Roche's New Drug Trial Misses Primary Goal
Written by Emily J. Thompson, Senior Investment Analyst
Updated: 10 hours ago
0mins
Source: Benzinga
- Trial Results: Roche's phase 3 persevERA breast cancer study of giredestrant combined with palbociclib failed to meet its primary goal of statistically significant improvement in progression-free survival compared to letrozole plus palbociclib, although it showed a numerical improvement, indicating that the efficacy of this combination still requires further validation.
- Safety Assessment: The adverse events associated with the giredestrant combination were manageable and consistent with the known safety profiles of each treatment, suggesting potential safety for clinical application of the drug.
- Future Research Plans: Roche's Chief Medical Officer Levi Garraway stated that despite the trial not meeting its primary goal, there is still confidence in the potential of combining giredestrant with a CDK4/6 inhibitor in the adjuvant setting, with plans for further studies to validate its clinical activity.
- Stock Reaction: Roche's shares fell by 5% in early Zurich trading, reflecting the market's negative reaction to the trial results, even though the FDA has accepted the New Drug Application based on evERA data, with a review date set for December 18.
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Analyst Views on LLY
Wall Street analysts forecast LLY stock price to rise
20 Analyst Rating
18 Buy
2 Hold
0 Sell
Strong Buy
Current: 990.330
Low
950.00
Averages
1192
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1500
Current: 990.330
Low
950.00
Averages
1192
High
1500
About LLY
Eli Lilly and Company is a medicine company, which discovers, develops, manufactures, markets, and sells pharmaceutical products worldwide. Its cardiometabolic health products include Basaglar; Humalog, Humalog Mix 75/25, Humalog U-100, Humalog U-200, Humalog Mix 50/50, insulin lispro, and others; Humulin, Humulin 70/30, and others; Jardiance; Mounjaro; Trulicity; Zepbound; VERVE-102; VERVE-201, and VERVE-301. Its oncology products include Cyramza, Erbitux, Tyvyt, and Verzenio. Its immunology products include Ebglyss, Olumiant, Omvoh, and Taltz. Its neuroscience products include Emgality and Kisunla. The Company is also engaged in radiopharmaceutical discovery, development, and manufacturing efforts, and clinical and pre-clinical radioligand therapies in development for the treatment of cancer. It is also developing an oral small molecule inhibitor of a4b7 integrin for inflammatory bowel disease (IBD). It is evaluating its novel gene therapy candidate, ixoberogene soroparvovec.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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