Neumora to Launch Phase 1 Trial for Oral Obesity Medication
Written by Emily J. Thompson, Senior Investment Analyst
Updated: Oct 27 2025
0mins
Should l Buy NMRA?
Source: SeekingAlpha
Phase 1 Study Announcement: Neumora Therapeutics plans to initiate a phase 1 study of its oral NLRP3 inhibitor NMRA-215 for diet-induced obesity in Q1 2026.
Weight Loss Results: The company reported significant weight loss results in mouse studies, showing up to 19% weight loss with NMRA-215 as a monotherapy and 26% when combined with semaglutide.
CEO Statement: CEO Paul Berns highlighted that the data indicates NMRA-215 can drive meaningful weight loss and has the potential for incretin-sparing dosing regimens.
Focus on Obesity Program: Neumora is prioritizing its obesity program with NMRA-215 among its upcoming clinical catalysts.
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Analyst Views on NMRA
Wall Street analysts forecast NMRA stock price to rise
8 Analyst Rating
5 Buy
2 Hold
1 Sell
Moderate Buy
Current: 3.250
Low
3.00
Averages
9.33
High
18.00
Current: 3.250
Low
3.00
Averages
9.33
High
18.00
About NMRA
Neumora Therapeutics Inc. is a clinical-stage biopharmaceutical company. The Company's therapeutic pipeline consists of seven clinical and preclinical neuroscience programs that target novel mechanisms of action for a broad range of underserved neuropsychiatric disorders and neurodegenerative diseases. Its advanced product candidate, navacaprant (NMRA-140), is a novel once-daily oral kappa opioid receptor (KOR) antagonist that is being developed for the treatment of depressive disorder (MDD). Navacaprant is being investigated in the KOASTAL pivotal Phase 3 program, evaluating navacaprant monotherapy in patients with moderate to severe MDD. The Company's next advanced product candidate is NMRA-511, which is a highly selective, novel antagonist of the vasopressin 1a receptor (V1aR) being developed for the treatment of agitation associated with dementia due to Alzheimer's disease (AD).
About the author
Emily J. Thompson
Emily J. Thompson, a Chartered Financial Analyst (CFA) with 12 years in investment research, graduated with honors from the Wharton School. Specializing in industrial and technology stocks, she provides in-depth analysis for Intellectia’s earnings and market brief reports.
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- Rising Investor Interest: Despite no new updates, Neumora Therapeutics and BioRestorative Therapies saw increases of 16.02% and 6.90% respectively, indicating broad investor interest and optimism in the biotech sector, which may fuel a wave of investment across the industry.
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