Valneva SE Reports Wider Net Loss for Fiscal 2025
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Mar 18 2026
0mins
Should l Buy VALN?
Source: NASDAQ.COM
- Financial Performance Decline: Valneva SE reported a net loss of €115.19 million for fiscal 2025, significantly widening from a loss of €12.25 million in 2024, primarily due to the absence of prior year gains and lower product sales, indicating severe challenges in profitability.
- Sales Decline: Product sales fell to €157.91 million in 2025 from €163.25 million in 2024, reflecting the planned wind-down of third-party sales, although proprietary product sales increased by 9% at constant exchange rates, highlighting a mixed sales performance.
- Positive Future Outlook: Valneva anticipates 2026 to be a potentially transformational year, with Phase 3 Lyme disease data expected in the first half of the year, which could significantly enhance the company's market position and investor confidence if results are favorable.
- Revenue Guidance Adjustment: The company expects total revenues for 2026 to range between €155 million and €170 million, including product sales between €145 million and €160 million, reflecting a cautious outlook on future sales amid the planned reduction of third-party sales.
Trade with 70% Backtested Accuracy
Stop guessing "Should I Buy VALN?" and start using high-conviction signals backed by rigorous historical data.
Sign up today to access powerful investing tools and make smarter, data-driven decisions.
Analyst Views on VALN
Wall Street analysts forecast VALN stock price to rise
2 Analyst Rating
1 Buy
1 Hold
0 Sell
Moderate Buy
Current: 6.170
Low
7.55
Averages
10.28
High
13.00
Current: 6.170
Low
7.55
Averages
10.28
High
13.00
About VALN
Valneva SE is a France-based company that specializes in the development, manufacture and commercialization of vaccines to protect people from infectious diseases through preventative medicine. The Company's portfolio includes two commercial vaccines for travelers: IXIARO/JESPECT, for the prevention of Japanese Encephalitis, and DUKORAL, which is indicated for the prevention of cholera and, in some countries, prevention of diarrhea caused by Enterotoxigenic escherichia coli (ETEC). The Company has also vaccines in development, including candidates against Lyme disease, COVID-19 and chikungunya. Its technologies and services segment cooperates with various pharmaceutical companies using its platform: EB66 vaccine production cell line and IC31 adjuvant. The Company is focused on research and development (R&D) programs, as well as holds investment in product candidates and commercial products.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
Biotech Landscape Update: Regulatory Approvals and Mergers
- Anavex Drug Withdrawal: Anavex Life Sciences Corp. (AVXL) withdrew its EU marketing application for Alzheimer's drug Blarcamesine after the EMA's CHMP indicated it could not issue a positive opinion, marking a significant setback for the company's lead candidate despite continued support from patient groups.
- Quoin FDA Alignment: Quoin Pharmaceuticals Ltd. (QNRX) received positive feedback from the FDA confirming that a single Phase 3 trial may suffice for U.S. approval of QRX003 for Netherton Syndrome, with plans to initiate Phase 3 in 2026 and potentially file an NDA in 2027.
- Corcept Drug Approval: Corcept Therapeutics Inc. (CORT) secured FDA approval for Lifyorli combined with nab-paclitaxel to treat platinum-resistant ovarian cancer, based on Phase 3 ROSELLA trial results involving 381 patients, marking the first FDA-approved selective glucocorticoid receptor antagonist.
- Merck Acquires Terns: Merck (MRK) announced a definitive agreement to acquire Terns Pharmaceuticals for $53.00 per share, totaling approximately $6.7 billion, which is expected to enhance Merck's presence in hematology, with the transaction anticipated to close in Q2 2026.
See More
Valneva to Participate in World Vaccine Congress 2026
- Congress Participation: Valneva SE will participate in the World Vaccine Congress from March 31 to April 2, 2026, in Washington D.C., with CEO Thomas Lingelbach leading a team of senior executives, showcasing the company's leadership in vaccine development.
- Vaccine Campaign Launch: In collaboration with Instituto Butantan, Valneva has initiated a pilot vaccination campaign for its IXCHIQ® vaccine in Brazil, with over 12,000 individuals vaccinated, aimed at evaluating the vaccine's effectiveness and safety for post-marketing commitment studies.
- Academic Engagement: On April 1, 2026, at 9:40 am EST, Valneva's Vice President of Clinical Development, Susanne Eder-Lingelbach, will present updates on chikungunya vaccine development, enhancing the company's academic influence in the vaccine sector.
- Strategic Partnership Expansion: Valneva will leverage the congress to meet with current and potential partners, demonstrating its strengths in vaccine development and commercialization, thereby furthering its global market expansion efforts.
See More
Valneva's Vaccine Trial Fails to Meet Primary Endpoint
- Vaccine Trial Results: Valneva and Pfizer's investigational 6-valent OspA-based Lyme disease vaccine PF-07307405 (LB6V) failed to meet its primary endpoint in the Phase 3 VALOR clinical trial, with the companies characterizing the data as positive despite a low incidence of disease cases.
- Stock Price Plunge: Following the trial results announcement, Valneva's American Depositary Receipt (ADR) price fell by $3.83, or 37.11%, closing at $6.49, reflecting strong market concerns regarding the vaccine's prospects.
- Legal Investigation Initiated: Pomerantz LLP is investigating whether Valneva and its executives engaged in securities fraud or other unlawful business practices, advising investors to contact them for more information, indicating a potential loss of confidence in the company's governance.
- Historical Context: Pomerantz LLP, recognized as a leading firm in securities class action litigation with over 85 years of experience, focuses on fighting for the rights of victims of securities fraud, suggesting that this incident may lead to broader legal ramifications.
See More
Valneva's Lyme Disease Vaccine Candidate Shows Over 70% Efficacy
- Significant Vaccine Efficacy: Valneva's Lyme disease vaccine candidate, developed in partnership with Pfizer, demonstrated over 70% efficacy in a large Phase 3 study, although it failed to meet the statistical threshold for the primary endpoint due to lower-than-expected case numbers, still providing confidence in the vaccine's potential.
- Strong Safety Profile: The vaccine was well tolerated with no safety concerns identified during the analysis, and Pfizer's Chief Vaccines Officer Annaliesa Anderson described the results as 'highly encouraging,' emphasizing the critical need for a preventive option for Lyme disease, indicating its strategic importance in the market.
- Robust Financial Position: Valneva reported €109.7 million in cash and cash equivalents at the end of 2025, with expectations of further declines in operating cash burn in 2026 while still supporting strategic R&D investments, showcasing the company's focus on financial management.
- Market Reaction Volatility: Despite the vaccine's strong efficacy, Valneva's stock closed down 1.67% on March 20, 2026, and fell 35.08% in pre-market trading, reflecting a cautious market sentiment regarding the vaccine's potential.
See More
Experimental Lyme Disease Vaccine Shows Over 70% Efficacy
- Vaccine Efficacy: Pfizer and Valneva announced that their experimental Lyme disease vaccine demonstrated over 70% efficacy in individuals aged five and older, although the clinical trial did not meet its primary endpoint, indicating both potential and market risks.
- Clinical Trial Results: The trial failed to meet its primary endpoint due to fewer Lyme disease cases than expected during the study period, which directly impacted Valneva's stock price, plunging over 38% on the Paris stock exchange, highlighting market sensitivity to clinical outcomes.
- Vaccine Development Outlook: Despite the disappointing trial results, Pfizer remains confident in the vaccine's potential and plans to submit applications to regulatory authorities in the U.S. and EU, indicating a long-term commitment to the vaccine market.
- Global Health Impact: Lyme disease is the most common tick-borne illness globally, with research in 2022 estimating that over 14% of the global population has been infected, and the potential increase in transmission rates due to climate change underscores the critical need for vaccine development.
See More
Pfizer and Valneva Report Phase 3 Results for Lyme Disease Vaccine
- Vaccine Efficacy: Pfizer and Valneva's Lyme disease vaccine candidate PF-07307405 demonstrated over 70% efficacy in individuals aged five and older, significantly boosting confidence in its potential to change Lyme disease prevention strategies.
- Safety Assessment: The investigational vaccine was well tolerated with no safety concerns identified during the analysis, laying a solid foundation for future regulatory submissions and indicating its feasibility for clinical use.
- Market Demand: Lyme disease can lead to serious consequences that disrupt daily life, work, and long-term health, and with no available vaccine currently, the development of this vaccine holds significant market importance.
- Regulatory Plans: Pfizer is planning submissions to regulatory authorities to advance the vaccine's market entry, reflecting the company's confidence in the candidate and its potential impact on public health.
See More
Biotech Landscape Update: Regulatory Approvals and Mergers
- Anavex Drug Withdrawal: Anavex Life Sciences Corp. (AVXL) withdrew its EU marketing application for Alzheimer's drug Blarcamesine after the EMA's CHMP indicated it could not issue a positive opinion, marking a significant setback for the company's lead candidate despite continued support from patient groups.
- Quoin FDA Alignment: Quoin Pharmaceuticals Ltd. (QNRX) received positive feedback from the FDA confirming that a single Phase 3 trial may suffice for U.S. approval of QRX003 for Netherton Syndrome, with plans to initiate Phase 3 in 2026 and potentially file an NDA in 2027.
- Corcept Drug Approval: Corcept Therapeutics Inc. (CORT) secured FDA approval for Lifyorli combined with nab-paclitaxel to treat platinum-resistant ovarian cancer, based on Phase 3 ROSELLA trial results involving 381 patients, marking the first FDA-approved selective glucocorticoid receptor antagonist.
- Merck Acquires Terns: Merck (MRK) announced a definitive agreement to acquire Terns Pharmaceuticals for $53.00 per share, totaling approximately $6.7 billion, which is expected to enhance Merck's presence in hematology, with the transaction anticipated to close in Q2 2026.
See More
Valneva to Participate in World Vaccine Congress 2026
- Congress Participation: Valneva SE will participate in the World Vaccine Congress from March 31 to April 2, 2026, in Washington D.C., with CEO Thomas Lingelbach leading a team of senior executives, showcasing the company's leadership in vaccine development.
- Vaccine Campaign Launch: In collaboration with Instituto Butantan, Valneva has initiated a pilot vaccination campaign for its IXCHIQ® vaccine in Brazil, with over 12,000 individuals vaccinated, aimed at evaluating the vaccine's effectiveness and safety for post-marketing commitment studies.
- Academic Engagement: On April 1, 2026, at 9:40 am EST, Valneva's Vice President of Clinical Development, Susanne Eder-Lingelbach, will present updates on chikungunya vaccine development, enhancing the company's academic influence in the vaccine sector.
- Strategic Partnership Expansion: Valneva will leverage the congress to meet with current and potential partners, demonstrating its strengths in vaccine development and commercialization, thereby furthering its global market expansion efforts.
See More
Valneva's Vaccine Trial Fails to Meet Primary Endpoint
- Vaccine Trial Results: Valneva and Pfizer's investigational 6-valent OspA-based Lyme disease vaccine PF-07307405 (LB6V) failed to meet its primary endpoint in the Phase 3 VALOR clinical trial, with the companies characterizing the data as positive despite a low incidence of disease cases.
- Stock Price Plunge: Following the trial results announcement, Valneva's American Depositary Receipt (ADR) price fell by $3.83, or 37.11%, closing at $6.49, reflecting strong market concerns regarding the vaccine's prospects.
- Legal Investigation Initiated: Pomerantz LLP is investigating whether Valneva and its executives engaged in securities fraud or other unlawful business practices, advising investors to contact them for more information, indicating a potential loss of confidence in the company's governance.
- Historical Context: Pomerantz LLP, recognized as a leading firm in securities class action litigation with over 85 years of experience, focuses on fighting for the rights of victims of securities fraud, suggesting that this incident may lead to broader legal ramifications.
See More
Valneva's Lyme Disease Vaccine Candidate Shows Over 70% Efficacy
- Significant Vaccine Efficacy: Valneva's Lyme disease vaccine candidate, developed in partnership with Pfizer, demonstrated over 70% efficacy in a large Phase 3 study, although it failed to meet the statistical threshold for the primary endpoint due to lower-than-expected case numbers, still providing confidence in the vaccine's potential.
- Strong Safety Profile: The vaccine was well tolerated with no safety concerns identified during the analysis, and Pfizer's Chief Vaccines Officer Annaliesa Anderson described the results as 'highly encouraging,' emphasizing the critical need for a preventive option for Lyme disease, indicating its strategic importance in the market.
- Robust Financial Position: Valneva reported €109.7 million in cash and cash equivalents at the end of 2025, with expectations of further declines in operating cash burn in 2026 while still supporting strategic R&D investments, showcasing the company's focus on financial management.
- Market Reaction Volatility: Despite the vaccine's strong efficacy, Valneva's stock closed down 1.67% on March 20, 2026, and fell 35.08% in pre-market trading, reflecting a cautious market sentiment regarding the vaccine's potential.
See More
Experimental Lyme Disease Vaccine Shows Over 70% Efficacy
- Vaccine Efficacy: Pfizer and Valneva announced that their experimental Lyme disease vaccine demonstrated over 70% efficacy in individuals aged five and older, although the clinical trial did not meet its primary endpoint, indicating both potential and market risks.
- Clinical Trial Results: The trial failed to meet its primary endpoint due to fewer Lyme disease cases than expected during the study period, which directly impacted Valneva's stock price, plunging over 38% on the Paris stock exchange, highlighting market sensitivity to clinical outcomes.
- Vaccine Development Outlook: Despite the disappointing trial results, Pfizer remains confident in the vaccine's potential and plans to submit applications to regulatory authorities in the U.S. and EU, indicating a long-term commitment to the vaccine market.
- Global Health Impact: Lyme disease is the most common tick-borne illness globally, with research in 2022 estimating that over 14% of the global population has been infected, and the potential increase in transmission rates due to climate change underscores the critical need for vaccine development.
See More
Pfizer and Valneva Report Phase 3 Results for Lyme Disease Vaccine
- Vaccine Efficacy: Pfizer and Valneva's Lyme disease vaccine candidate PF-07307405 demonstrated over 70% efficacy in individuals aged five and older, significantly boosting confidence in its potential to change Lyme disease prevention strategies.
- Safety Assessment: The investigational vaccine was well tolerated with no safety concerns identified during the analysis, laying a solid foundation for future regulatory submissions and indicating its feasibility for clinical use.
- Market Demand: Lyme disease can lead to serious consequences that disrupt daily life, work, and long-term health, and with no available vaccine currently, the development of this vaccine holds significant market importance.
- Regulatory Plans: Pfizer is planning submissions to regulatory authorities to advance the vaccine's market entry, reflecting the company's confidence in the candidate and its potential impact on public health.
See More
