Acrivon Therapeutics Inc. saw a significant price increase of 36.61%, reaching a 20-day high in pre-market trading. This surge comes amid broader market weakness, with the Nasdaq-100 down 0.22% and the S&P 500 down 0.17%. The stock's rise is attributed to the company's announcement of updated interim data for ACR-368, a selective CHK1/CHK2 inhibitor currently in Phase 2b development for endometrial cancer, which has received FDA Fast Track designation, indicating strong market potential.
The upcoming presentation of clinical data on January 8, 2026, has generated optimism among investors regarding Acrivon's R&D progress, which could influence future financing and partnership opportunities. Additionally, the company is expected to share early clinical data for ACR-2316, further enhancing investor confidence in its innovative pipeline.
Overall, Acrivon's strong financial position, with $134.4 million in cash and equivalents, supports its ongoing R&D efforts, making it well-positioned for future growth despite the current market conditions.
Wall Street analysts forecast ACRV stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for ACRV is 10.50 USD with a low forecast of 7.00 USD and a high forecast of 19.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
6 Analyst Rating
Wall Street analysts forecast ACRV stock price to rise over the next 12 months. According to Wall Street analysts, the average 1-year price target for ACRV is 10.50 USD with a low forecast of 7.00 USD and a high forecast of 19.00 USD. However, analyst price targets are subjective and often lag stock prices, so investors should focus on the objective reasons behind analyst rating changes, which better reflect the company's fundamentals.
5 Buy
1 Hold
0 Sell
Strong Buy
Current: 1.890
Low
7.00
Averages
10.50
High
19.00
Current: 1.890
Low
7.00
Averages
10.50
High
19.00
Piper Sandler
Overweight
maintain
$6 -> $8
2026-01-09
Reason
Piper Sandler
Price Target
$6 -> $8
AI Analysis
2026-01-09
maintain
Overweight
Reason
Piper Sandler raised the firm's price target on Acrivon Therapeutics to $8 from $6 and keeps an Overweight rating on the shares. The firm notes Acrivon hosted a virtual R&D event and updated Phase II data showing 105mg/m2 q2W ACR-368 achieved a 39% overall response rate among OncoSignature-positive endometrial cancer patients. Acrivon plans to submit an IND for newly unveiled CDK11 inhibitor ACR-6840 in Q4 2026.
Oppenheimer
Oppenheimer
Outperform
downgrade
$9 -> $8
2025-08-14
Reason
Oppenheimer
Oppenheimer
Price Target
$9 -> $8
2025-08-14
downgrade
Outperform
Reason
Oppenheimer lowered the firm's price target on Acrivon Therapeutics to $8 from $9 and keeps an Outperform rating on the shares following Q2 results. The firm notes Phase 1 trial of ACR-2316 is on track for the second half of 2025.
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JonesResearch
Buy
to
Hold
downgrade
2025-05-16
Reason
JonesResearch
Price Target
2025-05-16
downgrade
Buy
to
Hold
Reason
JonesResearch downgraded Acrivon Therapeutics to Hold from Buy without a price target. Investors may now be focused on ACR-2316 as a way to re-validate the company's tumor-selection platform, the analyst tells investors in a research note. The firm prefers to wait for initial data from ACR-2316 in the second half of 2025 and more meaningful data in 2026 before recommending the shares. Jones would like to see some "real de-risking clinical data to comfortably" value Acrivon's biomarker-based selection platform.
Oppenheimer
Oppenheimer
Outperform
downgrade
$10 -> $9
2025-05-14
Reason
Oppenheimer
Oppenheimer
Price Target
$10 -> $9
2025-05-14
downgrade
Outperform
Reason
Oppenheimer lowered the firm's price target on Acrivon Therapeutics to $9 from $10 and keeps an Outperform rating on the shares. The firm is adjusting its model after the company's Q1 results and updates on its cash and share position, the analyst tells investors in a research note.
About ACRV
Acrivon Therapeutics, Inc. is a clinical-stage biopharmaceutical company developing precision oncology medicines. It uses its precision Generative Phosphoproteomics platform, Acrivon Predictive Precision Proteomics (AP3), to develop its pipeline of oncology drug candidates. Its lead candidate, ACR-368, is a selective small molecule inhibitor which targets CHK1 and CHK2 at sub single-digit nM and single-digit nM potency in intact cells, respectively, in a registrational Phase II trial across multiple solid tumor types. Using its AP3 platform, it has developed a predictive OncoSignature test for ACR-368, called ACR-368 OncoSignature, that can predict patient response to ACR-368 monotherapy and therefore improve the clinical overall response rate (ORR) and has the potential to enable drug development. Its preclinical program, ACR-2316, is advancing in investigational new drug-enabling studies. It is a novel, dual WEE1 and PKMYT1 inhibitor small molecule development candidate.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
