Rigel Pharmaceuticals Updates R289 Clinical Data, Anticipates Phase 2 Dose Selection in 2026
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Dec 07 2025
0mins
Should l Buy RIGL?
Source: PRnewswire
- Clinical Trial Progress: Rigel Pharmaceuticals presented updated clinical data for R289 at the 67th American Society of Hematology Annual Meeting, highlighting its potential as a treatment for relapsed or refractory lower-risk myelodysplastic syndrome (MDS), with a recommended Phase 2 dose selection anticipated in the second half of 2026.
- Patient Enrollment Completion: As of July 2025, the dose escalation phase of R289 has completed enrollment, and the dose expansion phase began in October, planning to randomize up to 40 patients to receive either 500 mg once or twice daily to assess safety and preliminary efficacy.
- FDA Fast Track Designation: R289 has received Orphan Drug and Fast Track designations from the FDA, underscoring its significance in treating transfusion-dependent lower-risk MDS patients and potentially introducing a new therapeutic option in this area.
- Future Outlook: Rigel Pharmaceuticals is committed to developing new therapies to meet the unmet medical needs of lower-risk MDS patients, and the success of R289 could significantly improve patient quality of life while advancing the company's position in the biotechnology sector.
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Analyst Views on RIGL
Wall Street analysts forecast RIGL stock price to rise
4 Analyst Rating
2 Buy
2 Hold
0 Sell
Moderate Buy
Current: 29.520
Low
38.00
Averages
52.00
High
71.00
Current: 29.520
Low
38.00
Averages
52.00
High
71.00
About RIGL
Rigel Pharmaceuticals, Inc. is a biotechnology company. The Company is engaged in developing and providing novel therapies that significantly improve the lives of patients with hematologic disorders and cancer. It is focused on products that address signaling pathways that are critical to disease mechanisms. Its first product is TAVALISSE (fostamatinib disodium hexahydrate) tablets, the approved oral spleen tyrosine kinase inhibitor for the treatment of adult patients with chronic immune thrombocytopenia (ITP) who have had an insufficient response to a previous treatment. Its second product is REZLIDHIA (olutasidenib) capsules for the treatment of adult patients with relapsed or refractory (R/R) acute myeloid leukemia (AML) with a susceptible isocitrate dehydrogenase-1 (IDH1) mutation as detected by an FDA-approved test. Its GAVRETO (pralsetinib) product is a once daily, small molecule, oral, kinase inhibitor of wild type rearranged during transfection (RET) and oncogenic RET fusions.
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
Rigel Pharmaceuticals Shares Hit Four-Month Low Amid Revenue Decline Projections
- Revenue Decline Projection: Rigel Pharmaceuticals projects a revenue decline for 2026, estimating total revenue between $275 million and $290 million, which represents a ~4% year-over-year drop from last year's $294.3 million, indicating potential challenges ahead for the company's financial health.
- Sharp Drop in Contract Revenue: The company anticipates contract revenue to be between $20 million and $25 million, implying a staggering ~64% year-over-year decline, highlighting significant challenges in its collaborative partnerships that could impact its competitive position in the biotech sector.
- Product Sales Growth: Despite the overall revenue decline, Rigel expects net product sales to reach approximately $255 million to $265 million, reflecting an ~11% year-over-year increase, suggesting strong market demand for its core products, which may provide some financial stability.
- Earnings Exceed Expectations: Rigel reported Q4 2025 earnings of $13.54 per share on $69.8 million in revenue, both surpassing market expectations, demonstrating effective financial management and cost control, although the outlook remains concerning due to projected declines in revenue.
See More
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- Revenue Growth: Rigel Pharmaceuticals reported total revenues of $69.8 million for Q4 2025, with net product sales reaching $65.4 million, reflecting a 41% increase year-over-year, indicating strong market demand in hematologic disorders and cancer treatments.
- Product Sales Performance: Net product sales for TAVALISSE, GAVRETO, and REZLIDHIA were $45.6 million, $10.2 million, and $9.6 million respectively, representing growth of 47%, 27%, and 29% compared to 2024, demonstrating increasing market acceptance of the company's product line.
- Significant Net Income Increase: Rigel achieved a net income of $268.1 million in Q4 2025, with earnings per share of $14.72, a substantial rise from $14.3 million and $0.81 in the same quarter of 2024, reflecting a marked improvement in the company's profitability.
- Optimistic 2026 Outlook: Rigel anticipates total revenues of approximately $275 to $290 million for 2026 and plans to advance its R289 program, showcasing the company's confidence and strategic positioning for future growth.
See More
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- Revenue Growth: The company achieved Q4 revenues of $69.8 million, reflecting a 21.2% year-over-year increase and exceeding market expectations by $1.1 million, indicating sustained competitiveness of its products in the market.
- Future Outlook: Rigel anticipates total revenues for 2026 to be between $275 million and $290 million, with net product sales projected at $255 million to $265 million and contract revenues at $20 million to $25 million, showcasing confidence in future growth.
- Positive Market Response: Rigel Pharmaceuticals presented its ongoing financial performance and future catalysts at the 44th Annual J.P. Morgan Healthcare Conference, further solidifying its market position in the biopharmaceutical sector.
See More
Rigel Pharmaceuticals to Announce Q4 Earnings on March 3
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- Earnings Estimate Adjustments: Over the past three months, EPS estimates have seen four upward revisions and one downward adjustment, indicating increased analyst confidence in the company's profitability, while revenue estimates have also experienced three upward revisions and one downward, reflecting a positive market outlook for Rigel's future growth.
- Market Reaction Potential: As the earnings report approaches, investor interest in Rigel Pharmaceuticals is rising, particularly against the backdrop of its continued financial performance and potential catalysts in 2026, which could positively impact the stock price and further drive market interest in the company.
- Industry Analysis Perspective: Rigel Pharmaceuticals' short-term performance is supported by Seeking Alpha's Quant Rating, highlighting its attractiveness among small-cap stocks with high short interest, potentially drawing more investor attention to its future strategic developments.
See More
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- Commercial Execution Expertise: Miller previously served as Executive Vice President of U.S. Commercial at Jazz Pharmaceuticals and held senior commercial roles at Vivus and Genentech, and his extensive experience will aid Rigel in achieving its goals of growing its drug portfolio and exploring potential in-licensing opportunities.
- Company Growth Outlook: Miller noted that Rigel has evolved into a profitable company with a strong commercial engine capable of funding a promising development pipeline, a significant advantage in the biotechnology space.
- Commitment to Patient Care: Miller expressed excitement about joining Rigel and is committed to focusing on opportunities to serve more patients with hematologic disorders and cancer, underscoring the company's dedication to improving patient lives.
See More
Rigel Pharmaceuticals Shares Hit Four-Month Low Amid Revenue Decline Projections
- Revenue Decline Projection: Rigel Pharmaceuticals projects a revenue decline for 2026, estimating total revenue between $275 million and $290 million, which represents a ~4% year-over-year drop from last year's $294.3 million, indicating potential challenges ahead for the company's financial health.
- Sharp Drop in Contract Revenue: The company anticipates contract revenue to be between $20 million and $25 million, implying a staggering ~64% year-over-year decline, highlighting significant challenges in its collaborative partnerships that could impact its competitive position in the biotech sector.
- Product Sales Growth: Despite the overall revenue decline, Rigel expects net product sales to reach approximately $255 million to $265 million, reflecting an ~11% year-over-year increase, suggesting strong market demand for its core products, which may provide some financial stability.
- Earnings Exceed Expectations: Rigel reported Q4 2025 earnings of $13.54 per share on $69.8 million in revenue, both surpassing market expectations, demonstrating effective financial management and cost control, although the outlook remains concerning due to projected declines in revenue.
See More
Rigel Pharmaceuticals Reports Strong 2025 Financial Results
- Revenue Growth: Rigel Pharmaceuticals reported total revenues of $69.8 million for Q4 2025, with net product sales reaching $65.4 million, reflecting a 41% increase year-over-year, indicating strong market demand in hematologic disorders and cancer treatments.
- Product Sales Performance: Net product sales for TAVALISSE, GAVRETO, and REZLIDHIA were $45.6 million, $10.2 million, and $9.6 million respectively, representing growth of 47%, 27%, and 29% compared to 2024, demonstrating increasing market acceptance of the company's product line.
- Significant Net Income Increase: Rigel achieved a net income of $268.1 million in Q4 2025, with earnings per share of $14.72, a substantial rise from $14.3 million and $0.81 in the same quarter of 2024, reflecting a marked improvement in the company's profitability.
- Optimistic 2026 Outlook: Rigel anticipates total revenues of approximately $275 to $290 million for 2026 and plans to advance its R289 program, showcasing the company's confidence and strategic positioning for future growth.
See More
Rigel Pharmaceuticals Q4 Earnings Exceed Expectations
- Strong Earnings Report: Rigel Pharmaceuticals reported a Q4 GAAP EPS of $13.54, surpassing expectations by $12.31, which highlights a significant improvement in profitability and boosts investor confidence.
- Revenue Growth: The company achieved Q4 revenues of $69.8 million, reflecting a 21.2% year-over-year increase and exceeding market expectations by $1.1 million, indicating sustained competitiveness of its products in the market.
- Future Outlook: Rigel anticipates total revenues for 2026 to be between $275 million and $290 million, with net product sales projected at $255 million to $265 million and contract revenues at $20 million to $25 million, showcasing confidence in future growth.
- Positive Market Response: Rigel Pharmaceuticals presented its ongoing financial performance and future catalysts at the 44th Annual J.P. Morgan Healthcare Conference, further solidifying its market position in the biopharmaceutical sector.
See More
Rigel Pharmaceuticals to Announce Q4 Earnings on March 3
- Earnings Announcement Schedule: Rigel Pharmaceuticals is set to release its Q4 2023 earnings on March 3 after market close, with consensus EPS estimated at $1.20 and revenue projected at $68.7 million, reflecting a 19.3% year-over-year growth, which will provide crucial insights into the company's financial health.
- Earnings Estimate Adjustments: Over the past three months, EPS estimates have seen four upward revisions and one downward adjustment, indicating increased analyst confidence in the company's profitability, while revenue estimates have also experienced three upward revisions and one downward, reflecting a positive market outlook for Rigel's future growth.
- Market Reaction Potential: As the earnings report approaches, investor interest in Rigel Pharmaceuticals is rising, particularly against the backdrop of its continued financial performance and potential catalysts in 2026, which could positively impact the stock price and further drive market interest in the company.
- Industry Analysis Perspective: Rigel Pharmaceuticals' short-term performance is supported by Seeking Alpha's Quant Rating, highlighting its attractiveness among small-cap stocks with high short interest, potentially drawing more investor attention to its future strategic developments.
See More
Wall Street's First Trading Day of March Outlook
- Middle East Impact: The U.S.-Israeli attack on Iran is likely to ripple through financial markets, with oil prices rising due to geopolitical risk premiums, as Brent crude has surged from the low $60s to around $73, indicating potential for further volatility.
- CrowdStrike Earnings Preview: CrowdStrike is set to report its quarterly results after Tuesday's close, with Wall Street expecting fiscal 2026 Q4 revenue of $1.3 billion and EPS of $1.10, providing CEO George Kurtz an opportunity to highlight the cybersecurity sector's unique position amidst AI disruption fears.
- Broadcom Earnings Expectations: Broadcom will release its earnings on Wednesday, with anticipated fiscal 2026 Q1 revenue of $19.14 billion and EPS of $2.02, as market sentiment remains optimistic about AI chip demand despite concerns over potential disruptions to infrastructure software.
- Costco Quarterly Report: Costco is expected to report its fiscal 2026 Q2 results after Thursday's close, with projected revenue of $69.22 billion and EPS of $4.56, as management will address consumer spending trends and membership renewal rates amid high price pressures.
See More
Rigel Pharmaceuticals Appoints New Board Member
- New Board Member: Rigel Pharmaceuticals has appointed Michael P. Miller to its Board of Directors, bringing over 40 years of commercial and leadership experience in the biotechnology and pharmaceutical industries, which is expected to provide valuable insights for the company's strategic plans.
- Commercial Execution Expertise: Miller previously served as Executive Vice President of U.S. Commercial at Jazz Pharmaceuticals and held senior commercial roles at Vivus and Genentech, and his extensive experience will aid Rigel in achieving its goals of growing its drug portfolio and exploring potential in-licensing opportunities.
- Company Growth Outlook: Miller noted that Rigel has evolved into a profitable company with a strong commercial engine capable of funding a promising development pipeline, a significant advantage in the biotechnology space.
- Commitment to Patient Care: Miller expressed excitement about joining Rigel and is committed to focusing on opportunities to serve more patients with hematologic disorders and cancer, underscoring the company's dedication to improving patient lives.
See More
