focused on rapid and durable responses through the development of its investigational COMP360 psilocybin treatment. COMP360 is its psilocybin formulation that includes its pharmaceutical-grade polymorphic crystalline psilocybin, optimized for stability and purity. The Company’s initial focus is on treatment-resistant depression (TRD), comprising patients who are inadequately served by the current treatment paradigm. It commenced its Phase III program evaluating its COMP360 psilocybin treatment in TRD. In addition, the Company has ongoing Phase II trials in PTSD and anorexia nervosa. It also provides support to research institutions conducting investigator-initiated studies with COMP360 psilocybin in areas of serious unmet need.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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- Pre-Funded Warrants: The company also offered pre-funded warrants to purchase up to 1.25 million ADSs at $7.9999 each to certain institutional investors, enhancing the flexibility and attractiveness of its fundraising efforts.
- Use of Proceeds: The net proceeds will fund ongoing Phase 3 trials for COMP005 and COMP006, as well as a Phase 2b/3 trial of COMP360 for PTSD, indicating a strategic focus on advancing its clinical pipeline and commercial readiness.
- Underwriter Option: Underwriters have been granted a 30-day option for an additional 2.8125 million ADSs, which not only provides additional funding security for the company but also reflects optimistic market expectations for its future growth.
See More
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- Offering Size: Compass Pathways announced the pricing of 17,500,000 American Depositary Shares (ADSs) at $8.00 each, expecting gross proceeds of $150 million, indicating strong demand and investor confidence in the capital markets.
- Additional Option: The underwriters have a 30-day option to purchase an additional 2,812,500 ADSs, enhancing the offering's flexibility and potential inflow of funds, reflecting optimistic market sentiment regarding the company's future prospects.
- Use of Proceeds: The proceeds from this offering will fund ongoing Phase 3 trials for COMP005 and COMP006, as well as the Phase 2b/3 trial of COMP360 for PTSD, demonstrating the company's commitment to innovation and investment in mental health.
- Underwriting Team: Jefferies, TD Cowen, Cantor, and Stifel are acting as joint book-runners, indicating strong professional support in the capital markets, which enhances the company's market position in the biotechnology sector.
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- Use of Proceeds: The funds will support ongoing Phase 3 trials for COMP005 and COMP006, as well as the Phase 2b/3 trial of COMP360 for PTSD, highlighting the company's commitment to innovation in mental health treatments.
- Underwriting Team: Jefferies, TD Cowen, Cantor, and Stifel are acting as joint book-runners for the offering, which enhances market confidence in the transaction and lays a foundation for future capital activities.
- Regulatory Compliance: The offering is conducted under a previously filed S-3 registration statement, ensuring compliance and providing transparency to investors, thereby enhancing the company's credibility in the investment community.
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- Sales Miss: The quarterly sales of $175.694 million fell short of the analyst consensus estimate of $177.533 million, yet the overall performance reflects the company's resilience in a competitive fast-food market.
- Stock Surge: Following the earnings report, Wingstop's shares jumped 17.3% to $295.31 on Wednesday, signaling optimistic investor sentiment and potentially attracting more institutional interest in the stock.
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- Guidance Downgrade: Palo Alto lowered its full-year adjusted earnings guidance from a range of $3.80 to $3.90 per share to a new range of $3.65 to $3.70, below the market estimate of $3.86, which may impact investor confidence.
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